Patents by Inventor Pathiraja Arachchillage Gunatillake

Pathiraja Arachchillage Gunatillake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10266657
    Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.
    Type: Grant
    Filed: May 10, 2016
    Date of Patent: April 23, 2019
    Assignee: Commonwealth Scientific and Industrial Research Organisation
    Inventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
  • Publication number: 20180346654
    Abstract: The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.
    Type: Application
    Filed: October 28, 2016
    Publication date: December 6, 2018
    Inventors: Pathiraja Arachchillage GUNATILLAKE, Mark BOWN, Raju ADHIKARI
  • Publication number: 20170267803
    Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.
    Type: Application
    Filed: June 1, 2017
    Publication date: September 21, 2017
    Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
  • Patent number: 9695268
    Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: July 4, 2017
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
  • Publication number: 20170119923
    Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.
    Type: Application
    Filed: May 10, 2016
    Publication date: May 4, 2017
    Inventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
  • Patent number: 9540478
    Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: January 10, 2017
    Assignee: POLYNOVO BIOMATERIALS PTY. LIMITED
    Inventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Publication number: 20160375143
    Abstract: The invention relates to branched polymer comprising a support moiety and at least three homopolymer chains each covalently coupled to and extending from the support moiety, wherein the at least three homopolymer chains include a cationic homopolymer chain, a hydrophilic homopolymer chain, and a hydrophobic homopolymer chain.
    Type: Application
    Filed: July 4, 2014
    Publication date: December 29, 2016
    Inventors: Pathiraja Arachchillage GUNATILLAKE, Tracey Michelle HINTON, San Hoa THANG
  • Publication number: 20150246994
    Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.
    Type: Application
    Filed: April 14, 2015
    Publication date: September 3, 2015
    Applicant: Polynovo Biomaterials Pty Limited
    Inventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 9084827
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Grant
    Filed: December 6, 2013
    Date of Patent: July 21, 2015
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Publication number: 20150105530
    Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.
    Type: Application
    Filed: December 17, 2014
    Publication date: April 16, 2015
    Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
  • Publication number: 20150056158
    Abstract: The present invention relates to branched polymer comprising a support moiety and at least three block co-polymer chains covalently coupled to and extending from the moiety, wherein: (i) each of the at least three block co-polymer chains comprise (a) a cationic polymer block that is covalently coupled to a hydrophilic polymer block, or (b) a cationic polymer block that is covalently coupled to a hydrophobic polymer block, said hydrophobic polymer block being covalently coupled to a hydrophilic polymer block; and (ii) at least one of said covalent couplings associated with each of said block co-polymer chains is biodegradable.
    Type: Application
    Filed: February 1, 2013
    Publication date: February 26, 2015
    Inventors: Pathiraja Arachchillage Gunatillake, Tracey Michelle Hinton, San Thang, Mark Leslie Tizard
  • Patent number: 8962786
    Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.
    Type: Grant
    Filed: June 20, 2011
    Date of Patent: February 24, 2015
    Assignee: PolyNovo Biomaterials Pty Ltd
    Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
  • Publication number: 20150024488
    Abstract: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.
    Type: Application
    Filed: June 28, 2012
    Publication date: January 22, 2015
    Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION
    Inventors: Pathiraja Arachchillage Gunatillake, Carlos Gurrero-Sanchez, Tracey Michelle Hinton, San Hoa Thang, Mark Leslie Tizard
  • Patent number: 8729202
    Abstract: The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.
    Type: Grant
    Filed: March 3, 2005
    Date of Patent: May 20, 2014
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Publication number: 20140099277
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Application
    Filed: December 6, 2013
    Publication date: April 10, 2014
    Applicant: POLYNOVO BIOMATERIALS PTY LIMITED
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 8628761
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: January 14, 2014
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 8529880
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Grant
    Filed: October 31, 2012
    Date of Patent: September 10, 2013
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Publication number: 20130150964
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Application
    Filed: October 31, 2012
    Publication date: June 13, 2013
    Applicant: POLYNOVO BIOMATERIALS PTY LIMITED
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
  • Patent number: 8445581
    Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.
    Type: Grant
    Filed: August 2, 2007
    Date of Patent: May 21, 2013
    Assignee: Polynovo Biomaterials Pty Limited
    Inventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
  • Publication number: 20130121969
    Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.
    Type: Application
    Filed: October 31, 2012
    Publication date: May 16, 2013
    Applicant: POLYNOVO BIOMATERIALS PTY LIMITED
    Inventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake