Patents by Inventor Patrice A. Lee

Patrice A. Lee has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230190749
    Abstract: Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein.
    Type: Application
    Filed: October 28, 2022
    Publication date: June 22, 2023
    Applicant: Array BioPharma Inc.
    Inventors: Patrice A. Lee, Shannon L. Winski, Kevin Koch
  • Patent number: 11504370
    Abstract: Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein.
    Type: Grant
    Filed: May 2, 2019
    Date of Patent: November 22, 2022
    Assignee: ARRAY BIOPHARMA INC.
    Inventors: Patrice A. Lee, Shannon L. Winski, Kevin Koch
  • Publication number: 20210077463
    Abstract: This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of a MEK inhibitor and a PD-1 axis binding antagonist, or a combination of a MEK inhibitor and a PARP inhibitor, or a combination of a MEK inhibitor and a PD-1 axis binding antagonist and a PARP inhibitor to a patient in need thereof.
    Type: Application
    Filed: December 17, 2018
    Publication date: March 18, 2021
    Inventors: Christoffel Hendrik Boshoff, Rossano Cesari, Cristian Massacesi, Nuzhat Pathan, Patrice A. Lee, Shannon L. Winski
  • Publication number: 20200368205
    Abstract: This invention relates to a method of treating cancer by administering to a patient in need thereof, over a period of time, therapeutic agents that consist essentially of a MEK inhibitor which is binimetinib or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.
    Type: Application
    Filed: January 10, 2018
    Publication date: November 26, 2020
    Inventors: Patrice A. LEE, David CHANTRY, Shannon L. WINSKI
  • Publication number: 20190255051
    Abstract: Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein.
    Type: Application
    Filed: May 2, 2019
    Publication date: August 22, 2019
    Applicant: Array BioPharma Inc.
    Inventors: Patrice A. Lee, Shannon L. Winski, Kevin Koch
  • Publication number: 20190216923
    Abstract: This invention relates to a method of treating cancer by administering to a patient in need thereof, over a period of time, therapeutic agents that consist essentially of a MEK inhibitor which is binimetinib or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.
    Type: Application
    Filed: January 10, 2019
    Publication date: July 18, 2019
    Inventors: Patrice A. Lee, David Chantry, Shannon L. Winski
  • Publication number: 20190211102
    Abstract: This invention relates to a method of treating cancer by administering a combination therapy comprising a combination of CSF-1R inhibitor, which is ARRY-382 or a pharmaceutically acceptable salt thereof, and a PD-1 binding antagonist, to a patient in need thereof.
    Type: Application
    Filed: January 10, 2019
    Publication date: July 11, 2019
    Inventors: Patrice A. Lee, David Chantry, Shannon L. Winski
  • Publication number: 20150110780
    Abstract: Compounds for the treatment of brain cancer are provided herein. Pharmaceutical compositions comprised of those compounds for the treatment of brain cancer are also provided herein.
    Type: Application
    Filed: March 25, 2013
    Publication date: April 23, 2015
    Inventors: Patrice A. Lee, Shannon L. Winski, Kevin Koch
  • Patent number: 8597516
    Abstract: The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Grant
    Filed: October 28, 2010
    Date of Patent: December 3, 2013
    Assignee: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Publication number: 20110040228
    Abstract: The present invention relates to a method and system for using a very large pore hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Application
    Filed: October 28, 2010
    Publication date: February 17, 2011
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Patent number: 7837878
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Grant
    Filed: April 17, 2009
    Date of Patent: November 23, 2010
    Assignee: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Publication number: 20090204050
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Application
    Filed: April 17, 2009
    Publication date: August 13, 2009
    Applicant: IMMUNOCEPT, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Patent number: 7524420
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood. The replacement fluid may include pharmaceutical grade balanced salt solution containing albumin and/or other target receptor molecules and/or other physiological molecules in a sufficient concentration to adequately replenish ongoing losses.
    Type: Grant
    Filed: March 8, 2004
    Date of Patent: April 28, 2009
    Assignee: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Patent number: 7520992
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: April 21, 2009
    Assignee: Imunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Publication number: 20060163138
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Application
    Filed: March 23, 2006
    Publication date: July 27, 2006
    Inventors: David Radunsky, James Matson, Patrice Lee
  • Publication number: 20040199099
    Abstract: A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.
    Type: Application
    Filed: April 16, 2004
    Publication date: October 7, 2004
    Inventors: James R. Matson, Patrice A. Lee
  • Publication number: 20040173530
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Application
    Filed: March 8, 2004
    Publication date: September 9, 2004
    Applicant: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Patent number: 6787040
    Abstract: The present invention relates to a method and system for using a hemofilter to treat IMRD, hepatic failure, exogenous intoxication and other conditions associated with toxins in a patient's blood. One treatment includes the use of a very large pore hemofilter to remove target complex molecules and/or target molecules from a patient's blood and to infuse a replacement fluid into the patient's blood to maintain a prescribed albumin concentration in the patient's blood.
    Type: Grant
    Filed: May 15, 2001
    Date of Patent: September 7, 2004
    Assignee: Immunocept, L.L.C.
    Inventors: David Radunsky, James R. Matson, Patrice A. Lee
  • Publication number: 20040127446
    Abstract: The present invention relates to nucleic acid molecules, including antisense and enzymatic nucleic acid molecules, such as hammerhead ribozymes, DNAzymes, Inozymes, Zinzymes, Amberzymes, and G-cleaver ribozymes, which modulate the synthesis, expression and/or stability of an HCV or HBV RNA and methods for their use alone or in combination with other therapies. In addition, nucleic acid decoy molecules and aptamers that bind to HBV reverse transcriptase and/or HBV reverse transcriptase primer sequences and methods for their use alone or in combination with other therapies, are disclosed. Oligonucleotides that specifically bind the Enhancer I region of HBV DNA are further disclosed. The present invention further relates to the use of nucleic acids, such as decoy and aptamer molecules of the invention, to modulate the expression of Hepatitis B virus (HBV) genes and HBV viral replication.
    Type: Application
    Filed: September 23, 2003
    Publication date: July 1, 2004
    Inventors: Lawrence Blatt, Dennis Macejak, James McSwiggen, David Morrissey, Pamela Pavco, Patrice Lee, Kenneth Draper, Elisabeth Roberts
  • Patent number: 6730266
    Abstract: A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: May 4, 2004
    Assignee: Immunocept, L.L.C.
    Inventors: James R. Matson, Patrice A. Lee