Abstract: The invention relates to needleless syringe for injecting an active liquid principle. The inventive syringe comprises a container (3) closed by a movable shutter and containing the injectable liquid. Said container is initially insulated from an injector-receptacle provided with a cylinder bore (10) in which a downstream shutter is arranged and which comprises at least one protuberance reducing the section with respect to the upstream opening of the bore. The aim of said invention is to damp and prevent the downstream shutter bounce when it is disposed in the bore (10) of the receptacle.

Abstract: The technical field of the invention is that of prefilled and disposable needleless injection devices functioning with a gas generator and used for intradermal, subcutaneous and intramuscular injections. The invention relates to a needleless injection device (1) comprising a pyrotechnic gas generator (2), at least one piston (13, 14), a reserve of liquid active principle (9), and an injection nozzle (11). The principal characteristic of this device is that said generator (2) comprises a pyrotechnic charge (4) composed of a central energetic material which is surrounded by a second peripheral energetic material, the two energetic materials having different rates of combustion.

Abstract: The technical field of the invention is that of needleless syringes used for intradermal, subcutaneous or intramuscular injections of active principle for therapeutic purposes. More particularly, the invention concerns a needleless syringe (10) comprising a propelling system, the active principle and an application guide (8), mainly characterised in that the propelling system consists of an impact wave generating device (3) and the active principle is arranged in at least a blind cavity (7) of the downstream surface (6) of a barrier (4) extended by the application guide (8). Thus, the active principle is expelled in the form of streamlined jets, driven at very high speed.

Abstract: The invention relates to the realm of needleless syringes used for injecting liquid active substances. Said syringe comprises a reservoir that is enclosed by means of displaceable plugs which trap the liquid. The reservoir is initially isolated from an injector-receptacle (37) which is provided with at least two peripheral injection conduits (38) that are arranged outside the receptacle (37). Said receptacle (37) encompasses a pocket bore (31) which accommodates the plug located downstream such that the optimized inlets (39) of the conduits are unobstructed. The face of the receptacle (37), which is located upstream, comprises a multilobed sealing joint (34) which is disposed parallel to and as close as possible to the edges of the bore (31) and the inlets (39). The aim of the invention is to create an injector-receptacle (37) that is optimized regarding discharging and the resistance thereof to the injection pressure.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurised for injection.

Abstract: The invention relates to a method of assembling a needleless injection device (1), whereby a plurality of elements forming a circuit of elements is assembled to a body (2). The aforementioned circuit comprises elements such as an initiation device, a receptacle (5) containing an active agent to be injected, and an active agent injection system. The inventive method is characterised in that it comprises a step in which a gas-generating cartridge (6), which is adapted to the nature and/or quantity of active agent to be injected as well as to the skin penetration depth desired for same, is inserted directly into the circuit of elements, independently of said elements, from outside the body (2). The invention also relates to a needleless injection device (1).

Abstract: The invention relates to an injection device which may or may not be equipped with a needle, comprising an injection nozzle and a tube which is intended to receive the active substance to be injected, whereby the tube is fixed to the nozzle using connecting means. The inventive device is characterized in that the aforementioned connecting means comprise at least three identical bosses which are solidly connected to the nozzle. Moreover, each of said bosses comprises an inclined part which terminates in a flange, said flange co-operating with a collar which is formed on the tube and acts as a backstop for the tube when the latter is connected to the nozzle.

Abstract: A needleless syringe comprises a reservoir sealed with mobile closure elements enclosed the liquid, the reservoir being initially isolated from the injection system which is so designed that it comprises at least two peripheral injection conduits located outside a receptacle comprising a blind bore which receives the downstream closure element such that the inlets of the conduits are cleared.

Abstract: The invention relates to a needleless injection device (1) comprising a body (2) which supports and/or defines a plurality of elements that form a circuit of elements. The aforementioned circuit comprises, from upstream towards downstream, an initiation device which is associated with a pyrotechnic gas generator, a receptacle (5) housing a liquid system. According to the invention, the pyrotechnic gas generator comprises a pyrotechnic charge (62) which is placed in a combustion chamber (4). The inventive device is characterised in that it comprises at least one device for regulating the gas pressure level in the combustion chamber (4).

Abstract: The invention concerns the field of needleless syringes for injecting an active principle for therapeutic purposes. More particularly, it concerns a needleless syringe for injecting an active principle (7) initially set between an injector (1, 10) comprising at least an injection nozzle, said injector being contacted with the skin, and a wall (8) mobile under the effect of a propelling system (9) pressurizing and expelling the active principle through the injector located at the syringe downstream end (2). In order to produce nozzles in a considerable injector thickness and to control the jet coherence distance, said injector (1, 10) comprises at least two elements (3, 4) whereof the contact surfaces (30, 40, 40?) are oriented towards the skin, at least a groove (31, 41, 41?) forming an injection nozzle in the assembly of said elements.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurized for injection.

Abstract: The technical field is that of pre-filled disposable needleless syringes, operating with a gas generator (100) and used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic purposes in human and veterinary medicine. The inventive needleless syringe (1) is characterised in that it comprises a compact architecture body (2) and the gas generator (100) is released by a cap (17) covering said body (2), said cap (17) being adapted to slide along said body (2). Said releasing mode provides the syringe with great stability (1) at the time of injection.

Abstract: A needleless syringe for injecting a liquid active principle. The syringe improves bioavailability by providing injection at two speed levels. The syringe includes a reservoir contained between an injector and push means subjected to the action of a gas generator. The push means including an end, directed towards the active principle, which forms a delivery head whereof the cross-section is smaller than the powering head cross-section, and the powering travel in the power cylinder is less than the height of the active principle reservoir.

Abstract: The invention relates to a needleless syringe (1), comprising the following' successively: a gas generator, a gas expansion chamber (3), a means for retaining particles of the active agent and a tube (6) for ejecting said particles. The main characteristic of the inventive syringe is that the gas generator is a pyrotechnic generator (2), comprising a pyrotechnic charge (10) which generates gas, a gas generator and an initiation device. The invention is also characterized in that the retaining means comprise at least one lid (8), which is fixed to the ejection tube and is configured to break under the influence of the gases generated by the combustion of said charge (10).

Abstract: The invention concerns a needleless syringe (1) comprising a trigger, a gas generator (2) prolonged by a gas expansion chamber (3), a system for retaining particles and an ejection tube (4). The invention is characterised in that the particles are housed outside the ejection tube conduit (4) and the gases cause the particles to reach inside said tube (4) by displacing a plunger (13), prior to speeding them up by wave shock inside the tube (4).

Abstract: The technical field of the invention is that of pre-filled and disposable needleless syringes, used for intradermal, subcutaneous and intramuscular injections of liquid active principle for therapeutic use in human and veterinary medicine. The inventive syringes (1) are mainly characterized in that they function with a pyrotechnic charge (6) consisting of a mixture of powder with high burning rate and a powder with low burning rate. Indeed, the combustion of the powder with a high burning rate enables to communicate instantly, through a piston (3), a very high speed to the active principle (4), whereas the combustion of the powder with a low burning rate enables to maintain a threshold pressure level to proceed with the injection, so as to ensure that the active principle (4) penetrates through the skin. Thus, the injection is properly and homogeneously without any loss of active liquid (4).

Abstract: The invention relates to a needless syringe (1), comprising in succession, a gas generator (2), a gas expansion chamber (3) and a means for retaining the particles of an active agent, comprising at least one lid (8) which breaks under the influence of the gas coming from the generator (2). The main characteristic of the inventive syringe (1) is that the tube (6) has a cylindrical upstream part in which the means retaining the particles are fixed, said upstream part having a substantially constant cross-section over a length that is more than twice its inner diameter.

Abstract: The technical field of the invention is that of needleless syringes used for injecting active principles in powder form for therapeutic purposes. The invention concerns a needleless syringe (1) comprising successively a gas generator (2), a gas expanding chamber (3), means for retaining active particles and an ejection tube (4). The invention is characterised in that the particle retaining means consists of an inner seal (14) having at least a cavity (15), the inner seal (14) serves both to contain the active principle and to generate a shock wave when it is ruptured.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurised for injection.

Abstract: The invention concerns the field of needleless syringe having an injector with several ducts. The problem that needs to be solved is the long term compatibility of the injector with the liquid active principle. For that purpose the syringe (1) comprises a cylindrical reservoir (2), closed at its upstream part by a closure element (3) capable of being moved by driving means (70), and closed at its downstream part by an injector (4) comprising at least an injection duct and said reservoir being secured to the body (8) of the syringe, said syringe is such that the diaphragm (5), compatible with the active principle, isolates the latter from the injector (4) and said diaphragm can be passed through by the liquid (6) when pressurised for injection.