Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Abstract: A clamping mechanism comprising: a first part; a clamp coupled to said first part to enable the clamp to slide relative to said first part in a first linear direction, the clamp being provided with a first magnetic component; a second part for clamping by said clamp, the second part being provided with a second magnetic component. The mechanism is configured such that movement of the clamp in said first linear direction, between a clamping and an unclamped position, is effected by movement of the first part and the clamp, relative to said second part, in a second linear direction substantially orthogonal to said first linear direction as a result of alignment and misalignment of the magnetic components.

Abstract: A mechanism for fixing together first and second parts and comprising first and second guides provided respectively in or attached to the first and second parts. The mechanism further comprises first and second magnetic components coupled respectively to the first and second guides such that the first magnetic component is rotatable with the first guide and the first part, and the second magnetic component cannot rotate relative to the second guide, the magnetic components being moveable axially and rotationally with respect to each other and having magnetic poles oriented such that rotation of said first magnetic component causes relative axial movement of the magnetic components between a locking position in which one of the magnetic components straddles the two guides and an unlocking position in which it does not straddle the two guides.

Abstract: A mechanism comprising first and second components configured to allow mechanical connection and disconnection of the components together by relative sliding of the components in a first linear direction. The first and second components each comprise magnetic parts, at least one of which is moveable within or around a guide in a second direction substantially perpendicular to said first linear direction under the influence of the other magnetic part, in order to secure together and or release the first and second components. When in the secured state, separation in a third linear direction substantially perpendicular to said first and second linear directions is prevented.

Abstract: A clamping mechanism comprising a first part provided with a first magnetic component, a second part, and a third part provided with a second magnetic component and being coupled to the second part. The mechanism is such that, bringing the first and second parts together along an axis causes rotational alignment and relative radial movement of the first and second magnetic components to effect axial clamping of the first part to the second part, and wherein relative rotation of the first and third parts to misalign the first and second magnetic components reverses this radial movement and effects unclamping of the first and second parts.

Abstract: The present invention relates to the field of solid materials for the adsorption of lithium. In particular, the present invention relates to a new method for the preparation of a crystallized and shaped solid material, preferably in extruded form, of the formula (LiCl)x.2Al(OH)3,nH2O, wherein n is between 0.01 and 10, x is between 0.4 and 1, wherein it comprises a step a) of precipitation of boehmite under specific temperature and pH conditions, a step of bringing into contact the precipitate obtained with LiCl, at least one acid extrusion-kneading shaping step, wherein the method also comprises a final hydrothermal treatment step, all of which makes it possible to increase the lithium adsorption capacity, the adsorption kinetics, as well as the lithium/boron selectivity of the materials obtained with respect to the materials of the prior art, when it is used in a lithium extraction method of saline solutions.

Abstract: A mechanism comprising a first component having a first magnetic part, a second component, and a third component having a second magnetic part, the third component being moveable relative to said first component in a given direction to effect connection and or disconnection of the first and second components by causing interaction of the first and second magnetic parts, wherein, when connected, the first and second components are able to move relative to one another in said given direction. The mechanism further comprising a fourth component for engagement with said first component to prevent movement of the third component relative to the first component as a result of relative movement of the first and second components, thereby to prevent unintended disconnection of the first and second components.

Abstract: Wireless power is provided to a WPP-compliant wireless device by generating a first radio frequency (RF) signal at a first frequency. The transmitter circuit is inductively coupled to the compliant wireless device using the first RF signal. A second RF signal is generated at a second frequency. The presence of a WPP-noncompliant wireless device is detected by detecting a third RF signal at a third frequency that is a harmonic of the second frequency. The non-compliant wireless device is protected by reducing, in response to detecting the third RF signal, a signal strength for the first RF signal.

Abstract: The invention relates to compounds of formula (I): or a salt thereof, wherein R1, A, L, and R2 and n are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are ?v?1 integrin inhibitors that are useful for treating tissue specific fibrosis.

Abstract: Wireless power is provided to a WPP-compliant wireless device by generating a first radio frequency (RF) signal at a first frequency. The transmitter circuit is inductively coupled to the compliant wireless device using the first RF signal. A second RF signal is generated at a second frequency. The presence of a WPP-noncompliant wireless device is detected by detecting a third RF signal at a third frequency that is a harmonic of the second frequency. The non-compliant wireless device is protected by reducing, in response to detecting the third RF signal, a signal strength for the first RF signal.

Abstract: A mechanism for fixing together first and second parts and comprising first and second guides provided respectively in or attached to the first and second parts. The mechanism further comprises first and second magnetic components coupled respectively to the first and second guides such that the first magnetic component is rotatable with the first guide and the first part, and the second magnetic component cannot rotate relative to the second guide, the magnetic components being moveable axially and rotationally with respect to each other and having magnetic poles oriented such that rotation of said first magnetic component causes relative axial movement of the magnetic components between a locking position in which one of the magnetic components straddles the two guides and an unlocking position in which it does not straddle the two guides.

Abstract: A mechanism for fixing together first and second parts and comprising first and second guides provided respectively in or attached to the first and second parts. The mechanism further comprises first and second magnetic components coupled respectively to the first and second guides such that the first magnetic component is rotatable with the first guide and the first part, and the second magnetic component cannot rotate relative to the second guide, the magnetic components being moveable axially and rotationally with respect to each other and having magnetic poles oriented such that rotation of said first magnetic component causes relative axial movement of the magnetic components between a locking position in which one of the magnetic components straddles the two guides and an unlocking position in which it does not straddle the two guides.

Abstract: A clamping mechanism comprising a first part provided with a first magnetic component, a second part, and a third part provided with a second magnetic component and being coupled to the second part. The mechanism is such that, bringing the first and second parts together along an axis causes rotational alignment and relative radial movement of the first and second magnetic components to effect axial clamping of the first part to the second part, and wherein relative rotation of the first and third parts to misalign the first and second magnetic components reverses this radial movement and effects unclamping of the first and second parts.

Abstract: Disclosed is an integrated circuit, system or architecture suitable for NFC functionality and including an NFC companion block connectible to a power source and capable to providing a non-continuous power boost to NFC signals, inter alia, thereby facilitating use of a broader range of antennas, multiple antennas, and thereby providing greater NFC functionality and versatility Further disclosed is a detachable antenna embedded in a potentially detachable shell which closely fits a mobile device and is adapted for use with the above mentioned integrated circuit, system or architecture.

Abstract: Systems and methods provide a mechanism to create and maintain web pages and other types of output pages. The system and methods use an author markup language (AML) to define output pages. Additionally, a Component Markup Language (CML) may be used to define components that may be referenced by the AML. The AML and CML may be translated to an intermediate format, which may then be further processed at runtime to combine dynamic data with the intermediate format to produce the output page.

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidotes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

Abstract: The present invention relates antidotes to anticoagulants targeting factor Xa. The antidoes are factor Xa protein derivatives that bind to the factor Xa inhibitors thereby substantially neutralizing them but do not assemble into the prothrombinase complex. The derivatives describe herein lack or have reduced intrinsic coagulant activity. Disclosed herein are methods of stopping or preventing bleeding in a patient that is currently undergoing anticoagulant therapy with a factor Xa inhibitor.

Abstract: A method includes detecting a touch at a plurality of touch locations on a touch-sensitive display of an electronic device, identifying when the touch is a first gesture type based on touch attributes including a first touch location of the plurality of touch locations, and at least one of speed of the touch, time between detecting the touch at consecutive ones of the touch locations, distance between the consecutive ones of the touch locations, and direction of the touch.