Patents by Inventor Paola Maffei

Paola Maffei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220241193
    Abstract: The invention relates to gel compositions comprising pharmaceutical active ingredients. The composition comprises xyloglucan at a concentration between 0.1% and 10.0% by total weight of the composition, together with a primary alcohol at a concentration between 20.0 and 50.0% by total weight of the composition. The invention also describes a process for the preparation of the composition and its use in the treatment of pathologies wherein a controlled release of the active principle is useful.
    Type: Application
    Filed: June 11, 2020
    Publication date: August 4, 2022
    Applicant: ALFASIGMA S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola MAFFEI, Cristiana Bruno, Mascia Federici, Clelia Dispenza, Maria Antonietta Sabatino
  • Publication number: 20220054440
    Abstract: Provided are orally formulations of diclofenac potassium with improved stability in response to cold conditions, and excellent taste and palatability.
    Type: Application
    Filed: August 31, 2021
    Publication date: February 24, 2022
    Inventors: Giorgio REINER, Alberto REINER, Paola MAFFEI
  • Patent number: 11241452
    Abstract: The present invention describes a mucoadhesive composition comprising chondroitin sulfate, xyloglucan and glycerol for use in the treatment and prevention of gastroesophageal reflux. It is also described a process for preparing such composition, a dosage form for its administration and a kit comprising the same.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: February 8, 2022
    Assignee: ALFASIGMA S.P.A.
    Inventors: Paola Maffei, Marco Mascagni, Giuseppe Claudio Viscomi
  • Patent number: 11123318
    Abstract: Provided are orally formulations of diclofenac potassium with improved stability in response to cold conditions, and excellent taste and palatability.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: September 21, 2021
    Assignee: APR Applied Pharma Research S.A.
    Inventors: Giorgio Reiner, Alberto Reiner, Paola Maffei
  • Publication number: 20210244714
    Abstract: Disclosed herein are methods of treating a patient having an intestinal disorder, the methods comprising: administering to a patient in need thereof a pharmaceutical composition comprising a hydrate or solvate form of rifaximin in polymorphic form ?, alone or in a mixture with other crystalline, hydrate, solvate or amorphous forms of rifaximin, in gastroresistant microgranules, wherein the rifaximin is administered at a dose of at least 800 mg per day for a period of at least 7 days.
    Type: Application
    Filed: September 17, 2020
    Publication date: August 12, 2021
    Applicant: ALFASIGMA S.P.A.
    Inventors: Giuseppe Claudio VISCOMI, Paola MAFFEI, Giuseppe BOTTONI, Maria GRIMALDI
  • Publication number: 20200093772
    Abstract: Provided are orally formulations of diclofenac potassium with improved stability in response to cold conditions, and excellent taste and palatability.
    Type: Application
    Filed: July 30, 2019
    Publication date: March 26, 2020
    Inventors: Giorgio Reiner, Alberto Reiner, Paola Maffei
  • Publication number: 20190388411
    Abstract: Described herein are methods and systems for treatment and/or prevention of conditions associated with NSAID administration and related compositions.
    Type: Application
    Filed: June 28, 2019
    Publication date: December 26, 2019
    Inventors: Giuseppe Claudio VISCOMI, Maria GRIMALDI, Maria Vittoria FOGLI, Paola MAFFEI, Cecilia RENZULLI, Annalisa SFORZINI, Corrado BLANDIZZI, Carmelo SCARPIGNATO
  • Publication number: 20190314402
    Abstract: The present invention describes a mucoadhesive composition comprising chondroitin sulfate, xyloglucan and glycerol for use in the treatment and prevention of gastroesophageal reflux. It is also described a process for preparing such composition, a dosage form for its administration and a kit comprising the same.
    Type: Application
    Filed: September 18, 2018
    Publication date: October 17, 2019
    Applicant: ALFASIGMA S.P.A.
    Inventors: Paola Maffei, Marco Mascagni, Giuseppe Claudio Viscomi
  • Patent number: 10428086
    Abstract: The present invention describes a new crystalline form of rifaximin, characterized in that it is a solvated form of rifaximin called rifaximin ? The invention also describes a process for the preparation of rifaximin ?, a pharmaceutical composition comprising said rifaximin form, and its use for treating inflammations and infections.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: October 1, 2019
    Assignee: ALFASIGMA S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola Maffei, Annalisa Sforzini, Fabrizia Grepioni, Laura Chelazzi
  • Patent number: 10280177
    Abstract: Polyols stabilize polymorphous form of rifaximin, in particular the ? form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ? is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: May 7, 2019
    Assignee: ALFASIGMA S.P.A.
    Inventors: Paola Maffei, Milena Bachetti, Giuseppe Bottoni, Giuseppe Claudio Viscomi
  • Patent number: 10258610
    Abstract: The invention relates generally to pharmaceutical compositions comprising rifaximin effective at treating vaginal infections, and in particular bacterial vaginosis. The pharmaceutical compositions comprising rifaximin granules are characterized in that they release rifaximin in the vagina in a controlled way. The present invention also relates to processes for preparation of the rifaximin pharmaceutical compositions and their use in the treatment of vaginal infections. Effective dosages and courses of treatment useful and effective at recovering from the disease and preventing any possible relapse are also provided.
    Type: Grant
    Filed: July 26, 2012
    Date of Patent: April 16, 2019
    Assignee: ALFASIGMA S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola Maffei, Vittoria Lauro, Fiorella Calanni, Beatrice Vitali, Federica Cruciani
  • Publication number: 20180354971
    Abstract: The present invention describes a new crystalline form of rifaximin, characterized in that it is a solvated form of rifaximin called rifaximin ? The invention also describes a process for the preparation of rifaximin ?, a pharmaceutical composition comprising said rifaximin form, and its use for treating inflammations and infections.
    Type: Application
    Filed: February 27, 2018
    Publication date: December 13, 2018
    Inventors: Giuseppe Claudio VISCOMI, Paola MAFFEI, Annalisa SFORZINI, Fabrizia GREPIONI, Laura CHELAZZI
  • Patent number: 9938298
    Abstract: The present invention describes a new crystalline form of rifaximin, characterized in that it is a solvated form of rifaximin called rifaximin ?. The invention also describes a process for the preparation of rifaximin ?, a pharmaceutical composition comprising said rifaximin form, and its use for treating inflammations and infections.
    Type: Grant
    Filed: May 7, 2015
    Date of Patent: April 10, 2018
    Assignee: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola Maffei, Annalisa Sforzini, Fabrizia Grepioni, Laura Chelazzi
  • Publication number: 20170101417
    Abstract: Polyols stabilize polymorphous form of rifaximin, in particular the ? form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ? is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
    Type: Application
    Filed: May 12, 2016
    Publication date: April 13, 2017
    Inventors: Paola MAFFEI, Milena BACHETTI, Giuseppe BOTTONI, Giuseppe Claudio VISCOMI
  • Publication number: 20170088557
    Abstract: The present invention describes a new crystalline form of rifaximin, characterized in that it is a solvated form of rifaximin called rifaximin ?. The invention also describes a process for the preparation of rifaximin ?, a pharmaceutical composition comprising said rifaximin form, and its use for treating inflammations and infections.
    Type: Application
    Filed: May 7, 2015
    Publication date: March 30, 2017
    Inventors: Giuseppe Claudio VISCOMI, Paola MAFFEI, Annalisa SFORZINI, Fabrizia GREPIONI, Laura CHELAZZI
  • Publication number: 20170071916
    Abstract: Disclosed herein are methods of treating a patient having an intestinal disorder, the methods comprising: administering to a patient in need thereof a pharmaceutical composition comprising a hydrate or solvate form of rifaximin in polymorphic form ?, alone or in a mixture with other crystalline, hydrate, solvate or amorphous forms of rifaximin, in gastroresistant microgranules, wherein the rifaximin is administered at a dose of at least 800 mg per day for a period of at least 7 days.
    Type: Application
    Filed: April 15, 2016
    Publication date: March 16, 2017
    Inventors: Giuseppe Claudio VISCOMI, Paola MAFFEI, Giuseppe BOTTONI, Maria GRIMALDI
  • Patent number: 9498442
    Abstract: The present invention describes rifaximin powder and to a process for preparing the same. The invention relates also to a pharmaceutical composition in solid form comprising said rifaximin, pharmaceutically acceptable excipients and optionally other ingredients. The compositions according to the invention are suitable for oral administration and are characterized by producing a controlled release of rifaximin, whereby a long-lasting effect is obtained in a patient.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: November 22, 2016
    Assignee: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio Viscomi, Paola Maffei, Vittoria Lauro, Maria Barbanti, Donatella Confortini, Dario Braga
  • Publication number: 20150080421
    Abstract: Disclosed herein are methods of treating a patient having an intestinal disorder, the methods comprising: administering to a patient in need thereof a pharmaceutical composition comprising a hydrate or solvate form of rifaximin in polymorphic form ?, alone or in a mixture with other crystalline, hydrate, solvate or amorphous forms of rifaximin, in gastroresistant microgranules, wherein the rifaximin is administered at a dose of at least 800 mg per day for a period of at least 7 days.
    Type: Application
    Filed: April 11, 2014
    Publication date: March 19, 2015
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio VISCOMI, Paola MAFFEI, Giuseppe BOTTONI, Maria GRIMALDI
  • Publication number: 20150072002
    Abstract: Polyols stabilize polymorphous form of rifaximin, in particular the ? form. When polyols having at least two hydroxy groups are added to rifaximin powder, polymorph ? is stable and remains stable in time independently from the environment humidity. In this invention a method to prepare formulations constituted by pure and stable polymorphous forms able to give a pharmaceutical product is described.
    Type: Application
    Filed: April 28, 2014
    Publication date: March 12, 2015
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Paola MAFFEI, Milena BACHETTI, Giuseppe BOTTONI, Giuseppe Claudio VISCOMI
  • Publication number: 20140308350
    Abstract: Described herein are methods and systems for treatment and/or prevention of conditions associated with NSAID administration and related compositions.
    Type: Application
    Filed: April 11, 2014
    Publication date: October 16, 2014
    Applicant: ALFA WASSERMANN S.P.A.
    Inventors: Giuseppe Claudio VISCOMI, Maria GRIMALDI, Maria Vittoria FOGLI, Paola MAFFEI, Cecilia RENZULLI, Annalisa SFORZINI, Corrado BLANDIZZI, Carmelo SCARPIGNATO