Patents by Inventor Otto D. Hensens

Otto D. Hensens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bis-aryl ethers, compositions containing such compounds and methods of treatment
    Patent number: 5994412
    Abstract: A compound represented by the formula I is disclosed: ##STR1## or a pharmaceutically acceptable salt or hydrate thereof. The compound has inhibitory activity against the oncoprotein Raf.Also included are pharmaceutical compositions, methods of treating cancer, cultures of the producing fungal microorganism and methods of fermentative production of the compound.
    Type: Grant
    Filed: July 2, 1998
    Date of Patent: November 30, 1999
    Assignee: Merck & Co., Inc.
    Inventors: Seok H. Lee, Maria T. Diez, Fernando Pelaez, Marina Mojena Sanchez, M. Dolores Vilella Amils, Hans E. Huber, Denis R. Patrick, Otto D. Hensens, Rosalind G. Jenkins, Leeyuan Huang, Annie Z. Zhao, Deborah L. Zink, Anne Dombrowski, Gerald F. Bills
  • Antifungal agents
    Patent number: 5770587
    Abstract: There are disclosed novel compounds having the formula ##STR1## which exhibit antifungal activity.
    Type: Grant
    Filed: October 21, 1996
    Date of Patent: June 23, 1998
    Assignee: Merck & Co., Inc.
    Inventors: Angela Basilio, Fernando Pelaez, Maria Teresa Diez, Francisca Vicente, Sandra A. Morris, James E. Curotto, Gerald F. Bills, Sarah J. Dreikorn, Otto D. Hensens, Jerrold M. Liesch, Rosalind G. Jenkins, John R. Thompson
  • Antiparasitic agents
    Patent number: 5614546
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: December 20, 1994
    Date of Patent: March 25, 1997
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Indole diterpene alkaloid compounds
    Patent number: 5541208
    Abstract: The present invention relates to compounds of the formula: ##STR1## and the pharmaceutically acceptable salts thereof which are useful as potassium channel antagonists, particularly Maxi-K channel antagonists, and thus useful in treating Alzheimer's Disease and other cognitive disorders. This invention is also related to a method of making the compound of formula (I).
    Type: Grant
    Filed: January 24, 1994
    Date of Patent: July 30, 1996
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Seok H. Lee, Owen B. McManus, Deborah L. Zink
  • Gamma-pyrone-3-acetic acid as an inhibitor or interleukin-1 .beta. inventory enzyme
    Patent number: 5411985
    Abstract: Novel peptidyl derivatives of formula I are found to be potent inhibitors of interleukin-1.beta. converting enzyme (ICE). Compounds of formula I may be useful in the treatment of inflammatory or immune-based diseases of the lung and airways; central nervous system and surrounding membranes; the eyes and ears; joints, bones, and connective tissues; cardiovascular system including the pericardium; the gastrointestinal and urogenital systems; the skin and mucosal membranes. Compounds of formula I are also useful in treating the complications of infection (e.g., gram negative shock) and tumors in which IL 1 functions as an autocrine growth factor or as a mediator of cachexia.
    Type: Grant
    Filed: May 17, 1993
    Date of Patent: May 2, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Otto D. Hensens, Jerrold M. Liesch, Russel B. Lingham, Jon D. Polishook, Michael J. Salvatore, Susan L. Raghoobar
  • Antiparasitic agents
    Patent number: 5399582
    Abstract: There are disclosed novel compounds which are derived from the fermentation of a strain of Nodulisporium sp. The compounds are highly potent ectoparasiticidal, antiparasitic and, insecticidal gents.
    Type: Grant
    Filed: November 1, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Anne W. Dombrowski, Richard G. Endris, Gregory L. Helms, Otto D. Hensens, John G. Ondeyka, Dan A. Ostlind, Jon D. Polishook, Deborah L. Zink
  • Biologically active compounds
    Patent number: 5399587
    Abstract: The present invention relates to novel potassium channel agonists which are useful in activating the calcium activated Maxi-K potassium channel in mammalian neuronal and smooth muscle tissue. The claimed compounds are of the general formula: ##STR1## In addition, a novel microbiological process for producing the claimed compounds is described.
    Type: Grant
    Filed: December 13, 1993
    Date of Patent: March 21, 1995
    Assignee: Merck & Co., Inc.
    Inventors: Maria L. Garcia, Robert A. Giacobbe, Otto D. Hensens, Gregory J. Kaczorowski, Seok H. Lee, Owen B. McManus, Deborah L. Zink
  • Antibiotic agent
    Patent number: 5366880
    Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H or OH and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: May 21, 1993
    Date of Patent: November 22, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Prakash S. Masurekar, David F. Sesin, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
  • Antibiotic agent
    Patent number: 5306708
    Abstract: A new antibiotic cyclic lipopeptide having the formula ##STR1## wherein R is H SEQ ID NO:1 or OH SEQ ID NO:2 and a method of producing is described. The agent has very high activity against human pathogens and is of very low mammalian toxicity.
    Type: Grant
    Filed: December 19, 1990
    Date of Patent: April 26, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, David F. Sesin, Prakash S. Masurekar, Jerrold M. Liesch, Thomas C. Hallada, Otto D. Hensens
  • Antibiotic agents
    Patent number: 5276055
    Abstract: Compounds having the formula ##STR1## wherein R and R.sup.1 may be H or COCH.sub.3 provided that when R.sup.1 is COCH.sub.3, R is COCH.sub.3 are described.
    Type: Grant
    Filed: October 19, 1992
    Date of Patent: January 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Angeles Cabello, Guy Harris, Robert A. Giacobbe, Gregory L. Helms, Otto D. Hensens, Suzanne M. Mandala, E. Tracy T. Jones, Isabel Martin, Walter Rozdilsky
  • Substituted hexahydrobenzopyran derivatives as angiotensin II antagonists
    Patent number: 5276054
    Abstract: Substituted hexahydrobenzopyran derivatives of the Formulae A, B, or C are useful as angiotensin II antagonists: ##STR1##
    Type: Grant
    Filed: October 16, 1992
    Date of Patent: January 4, 1994
    Assignee: Merck & Co., Inc.
    Inventors: Maria T. Diez, Michael A. Goetz, Robert A. Giacobbe, Otto D. Hensens, Leeyan Huang, Isabel Martin, E. Tracy T. Jones, Siobhan Stevens-Miles, Yu L. Kong
  • Antibiotic cyclopeptide fermentation product
    Patent number: 5202309
    Abstract: An antibiotic agent produced by the cultivation of Zalerion arboricola which is a cyclic lipopeptide with very high activity against human pathogens and of very low mammalian toxicity is described. Its production and isolation are also described.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: April 13, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Robert E. Schwartz, Jerrold M. Liesch, Raymond F. White, Otto D. Hensens, Henry Joshua, Dennis M. Schmatz
  • Fermentation analogs of Virginiamycin M.sub.1 to treat panic and anxiety disorder
    Patent number: 5189050
    Abstract: Pharmaceutical compositions containing Virginiamycin M.sub.1 having the Formula: ##STR1## and Virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## are disclosed which are useful in the treatment of panic disorder or anxiety disorder.
    Type: Grant
    Filed: June 3, 1991
    Date of Patent: February 23, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Roger M. Freidinger, Mark G. Bock, Yiu-Kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
  • Antiviral agent
    Patent number: 5183826
    Abstract: An antiviral agent produced by Hypoxylon fragiforme and having the structure: ##STR1## is described. The product has high activity as an HIV protease enzyme inhibitor and is useful in the treatment of diseases in which control of HIV protease activity is desirable.
    Type: Grant
    Filed: September 25, 1990
    Date of Patent: February 2, 1993
    Assignee: Merck & Co., Inc.
    Inventors: Gerald F. Bills, Otto D. Hensens, Lawrence Koupal, Russell B. Lingham, John G. Ondeyka, Deborah L. Zink
  • Antifungal agent
    Patent number: 5164375
    Abstract: A phospholipid having the formula ##STR1## is described. The compound has antifungal properties.
    Type: Grant
    Filed: September 27, 1991
    Date of Patent: November 17, 1992
    Assignee: Merck & Company, Inc.
    Inventors: Frank VanMiddlesworth, Kenneth E. Wilson, Otto D. Hensens, Deborah Zink, Maria B. Lopez
  • Therapeutic virginiamycin M.sub.1 analogs
    Patent number: 5137900
    Abstract: Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.
    Type: Grant
    Filed: January 23, 1991
    Date of Patent: August 11, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Yiu-kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
  • Squalene synthetase inhibitors
    Patent number: 5132320
    Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.
    Type: Grant
    Filed: March 21, 1990
    Date of Patent: July 21, 1992
    Assignee: Merck & Co., Inc.
    Inventors: James D. Bergstrom, Otto D. Hensens, Claude Dufresne, Leeyuan Huang, Janet C. Onishi, Deborah L. Zink
  • Antifungal substances and process for their production
    Patent number: 5130445
    Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds structures are presented based upon analytical studies. The compounds have antifungal activity.
    Type: Grant
    Filed: February 25, 1991
    Date of Patent: July 14, 1992
    Assignee: Merck & Co., Inc.
    Inventors: Richard W. Burg, Jerrold M. Liesch, Otto D. Hensens, Sebastian Hernandez
  • HMG-CoA reductase inhibitors
    Patent number: RE36481
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1##
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 4, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Edward S. Inamine, Otto D. Hensens, David R. Houck, Ta J. Lee, Robert L. Smith, Wasyl Halczenko, George D. Hartman, Gerald E. Stokker
  • HMG-CoA reductase inhibitors
    Patent number: RE36520
    Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##
    Type: Grant
    Filed: November 4, 1998
    Date of Patent: January 18, 2000
    Assignee: Merck & Co., Inc.
    Inventors: Robert L. Smith, Wasyl Halczenko, George D. Hartman, Gerald E. Stokker, Edward S. Inamine, Otto D. Hensens, David R. Houck, Ta Jyh Lee