Abstract: A hosting service enables streamlined scaling of features that relate to data storage management. The scaling is powered by deployment of microservices, each one directed to a discrete feature of a data storage management system. In addition to scaling on demand, the disclosed hosting service provides additional value-added features, such as streamlining intra-system handling, auditing, and reporting of logs generated by microservices; standardizing exception handling; mediating port assignments for co-located microservices to avoid collisions; streamlining formats for inter-microservice communications; streamlining local database access; etc. Advantageously, the disclosed solution off-loads the storage manager, and additionally improves system performance by scaling various functions and by streamlining interoperability among components.

Abstract: A transdermal delivery system is described, where the system comprises a drug reservoir layer comprising an active agent and a skin contact adhesive layer. A microporous membrane that has been pretreated with a membrane treatment composition before the membrane is incorporated into the system is disposed between the drug reservoir layer and the skin contact adhesive layer.

Abstract: Techniques for live event server-side content synchronization are described. According to some examples, a computer-implemented method includes receiving, at a content delivery service, a first live stream of an event and a first timestamp for the first live stream, and a second live stream of the event and a second timestamp for the second live stream; determining, by the content delivery service, a time offset between the first live stream of the event and the second live stream of the event; modifying, by the content delivery service, the second timestamp based at least in part on the time offset to generate a modified second timestamp for the second live stream to align the second live stream with the first live stream; and sending, by the content delivery service, the second live stream and the modified second timestamp to a client device or a storage.

Abstract: Provided herein is a microstructure array comprising a plurality of dissolving microstructures such as microprojections attached to a base. The plurality of microstructures comprise an active agent in a biocompatible and water-soluble matrix, where the water-soluble matrix preferably comprises a polysaccharide polymer and a sugar alcohol, and the base typically comprises a non-water soluble matrix. The plurality of microstructures, upon penetration of the subject's skin, undergo dissolution to deliver the active agent. Also provided are related microstructure formulations, in dried and liquid form, methods for preparing the above-described microstructure arrays, and methods for administering an active agent by application of a microstructure array as provided herein to a subject's skin, among other features.

Abstract: A control application facilitates interactions with, and configurations of, the information management system that manages one or more client computing devices of an information management system. The control application may be implemented using a variety of modules that allow a user to interact with the information management system services in various ways. Using the control application, a user may view a backup status of the information management system, and view the backup status of specific client computing devices that are managed by the information management system. The user may also search for various entities and/or objects within the information management system using the control application. In addition, a user may view the status of one or more backup jobs configured within the information management system, as well as backup plans that have been established for one or more of the client computing devices.

Abstract: A hosting service enables streamlined scaling of features that relate to data storage management. The scaling is powered by deployment of microservices, each one directed to a discrete feature of a data storage management system. In addition to scaling on demand, the disclosed hosting service provides additional value-added features, such as streamlining intra-system handling, auditing, and reporting of logs generated by microservices; standardizing exception handling; mediating port assignments for co-located microservices to avoid collisions; streamlining formats for inter-microservice communications; streamlining local database access; etc. Advantageously, the disclosed solution off-loads the storage manager, and additionally improves system performance by scaling various functions and by streamlining interoperability among components.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: Compositions, devices, and methods for transdermal administration of active agents provided in their salt form instead of neutral form are provided.

Abstract: A method and a drug delivery system for transdermally administering parathyroid hormone (PTH) in a pulsatile fashion are provided, where the drug delivery system comprises an array of microprojections each comprising PTH.

Abstract: A method of forming a master mold (52), comprising: a) forming a plurality of microstructure portions (42) in a substrate formed of a first material by a first micromachining process, each microstructure portion comprising a shaft (40) and a distal tip (38); b) preparing a negative mold (46) of the plurality of microstructure portions, wherein the mold is formed of a second material and comprises a plurality of cavities (48) corresponding to each microstructure portion in the plurality of microstructure portions (42); c) electroplating a metal (50) onto the negative mold to fill each cavity in the plurality of cavities and to form a base layer (54) extending from the negative mold; d) forming a proximal section (56) for each of the microstructures in the base layer using a second micromachining process (e.g. mechanical micromachining); and e) before or after said step d), removing the negative mold from the metal to form a master mold.

Abstract: A microprojection array comprising an approximately planar base and a plurality of microprojections, wherein the array comprises a therapeutic agent that is poorly soluble in water or an aqueous solvent.

Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.

Abstract: A control application facilitates interactions with, and configurations of, the information management system that manages one or more client computing devices of an information management system. The control application may be implemented using a variety of modules that allow a user to interact with the information management system services in various ways. Using the control application, a user may view a backup status of the information management system, and view the backup status of specific client computing devices that are managed by the information management system. The user may also search for various entities and/or objects within the information management system using the control application. In addition, a user may view the status of one or more backup jobs configured within the information management system, as well as backup plans that have been established for one or more of the client computing devices.

Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.

Abstract: In an aspect of the invention, an array of microprotrusions is formed by providing a mold with cavities corresponding to the negative of the microprotrusions, casting atop the mold a first solution comprising a biocompatible material and a solvent, removing the solvent, casting a second solution atop the first cast solution, removing the solvent from the second solution, and demolding the resulting array from the mold. The first solution preferably contains an active ingredient.

Abstract: A hosting service enables streamlined scaling of features that relate to data storage management. The scaling is powered by deployment of microservices, each one directed to a discrete feature of a data storage management system. In addition to scaling on demand, the disclosed hosting service provides additional value-added features, such as streamlining intra-system handling, auditing, and reporting of logs generated by microservices; standardizing exception handling; mediating port assignments for co-located microservices to avoid collisions; streamlining formats for inter-microservice communications; streamlining local database access; etc. Advantageously, the disclosed solution off-loads the storage manager, and additionally improves system performance by scaling various functions and by streamlining interoperability among components.

Abstract: A control application facilitates interactions with, and configurations of, the information management system that manages one or more client computing devices of an information management system. The control application may be implemented using a variety of modules that allow a user to interact with the information management system services in various ways. Using the control application, a user may view a backup status of the information management system, and view the backup status of specific client computing devices that are managed by the information management system. The user may also search for various entities and/or objects within the information management system using the control application. In addition, a user may view the status of one or more backup jobs configured within the information management system, as well as backup plans that have been established for one or more of the client computing devices.

Abstract: A transdermal delivery system for systemic delivery of donepezil is described, where the system comprises an adhesive matrix drug reservoir layer comprised of a copolymer of acrylic acid/vinyl acetate, triethyl citrate, and donepezil base generated in situ by reaction of donepezil HCl and an alkaline salt. The system is provided for treatment of Alzheimer's disease, and achieves transdermal delivery of the therapeutic agent at steady state that is bioequivalent to administration of the therapeutic agent orally.

Abstract: Devices, systems, compositions and methods for long term or prolonged transdermal administration of an active agent are provided.