Patents by Inventor Pal Rongved
Pal Rongved has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20020102215Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilized by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: ApplicationFiled: January 22, 2001Publication date: August 1, 2002Applicant: NYCOMED IMAGING ASInventors: Jo Klaveness, Pal Rongved, Anders Hogset, Helge Tolleshaug, Anne Naevestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Lovhaug, Magne Solbakken
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Publication number: 20020090341Abstract: The invention provides a method of detecting myocardial ischemia in a human or a non-human body, said method comprising administering to said body a physiologically acceptable manganese complex or salt thereof, subjecting said body to a magnetic resonance imaging procedure capable of generating images with time intervals of less than 0.5 seconds and thereafter providing a series of images of the myocardium of said body whereby to identify regions of abnormal blood flow. The method in accordance with the invention is of use not only in detecting myocardial ischemia, but also in discriminating between reversibly and irreversibly injured myocardial tissues, thereby providing important information about myocardial viability, e.g. during or following a severe heart attack or coronary occlusion. The method of the invention also provides an effective means of monitoring reperfusion of the myocardium.Type: ApplicationFiled: October 12, 2001Publication date: July 11, 2002Applicant: NYCOMED IMAGING ASInventors: Alan David Watson, Michael Wendland, Per Jynge, Jan Olof Karlsson, Heidi Brurok, Pal Rongved, Maythem Saeed
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Patent number: 6375931Abstract: Ultrasonic visualization of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.Type: GrantFiled: April 14, 1999Date of Patent: April 23, 2002Assignee: Nycomed Imaging ASInventors: Jonny Østensen, Morten Eriksen, Sigmund Frigstad, Pål Rongved
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Patent number: 6331289Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, comprising a suspension in an aqueous carrier liquid of a reporter comprising gas-containing or gas-generating material, said agent being capable of forming at least two types of binding pairs with a target.Type: GrantFiled: October 28, 1997Date of Patent: December 18, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Alan Cuthbertson, Lars Hoff, Klaus Bryn, Halldis Hellebust, Magne Solbakken
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Publication number: 20010022963Abstract: The present invention relates to the use of particulate materials as contrast agents in in vivo light imaging.Type: ApplicationFiled: December 11, 2000Publication date: September 20, 2001Applicant: Nycomed Imaging AS, a Oslo, Norway CorporationInventors: Jo Klaveness, Bjorn Fuglass, Pal Rongved, Edvin Johannesen, Paul Mark Henrichs, Wolfgang Hans Heinrich Gunther, Edward Richard Bacon, John Luke Toner, Gregory Lynn McIntire, Vinay C. Desai
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Publication number: 20010019710Abstract: Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.Type: ApplicationFiled: December 5, 2000Publication date: September 6, 2001Applicant: NYCOMED IMAGING ASInventors: Arne Berg, Harald Dugstad, Per Antonius Foss, Jo Klaveness, Jonny Ostensen, Pal Rongved, Per Strande
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Patent number: 6274120Abstract: Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.Type: GrantFiled: October 14, 1999Date of Patent: August 14, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Per Antonius Foss, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jan Solberg, Inger Reidun Fjeldskaar Aukrust
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Publication number: 20010010811Abstract: Microbubble dispersions stabilized by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilized by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: ApplicationFiled: February 15, 2001Publication date: August 2, 2001Inventors: Harald Dugstad, Jo Klaveness, Pal Rongved, Roald Skurtveit, Jorunn Braenden
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Patent number: 6264917Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: GrantFiled: October 28, 1997Date of Patent: July 24, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pål Rongved, Dagfinn Løvhaug
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Patent number: 6261537Abstract: Targetable diagnostic and/or therapeutically active agents, e.g. ultrasound contrast agents, having reporters comprising gas-filled microbubbles stabilised by monolayers of film-forming surfactants, the reporter being coupled or linked to at least one vector.Type: GrantFiled: October 29, 1997Date of Patent: July 17, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pål Rongved, Anders Høgset, Helge Tolleshaug, Anne Nævestad, Halldis Hellebust, Lars Hoff, Alan Cuthbertson, Dagfinn Løvhaug, Magne Solbakken
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Publication number: 20010002993Abstract: Ultrasonic visualisation of a subject, particularly of perfusion in the myocardium and other tissues, is performed using novel gas-containing contrast agent preparations which promote controllable and temporary growth of the gas phase in vivo following administration and can therefore act as deposited perfusion tracers. The preparations include a coadministerable composition comprising a diffusible component capable of inward diffusion into the dispersed gas phase to promote temporary growth thereof. In cardiac perfusion imaging the preparations may advantageously be coadministered with vasodilator drugs such as adenosine in order to enhance the differences in return signal intensity from normal and hypoperfused myocardial tissue respectively.Type: ApplicationFiled: April 14, 1999Publication date: June 7, 2001Inventors: JONNY OSTENSEN, MORTEN ERIKSEN, SIGMUND FRIGSTAD, PAL RONGVED
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Patent number: 6221337Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful as efficacious contrast agents. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: GrantFiled: August 19, 1998Date of Patent: April 24, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jorunn Brænden
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Patent number: 6217850Abstract: Microbubble dispersions stabilised by phospholipids predominantly comprising molecules which individually have an overall net charge exhibit advantageous stability, rendering them useful both as efficacious contrast agents per se and as intermediates in the preparation of contrast agents wherein the phospholipids are crosslinked or polymerised. An improved process for preparing microbubble-containing contrast agents is also disclosed, this comprising lyophilising an aqueous dispersion of gas microbubbles stabilised by one or more membrane-forming lipids to yield a dried product which may be reconstituted in an injectable carrier liquid to generate a microbubble-containing contrast agent.Type: GrantFiled: May 26, 1998Date of Patent: April 17, 2001Assignee: Nycomed Imaging ASInventors: Harald Dugstad, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jorunn Braenden
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Patent number: 6177061Abstract: A contrast agent for use in diagnostic studies, particularly ultrasound imaging, comprising a dispersion in an injectable aqueous medium of a biocompatible azeotropic mixture which is in gaseous form at 37° C., at least one component of said mixture being a halocarbon having a molecular weight of at least 100.Type: GrantFiled: October 21, 1999Date of Patent: January 23, 2001Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Roald Skurtveit, Pål Rongved, Lars Hoff
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Patent number: 5932190Abstract: An x-ray contrast medium containing a multinuclear complex of the formula (M.sub.6 (.mu..sub.3 B).sub.8 A.sub.v).sub.x L.sub.w, wherein M is Mo, W, Re Tc, V, Nb, Ta, Ru, or Fe; .mu..sub.3 B represent a tridentate bridging atom; A is a non-bridging atom; L is a ligand coordinately bonded to at least one M atom; x is a positive integer; and v and w are independently zero or positive integers.Type: GrantFiled: June 7, 1995Date of Patent: August 3, 1999Assignee: Nycomed Salutar, Inc.Inventors: Torsten Almen, Arne Berg, Michael Droege, Harald Dugstad, Jere D. Fellman, Sook-Hui Kim, Jo Klaveness, Scott M. Rocklage, Pal Rongved, Brent Segal, Alan D. Watson
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Patent number: 5827502Abstract: The present invention relates to contrast agents comprising microbubble-generating carbohydrate particles having a surfactant admixed within the microparticulate structure, wherein the microbubbles generated by the microparticles comprise a biocompatible low molecular weight fluorinated hydrocarbon. The contrast agents exhibit useful levels of contrast efficiency and/or stability and may be used in diagnostic applications such as ultrasound and MR imaging.Type: GrantFiled: June 7, 1995Date of Patent: October 27, 1998Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Lars Stubberud
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Patent number: 5718884Abstract: The present invention pertains to proteinaceous gas- or gas precursor-containing microbubble contrast agents for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g., a dialdehyde such as glutaraldehyde or an .alpha.,.beta.-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH. The contrast agents exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.Type: GrantFiled: May 4, 1995Date of Patent: February 17, 1998Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, John Henrik Johansen, Per Antonius Foss, Anders H.o slashed.gset, Anne Marie Hvoslef
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Patent number: 5716598Abstract: There is provided a contrast medium composition for magnetic resonance imaging comprising a physiologically tolerable manganese compound, a physiologically tolerable reducing compound containing an .alpha.-hydroxy ketone group, or salt thereof and a physiologically tolerable carrier or excipient, having a manganese concentration of at least 0.3 mM or being in a dosage unit form containing at least 300 .mu.mol manganese. Such compositions are particularly suitable for imaging of the liver.Type: GrantFiled: June 5, 1995Date of Patent: February 10, 1998Assignee: Nycomed Imaging ASInventors: Klaes Golman, Goran Pettersson, Arne Berg, Jo Klaveness, Pal Rongved, Peter Leander
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Patent number: 5676928Abstract: The invention provides a diagnostic composition for administration to human or animal subjects, the composition containing multilamellar liposomes, optionally together with unilamellar liposomes, the liposomes containing at least one imaging agent and being suspended in an aqueous medium containing said imaging agent, wherein the liposomes comprise a neutral phospholipid and a charged phospholipid, the average particle diameter of the liposomes is 50-3000 nm and the concentration of imaging agent in any aqueous phase filling the interior of the liposomes is substantially the same as that in the aqueous medium in which the liposomes are suspended. The contrast agents concerned are typically X-ray, MRI or ultrasound contrast agents.Type: GrantFiled: June 6, 1995Date of Patent: October 14, 1997Assignees: Nycomed Imaging AS, Daiichi Pharmaceutical Co., Ltd.Inventors: Jo Klaveness, Arne Berg, Trond Vegard Jacobsen, Pal Rongved, Thorfinn Ege, Hiroshi Kikuchi, Kiyoto Yachi
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Patent number: 5674468Abstract: Contrast agents comprising gas-containing or gas-generating polymer microparticles and/or microballoons, in which the polymer is a biodegradable polymer containing units of formula--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(wherein R.sup.1 and R.sup.2 each represent hydrogen or a carbon-attached monovalent organic group or together form a carbon-attached divalent organic group, and m and n are each independently zero or one) may be used in diagnostic applications such as ultrasound and MR imaging.Type: GrantFiled: September 6, 1994Date of Patent: October 7, 1997Assignee: Nycomed Imaging ASInventors: Jo Klaveness, Pal Rongved, Jan Solberg, Per Strande, Unni Nordby Wiggen, Keith Redford