Abstract: A MALDI mass spectrometer has a laser steering assembly operable to steer or otherwise direct movement of a laser focus over the MALDI sample being tested. Such a laser steering assembly may include a mirror array having a pair of independently controlled mirrors. The first of such a pair of mirrors is operable to move the laser focus along the X-axis of the MALDI sample, whereas the second of such a pair of mirrors is operable to move the laser focus along the Y-axis of the MALDI sample. A method of operating a MALDI mass spectrometer is also disclosed.

Abstract: A MALDI mass spectrometer directs a laser shot onto a MALDI sample to generate a sample spectrum which is analyzed to determine if the sample spectrum meets a predetermined criteria. If so, subsequent laser shots are directed to predetermined locations on the MALDI sample. In essence, if the analysis of a previous laser shot indicates that a “sweet spot” of the MALDI sample has be located, subsequent laser shots may be directed to areas proximate to the previous shot thereby allowing the sweet spot to be thoroughly sampled. A method of operating a MALDI mass spectrometer is also disclosed.

Abstract: A remotely activated control device responsive to a specific transmitter operating in a frequency band assigned to radio telephone equipment, such as cellular telephone networks, cordless telephones, etc. The control device includes a radio receiver which provides a received pulse train to an assurance logic circuit. The assurance logic circuit determines if the received pulse train is limited to no more than a transmitter identification code and an action code, the combination of which is less than the code required to activate a relay network or initiate a radio telephone connection. Pulse trains accepted by the assurance logic circuit are compared to a stored code by a comparitor. The stored code includes the identification of a specific transmitter or group of transmitters and at least one action code. If the received pulse train matches the stored code, a switching circuit is activated to control a user supplied device.

Abstract: A device for placement of effluent comprises a substrate positioner, a deposition conduit, and a conduit positioner. The substrate positioner supports and positions a substrate on which effluent exiting from the deposition conduit is to be deposited. The conduit positioner moves an exit end of the deposition conduit relative to the substrate.

Abstract: The present invention provides improved methods, systems, devices and kits for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions where isolation of a lung segment or reduction of lung volume is desired. The methods are minimally invasive with instruments being introduced through the mouth (endotracheally) and rely on isolating the target lung tissue segment from other regions of the lung. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including coupling an aspiration catheter to an inlet port on the obstruction device and aspirating through the port.

Abstract: An easy to clean, flexible plastic mesh thistle seed containing sack provides a broad substantially planar surface for simultaneously viewing a surprisingly large number of colorful birds. Its mesh openings are configured to enable perching of small birds during feeding, and several substantially separated discrete centrally positioned feeding apertures are dimensioned to make it easy for the birds to feed, to keep them at the feeder, and yet without wasting of tiny thistle seed. An opening is formed within an upper portion of the flexible mesh thistle seed containing sack for inserting seed therein, and a closure member is seated over the opening, providing easy access for refilling of seed. The closure member remains seated upon the top of the sack by gravity and yet can be readily displaced upwardly for gaining access to the sack. The closure member at the same time also functions as a bird supporting perch.

Abstract: A computer-implemented system (10) for designing communications circuits includes one or more route plans (16) each with a first route point group (38) for a first circuit end point (34), a second route point group (38) associated with a second circuit end point (34), and one or more routes (32) connecting the first and second route point groups (38). Each route (32) is available for use in designing the circuit. A design engine (12) accesses a particular route plan (16), selects a route (32) according to the route plan (16), and automatically assigns the selected route (32) to the circuit in designing the circuit. The design engine (12) may select the particular route plan (16) from among multiple route plans (16) according to a service application (14) that is automatically derived from an associated circuit order.

Abstract: One illustrative embodiment of a voltage pulser circuit comprises a voltage source producing a first voltage, and a thyratron tube having an anode coupled to the output of the voltage source, a cathode connected to a reference potential and a grid responsive to a grid control voltage to electrically connect the anode to the cathode to thereby cause the first thyratron tube to switch the anode between the first voltage and the reference potential. A pulse-shaping circuit may be connected to the anode of the tube to effectuate desired rise and fall times of the voltage pulses produced by the voltage pulser circuit. Such a voltage pulser circuit is particularly suited for use in connection with the operation of pulsed spectrometer instruments, such as time-of-flight mass spectrometers and the like.

Abstract: Methods, systems, devices and kits for performing lung volume reduction in patients suffering from chronic obstructive pulmonary disease or other conditions using and comprising minimally invasive instruments introduced through the mouth (endotracheally) to isolate a target lung tissue segment from other regions of the lung and reduce lung volume. Isolation is achieved by deploying an obstructive device in a lung passageway leading to the target lung tissue segment. Once the obstructive device is anchored in place, the segment can be aspirated through the device. This may be achieved by a number of methods, including coupling an aspiration catheter to an inlet port on the obstruction device and aspirating through the port. Or, providing the port with a valve which allows outflow of gas from the isolated lung tissue segment during expiration of the respiratory cycle but prevents inflow of air during inspiration. In addition, a number of other methods may be used.

Abstract: A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. Electrostatic time-of-flight calculations are conducted in conjunction with an iterative procedure, preferably a simplex optimization procedure, to thereby minimize a residual error between the electrostatic time-of-flight calculations and the measured time-of-flight data values for each of the known mass values. While conventional curve fitting mass calibration techniques are devoid of information that describe ion behavior, the mass calibration technique of the present invention, by contrast, takes into account all of the instrument operational parameters in arriving at a final calibration.

Abstract: A time-of-flight mass spectra calibration technique uses time-of-flight mass spectrometer instrument operational parameters and known mass and measured time-of-flight data pairs to optimize values of chosen ones of the instrument operational parameters. Electrostatic time-of-flight calculations are conducted in conjunction with an iterative procedure, preferably a simplex optimization procedure, to thereby minimize a residual error between the electrostatic time-of-flight calculations and the measured time-of-flight data values for each of the known mass values. While conventional curve fitting mass calibration techniques are devoid of information that describe ion behavior, the mass calibration technique of the present invention, by contrast, takes into account all of the instrument operational parameters in arriving at a final calibration.

Abstract: A computer-implemented system (10) for designing communications circuits includes one or more route plans (16) each with a first route point group (38) for a first circuit end point (34), a second route point group (38) associated with a second circuit end point (34), and one or more routes (32) connecting the first and second route point groups (38). Each route (32) is available for use in designing the circuit. A design engine (12) accesses a particular route plan (16), selects a route (32) according to the route plan (16), and automatically assigns the selected route (32) to the circuit in designing the circuit. The design engine (12) may select the particular route plan (16) from among multiple route plans (16) according to a service application (14) that is automatically derived from an associated circuit order.

Abstract: An ion mobility and mass spectrometer instrument includes an ion source region coupled to an ion mobility spectrometer having an ion outlet coupled to a quadrupole mass filter. An output of the filter is coupled to a collision cell which has an ion outlet coupled to an ion acceleration region of a mass spectrometer such as a time of flight mass spectrometer. The instrument is particularly well suited for sequencing analysis wherein a sample is ionized and a resulting three-dimensional ion spectrum (ion intensity vs. ion mobility and ion mass) is observed. If the spectrum reveals that no ions overlap in mobility values, the collision cell is filled with a suitable buffer gas and the instrument is reactivated whereby a complete three-dimensional spectrum of parent and daughter ions results.

Abstract: A coherent multiple beam laser system including a plurality of slab lasers and a feedback device responsive to the output of at least one of the slab lasers, for feeding back a portion of the slab laser output to the remaining slab lasers for synchronizing the phase of the outputs of all the slab lasers.

Abstract: A hybrid ion mobility and time-of-flight mass spectrometer includes an ion source region coupled to an ion mobility spectrometer (IMS) which feeds directly into an ion accelerating region of a time-of-flight mass spectrometer (TOFMS). In one embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is perpendicular to the drift tube axis of the IMS. In an alternate embodiment, the TOFMS is positioned relative to the IMS so that the flight tube axis of the TOFMS is non-perpendicular to the drift tube axis of the IMS. In the alternate embodiment, a known quadrupole ion trap is positioned between the IMS and the TOFMS to provide the capability of controlling the injection of ion packets into the TOFMS. The ion source may be a MALDI source, an electrospray ionization source, or an ion trap positioned between the IMS and any known ion source. In each case, the IMS, TOFMS and ion sources are preferably controlled by a computer.

Abstract: A knowledge based planning and analysis system (30) is provided which includes a toolset (32) of expert systems and a knowledge base, or object repository (40). The system (30) assists a user in developing, customizing and analyzing reusable objects which are used to build model businesses. The models include data objects and activity objects which are decomposed in parallel until they can no longer be decomposed or until the process is terminated by the user.

Abstract: A dry bottom ash handling system contemplates a plurality of hoppers disposed beneath a solid fuel-fired steam boiler. Each hopper includes angled walls converging at a generally rectangular opening controlled by a grate door. Air inlets are provided at intersections between adjacent angled walls to (1) facilitate combustion of unburned fuel in the storage hopper, and (2) facilitate flow of ash through the hopper opening. Ash flowing through the hopper opening enters a crusher and is then conveyed via a vacuum line to a point of disposal including a mobile tank truck that receives heavier ash particles and allows bypassing of lighter particles to a silo.

Abstract: A truck is parked adjacent a coal boiler ash recovery unit and includes a first inlet pipe provided to receive ash from the recovery unit and an outlet pipe provided to convey dust from within the storage chamber of the truck to a bag house where the dust is loaded onto another truck. Water spray may be provided within the storage compartment of the first-mentioned truck to moisten the captured material to reduce dusting.

Abstract: A truck is parked adjacent a coal boiler ash recovery unit and includes a first inlet pipe provided to receive ash from the recovery unit and an outlet pipe provided to convey dust from within the storage chamber of the truck to a bag house where the dust is loaded onto another truck. Water spray may be provided within the storage compartment of the first-mentioned truck to moisten the captured material to reduce dusting.

Abstract: An apparatus and method for minimizing ion peak width measurements in a time-of-flight mass spectrometer to thereby minimize the effects of initial ion position distributions and initial ion velocity distributions on the mass resolution of the spectrometer are provided. Where the ion source and ion generation geometries indicate a functional relationship between the initial ion position and initial ion velocity, this relationship is substituted into the time-of-flight equation and the instrument parameters are thereafter optimized to achieve minimization of ion peak width broadening. Experimental results using MALDI indicate reductions in ion peak widths of up to 96% over those observed with traditional MALDI techniques.