Patents by Inventor Pathiraja Arachchillage Gunatillake
Pathiraja Arachchillage Gunatillake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11053342Abstract: The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.Type: GrantFiled: October 28, 2016Date of Patent: July 6, 2021Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
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Patent number: 10844158Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: June 1, 2017Date of Patent: November 24, 2020Assignee: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
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Patent number: 10723844Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.Type: GrantFiled: March 26, 2019Date of Patent: July 28, 2020Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
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Publication number: 20190284343Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.Type: ApplicationFiled: March 26, 2019Publication date: September 19, 2019Inventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
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Patent number: 10266657Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.Type: GrantFiled: May 10, 2016Date of Patent: April 23, 2019Assignee: Commonwealth Scientific and Industrial Research OrganisationInventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
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Publication number: 20180346654Abstract: The present disclosure provides soft block copolymer segments of Formula 1 for thermoplastic polyurethane or polyurethaneurea elastomer materials and their reaction products with divalent compounds, such as diisocyanates, chain extenders and optional additional polyols or polyamines. Also disclosed herein are methods for the production of the soft block copolymer segments, and possible applications of these materials in the formation of biomaterials for articles including medical devices such as implants, heart valves and drug delivery devices.Type: ApplicationFiled: October 28, 2016Publication date: December 6, 2018Inventors: Pathiraja Arachchillage GUNATILLAKE, Mark BOWN, Raju ADHIKARI
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Publication number: 20170267803Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.Type: ApplicationFiled: June 1, 2017Publication date: September 21, 2017Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
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Patent number: 9695268Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: December 17, 2014Date of Patent: July 4, 2017Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
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Publication number: 20170119923Abstract: A valve in the form of a medical device, article, or implant that is composed wholly or partly of a biomaterial, the biomaterial comprising a polyurethane or polyurethane urea elastomeric composition having a plurality of soft segments and hard segments, such that the plurality of soft segments are each derived from at least one block copolymer segment of Formula 1 and optionally an additional polyol or polyamine. The valve may include a plurality of valve leaflets and a support structure with one or more of the valve leaflets being composed wholly or partly of the biomaterial.Type: ApplicationFiled: May 10, 2016Publication date: May 4, 2017Inventors: Pathiraja Arachchillage Gunatillake, Mark Bown, Raju Adhikari
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Patent number: 9540478Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.Type: GrantFiled: April 14, 2015Date of Patent: January 10, 2017Assignee: POLYNOVO BIOMATERIALS PTY. LIMITEDInventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Publication number: 20160375143Abstract: The invention relates to branched polymer comprising a support moiety and at least three homopolymer chains each covalently coupled to and extending from the support moiety, wherein the at least three homopolymer chains include a cationic homopolymer chain, a hydrophilic homopolymer chain, and a hydrophobic homopolymer chain.Type: ApplicationFiled: July 4, 2014Publication date: December 29, 2016Inventors: Pathiraja Arachchillage GUNATILLAKE, Tracey Michelle HINTON, San Hoa THANG
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Publication number: 20150246994Abstract: This invention relates to biocompatible, biodegradable thermoplastic polyurethane or polyurethane/ureas comprising isocyanate, polyol and a conventional chain extender and/or a chain extender having a hydrolysable linking group and their use in tissue engineering and repair applications, particularly as stents and stent coating.Type: ApplicationFiled: April 14, 2015Publication date: September 3, 2015Applicant: Polynovo Biomaterials Pty LimitedInventors: Timothy G. Moore, Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Patent number: 9084827Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: December 6, 2013Date of Patent: July 21, 2015Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Publication number: 20150105530Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: ApplicationFiled: December 17, 2014Publication date: April 16, 2015Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
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Publication number: 20150056158Abstract: The present invention relates to branched polymer comprising a support moiety and at least three block co-polymer chains covalently coupled to and extending from the moiety, wherein: (i) each of the at least three block co-polymer chains comprise (a) a cationic polymer block that is covalently coupled to a hydrophilic polymer block, or (b) a cationic polymer block that is covalently coupled to a hydrophobic polymer block, said hydrophobic polymer block being covalently coupled to a hydrophilic polymer block; and (ii) at least one of said covalent couplings associated with each of said block co-polymer chains is biodegradable.Type: ApplicationFiled: February 1, 2013Publication date: February 26, 2015Inventors: Pathiraja Arachchillage Gunatillake, Tracey Michelle Hinton, San Thang, Mark Leslie Tizard
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Patent number: 8962786Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: June 20, 2011Date of Patent: February 24, 2015Assignee: PolyNovo Biomaterials Pty LtdInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
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Publication number: 20150024488Abstract: The present invention relates to a complex comprising a cationic block copolymer and a nucleic acid, the cationic block copolymer having at least a tri-block structure comprising a cationic block and two hydrophilic blocks, or a hydrophilic block and two cationic blocks.Type: ApplicationFiled: June 28, 2012Publication date: January 22, 2015Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATIONInventors: Pathiraja Arachchillage Gunatillake, Carlos Gurrero-Sanchez, Tracey Michelle Hinton, San Hoa Thang, Mark Leslie Tizard
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Patent number: 8729202Abstract: The present invention provides a biocompatible polymer composition for use in biomedical applications comprising a base molecule, a linker molecule and at least one initiator compound, said base molecule having at least two differing functionalities, and said linker molecule having a functionality reactive with at least one functionality of said base molecule, the first of said at least two functionalities of said base molecule enabling a first curing stage of said polymer composition by reaction with said linker molecule, and the second and any further functionality of said base molecule enabling second and further curing stages of said polymer composition, said first, second and any further curing stages being capable of activation simultaneously or independently of each other as required.Type: GrantFiled: March 3, 2005Date of Patent: May 20, 2014Assignee: Polynovo Biomaterials Pty LimitedInventors: Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Publication number: 20140099277Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: December 6, 2013Publication date: April 10, 2014Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
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Patent number: 8628761Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: October 31, 2012Date of Patent: January 14, 2014Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake