Patents by Inventor Palaniyandi Manivasakam

Palaniyandi Manivasakam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinations for the treatment of rheumatoid arithritis
    Publication number: 20060148770
    Abstract: The invention features a method for treating a patient diagnosed with rheumatoid arthitis by systemically administering an azole and a steroid to the patient. The invention also features a pharmaceutical composition containing an azole and a steroid for the treatment of rheumatoid arthritis.
    Type: Application
    Filed: June 5, 2003
    Publication date: July 6, 2006
    Inventors: Jason Fong, Edward Jost-Price, Curtis Keith, Palaniyandi Manivasakam, Grant Zimmermann, Robyn Sackeyfio, Grant Zimmermann
  • Combinations for the treatment of inflammatory skin disorders
    Publication number: 20060100181
    Abstract: The invention features methods and compositions for the treatment of inflammatory skin conditions.
    Type: Application
    Filed: May 2, 2003
    Publication date: May 11, 2006
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Grant Zimmermann, Jason Fong, Nicole Hurst, Benjamin Auspitz, M Nichols, Curtis Keith
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050271661
    Abstract: The invention involves the treatment, prevention, and reduction of immunoinflammatory disorders involving the combination of an agent that increases the signal activity of a glucocorticoid receptor (e.g., glucocorticoid receptor agonist) and an agent that modulates the signaling activity of one or more signaling pathways selected from the NF-?B pathway, NFAT pathway, AP-1 pathway, and Elk-1 pathway such that proinflammatory cytokine secretion or production, or any other inflammatory response, is reduced. Further, screening methods are provided for identifying candidate compounds and strategies useful for treating, preventing, or reducing such conditions.
    Type: Application
    Filed: May 16, 2005
    Publication date: December 8, 2005
    Applicant: CombinatoRx, Incorporated
    Inventors: Palaniyandi Manivasakam, Edward Jost-Price, Jane Staunton, Curtis Keith
  • Combinations for the treatment of inflammatory disorders
    Patent number: 6955815
    Abstract: The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.
    Type: Grant
    Filed: September 29, 2003
    Date of Patent: October 18, 2005
    Assignee: CombinatoRx, Incorporated
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050192261
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient an antihistamine, either alone or in combination with one or more additional agents. The invention also features a pharmaceutical composition containing an antihistamine in combination with one or more additional agents.
    Type: Application
    Filed: September 14, 2004
    Publication date: September 1, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Bradley Brasher, Brendan Smith, Noah Sachs, Benjamin Auspitz, Todd Chappell, Micheal Slavonic
  • Methods and reagents for the treatment of inflammatory disorders
    Publication number: 20050187203
    Abstract: The invention features a method for treating an immunoinflammatory administering a compound of formula (I), e.g., ibudilast or KC-764, alone or in combination with a corticosteroid, tetra-substituted pyrimidopyrimidine, or other compound. The invention also features pharmaceutical compositions including the combination above for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: November 19, 2004
    Publication date: August 25, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Michael Slavonic, Benjamin Auspitz
  • Methods and reagents for the treatment of inflammatory disorders
    Publication number: 20050187200
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a tricyclic compound and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing a tricyclic compound and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: November 12, 2004
    Publication date: August 25, 2005
    Inventors: Benjamin Auspitz, Alexis Borisy, Jason Fong, Nicole Hurst, Edward Jost-Price, Curtis Keith, Palaniyandi Manivasakam, Robyn Sackeyfio, Michael Slavonic, Brendan Smith, Grant Zimmermann
  • Combinations for the treatment of immunoinflammatory disorders and proliferative skin diseases
    Publication number: 20050159485
    Abstract: The invention features a method for treating a patient who has an immunoinflammatory disorder or a proliferative skin disease, or is at risk for developing an immunoinflammatory disorder or a proliferative skin disease, by administering to the patient a prostaglandin and a retinoid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammatory or dermal/epidermal proliferation.
    Type: Application
    Filed: January 2, 2003
    Publication date: July 21, 2005
    Inventors: Edward Jost-Price, Palaniyandi Manivasakam, Grant Zimmermann, Nicole Hurst, Jason Fong, Curtis Keith, Alexis Borisy
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20050153947
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 20, 2004
    Publication date: July 14, 2005
    Inventors: Mahesh Padval, Edward Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin Auspitz, M. Nichols, Curtis Keith, Grant Zimmerman, Bradley Brasher, Noah Sachs, Todd Chappell
  • Methods and reagents for the treatment of immunoinflammatory disorders
    Publication number: 20050119160
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering to the patient a tetra-substituted pyrimidopyrimidine, either alone or in combination with one or more additional agents. The invention also features a composition containing a tetra-substituted pyrimidopyrimidine in combination with one or more additional agents.
    Type: Application
    Filed: October 15, 2004
    Publication date: June 2, 2005
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmermann, Edward Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael Foley, Michael Slavonic, Brendan Smith, Benjamin Auspitz
  • Combinations for the treatment of inflammatory disorders
    Patent number: 6897206
    Abstract: The invention features a method for treating a patient having an inflammatory disorder, by administering to the patient (i) a tricyclic antidepressant (e.g., amoxapine); and (ii) a corticosteroid (e.g., prednisolone) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit inflammation.
    Type: Grant
    Filed: July 9, 2002
    Date of Patent: May 24, 2005
    Assignee: CombinatoRx, Inc.
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040229849
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 18, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell
  • Combination therapy for the treatment of immunoinflammatory disorders
    Publication number: 20040224876
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering a non-steroidal immunophilin-dependent immunosuppressant (NsIDI) and an NsIDI enhancer (NsIDIE) or analog or metabolite thereof to the patient. The invention also features a pharmaceutical composition containing an NsIDI and NsIDIE or analog or metabolite thereof for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: February 12, 2004
    Publication date: November 11, 2004
    Inventors: Edward Roydon Jost-Price, Bradley B. Brasher, Todd W. Chappell, Palaniyandi Manivasakam, Noah Sachs, Brendan Smith, Benjamin A. Auspitz
  • Methods and reagents for the treatment of diseases and disorders associated with increased levels of proinflammatory cytokines
    Publication number: 20040220153
    Abstract: The invention features a method for treating a patient diagnosed with, or at risk of developing, an immunoinflammatory disorder by administering an SSRI or analog or metabolite thereof and, optionally, a corticosteroid or other compound to the patient. The invention also features a pharmaceutical composition containing an SSRI or analog or metabolite thereof and a corticosteroid or other compound for the treatment or prevention of an immunoinflammatory disorder.
    Type: Application
    Filed: September 24, 2003
    Publication date: November 4, 2004
    Inventors: Edward Roydon Jost-Price, Palaniyandi Manivasakam, Brendan Smith, Jason Fong, Benjamin A. Auspitz, M. James Nichols, Curtis Keith, Grant R. Zimmermann, Bradley B. Brasher, Noah Sachs, Todd W. Chappell
  • Combinations for the treatment of inflammatory disorders
    Publication number: 20040116395
    Abstract: The invention features a pharmaceutical composition that includes amoxapine and a corticosteroid.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 17, 2004
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Combinations for the treatment of inflammatory disorders
    Publication number: 20040110734
    Abstract: The invention features methods and compositions for the treatment of immunonflammatory disorders.
    Type: Application
    Filed: November 19, 2003
    Publication date: June 10, 2004
    Inventors: Robyn Sackeyflo, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy
  • Combinations for the treatment of immunoinflammatory disorders
    Publication number: 20030119786
    Abstract: The invention features a method for treating a patient having an immunoinflammatory disorder, by administering to the patient (i) a tetra-substituted pyrimidopyrimidine, and (ii) a corticosteroid simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit immunoinflammation.
    Type: Application
    Filed: October 4, 2002
    Publication date: June 26, 2003
    Inventors: Curtis Keith, Alexis Borisy, Grant Zimmerman, Edward Roydon Jost-Price, Palaniyandi Manivasakam, Nicole Hurst, Michael A. Foley
  • Combinations for the treatment of inflammatory disorders
    Publication number: 20030078246
    Abstract: The invention features a method for treating a patient having an inflammatory disorder, by administering to the patient (i) a tricyclic antidepressant (e.g., amoxapine); and (ii) a corticosteroid (e.g., prednisolone) simultaneously or within 14 days of each other in amounts sufficient to reduce or inhibit inflammation.
    Type: Application
    Filed: July 9, 2002
    Publication date: April 24, 2003
    Inventors: Robyn Sackeyfio, Jason Fong, Nicole Hurst, Palaniyandi Manivasakam, Edward Roydon Jost-Price, Grant Zimmermann, Curtis Keith, Alexis Borisy