Patents by Inventor Paola Daverio

Paola Daverio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Levalbuterol hydrochloride polymorph B
    Publication number: 20050267216
    Abstract: The invention is directed to levalbuterol HCl Form B and methods of making the same.
    Type: Application
    Filed: May 20, 2005
    Publication date: December 1, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio, Angelo Spreafico, Judith Aronhime, Adrienne Kovacsne-Mezei
  • Preparation of levalbuterol hydrochloride
    Publication number: 20050261368
    Abstract: Provided are processes for the preparation of (R)-SLB.D-DBTA salt and levalbuterol hydrochloride. Also provided are levalbuterol hydrochloride degradation products and processes for preparing them. Pharmaceutical compositions comprising at least one levalbuterol hydrochloride of the invention and at least one pharmaceutically-acceptable excipient are also provided.
    Type: Application
    Filed: May 20, 2005
    Publication date: November 24, 2005
    Inventors: Valeriano Merli, Silvia Mantovani, Stefano Bianchi, Paola Daverio
  • Racemization and enantiomer separation of clopidogrel
    Publication number: 20050049275
    Abstract: Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
    Type: Application
    Filed: October 4, 2004
    Publication date: March 3, 2005
    Inventors: Merli Valeriano, Paola Daverio, Stefano Bianchi
  • Racemization and enantiomer separation of clopidogrel
    Patent number: 6800759
    Abstract: Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
    Type: Grant
    Filed: March 19, 2003
    Date of Patent: October 5, 2004
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Merli Valeriano, Paola Daverio, Stefano Bianchi
  • Racemization and enantiomer separation of clopidogrel
    Patent number: 6737411
    Abstract: Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
    Type: Grant
    Filed: November 22, 2002
    Date of Patent: May 18, 2004
    Assignee: Teva Pharmaceutical Industries Ltd.
    Inventors: Merli Valeriano, Paola Daverio, Stefano Bianchi
  • RACEMIZATION AND ENANTIOMER SEPARATION OF CLOPIDOGREL
    Publication number: 20040024011
    Abstract: Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
    Type: Application
    Filed: November 22, 2002
    Publication date: February 5, 2004
    Inventors: Merli Valeriano, Paola Daverio, Stefano Bianchi
  • Racemization and enantiomer separation of clopidogrel
    Publication number: 20040024012
    Abstract: Processes for separation of enantiomers of clopidogrel, and converting one enantiomer of clopidogrel to another enantiomer of clopidogrel are provided. The enantiomers are separated by crystallizing the (S) enantiomer as camphor sulfonate salt from a hydrocarbon, or a mixture of a hydrocarbon and a co-solvent, preferably DMF:toluene. The (R) enantiomer is then racemized and recycled by reaction with a catalytic amount of a base, preferably with t-butoxide.
    Type: Application
    Filed: March 19, 2003
    Publication date: February 5, 2004
    Inventors: Merli Valeriano, Paola Daverio, Stefano Bianchi