Patents by Inventor Otto D. Hensens
Otto D. Hensens has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5116870Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as antihypercholesterolemic agents and are represented by the following general structural formula (II): ##STR1##Type: GrantFiled: June 6, 1990Date of Patent: May 26, 1992Assignee: Merck & Co., Inc.Inventors: Robert L. Smith, Wasyl Halczenko, George D. Hartman, Gerald E. Stokker, Edward S. Inamine, Otto D. Hensens, David R. Houck, Ta J. Lee
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Patent number: 5096923Abstract: This invention relates to compounds of structural formula (I): ##STR1## which are squalene synthetase inhibitors and thus useful as cholesterol lowering agents.Type: GrantFiled: March 21, 1990Date of Patent: March 17, 1992Assignee: Merck & Co., Inc.Inventors: James D. Bergstrom, Otto D. Hensens, Leeyuan Huang, Jerrold M. Liesch, Janet C. Onishi, Frank L. Vanmiddlesworth
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Patent number: 5095003Abstract: Cyclic peptides are produced by the controlled aerobic fermentation of Streptomyces silvensis, ATTCC No. 53525 or ATCC No. 53526. These compounds are antagonists of oxytocin and are useful in the treatment of preterm labor and vasopressin and are thus useful in the treatment and prevention of disease states wherein vasopressin may be involved, for example congestive heart failure, hypertension, edema and hyponatremia.Type: GrantFiled: October 23, 1990Date of Patent: March 10, 1992Assignee: Merck & Co., Inc.Inventors: Michael A. Goetz, Lawrence R. Koupal, Cheryl D. Schwartz, Jerrold M. Liesch, Otto D. Hensens, Paul S. Anderson, Roger Freidinger, Douglas J. Pettibone
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Patent number: 5089530Abstract: The fermentation of a fungal organism identified as Chrysosporium meridarium produces a novel binaphthalene compound which is a highly potent antiparasitic, insecticidal, and anthelminthic agent.Type: GrantFiled: August 3, 1990Date of Patent: February 18, 1992Assignee: Merck & Co., Inc.Inventors: Athanasios Tsipouras, Dan A. Ostlind, Otto D. Hensens, Deborah L. Zink
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Patent number: 5064856Abstract: Compound of formulae (I) and (II) are HMG-CoA synthase inhibitors and exhibit antifungal activity.Type: GrantFiled: July 31, 1989Date of Patent: November 12, 1991Assignee: Merck & Co., Inc.Inventors: George M. Garrity, Robert Giacobbe, Michael D. Greenspan, Otto D. Hensens, Henry Joshua, Maria T. D. Matas, Isabel Martin, James A. Milligan, Sagrario M. del Val, Walter Rozdilsky, Janet C. Onishi, Jerrold M. Liesch
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Patent number: 5028537Abstract: There is disclosed a series of macrolides isolated from the fermentation broth of a microorganism identified as MA-5000 which morphological analysis reveals to be a strain of Streptomyces hygroscopicus. The compounds' structures are present based upon analytical studies. The compounds have antifungal activity.Type: GrantFiled: June 6, 1988Date of Patent: July 2, 1991Assignee: Merck & Co. Inc.Inventors: Richard W. Burg, Otto D. Hensens, Jerrold M. Liesch, Sebastian Hernandez, Lucille J. Cole
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Patent number: 5019593Abstract: A mixture of derivatives of 2-amino-3,4,5,14-tetrahydroxy-6-eicosenoic acid has been isolated from a culture medium after cultivation of microorganisms belonging to the genus Aspergillus. The compounds are useful as antifungal agents.Type: GrantFiled: July 29, 1987Date of Patent: May 28, 1991Assignee: Merck & Co., Inc.Inventors: George M. Garrity, Maria B. Lopez, Otto D. Hensens, Richard L. Monaghan, Deborah L. Zink
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Patent number: 5006466Abstract: Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527, while the analog of Formula II is produced by chemical synthesis.Type: GrantFiled: October 26, 1989Date of Patent: April 9, 1991Assignee: Merck & Co., Inc.Inventors: Yiu-kuen T. Lam, Otto D. Hensens, Raymond S. Chang, Cheryl D. Schwartz, Deborah L. Zink
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Patent number: 4952604Abstract: Pyranyl ester compounds isolated from the fermentation of the species Penicillium are described. The compounds are useful as antifungal agents.Type: GrantFiled: May 3, 1989Date of Patent: August 28, 1990Assignee: Merck & Co., Inc.Inventors: Otto D. Hensens, Jerrold M. Liesch, James A. Milligan, Sagrario M. Del Val, Robert E. Schwartz, Carol Wichmann
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Patent number: 4940727Abstract: Novel 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors are useful as anti-hypercholesterolemic agents and are represented by the following general structural formulae (I) and (II): ##STR1##Type: GrantFiled: October 6, 1988Date of Patent: July 10, 1990Assignee: Merck & Co., Inc.Inventors: Edward S. Inamine, Otto D. Hensens, David R. Houck, Ta J. Lee, Robert L. Smith, Wasyl Halczenko, George D. Hartman, Gerald E. Stokker
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Patent number: 4894370Abstract: Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.Type: GrantFiled: March 25, 1988Date of Patent: January 16, 1990Assignee: Merck & Co., Inc.Inventors: Yiu-kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
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Patent number: 4871727Abstract: There are disclosed anti-inflammatory and antidegenerative compounds which are natural products produced by cultivation of sail microorganism L-681,512 under controlled fermentation conditions.Type: GrantFiled: December 21, 1987Date of Patent: October 3, 1989Assignee: Merck & Co, Inc.Inventors: Richard W. Burg, Eugene L. Dulaney, Otto D. Hensens, Jerrold M. Liesch, John G. Ondeyka, Carol F. Wichmann
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Patent number: 4859690Abstract: Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No. 53527. The analog of Formula II is produced by chemical synthesis.Type: GrantFiled: November 21, 1986Date of Patent: August 22, 1989Assignee: Merck & Co., Inc.Inventors: Yiu-kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
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Patent number: 4847284Abstract: A novel pyrrolidinol isolated from the fermentation of Aspergillus ochraceus and certain derivatives thereof are described. The compounds are broad spectrum antifungal agents.Type: GrantFiled: March 23, 1988Date of Patent: July 11, 1989Assignee: Merck & Co., Inc.Inventors: Robert E. Schwartz, Janet C. Onishi, Richard L. Monaghan, Jerrold M. Liesch, Otto D. Hensens
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Patent number: 4816448Abstract: The present invention relates to novel antibacterial compounds referred to herein generally as a thermal isomer of difficidin and thermal isomer of oxydifficidin. Also disclosed is process for preparing, isolating and purifying said compounds.Type: GrantFiled: February 5, 1987Date of Patent: March 28, 1989Assignee: Merck & Co., Inc.Inventors: Kenneth E. Wilson, James E. Flor, Otto D. Hensens, Jerrold M. Liesch, Reamer, Robert A.
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Patent number: 4814324Abstract: The compounds of Formula I are produced by the aerobic fermentation of a fungus of the genus GLIOCLADIUM, ATCC No. 20826. ##STR1## The compounds of Formula I are inhibitors of testosterone 5.alpha.-reductase and are useful in the treatment and prevention of acne, seborrhea, female hirsutism and benign prostatic hypertrophy.Type: GrantFiled: March 6, 1987Date of Patent: March 21, 1989Assignee: Merck & Co., Inc.Inventors: Robert P. Borris, Richard W. Burg, Otto D. Hensens, Leeyuan Huang, Livia Kelemen, Sagrario Mochales
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Patent number: 4806565Abstract: The invention relates to a novel tri-yne carbonate of formula I. Such compound can be produced by isolating it from the fermentation broth of ATCC-53614, ATCC-53615 OR ATCC-53616. The tri-yne carbonate has antifungal activity.Type: GrantFiled: May 26, 1987Date of Patent: February 21, 1989Assignee: Merck & Co., Inc.Inventors: Otto D. Hensens, August J. Kempf, Robert E. Schwartz, Ruth S. Sykes, Carol F. Wichmann, Kenneth E. Wilson, Sheldon B. Zimmerman, Deborah L. Zink
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Patent number: 4762923Abstract: Virginiamycin M.sub.1 having the Formula: ##STR1## and virginiamycin M.sub.1 analogs having the Formulae I-IV: ##STR2## Virginiamycin M.sub.1 and the analogs I-IV are antagonists of cholecystokinin (CCK) and gastrin. Cholecystokinin antagonists are useful as analgesics and in the treatment and prevention of disorders of the gastrointestinal, central nervous and appetite regulatory systems in animals, especially humans. Gastrin antagonists are useful in blocking the receptors for gastrin in humans and may function as agents for the treatment of ulcers, tumors or other gastrointestinal disorders. The compounds of Formulae I-IV are also antibiotics and are useful as antimicrobial agents in animals including man and are useful as food additives to promote feed utilization in animals. Virginiamycin M.sub.1 and the analogs of Formula I, III, and IV are produced by the controlled aerobic fermentation of a strain of Streptomyces olivaceus, ATCC No.Type: GrantFiled: November 21, 1986Date of Patent: August 9, 1988Assignee: Merck & Co. Inc.Inventors: Yiu-Kuen T. Lam, Raymond S. Chang, Otto D. Hensens, Cheryl D. Schwartz, Deborah L. Zink
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Patent number: 4681846Abstract: Process for the preparation of difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.Type: GrantFiled: May 6, 1985Date of Patent: July 21, 1987Assignee: Merck & Co., Inc.Inventors: Kenneth E. Wilson, Richard L. Monaghan, Cheryl DeRiso, Sheldon B. Zimmerman, Otto D. Hensens, James E. Flor, Sagrario M. Del Val, Maria I. M. Fernandez
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Patent number: 4545991Abstract: Difficidin and derivative antibacterial compounds of the formula: ##STR1## where R.sub.a and R.sub.b are members independently selected from the group consisting of hydrogen; alkali metal and alkaline earth metal cations; ammonium; and substituted ammonium; and R.sup.1 is hydrogen or hydroxy.Type: GrantFiled: June 13, 1983Date of Patent: October 8, 1985Assignee: Merck & Co., Inc.Inventors: Sheldon B. Zimmerman, Kenneth E. Wilson, Richard L. Monaghan, Sagrario M. Del Val, Maria I. M. Fernandez, Otto D. Hensens, James E. Flor, Cheryl Deriso