Abstract: The present disclosure provides a compound having a novel structure as a PRMT5 inhibitor, a method for preparing the compound, and use thereof in the treatment of a disease mediated by a PRMT5 inhibitor. Experiments have shown that these compounds have a strong inhibitory effect on PRMT5, and can be used as promising candidate compounds for treatment of diseases mediated by PRMT5 inhibitors. In addition, a specific synthetic method is developed in the present disclosure, which has a simple process and convenient operation, and is beneficial to industrial mass production and application.

Abstract: Provided are a method and apparatus for transmitting signaling information, a communication node and a storage medium. The method for transmitting signaling information includes the following steps: signaling information is received; and channel state information of M physical uplink channels is determined based on the signaling information, where M is a positive integer greater than 1.

Abstract: A driving circuit, a driving method, a pixel circuit, a display panel and a display device are provided. The driving circuit includes a first switching circuit and a scanning signal generation circuit; the first switching circuit is electrically connected to a first gating control line, at least two data output terminals of a source driver and the scanning signal generation circuit, and is configured to write a data signal provided by the at least two data output terminals into the scanning signal generation circuit under the control of a first gating control signal provided by the first gating control line; the scanning signal generation circuit is configured to generate a scanning signal according to the data signal, and output the scanning signal through the scanning signal output terminal.

Abstract: Embodiments of this application provide a synchronization processing method, apparatus, and device, and a medium. The method includes obtaining a skeleton set and a synchronization task set, the skeleton set being used for storing M blocks to be synchronized by the first node device, the skeleton set comprising P skeletons, the synchronization task set comprising P synchronization tasks, the P skeletons being of a one-to-one correspondence to the P synchronization tasks, and M and P both being positive integers; selecting a second node device from the candidate node set, the second node device being a candidate node device in the candidate node set; concurrently transmitting synchronization tasks in the synchronization task set to the second node device, the second node device performing the synchronization tasks and returning the M blocks; and filling the M blocks into the skeletons in the skeleton set.

Abstract: A display apparatus is provided. The display apparatus includes a display panel having a display portion, a connecting portion, and a bending portion; a main support layer; and an auxiliary support layer including a main portion and a folded-back portion connected to the main portion as a unitary structure. An edge portion of the display apparatus includes a stacked structure. The stacked structure includes the connecting portion; the folded-back portion on the connecting portion; at least a part of the main portion on a side of the folded-back portion away from the connecting portion; a part of the main support layer; and a part of the display portion on a side of the part of the main support layer away from the main portion. Layers of the stacked structure is curved toward a back side of the display apparatus.

Abstract: Provided is a compound represented by formula (I) and a pharmaceutical composition thereof, as well as a method for using a compound represented by formula (I) to prevent and/or treat immune-related disorders.

Abstract: The present invention discloses the inhibitory effect of azvudine as an immunomodulator on mice bearing CT-26 tumor. It is found that azvudine has no significant anti-tumor effect on immunodeficient B-NDG mice bearing CT-26 tumor, yet has an antitumor effect on BALB/c mice with normal immunity bearing CT-26 tumor model. The present invention further studies the combined effect of azvudine and PD-1 antibody, and finds that compared with a single drug, the combined administration has a synergistic anti-tumor effect.

Abstract: A power tool includes an electric motor including a rotor and three-phase stator windings, where the stator windings have a certain electrical conduction angle when the electric motor operates; a driver circuit having multiple semiconductor switching elements; a parameter detection module for detecting a working parameter of the operating electric motor; and a controller electrically connected to at least the driver circuit and the electric motor. The controller is configured to acquire the working parameter; and according to the working parameter, correct the electrical conduction angle of the stator windings of the operating electric motor. A power tool that can accurately detect a commutation point and adjust the conduction angle of the electric motor windings accordingly is provided.

Abstract: An electronic device includes a main support, a first steel sheet, a camera assembly, and a fixation assembly, where the main support is provided with a mounting space, with a first face and a second face that are opposite each other. The first steel sheet is mounted to the first face of the main support and provided with a mounting portion located inside the mounting space. The camera assembly is mounted in the mounting portion, and a fixation assembly is mounted to the second face of the main support to fix the camera assembly in the mounting portion, where a gap is left between the mounting portion and the first face of the main support. The disclosed electronic device can increase space of a downside region of a mainboard, so as to satisfy the need of mounting of components.

Abstract: The present invention discloses a pharmaceutical composition comprising azvudine and a chemotherapeutic agent. The pharmaceutical composition of the present invention shows a good synergistic effect in antitumor, and can reduce the dosage of chemotherapeutic agent, and improve the therapeutic effect and safety, thereby achieving the goal of prolonging the survival of patients.

Abstract: This application discloses a method and apparatus for processing data based on a block chain. The method includes adding transaction data in at least two blocks into an execution queue according to a block height sequence and transaction data sequence numbers; executing contract services and acquiring a read cache and a write cache of a parallel transaction generated by executing each contract service, the at least two pieces of transaction data comprising target transaction data; determining a write cache of a merged transaction in block caches, and acquiring a read cache of an updated transaction; determining a write cache of the transaction to be merged of the target transaction data according to the read cache of the updated transaction; and merging the write cache of the transaction to be merged of the target transaction data into a block cache to which the target transaction data belongs.

Abstract: This application discloses a key generation method and apparatus, a device, and a medium. The method includes transmitting a key negotiation request to a consensus node in a blockchain network, to request a key verification parameter; negotiating a collaboration key pair with a second device to obtain a first private key component and a shared public key in the collaboration key pair; signing the key verification parameter by using the first private key component, to obtain a first signature component; generating transaction data according to the first signature component and the key verification parameter; transmitting the transaction data to the second device. The consensus node performs a consensus on the negotiation result data, and after the negotiation result data passes the consensus, submits the negotiation result data to a blockchain of the blockchain network.

Abstract: The present disclosure provides compounds of Formula (I), pharmaceutical compositions thereof, and methods of using compounds of Formula (I) to prevent and/or treat immune-related disorders.

Abstract: The disclosure provides methods of generating a modulus gradient in a polymeric silicone material, resin mixtures for such methods, and polymeric silicone materials thereof having at least a modulus gradient.

Abstract: An array substrate is provided. The array substrate includes a plurality of first reset signal lines configured to provide a plurality of first reset signals, a plurality of second reset signal lines configured to provide a plurality of second reset signals, a plurality of third reset signal lines, and a plurality of first connecting lines. A respective first reset signal line is connected to a row of first connecting lines, which in turn are connected to source electrodes of first reset transistors in a row of subpixels, respectively. The plurality of second reset signal lines and the plurality of third reset signal lines form an interconnected reset signal supply network. A respective second reset signal line is connected to one or more of the plurality of third reset signal lines. A respective third reset signal line is connected to one or more of the plurality of second reset signal lines.

Abstract: A method for driving a display panel is provided. The method includes receiving image data of a frame of image, the image data including a plurality of initial grayscale values respectively for a plurality of subpixels in the display panel; and converting the image data into a converted image data including a plurality of converted grayscale values respectively for the plurality of subpixels. Converting the image data includes compensating a respective initial grayscale value for a respective subpixel by at least a respective delay-compensating factor to obtain a respective converted grayscale value. With respect to a p-th subpixel and a q-th subpixel respectively connected to a respective data line and having a same initial grayscale values, a p-th delay-compensating factor for the p-th subpixel is greater than a q-th delay-compensating factor for the q-th subpixel.

Abstract: A display panel includes a plurality of sub-pixels, a sub-pixel includes a pixel driving circuit, and the pixel driving circuit includes at least a driving transistor and a storage capacitor. The display panel further includes a substrate, and a first gate conductive layer, a semiconductor layer and a second gate conductive layer that are disposed on the substrate. The first gate conductive layer includes a first electrode plate of the storage capacitor. The semiconductor layer includes an active layer pattern of the driving transistor. At least part of the active layer pattern of the driving transistor and at least part of the first electrode plate are disposed in a same layer. The second gate conductive layer includes a second electrode plate of the storage capacitor and a gate electrode of a driving transistor electrically connected to the second electrode plate.

Abstract: A display substrate includes a base substrate including a display region and a frame region, multiple pixel circuits, first light-emitting elements and at least one first data line, located in a first sub-display region, multiple second light-emitting elements located in a second sub-display region. The display region includes a foldable first display region and second display region each including a first sub-display region and second sub-display region; multiple pixel circuits includes multiple first pixel circuits and second pixel circuits distributed among multiple first pixel circuits; at least one first pixel circuits is connected with at least one of multiple-first light-emitting elements; at least one of multiple second pixel circuits is connected with at least one of multiple second light-emitting elements; the first data line at least includes one sub-data line connected with the first pixel circuit and at least includes another sub-data line connected with the second pixel circuit.

Abstract: A display panel and a display apparatus, including a light emitting structure layer (12), the light emitting structure layer (12) includes a pixel define layer (122). The pixel define layer (122) includes a first dam portion (201) and a second dam portion (202). The first dam portion (201) and the second dam portion (202) are formed a plurality of pixel openings, a distance between a surface of a side of the first dam portion (201) away from the base substrate (10) and a surface of a side of the planarization layer away from the base substrate (10) is smaller than a distance between a surface of a side of the second dam portion (202) away from the base substrate (10) and a surface of a side of the planarization layer away from the base substrate (10).

Abstract: A fluidized bed reactor, a device for preparing low-carbon olefin, and a method for preparing low-carbon olefin are provided. The reaction zone of the fluidized bed reactor is sequentially, from bottom to top, provided with a raw material first distributor, a raw material second distributor and a catalyst distributor; the catalyst distributor is connected with the catalyst second feeding inlet; a dense-phase zone is formed between the raw material first distributor and the raw material second distributor, and the area where the catalyst distributor is located is formed as a catalyst distribution zone connected with the dense-phase zone; and at least one catalyst first feeding inlet(s) is provided on the side wall of reactor of the dense-phase zone. The distribution of the catalyst and the full contact of the catalyst with the raw materials can be achieved using the fluidized bed reactor and the device.