Abstract: A propulsion assembly for an aircraft equipped with a thrust reverser comprising an actuator for moving a movable structure between an advanced direct thrust position and a retracted thrust reversal position, the propulsion assembly further comprising an actuator support device equipped with a first connecting part for connecting it to the deflection edge and/or to the outer shell of the intermediate casing, with a second connecting part for connecting it to a body of the actuator, and with a central part running axially between the shell and the actuator. Moreover, the actuator support device forms a guide for a set of cascades of the movable structure.

Abstract: A thrust reverser for an aircraft propulsion assembly, including at least one sealing membrane designed to deflect at least one portion of the secondary flow towards a set of cascades when the movable structure of the reverser is in the retracted thrust reversal position, the reverser also including a first flexible hook connecting a first end of the membrane to the fixed structure of the reverser, a second hook connecting a second end of the membrane to the fixed structure or to the movable structure, the second hook being fixed to the radially inner delimiting wall of the secondary vein, or guided by an internal guide fixed to the same radially inner delimiting wall.

Abstract: A thrust reverser for an aircraft propulsion assembly, including a fixed structure equipped with at least one cascade as well as a radially inner delimiting wall of a secondary vein, and a movable structure including at least one reverser cowling, the cascade being arranged, in the forward direct thrust position, in a housing of the reverser cowling, and, in the retracted thrust reversal position, the wall reveals a passage opening of the secondary vein towards the cascade, the thrust reverser also including at least one sealing membrane designed to deflect at least one portion of the secondary flow. A hook is provided for securing the membrane to a rear cascade support frame, and to the radially inner delimiting wall of the secondary vein.

Abstract: A thrust reverser for a propulsion unit, incudes movable grids, two half-assemblies forming part of a secondary stream and, at the six o'clock position, a connecting beam intended to be mounted in cantilever with a fan housing. The half-assemblies are hinged at the twelve o'clock position so as to enable their “butterfly” movement between a flight configuration and a maintenance configuration. The connecting beam includes a connecting member configured to cooperate, in the form of a tenon and groove connection, with the half-assemblies when these are in flight configuration. The reverser also includes, downstream of the connecting member, locks capable of locking the half-assemblies in flight configuration.

Abstract: In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of pulmonary arterial hypertension, particularly treating, preventing or reducing the progression rate and/or severity of one or more pulmonary arterial hypertension associated complications.

Abstract: In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of post-capillary pulmonary hypertension (PcPH), particularly treating, preventing or reducing the progression rate and/or severity of one or more PcPH-associated complications.

Abstract: A movable-cascade thrust reverser includes a multi-functional annular fixed structure configured to be rigidly connected to a turbine engine fan casing or to an intermediate casing secured to the fan casing

Abstract: In some aspects, the disclosure relates to ActRII-ALK4 antagonists and methods of using ActRII-ALK4 antagonists to treat, prevent, or reduce the progression rate and/or severity of heart failure (HF), particularly treating, preventing or reducing the progression rate and/or severity of one or more HF-associated comorbidities. The disclosure also provides methods of using an ActRII-ALK4 antagonist to treat, prevent, or reduce the progression rate and/or severity of heart failure associated with a variety of conditions including, but not limited to, heart failure associated with metabolic complications (e.g., diabetes, obesity).

Abstract: An assembly for an aircraft gas turbine engine includes a nacelle extending substantially around a longitudinal axis and including a fixed structure disposed around the aircraft gas turbine engine, the fixed structure including an internal surface suitable for delimiting with an external surface of the gas turbine engine a fire zone of the nacelle, a thermal protection covering the internal surface of the fixed structure of the nacelle at the level of the fire zone of the nacelle, and an extinguisher designed to extinguish a fire in the fire zone of the nacelle, the extinguisher including a tank suitable for containing an extinguishing agent. The tank is located between the thermal protection and the internal surface of the fixed structure of the nacelle.

Abstract: An assembly for an aircraft propulsion system including a nacelle extending around a longitudinal axis and including an internal face that delimits, with an external face of the aircraft propulsion system, a fire zone, an extinguisher for extinguishing a fire in the fire zone, the extinguisher including a tank for containing an extinguishing agent, and a spraying nozzle for spraying the extinguishing agent out of the tank and into the fire zone, an activation device for activating the extinguisher, and a controller that transmits a control order to the activation device, the activation device receiving the control order and transmitting an activation order to the extinguisher, the activation order activating the extinguisher so as to cause the expulsion of the extinguishing agent via the nozzle. The extinguisher is mounted on the nacelle. The assembly includes one or more of a wireless communicator and a cable.

Abstract: A thrust reverser for an aircraft propulsion unit, including a movable system with cascade vanes and an actuator allowing moving a movable system between an advanced direct thrust position and a backward thrust reversal position, the system also including an inter-cascade structure for limiting buckling of the actuator, forming a channel crossed by the actuator and delimited by a cylindrical internal surface extending along a first closed directrix curve, the fixed portion of the actuator including an end equipped with an external ring for limiting buckling of the actuator, the ring having a cylindrical external surface extending along a second closed directrix curve, the first and second closed directrix curves preferably having the same shapes and being concentric while being spaced apart from one another with the same spacing.

Abstract: Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

Abstract: Disclosed herein are pharmaceutical agents and compositions that activate integrin heterodimers that contain beta-1 integrin protein that specifically bind laminin protein. Such agents and compositions are useful for treating diseases related to muscle malfunction, including muscular dystrophies.

Abstract: A thrust reverser for an aircraft propulsion unit, including a movable system with cascade vanes and an actuator allowing moving a movable system between an advanced direct thrust position and a backward thrust reversal position, the system also including an inter-cascade structure for limiting buckling of the actuator, forming a channel crossed by the actuator and delimited by a cylindrical internal surface extending along a first closed directrix curve, the fixed portion of the actuator including an end equipped with an external ring for limiting buckling of the actuator, the ring having a cylindrical external surface extending along a second closed directrix curve, the first and second closed directrix curves preferably having the same shapes and being concentric while being spaced apart from one another with the same spacing.

Abstract: A thrust reverser with movable grids, includes structure for connecting, by recessing, a front frame of an outer cowl and a rear frame of the grids. The reverser includes loading structure configured to exert a stress pressing against the connecting structure, under the action of a circumferential pull of the front frame of the outer cowl or of a tightening band supported by the front frame.

Abstract: A propulsion unit includes a fairing delimiting a flow conduit for a secondary flow. This fairing comprises includes panels, at least one of which is articulated on a mast via connecting members such as clevises.

Abstract: In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension associated with lung disease (e.g, pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)), particularly treating, preventing or reducing the progression rate and/or severity of one or more pulmonary hypertension associated with lung disease (e.g., pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)) associated complications.

Abstract: In some aspects, the disclosure relates to compositions and methods comprising ActRII polypeptides and TßRII polypeptides to treat, prevent, or reduce the progression rate and/or severity of pulmonary hypertension associated with lung disease (e.g., pulmonary hypertension associated with chronic obstructive pulmonary disease (COP)), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)), particularly treating, preventing or reducing the progression rate and/or severity of one or more pulmonary hypertension associated with lung disease (e.g., pulmonary hypertension associated with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD), or combined pulmonary fibrosis and emphysema (CPFE)) associated complications.

Abstract: In some aspects, the disclosure relates to ActRII-ALK4 antagonists and methods of using ActRII-ALK4 antagonists to treat, prevent, or reduce the progression rate and/or severity of heart failure (HF), particularly treating, preventing or reducing the progression rate and/or severity of one or more HF-associated comorbidities. The disclosure also provides methods of using an ActRII-ALK4 antagonist to treat, prevent, or reduce the progression rate and/or severity of heart failure associated with a variety of conditions including, but not limited to, genetic cardiomyopathies, muscle wasting diseases, and muscular dystrophies.

Abstract: A propulsion assembly including an actuator connected to an outer casing of a turbomachine by a connecting structure. The connecting structure is fastened in line with a structural arm connecting the outer casing to a hub of the turbomachine, with a common fastening device, with the result that the arm can withstand loading forces of the actuator while relieving the outer casing.