Patents by Inventor Pal Rongved
Pal Rongved has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20050002865Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: ApplicationFiled: December 15, 2003Publication date: January 6, 2005Applicant: Amersham Health ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Naevestad, Dagfinn Lovhaug, Halldis Hellebust, Magne Solbakken
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Publication number: 20040230122Abstract: A combined preparation comprising:Type: ApplicationFiled: June 14, 2004Publication date: November 18, 2004Inventors: Morten Eriksen, Jonny Ostensen, Sigmund Frigstad, Pal Rongved
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Patent number: 6811766Abstract: A combined preparation comprising: i) an ultrasound contrast agent capable of accumulation in tissue microvasculature; and ii) a pharamacologically effective amount of a vasodilator drug may be used in perfusion imaging, especially of the myocardium. The contrast agent accumulates in tissue in concentrations related to the regional rate of tissue perfusion, and the vasodilator drug enhances distinction between normally perfused and underperfused tissue.Type: GrantFiled: April 20, 2000Date of Patent: November 2, 2004Assignee: Amersham Health ASInventors: Morten Eriksen, Jonny Østensen, Sigmund Frigstad, Pål Rongved
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Patent number: 6783752Abstract: Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.Type: GrantFiled: December 5, 2001Date of Patent: August 31, 2004Assignee: Amersham Health ASInventors: Jonny Østensen, Morten Eriksen, Sigmund Frigstad, Pål Rongved
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Publication number: 20040146462Abstract: Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations comprise an injectable aqueous medium comprising dispersed gas and an injectable oil-in-water emulsion in which the oil phase comprises a diffusible component capable of diffusion in vivo into the dispersed gas to promote temporary growth thereof, such that material present at the surfaces of the dispersed gas phase and material present at the surfaces of the dispersed oil phase have affinity for each other, e.g. as a result of having opposite charges.Type: ApplicationFiled: November 19, 2003Publication date: July 29, 2004Inventors: Morten Eriksen, Helge Tolleshaug, Roald Skurtveit, Alan Cuthbertson, Jonny Ostensen, Sigmund Frigstad, Pal Rongved
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Publication number: 20040141921Abstract: Ultrasonic visualisation of a suject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.Type: ApplicationFiled: December 5, 2001Publication date: July 22, 2004Inventors: Jonny Ostensen, Morten Eriksen, Sigmund Frigstad, Pal Rongved
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Publication number: 20040141922Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: ApplicationFiled: November 26, 2003Publication date: July 22, 2004Applicant: NYCOMED IMAGING ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Anne Naevestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Lovhaug, Magne Solbakken
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Publication number: 20040131549Abstract: The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.Type: ApplicationFiled: August 13, 2003Publication date: July 8, 2004Applicant: Nycomed Imaging AS.Inventors: Jo Klaveness, Pal Rongved, Per Strande
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Publication number: 20040131548Abstract: The present invention provides contrast agents for use in diagnostic ultrasound studies comprising microbubbles of gas or a gas precursor encapsulated by non-proteinaceous crosslinked or polymerised amphiphilic moieties.Type: ApplicationFiled: May 29, 2003Publication date: July 8, 2004Applicant: Amersham Health ASInventors: Jo Klaveness, Hanno Priebe, Pal Rongved, Lars Stubberud
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Patent number: 6680047Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: GrantFiled: August 10, 2001Date of Patent: January 20, 2004Assignee: Amersham Health ASInventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Nævestad, Dagfinn Løvhaug, Halldis Hellebust, Magne Solbakken
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Patent number: 6662040Abstract: The invention relates to a method of generating an image of an animate human or non-human animal body or part thereof. The method comprises administering to said body a physiologically tolerable contrast agent comprising a radiation absorbing component and/or a pressure inducing component, exposing said body to radiation, detecting pressure waves generated in said body by said radiation and generating an optoacoustic image therefrom of at least a part of said body containing the administered contrast agent.Type: GrantFiled: December 10, 1999Date of Patent: December 9, 2003Assignee: Amersham Health ASInventors: Paul Mark Henrichs, Marten Eriksen, Pal Rongved, Wolfgang Hans Heinrich Gunther, Robert Allen Snow, Kenneth Robert Hollister, Gregory Lynn McIntire, Steven Blair Coffey
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Publication number: 20030202942Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: ApplicationFiled: November 22, 2002Publication date: October 30, 2003Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Publication number: 20030157021Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.Type: ApplicationFiled: November 1, 2002Publication date: August 21, 2003Inventors: Jo Klaveness, Bjorn Fuglaas, Pal Rongved, Edvin Johannesen, Paul Mark Henrichs, Wolfgang Hans Heinrich Gunther, Edward Richard Bacon, John Luke Toner, Gregory Lynn McIntire, Vinay C. Desai
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Publication number: 20030104359Abstract: Separation of target material from a liquid sample is achieved by coupling the target to targetable encapsulated gas microbubbles, allowing the microbubbles and coupled target to float to the surface of the sample to form a floating microbubble/target layer, and separating this layer from the sample. In a positive separation process the microbubbles are then removed from the target, e.g. by bursting. In a negative separation process target-free sample material is recovered following separation of the floating layer. The method may also be used diagnostically to detect the presence of a disease marker in a sample. Novel separation apparatus is also described.Type: ApplicationFiled: November 15, 2002Publication date: June 5, 2003Applicant: NYCOMED IMAGING ASInventors: Alan Cuthbertson, Dagfinn Lovhaug, Hege Fjerdingstad, Pal Rongved, Magne Solbakken, Aslak Godal
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Patent number: 6540981Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.Type: GrantFiled: December 11, 2000Date of Patent: April 1, 2003Assignee: Amersham Health ASInventors: Jo Klaveness, Bjorn Fuglass, Pål Rongved, Edvin Johannesen, Paul Mark Hendrichs, Wolfgang Hans Heinrich Gunther, Edward Richard Bacon, John Luke Toner, Gregory Lynn McIntire, Vinay C. Desai
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Publication number: 20030059373Abstract: Contrast agents comprising microbubble-generating carbohydrate microparticles having a surfactant admixed within the microparticulate structure, with the proviso that the surfactant is not a C10-20 fatty acid, are disclosed. Processes for preparing contrast agents also are disclosed.Type: ApplicationFiled: February 8, 2002Publication date: March 27, 2003Applicant: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Lars Stubberud
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Publication number: 20030031629Abstract: The invention relates to ultrasound contrast agents comprising vesicles comprising a protein capable of formation of gas-containing vesicles, wherein the vesicles contain gas which comprises sulphur hexafluoride or a low molecular weight fluorinated hydrocarbon. These contrast agents exhibit stability in vivo upon administration so as to permit ultrasound visualization while allowing rapid subsequent elimination from the system.Type: ApplicationFiled: February 8, 2002Publication date: February 13, 2003Applicant: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Per Strande
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Publication number: 20020172643Abstract: The present invention provides contrast agents for use in diagnostic ultrasound studies comprising microbubbles of gas or a gas precursor encapsulated by non-proteinaceous crosslinked or polymerised amphiphilic moieties.Type: ApplicationFiled: August 10, 2001Publication date: November 21, 2002Applicant: Nycomed Imaging ASInventors: Jo Klaveness, Hanno Priebe, Pal Rongved, Lars Stubberud
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Publication number: 20020106328Abstract: Ultrasound contrast agents comprising microbubbles of biocompatible gas, e.g. a sulphur halide or a perfluorocarbon, stabilized by opsonisable amphiphilic material, e.g. a membrane-forming lipid such as a phospholipid, especially a negatively charged phospholipid such as a phosphatidylserine, may exhibit prolonged contrast-generating residence time in the liver following intravenous administration.Type: ApplicationFiled: September 13, 2001Publication date: August 8, 2002Inventors: David Johnson, Jonny Ostensen, Morten Eriksen, Audun Tornes, Sigmund Frigstad, Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Publication number: 20020102217Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: ApplicationFiled: August 10, 2001Publication date: August 1, 2002Applicant: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Alan Cuthbertson, Aslak Godal, Lars Hoff, Geir Gogstad, Klaus Bryn, Anne Naevestad, Dagfinn Lovhaug, Halldis Hellebust, Magne Solbakken