Patents by Inventor Paola Vianello

Paola Vianello has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20210300935
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: October 30, 2020
    Publication date: September 30, 2021
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • Indole derivatives as histone demethylase inhibitors
    Patent number: 10980777
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: August 17, 2018
    Date of Patent: April 20, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Anna Cappa, Paola Vianello, Loris Moretti, Luca Sartori, Ciro Mercurio
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10961255
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: March 30, 2021
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro′, Mario Varasi, Luca Sartori, Ciro Mercurio
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200299303
    Abstract: The present invention relates to imidazole derivatives, wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 20, 2019
    Publication date: September 24, 2020
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • INDOLE DERIVATIVES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20200289463
    Abstract: The present application relates to compounds of formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: August 17, 2018
    Publication date: September 17, 2020
    Inventors: Mario VARASI, Anna CAPPA, Paola VIANELLO, Loris MORETTI, Luca SARTORI, Ciro MERCURIO
  • Imidazoles as histone demethylase inhibitors
    Patent number: 10562914
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: February 18, 2020
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Alessia Romussi, Anna Cappa, Paolo Trifiro', Mario Varasi, Luca Sartori, Ciro Mercurio
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20190194214
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: March 4, 2019
    Publication date: June 27, 2019
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • IMIDAZOLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20190152987
    Abstract: The present invention relates to imidazole derivatives of Formula (I), wherein A, R, R1, and R2 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 18, 2017
    Publication date: May 23, 2019
    Inventors: Paola VIANELLO, Alessia ROMUSSI, Anna CAPPA, Paolo TRIFIRO', Mario VARASI, Luca SARTORI, Ciro MERCURIO
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 10280176
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: May 7, 2019
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Cyclopropylamine compounds as histone demethylase inhibitors
    Patent number: 10233165
    Abstract: The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 19, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Mario Varasi, Ciro Mercurio, Anna Cappa, Giuseppe Meroni, Manuela Villa, Antonello Mai, Sergio Valente
  • Thienopyrroles as histone demethylase inhibitors
    Patent number: 10183952
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Grant
    Filed: September 4, 2015
    Date of Patent: January 22, 2019
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Paola Vianello, Luca Sartori, Mario Varasi, Ciro Mercurio, Elisa Zagarri, Anna Cappa, Alessia Romussi, Manuela Villa, Giuseppe Meroni, Loris Moretti
  • Cycloproplyamine derivatives useful as inhibitors of histone demethylases KDM1A
    Patent number: 9944589
    Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Grant
    Filed: December 3, 2013
    Date of Patent: April 17, 2018
    Assignee: Istituto Europeo di Oncologia S.r.l.
    Inventors: Mario Varasi, Paola Vianello, Florian Thaler, Paolo Trifiro′, Ciro Mercurio, Giuseppe Meroni
  • THIENOPYRROLES AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170260197
    Abstract: The present application relates to thienopyrrole derivatives, compounds of Formulas (I) and (Ia), wherein R, R1, R2 and R3 are as defined in the specification, pharmaceutical compositions containing such compounds and to their use in therapy. The compounds of the application can be useful for inhibiting KDM1 and the prevention and/or treatment of cancer, infectious disease, or a disease characterized by aberration of cellular energy metabolism, e.g., obesity.
    Type: Application
    Filed: September 4, 2015
    Publication date: September 14, 2017
    Inventors: Paola VIANELLO, Luca SARTORI, Mario VARASI, Ciro MERCURIO, Elisa ZAGARRI, Anna CAPPA, Alessia ROMUSSI, Manuela VILLA, Giuseppe MERONI, Loris MORETTI
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20170190714
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: March 23, 2017
    Publication date: July 6, 2017
    Inventors: Gabriella TRAQUANDI, Maria Gabriella BRASCA, Roberto D'ALESSIO, Paolo POLUCCI, Fulvia ROLETTO, Anna VULPETTI, Paolo PEVARELLO, Achille PANZERI, Francesca QUARTIERI, Ron FERGUSON, Paola VIANELLO, Daniele FANCELLI
  • CYCLOPROPYLAMINE COMPOUNDS AS HISTONE DEMETHYLASE INHIBITORS
    Publication number: 20170190680
    Abstract: The present disclosure relates to cyclopropyl compounds of general formula (I), wherein R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: May 29, 2015
    Publication date: July 6, 2017
    Inventors: Paola VIANELLO, Mario VARASI, Ciro MERCURIO, Anna CAPPA, Giuseppe MERONI, Manuela VILLA, Antonello MAI, Sergio VALENTE
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 9637497
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: September 6, 2016
    Date of Patent: May 2, 2017
    Assignee: Nerviano Medical Sciences, S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20170050972
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: September 6, 2016
    Publication date: February 23, 2017
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • Pyrazolo-quinazoline derivatives, process for their preparation and their use as kinase inhibitors
    Patent number: 9464090
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 11, 2016
    Assignee: Nerviano Medical Sciences S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli
  • CYCLOPROPYLAMINE DERIVATIVES USEFUL AS INHIBITORS OF HISTONE DEMETHYLASES KDM1A
    Publication number: 20150315126
    Abstract: The present invention relates to cyclopropyl derivatives of general formula (I), wherein A, R1, and R2 are as defined in the specification. The present application also relates to pharmaceutical compositions containing such compounds and to their use in therapy.
    Type: Application
    Filed: December 3, 2013
    Publication date: November 5, 2015
    Inventors: Mario Varasi, Paola Vianello, Florian Thaler, Paolo Trifiro', Ciro Mercurio, Giuseppe Meroni
  • PYRAZOLO-QUINAZOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS KINASE INHIBITORS
    Publication number: 20150158876
    Abstract: Pyrazolo-quinazoline derivatives of formula (Ia) or (Ib) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
    Type: Application
    Filed: February 18, 2015
    Publication date: June 11, 2015
    Applicant: NERVIANO MEDICAL SCIENCES S.R.L.
    Inventors: Gabriella Traquandi, Maria Gabriella Brasca, Roberto D'Alessio, Paolo Polucci, Fulvia Roletto, Anna Vulpetti, Paolo Pevarello, Achille Panzeri, Francesca Quartieri, Ron Ferguson, Paola Vianello, Daniele Fancelli