Abstract: Nucleic acids encoding modified FGF-21 polypeptides, optionally containing at least one non-codon encoding a naturally-encoded amino acid, and vectors and cells containing are provided. These nucleic acids can be used to express the modified FGF-21 polypeptide encoded thereby. The expressed FGF-21 polypeptides may be used as therapeutics, e.g., in the treatment of diseases associated with fibrosis.

Abstract: Some noise compensation methods involve receiving microphone signals corresponding to ambient noise from a noise source location in or near an audio environment, determining or estimating a listener position in the audio environment and estimating at least one critical distance, which is a distance from the noise source location at which directly propagated sound pressure is equal to diffuse field sound pressure. Some examples involve estimating whether the listener position is within the at least one critical distance and implementing a noise compensation method for the ambient noise based, at least in part, on an estimate of whether the listener position is within the critical distance.

Abstract: A digital storage stethoscope is provided. The digital storage stethoscope includes a noise canceling microphone apparatus configured to detect an analog signal from a sound generating source, an amplifier electrically connected to the noise canceling microphone apparatus and configured to amplify and add electrical gain to the analog signal from the noise canceling microphone apparatus, an analog to digital converter electrically connected to the amplifier and configured to: a) receive the analog signal, b) convert the analog signal to a digital signal, and c) add digital gain to the digital signal, a controller electrically connected to the converter and configured to receive the digital signal from the converter into a data file, a memory storage electrically connected to the controller for storing the data file, and a data transmitter electrically connected to the controller and being configured to transmit the data file from the controller.

Abstract: Noise compensation method comprising: (a) receiving a content stream including content audio data; (b) receiving first microphone signals from a first device; (c) detecting ambient noise from a noise source location in or near the audio environment; (d) causing a first wireless signal to be transmitted from the first device to a second device, the first wireless signal including instructions for the second device to record an audio segment (e) receiving a second wireless signal from the second device; (f) determining a content stream audio segment time interval for a content stream audio segment; (g) receiving a third wireless signal from the second device, including a recorded audio segment captured via a second device microphone; (h) determining a second device ambient noise signal at the second device location; and (i) implementing a noise compensation method for the content audio data based, at least in part, on the second device ambient noise signal.

Abstract: An apparatus and method of loudspeaker equalization. The method combines default tunings (generated based on a default listening environment) and room tunings (generated based on an end user listening environment) to result in combined tunings that account for differences between the end user listening environment and the default listening environment.

Abstract: Apparatuses, systems, wireless signal transmission devices, tire pressure monitoring system (TPMS) sensors, and methods of using a loop antenna element for wireless signal transmission are disclosed. In a particular embodiment, a TPMS sensor is disclosed that includes one or more sub-sensors configured to sense data associated with a tire. In this embodiment, the TPMS sensor also includes a printed circuit board (PCB) coupled to the one or more sub-sensors. The PCB has a top surface, a bottom surface substantially parallel to the top surface, and an edge surface between the top surface and the bottom surface. According to this embodiment, the TPMS sensor also includes a loop antenna element on the edge surface of the PCB.

Abstract: Noise compensation method comprising: (a) receiving a content stream including content audio data; (b) receiving first microphone signals from a first device; (c) detecting ambient noise from a noise source location in or near the audio environment; (d) causing a first wireless signal to be transmitted from the first device to a second device, the first wireless signal including instructions for the second device to record an audio segment (e) receiving a second wireless signal from the second device; (f) determining a content stream audio segment time interval for a content stream audio segment; (g) receiving a third wireless signal from the second device, including a recorded audio segment captured via a second device microphone; (h) determining a second device ambient noise signal at the second device location; and (i) implementing a noise compensation method for the content audio data based, at least in part, on the second device ambient noise signal.

Abstract: Some noise compensation methods involve receiving microphone signals corresponding to ambient noise from a noise source location in or near an audio environment, determining or estimating a listener position in the audio environment and estimating at least one critical distance, which is a distance from the noise source location at which directly propagated sound pressure is equal to diffuse field sound pressure. Some examples involve estimating whether the listener position is within the at least one critical distance and implementing a noise compensation method for the ambient noise based, at least in part, on an estimate of whether the listener position is within the critical distance.

Abstract: An apparatus and method of loudspeaker equalization. The method combines default tunings (generated based on a default listening environment) and room tunings (generated based on an end user listening environment) to result in combined tunings that account for differences between the end user listening environment and the default listening environment.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: Flight data recorder receives from an aircraft a data stream specifying values for flight data parameters while an aircraft is in flight. The flight data recorder stores the values in a crash survivable non-volatile memory unit of the flight data recorder. The flight data recorder determines an occurrence during flight of an exception condition based on an evaluation of at least one exception parameter. Responsive to determining the occurrence of the exception condition, the flight data recorder wirelessly communicates selected aircraft data to a remote location external of the aircraft using a wireless transmitter under the exclusive control of the flight data recorder.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: In some embodiments, a method for benchmarking an audio processing algorithm (“APA”) while the APA is executed in a manner simulating expected real time execution by a deployed system. Other embodiments include a method including steps of determining a synthetic APA which corresponds to a counterpart APA (intended for real use by a first deployed system), and benchmarking the synthetic APA while it is executed in a manner simulating expected real time execution of the synthetic APA by a contemplated deployed system. Other aspects include a system or device configured to implement any embodiment of the inventive method, or including a memory which stores data indicative of at least one synthetic APA determined in accordance with, or a benchmark generated by, an embodiment of the inventive method or steps thereof, and a computer readable medium which stores code for implementing any embodiment of the inventive method or steps thereof.

Abstract: Embodiments of the invention describe a headworks and dewatering component coupled to an inlet and disposed above a base of the basin, the headworks and dewatering component to include a filtration element to define a flow restriction for solid materials, dewater the solid materials from the wastewater influent, and pass a remainder of the wastewater influent (e.g., to another compartment of a host WWTP container). In one embodiment, the headworks and dewatering component comprises a box shape (i.e., orthogonal polyhedral). In other embodiments, said component may comprise a circular or free-form shape. In one embodiment, the filtration element defines a flow restriction for solid materials based, at least in part, on dimensions of the solid materials. Said filtration element may comprise fabric netting, or metal mesh netting.

Abstract: Modified FGF-21 polypeptides and uses thereof are provided, for example, for the treatment of diseases associated with fibrosis. Modified FGF-21 polypeptides are disclosed that contain an internal deletion and optionally replacement peptide, optionally modified with at least one non-naturally-encoded amino acid, and/or optionally fused to a fusion partner.

Abstract: In some embodiments, a method for benchmarking an audio processing algorithm (“APA”) while the APA is executed in a manner simulating expected real time execution by a deployed system. Other embodiments include a method including steps of determining a synthetic APA which corresponds to a counterpart APA (intended for real use by a first deployed system), and benchmarking the synthetic APA while it is executed in a manner simulating expected real time execution of the synthetic APA by a contemplated deployed system. Other aspects include a system or device configured to implement any embodiment of the inventive method, or including a memory which stores data indicative of at least one synthetic APA determined in accordance with, or a benchmark generated by, an embodiment of the inventive method or steps thereof, and a computer readable medium which stores code for implementing any embodiment of the inventive method or steps thereof.

Abstract: A system receives an indication of selection of an item in a broadcast segment from an end device. A broadcast segment is identified by the selection and a broadcast segment schedule. An item ID is determined using the identified broadcast segment and the broadcast segment schedule, and a corresponding sponsor of the item is determined using the item ID and the identified broadcast segment. An anonymized message, including the item ID and a request for information, is sent to the corresponding sponsor. A reply is received from the corresponding sponsor, and forwarded to an end user contact.

Abstract: Methods of identifying polypeptides have been developed using a de novo sequencing technique. Methods use photodissociation and low-energy fragmentation and the spectra of peptide ions obtained therefrom, such as obtained by post-source decay (PSD), have been developed. The methods include photodissociation and the spectra therefrom obtainable from treating ions with predetermined wavelengths of radiation in the vacuum ultraviolet range of the electromagnetic spectrum. The confidence of amino acid assignments based on x-type ions is evaluated by observing complementary y-, v- and w-type ions that provide additional constraints to sequence identification.