Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: Provided are a display substrate and a display device. The display substrate includes a driving transistor and a storage capacitor, the storage capacitor includes a first electrode plate and a second electrode plate, the second electrode plate is arranged in a same layer as the channel of the driving transistor, the second electrode plate is closer to the base substrate than the first electrode plate, an orthographic projection of the second electrode plate on the base substrate overlaps with an orthographic projection of the pixel opening on the base substrate, the display substrate satisfies a following relationship: a value range of (W*L+S2)*M1/M2 is [0.014, 0.133], and a value range of S2/(W*L) is [2.82, 28.

Abstract: A display substrate includes: a base, and pixel units arranged in an array, each pixel unit including at least two sub-pixels each including: a pixel driving circuit, and a light-emitting element. The light-emitting element includes: a first electrode, a light-emitting layer, and a second electrode arranged on the base sequentially. Each sub-pixel is configured with a corresponding operating voltage transmission line. The pixel driving circuit includes: a driving transistor with a first pole electrically connected to the operating voltage transmission line. Each pixel unit includes two first sub-pixels, one second sub-pixel, and one third sub-pixel. The first operating voltage transmission line is configured to transmit a first operating voltage to both the two first sub-pixels and the one third sub-pixel, the second operating voltage transmission line is configured to transmit a second operating voltage, which is different from the first operating voltage, to the one second sub-pixel.

Abstract: Provided are a display substrate and a display device. The display substrate includes: a base substrate and a plurality of sub-pixels on the base substrate; each sub-pixel includes: a pixel circuit including a storage capacitor including a first electrode plate and a second electrode plate; a light-emitting element; and a pixel definition layer. The sub-pixels include a plurality of openings, orthographic projections of the opening and the second electrode plate on the base substrate are overlapped; the second electrode plate includes a first edge and a second edge extending in the first direction; the opening includes a first edge and a second edge extending in the first direction; the first edge of the second electrode plate is closer to the first edge of the opening; the second edge of the second electrode plates is closer to the second edge of the opening.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The disclosure provides a display panel and a display device. The display panel includes: a base substrate, a transistor array layer, a pixel defining layer, touch electrodes. The area of opening region of first color sub-pixel is smaller than that of opening region of third color sub-pixel, the area of opening region of second color sub-pixel is smaller than that of opening region of third color sub-pixel. An orthogonal projection of second capacitor in first color sub-pixel and an orthogonal projection of touch electrodes have a first auxiliary overlap area, an orthogonal projection of second capacitor in second color sub-pixel and orthogonal projection of the touch electrodes have a second auxiliary overlap area, an orthogonal projection of second capacitor in third color sub-pixel and orthogonal projection of touch electrodes have a third auxiliary overlap area. The first and/or second auxiliary overlap area is larger than the third auxiliary overlap area.

Abstract: A display substrate, a preparation method thereof, and a display apparatus, the display substrate includes a base substrate; a drive circuit layer provided on the base substrate; a light-emitting structure layer provided on a side of the drive circuit layer away from the base substrate, the light-emitting structure layer includes a pixel defining layer and an organic light-emitting layer, the pixel defining layer defines multiple sub-pixel regions and includes a first opening at least partially exposing the drive circuit layer, the organic light-emitting layer is located in the sub-pixel region and is overlapped with the first opening of the pixel defining layer; and a color film structure layer provided on a side of the light-emitting structure layer away from the base substrate, the color film structure layer includes a color film and a black matrix, the black matrix includes a second opening at least partially exposing the first opening.

Abstract: A display device and a driving method thereof. The display device includes a display substrate and at least one optical sensing unit; the display substrate includes a light-emitting region and a plurality of pixel units located in the light-emitting region; wherein the light-emitting region comprises a single-sided light-emitting region and at least one double-sided light-emitting region, and each of the pixel units in the plurality of pixel units comprises a plurality of sub-pixels; and the at least one optical sensing unit corresponds to the at least one double-sided light-emitting region from a non-display side of the display substrate, and configured to sense light emitted by the sub-pixels during operation in the at least one double-sided light-emitting region, and to provide sensing brightness information of the at least one double-sided light-emitting region to perform brightness compensation on the light-emitting region.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A display substrate includes: a base, and pixel units arranged in an array, each pixel unit including at least two sub-pixels each including: a pixel driving circuit, and a light-emitting element. The light-emitting element includes: a first electrode, a light-emitting layer, and a second electrode arranged on the base sequentially. Each sub-pixel is configured with a corresponding operating voltage transmission line. The pixel driving circuit includes: a driving transistor with a first pole electrically connected to the operating voltage transmission line. The operating voltage transmission line is located between a layer structure where a control pole of the driving transistor is located and a layer structure where the first electrode is located. The at least two sub-pixels include: at least one first sub-pixel and at least one second sub-pixel. The first and second sub-pixels are configured with first and second operating voltage transmission lines insulated from each other, respectively.

Abstract: This application provides a spread spectrum clock negotiation method, and a peripheral component interconnect express device and system, to implement dynamic negotiation between a transmit end and a receive end on an SSC capability in the peripheral component interconnect express system. The method includes: A second PCIe device generates first indication information, where the first indication information is used to indicate whether the second PCIe device has a spread spectrum clock capability. The second PCIe device sends the first indication information to a first PCIe device. The first PCIe device determines, based on the first indication information, whether to perform spread spectrum clock on a reference clock of the first PCIe device.

Abstract: The disclosure relates to a cryoablation catheter and a cryoablation system. The cryoablation catheter comprises a catheter body and a freezing unit. The catheter body comprises a cold-source fluid input lumen and a cold-source fluid output lumen, both extending in an axial direction of the catheter body, and the freezing unit is arranged at a distal portion of the catheter body, and comprises a first balloon in fluid communication with the cold-source fluid input lumen and the cold-source fluid output lumen, and a second balloon arranged external to the first balloon with the length of the first balloon being less than the length of the second balloon. When the first balloon and the second balloon are dilated, a cavity is formed between the first balloon and the second balloon, to prevent the energy transfer in a space of the freezing unit corresponding to the cavity.

Abstract: The present invention provides a stable and reliable biosensor (GO-TNA) composed of chemically modified TNA capture probes onto graphene oxide (GO) for detecting and imaging of target nucleic acids in vitro and in vivo, discriminating single nucleobase mismatch and monitoring target miRNA dynamic changes. The TNA capture probes in the invention brings significant improvement by 1000 times in the detection limit when compared to TNA probes itself. This detection platform is facile and cost-effective to prepare, which are critical advantages for real-time analysis, and thus brings new opportunities in the field of disease diagnosis for rapid and accurate detecting and imaging of a variety of disease-related nucleic acid molecules at the in vivo level. Apart from healthcare, they may also lead to potential applications in the areas of environmental analysis and food safety through detection of pesticides, antibiotics, or even foodborne pathogenic agents.

Abstract: A control device includes a memory and a processor. The memory is configured to store a time comparison table. The processor is configured to determine whether a displayed image is a still image. When the displayed image is determined to be a still image, the time comparison table is queried for a corresponding still image judgment duration according to an average pixel level and a type of the still image.

Abstract: Automatic container image registry selection is provided. A predefined number of top performing container image registries is selected from a top of a sorted list of a plurality of container image registries listed in descending order. A cluster of host nodes where a container is deployed is enabled to pull a same container image corresponding to the container utilizing different predefined pulling percentages from the predefined number of top performing container image registries. The cluster of host nodes utilizes a different predefined pulling percentage to pull the same container image from each respective top performing container image registry. A current real time average pulling speed of the cluster of host nodes for the same container image from each respective top performing container image registry of the predefined number of top performing container image registries is recorded over a defined time period.

Abstract: A display substrate and a display device are provided. The display substrate includes functional elements including a functional layer and a pixel-defining pattern. The pixel-defining pattern includes openings and a defining portion. The display substrate includes first regions corresponding to the openings and second regions covered by the defining portion; the second regions include recessed regions, the functional layer includes a portion located in the recessed region and a portion located in a light-exiting region, an area of the recessed region is not greater than that of the light-exiting region, heights of a surface closest to the base substrate of the functional layer located in the recessed region relative to the base substrate and located in the light-exiting region adjacent to the recessed region relative to the base substrate are a first height and a second height, and the first height is not greater than the second height.

Abstract: This application provides a spread spectrum clock negotiation method, and a peripheral component interconnect express device and system, to implement dynamic negotiation between a transmit end and a receive end on an SSC capability in the peripheral component interconnect express system. The method includes: A second PCIe device generates first indication information, where the first indication information is used to indicate whether the second PCIe device has a spread spectrum clock capability. The second PCIe device sends the first indication information to a first PCIe device. The first PCIe device determines, based on the first indication information, whether to perform spread spectrum clock on a reference clock of the first PCIe device.

Abstract: The present disclosure provides a compound having a novel structure as a PRMT5 inhibitor, a method for preparing the compound, and use thereof in the treatment of a disease mediated by a PRMT5 inhibitor. Experiments have shown that these compounds have a strong inhibitory effect on PRMT5, and can be used as promising candidate compounds for treatment of diseases mediated by PRMT5 inhibitors. In addition, a specific synthetic method is developed in the present disclosure, which has a simple process and convenient operation, and is beneficial to industrial mass production and application.

Abstract: Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.