Abstract: The present invention provides, among other things, improved anti-CCL2 antibodies characterized with high affinity, potency, tissue selectivity and/or epitope specificity, and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on an anti-CCL2 antibody having an affinity of 10?12M or greater.

Abstract: A CMOS image sensor for a camera assembly is provided, having a sensor die with opposing faces, an upper face, and a lower face. On the upper face, the sensor die is provided with a sensor array, an analog-to-digital conversion module, a digital logic circuit, and a timing and clock control circuit. The sensor array is substantially centered on the sensor die. The analog-to-digital conversion module is split into two submodules. Each submodule is disposed adjacent to the sensor array and positioned on opposing sides of the sensor array. The digital logic circuit forms a first row. The timing and clock control circuit and the analog signal processing circuit are adjacent and form a second row. The first and second rows have similar dimensions and are disposed on opposite sides of the sensor array.

Abstract: Point-of sale (POS) devices and checkout devices are provided. An exemplary checkout apparatus includes a plurality of sensing elements arranged in fixed relationship with each other at the mouth of a bag. At least one of the sensing elements senses a code arranged on a product as the product is being placed into the bag.

Abstract: Systems for power management of a fleet of devices through information storage sharing are described. According to one embodiment, each one of a group of networked devices offloads information to a substantially powered hub device before entering a low power consumption mode and receives the respective information back from the hub device upon wake. Another embodiment describes a system of networked devices in which each one of the networked devices offloads information to a selected networked device before entering a sleep mode and receives the respective information back from that selected networked device after entering a wake mode. Another embodiment describes a system whereby the original selected networked device then backups to a new selected networked device if the original selected networked device needs to enter a low power consumption mode, and the other networked devices receive the respective information back from the new selected networked device.

Abstract: A dual mode image sensor is provided. The image sensor includes an on-chip sensing array, on-chip analog-to-digital converters, and an on-chip processor. The sensor array has rows and columns of discrete sensor elements. The dual mode image sensor has a scene sensing mode and an image capture mode, which use the same set of imaging optics. The processor includes a dual context register; one being for the scene sensing mode and the other for image capture mode. The scene sensing mode is configured to output results of object sensing, motion detection, focus evaluation and illumination measurement to the analog-to-digital converters. The image capture mode is configured to output captured images to the analog-to-digital converters, which are configured to send the digital data to the processor. The processor is configured to switch from scene sensing mode to image capture mode based upon the scene sensing mode output results.

Abstract: A dual mode image sensor is provided. The image sensor includes an on-chip sensing array, on-chip analog-to-digital converters, and an on-chip processor. The sensor array has rows and columns of discrete sensor elements. The dual mode image sensor has a scene sensing mode and an image capture mode, which use the same set of imaging optics. The processor includes a dual context register; one being for the scene sensing mode and the other for image capture mode. The scene sensing mode is configured to output results of object sensing, motion detection, focus evaluation and illumination measurement to the analog-to-digital converters. The image capture mode is configured to output captured images to the analog-to-digital converters, which are configured to send the digital data to the processor. The processor is configured to switch from scene sensing mode to image capture mode based upon the scene sensing mode output results.

Abstract: A CMOS image sensor for a camera assembly is provided, having a sensor die with opposing faces, an upper face, and a lower face. On the upper face, the sensor die is provided with a sensor array, an analog-to-digital conversion module, a digital logic circuit, and a timing and clock control circuit. The sensor array is substantially centered on the sensor die. The analog-to-digital conversion module is split into two submodules. Each submodule is disposed adjacent to the sensor array and positioned on opposing sides of the sensor array. The digital logic circuit forms a first row. The timing and clock control circuit and the analog signal processing circuit are adjacent and form a second row. The first and second rows have similar dimensions and are disposed on opposite sides of the sensor array.

Abstract: Detecting glycosaminoglycans (GAGs) and/or determining the level of one or more glycosaminoglycans can be useful, e.g., in identifying or monitoring various medical conditions, the status of patients having various medical conditions, and/or the response to treatment of individuals having various medical conditions. The present invention provides methods for detecting glycosaminoglycans and/or determining the level of glycosaminoglycans through the use of, e.g., mass spectrometry.

Abstract: A computer system for decoding a signal of decodable indicia is disclosed. The computer system includes a laser scanner configured that outputs a signal of decodable indicia and a microprocessor that include a camera sensor interface that is configured to receive the signal from the laser scanner.

Abstract: Systems for power management of a fleet of devices through information storage sharing are described. According to one embodiment, each one of a group of networked devices offloads information to a substantially powered hub device before entering a low power consumption mode and receives the respective information back from the hub device upon wake. Another embodiment describes a system of networked devices in which each one of the networked devices offloads information to a selected networked device before entering a sleep mode and receives the respective information back from that selected networked device after entering a wake mode. Another embodiment describes a system whereby the original selected networked device then backups to a new selected networked device if the original selected networked device needs to enter a low power consumption mode, and the other networked devices receive the respective information back from the new selected networked device.

Abstract: A point of sale system capable of operating in an indicia-reading mode or a verification mode is disclosed. In the indicia-reading mode, the point of sale system configures its illumination, imaging, and processing to read indicia as part of a normal checkout process. If triggered by a user or by an event, the point of sale system may operate in a verification mode. In the verification mode, the point of sale system enables the necessary illumination, imaging, and processing to verify an item. This verification includes illuminating the item in a way that causes a noticeable response from a security mark (or marks) on the item. An image of the response may be captured and processed to authenticate/verify the item. The point of sale system may then respond to the verification and/or may store the image/results as a record of the verification.

Abstract: A system and method of determining if a surface contains print or is a screen of a device is provided. The method is comprised of the steps of: acquiring a spectral wavelength signature of the surface; comparing the spectral wavelength signature of the surface to RGB triple-peak emission spectra; scanning the surface with an image-based scanner in non-illumination mode based upon the spectral wavelength signature of the surface corresponding to the RGB triple-peak emission spectra, and scanning the surface with an image-based scanner in illumination mode based upon the spectral wavelength signature of the surface not corresponding to the RGB triple-peak emission spectra.

Abstract: A computer system for decoding a signal of decodable indicia is disclosed. The computer system includes a laser scanner configured that outputs a signal of decodable indicia and a microprocessor that include a camera sensor interface that is configured to receive the signal from the laser scanner.

Abstract: Existing currency validation (CVAL) devices, systems, and methods are too slow, costly, intrusive, and/or bulky to be routinely used in common transaction locations (e.g., at checkout, at an automatic teller machine, etc.). Presented herein are devices, systems, and methods to facilitate optical validation of documents, merchandise, or currency at common transaction locations and to do so in an obtrusive and convenient way. More specifically, the present invention embraces a validation device that may be used alone or integrated within a larger system (e.g., point of sale system, kiosk, etc.). The present invention also embraces methods for currency validation using the validation device, as well as methods for improving the quality and consistency of data captured by the validation device for validation.

Abstract: A point of sale system capable of operating in an indicia-reading mode or a verification mode is disclosed. In the indicia-reading mode, the point of sale system configures its illumination, imaging, and processing to read indicia as part of a normal checkout process. If triggered by a user or by an event, the point of sale system may operate in a verification mode. In the verification mode, the point of sale system enables the necessary illumination, imaging, and processing to verify an item. This verification includes illuminating the item in a way that causes a noticeable response from a security mark (or marks) on the item. An image of the response may be captured and processed to authenticate/verify the item. The point of sale system may then respond to the verification and/or may store the image/results as a record of the verification.

Abstract: A system and method of determining if a surface contains print or is a screen of a mobile device is provided. The method is comprised of the steps of: acquiring a spectral wavelength signature of the surface; comparing the spectral wavelength signature of the surface to RGB triple-peak emission spectra; scanning the surface with an image-based scanner in non-illumination mode based upon the spectral wavelength signature of the surface corresponding to the RGB triple-peak emission spectra, and scanning the surface with an image-based scanner in illumination mode based upon the spectral wavelength signature of the surface not corresponding to the RGB triple-peak emission spectra.

Abstract: A system and method of determining if a surface contains print or is a screen of a mobile device is provided. The method is comprised of the steps of: acquiring a spectral wavelength signature of the surface; comparing the spectral wavelength signature of the surface to RGB triple-peak emission spectra; scanning the surface with an image-based scanner in non-illumination mode based upon the spectral wavelength signature of the surface corresponding to the RGB triple-peak emission spectra, and scanning the surface with an image-based scanner in illumination mode based upon the spectral wavelength signature of the surface not corresponding to the RGB triple-peak emission spectra.

Abstract: Systems for power management of a fleet of devices through information storage sharing are described. According to one embodiment, each one of a group of networked devices offloads information to a substantially powered hub device before entering a low power consumption mode and receives the respective information back from the hub device upon wake. Another embodiment describes a system of networked devices in which each one of the networked devices offloads information to a selected networked device before entering a sleep mode and receives the respective information back from that selected networked device after entering a wake mode. Another embodiment describes a system whereby the original selected networked device then backups to a new selected networked device if the original selected networked device needs to enter a low power consumption mode, and the other networked devices receive the respective information back from the new selected networked device.

Abstract: Approaches are described for displaying rotated character strings within cells of tables. In particular embodiments, the display of the rotated character string is handled such that the character string does not extend beyond the edges of the cell. Further, in certain implementations, the character string may be displayed as wrapped and rotated text within the cell, wherein each line of the wrapped character string does not extend beyond the edges of the cell.

Abstract: A point of sale system capable of operating in an indicia-reading mode or a verification mode is disclosed. In the indicia-reading mode, the point of sale system configures its illumination, imaging, and processing to read indicia as part of a normal checkout process. If triggered by a user or by an event, the point of sale system may operate in a verification mode. In the verification mode, the point of sale system enables the necessary illumination, imaging, and processing to verify an item. This verification includes illuminating the item in a way that causes a noticeable response from a security mark (or marks) on the item. An image of the response may be captured and processed to authenticate/verify the item. The point of sale system may then respond to the verification and/or may store the image/results as a record of the verification.