Abstract: The present invention provides compounds of Formula I, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A display panel is provided. The display panel includes a base substrate and a plurality of sub-pixels, each of at least part of the sub-pixels includes a pixel driving circuit and a light-emitting device, the pixel driving circuit includes a first metal pattern, an active pattern and a second metal pattern, and the light-emitting device includes an electrode pattern electrically connected to the second metal pattern, the at least part of the sub-pixels includes a first color sub-pixel and a second color sub-pixel, in the first color sub-pixel, a ratio of an overlapping area of the active pattern and the first metal pattern to an area of the electrode pattern is X1, in the second color sub-pixel, a ratio of an overlapping area of the active pattern and the first metal pattern to an area of the electrode pattern is X2, and ½?X1/X2<1.

Abstract: A display substrate and a display device are provided. The display substrate includes a drive structure layer (131) and a light emitting structure layer that are stacked sequentially on a base substrate (121); the light emitting structure layer includes an anode layer, a pixel definition layer (171), a light emitting functional layer (181) and a cathode layer (191) that are disposed sequentially in a direction away from the base substrate (121); the anode layer includes multiple anodes (24), the pixel definition layer (171) is disposed on a side of the multiple anodes (24) facing away from the base substrate (121) and is provided with multiple pixel openings (172), the pixel openings (172) expose the anodes (24), the light emitting functional layer (181) and the cathode layer (191) are stacked sequentially on a side of the anodes (24) facing away from the base substrate (121).

Abstract: The present invention provides compounds of Formula (I) or (II), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) or (II) to prevent and/or treat immune-related disorders.

Abstract: A rod-spring structured clamping and loosening device for a downhole belt replacement apparatus includes an upper and a lower cylinder fixed seat. The upper and the lower cylinder fixed seat are respectively connected to a first and a second set of pull rods, and each set of the pull rods pass through a first transition plate, a second transition plate, and a third transition plate. A first chuck is mounted on a side of the first transition plate facing the upper cylinder fixed seat, a second chuck is mounted on a side of the third transition plate facing the lower cylinder fixed seat, and the first and the second set of the pull rods are fixed at the first and the second chuck. A disc spring is mounted between the first and the second transition plate, and a jack is mounted between the second and the third transition plate.

Abstract: Provided is a compound having anti-tumor activity and a use thereof. As a PRMT5 inhibitor, the compound has a structure represented by formula (I). Experiments have confirmed that these compounds have strong inhibitory effects on PRMT5 enzyme activity and tumor cell growth, and can be used as promising compounds for treating PRMT5-mediated diseases. Furthermore, a specific synthesis method is further studied. The synthesis method is simple in process, convenient to operate, and beneficial to large-scale industrial production and application.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: At least one embodiment of the present disclosure provides a display panel and a display device, the display panel includes a base substrate; an active layer, a gate electrode and a source-drain electrode layer which are sequentially stacked on the base substrate; a planarization layer, arranged at a side of the source-drain electrode layer away from the base substrate, an orthographic projection of the gate electrode on the base substrate is located within orthographic projections of the source-drain electrode layer and the active layer on the base substrate, in a direction perpendicular to a main surface of the base substrate, a thickness of the source-drain electrode layer is greater than a thickness of the gate electrode, by designing the gate electrode, the source-drain electrode layer and the active layer to have the above structural relationship, the flatness of a planarization layer above the source-drain electrode layer can be improved.

Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: Provided are a display substrate and a display device. The display substrate includes a driving transistor and a storage capacitor, the storage capacitor includes a first electrode plate and a second electrode plate, the second electrode plate is arranged in a same layer as the channel of the driving transistor, the second electrode plate is closer to the base substrate than the first electrode plate, an orthographic projection of the second electrode plate on the base substrate overlaps with an orthographic projection of the pixel opening on the base substrate, the display substrate satisfies a following relationship: a value range of (W*L+S2)*M1/M2 is [0.014, 0.133], and a value range of S2/(W*L) is [2.82, 28.

Abstract: Provided are a display substrate and a display device. The display substrate includes: a base substrate and a plurality of sub-pixels on the base substrate; each sub-pixel includes: a pixel circuit including a storage capacitor including a first electrode plate and a second electrode plate; a light-emitting element; and a pixel definition layer. The sub-pixels include a plurality of openings, orthographic projections of the opening and the second electrode plate on the base substrate are overlapped; the second electrode plate includes a first edge and a second edge extending in the first direction; the opening includes a first edge and a second edge extending in the first direction; the first edge of the second electrode plate is closer to the first edge of the opening; the second edge of the second electrode plates is closer to the second edge of the opening.

Abstract: A display substrate includes: a base, and pixel units arranged in an array, each pixel unit including at least two sub-pixels each including: a pixel driving circuit, and a light-emitting element. The light-emitting element includes: a first electrode, a light-emitting layer, and a second electrode arranged on the base sequentially. Each sub-pixel is configured with a corresponding operating voltage transmission line. The pixel driving circuit includes: a driving transistor with a first pole electrically connected to the operating voltage transmission line. Each pixel unit includes two first sub-pixels, one second sub-pixel, and one third sub-pixel. The first operating voltage transmission line is configured to transmit a first operating voltage to both the two first sub-pixels and the one third sub-pixel, the second operating voltage transmission line is configured to transmit a second operating voltage, which is different from the first operating voltage, to the one second sub-pixel.

Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: The disclosure provides a display panel and a display device. The display panel includes: a base substrate, a transistor array layer, a pixel defining layer, touch electrodes. The area of opening region of first color sub-pixel is smaller than that of opening region of third color sub-pixel, the area of opening region of second color sub-pixel is smaller than that of opening region of third color sub-pixel. An orthogonal projection of second capacitor in first color sub-pixel and an orthogonal projection of touch electrodes have a first auxiliary overlap area, an orthogonal projection of second capacitor in second color sub-pixel and orthogonal projection of the touch electrodes have a second auxiliary overlap area, an orthogonal projection of second capacitor in third color sub-pixel and orthogonal projection of touch electrodes have a third auxiliary overlap area. The first and/or second auxiliary overlap area is larger than the third auxiliary overlap area.

Abstract: A display substrate, a preparation method thereof, and a display apparatus, the display substrate includes a base substrate; a drive circuit layer provided on the base substrate; a light-emitting structure layer provided on a side of the drive circuit layer away from the base substrate, the light-emitting structure layer includes a pixel defining layer and an organic light-emitting layer, the pixel defining layer defines multiple sub-pixel regions and includes a first opening at least partially exposing the drive circuit layer, the organic light-emitting layer is located in the sub-pixel region and is overlapped with the first opening of the pixel defining layer; and a color film structure layer provided on a side of the light-emitting structure layer away from the base substrate, the color film structure layer includes a color film and a black matrix, the black matrix includes a second opening at least partially exposing the first opening.

Abstract: A display device and a driving method thereof. The display device includes a display substrate and at least one optical sensing unit; the display substrate includes a light-emitting region and a plurality of pixel units located in the light-emitting region; wherein the light-emitting region comprises a single-sided light-emitting region and at least one double-sided light-emitting region, and each of the pixel units in the plurality of pixel units comprises a plurality of sub-pixels; and the at least one optical sensing unit corresponds to the at least one double-sided light-emitting region from a non-display side of the display substrate, and configured to sense light emitted by the sub-pixels during operation in the at least one double-sided light-emitting region, and to provide sensing brightness information of the at least one double-sided light-emitting region to perform brightness compensation on the light-emitting region.

Abstract: The present invention provides compounds of Formula I?, or pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods of use thereof for treating cellular proliferative disorders (e.g., cancer).

Abstract: A display substrate includes: a base, and pixel units arranged in an array, each pixel unit including at least two sub-pixels each including: a pixel driving circuit, and a light-emitting element. The light-emitting element includes: a first electrode, a light-emitting layer, and a second electrode arranged on the base sequentially. Each sub-pixel is configured with a corresponding operating voltage transmission line. The pixel driving circuit includes: a driving transistor with a first pole electrically connected to the operating voltage transmission line. The operating voltage transmission line is located between a layer structure where a control pole of the driving transistor is located and a layer structure where the first electrode is located. The at least two sub-pixels include: at least one first sub-pixel and at least one second sub-pixel. The first and second sub-pixels are configured with first and second operating voltage transmission lines insulated from each other, respectively.

Abstract: This application provides a spread spectrum clock negotiation method, and a peripheral component interconnect express device and system, to implement dynamic negotiation between a transmit end and a receive end on an SSC capability in the peripheral component interconnect express system. The method includes: A second PCIe device generates first indication information, where the first indication information is used to indicate whether the second PCIe device has a spread spectrum clock capability. The second PCIe device sends the first indication information to a first PCIe device. The first PCIe device determines, based on the first indication information, whether to perform spread spectrum clock on a reference clock of the first PCIe device.