Patents by Inventor Pathiraja Arachchillage Gunatillake
Pathiraja Arachchillage Gunatillake has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 8529880Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: GrantFiled: October 31, 2012Date of Patent: September 10, 2013Assignee: Polynovo Biomaterials Pty LimitedInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
-
Publication number: 20130150964Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: October 31, 2012Publication date: June 13, 2013Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
-
Patent number: 8445581Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.Type: GrantFiled: August 2, 2007Date of Patent: May 21, 2013Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
-
Publication number: 20130121969Abstract: The present invention relates to biocompatible, biodegradable polyurethane/urea polymeric compositions that are capable of in-vivo curing with low heat generation to form materials suitable for use in scaffolds in tissue engineering applications such as bone and cartilage repair. The polymers are desirably flowable and injectable and can support living biological components to aid in the healing process. They may be cured ex-vivo for invasive surgical repair methods, or alternatively utilized for relatively non-invasive surgical repair methods such as by arthroscope. The invention also relates to prepolymers useful in the preparation of the polymeric compositions, and to methods of treatment of damaged tissue using the polymers of the invention.Type: ApplicationFiled: October 31, 2012Publication date: May 16, 2013Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Raju Adhikari, Pathiraja Arachchillage Gunatillake
-
Patent number: 8357767Abstract: The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%. The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopedic implant, a drug delivery coating or in tissue engineering.Type: GrantFiled: October 3, 2008Date of Patent: January 22, 2013Assignee: Polynovo Biomaterials LimitedInventors: Timothy Graeme Moore, Pathiraja Arachchillage Gunatillake, Raju Adhikari, Shadi Houshyar
-
Publication number: 20110287102Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering. The chain extenders comprise a compound of formula.Type: ApplicationFiled: June 20, 2011Publication date: November 24, 2011Applicant: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
-
Patent number: 7964696Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: GrantFiled: September 20, 2006Date of Patent: June 21, 2011Assignee: Polynovo Biomaterials Pty LimitedInventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
-
Publication number: 20090324675Abstract: The present invention provides a biocompatible prepolymer comprising hydrophilic and hydrophobic segments, wherein the hydrophobic segments have at least one ethylenically unsaturated functional group and at least 5% of the segments have two or more ethylenically unsaturated functional groups and water. The invention further provides a biocompatible prepolymer composition comprising hydrophilic and hydrophobic prepolymers, wherein at least one of the hydrophobic prepolymers has at least one ethylenically unsaturated functional group and at least 5% of the prepolymers have two or more ethylenically unsaturated functional groups and water. The invention further provides use of the prepolymer or prepolymer compositions of the invention in biomedical applications such as tissue engineering, as bone substitutes or scaffolds, and in wound treatment.Type: ApplicationFiled: August 2, 2007Publication date: December 31, 2009Applicant: POLYNOVO BIOMATERIALS PTY LIMITEDInventors: Pathiraja Arachchillage Gunatillake, Roshan Tyrrel Anton Mayadunne, Raju Adhikari, Heng Chy Taing, Tam Phuong Thi Le, Jerome Anthony Werkmeister, John Alan Maurice Ramshaw, Jacinta Frances White, Tracy Ann Tebb
-
Publication number: 20090175921Abstract: The present invention relates to chain extenders, processes for their preparation and their use in the preparation of biocompatible biodegradable polyurethanes and polyurethane ureas for biomedical applications such as stents, scaffolds for tissue engineering.Type: ApplicationFiled: September 20, 2006Publication date: July 9, 2009Inventors: Pathiraja Arachchillage Gunatillake, Timothy Graeme Moore, Raju Adhikari
-
Publication number: 20090099600Abstract: The present invention provides a polyurethane or polyurethane/urea composition which has a tensile strength greater than 10 MPa, a modulus of elasticity greater than 400 MPa and an elongation at break greater than 30% at a temperature of between 0° C. and 60° C. and at a relative humidity of between 0% and 100%. The invention further provides uses of the compositions of the invention in biomedical vascular stents, an orthopaedic implant, a drug delivery coating or in tissue engineering.Type: ApplicationFiled: October 3, 2008Publication date: April 16, 2009Inventors: Timothy Graeme Moore, Pathiraja Arachchillage Gunatillake, Raju Adhikari, Shadi Houshyar
-
Patent number: 7452377Abstract: The invention provides in one form a macromonomer comprising a polysiloxane copolymer having a backbone structure derived from siloxane monomer units that are substituted or unsubstituted arylsiloxanes, arylalkylsiloxanes, alky(alkyl)siloxanes of the general formula —R1R2SiO— and wherein the terminal groups of the copolymer backbone include crosslinkable groups and wherein pendent from the backbone are at least two crosslinkable groups. The macromonomer may be cured in vivo by ultraviolet or visible light. The invention includes intraocular lenses formed by such macromonomers.Type: GrantFiled: July 30, 2003Date of Patent: November 18, 2008Inventors: Jason Watling, Justine Leigh Jeffery, Pathiraja Arachchillage Gunatillake, Timothy Charles Hughes
-
Patent number: 6627724Abstract: The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation-resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissue or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane and at least one polyether and/or polycarbonate macrodiol and processes for its preparation.Type: GrantFiled: December 13, 2000Date of Patent: September 30, 2003Assignee: Aortech Biomaterials PTY LTDInventors: Gordon Francis Meijs, Pathiraja Arachchillage Gunatillake, Simon John McCarthy
-
Publication number: 20030018156Abstract: The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissues or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from about 60 to about 98 wt. % of at least one polysiloxane macrodiol and about 2 to about 40 wt. % of at least one polyether and/or polycarbonate macrodiol and processes for its preparation.Type: ApplicationFiled: December 13, 2000Publication date: January 23, 2003Applicant: Cardiac CRC Nominees Pty Ltd.Inventors: Gordon Francis Meijs, Pathiraja Arachchillage Gunatillake, Simon John McCarthy
-
Patent number: 6313254Abstract: The present invention relates to a material having improved mechanical properties, clarity, processability and/or degradation resistance comprising a polyurethane elastomeric composition which includes a soft segment derived from at least one polysiloxane macrodiol and at least one polyether and/or polycarbonate macrodiol. This material can function as a degradation resistant material or biomaterial and is particularly useful in the manufacture of medical devices, articles or implants which contact living tissues or bodily fluids. The present invention also provides a polyurethane elastomeric composition which includes a soft segment derived from about 60 to 98 wt % of at least one polysiloxane macrodiol and about 2 to 40 wt % of at least one polyether and/or polycarbonate macrodiol and processes for its preparation.Type: GrantFiled: May 17, 1999Date of Patent: November 6, 2001Assignee: Cardiac CRC Nominees PTY LTDInventors: Gordon Francis Meijs, Pathiraja Arachchillage Gunatillake, Simon John McCarthy