Abstract: The present invention provides, among other things, improved anti-CCL2 antibodies characterized with high affinity, potency, tissue selectivity and/or epitope specificity, and uses thereof, in particular, for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions. In some embodiments, the present invention provides methods and compositions for treatment of scleroderma and related fibrotic and/or inflammatory diseases, disorders and conditions based on an anti-CCL2 antibody having an affinity of 10?12 M or greater.

Abstract: A decodable indicia reading terminal can comprise a laser-based scanner, an imager-based scanner, a central processing unit (CPU), and an illumination assembly. The laser-based scanner can include a laser source, a photo-detector, and an analog-to-digital (A/D) converter. The laser source can be configured to emit a laser beam onto a substrate bearing decodable indicia. The photo-detector can be configured to receive a beam of a variable intensity reflected by the decodable indicia, and to output a first analog signal representative of the variable intensity. The A/D converter can be configured to convert the first analog signal into a first digital signal. The imager-based scanner can include a multiple pixel image sensor, an imaging lens, and an A/D converter. The imaging lens can be configured to focus an image of the decodable indicia on the image sensor.

Abstract: Systems and methods for determining the performance of a content network include determining a differential performance for the network. A first performance metric for the content network may be determined for content auctions that the content network won. A second performance metric may also be determined that represents a performance metric based on predicted auction results that disregard the participation of the content network in the auctions. A differential performance metric for the content network may also be determined based on the difference between the first and second performance metrics.

Abstract: A computer system for decoding a signal of decodable indicia. The computer system includes a laser scanner configured that outputs a signal of decodable indicia and a microprocessor that include a camera sensor interface that is configured to receive the signal from the laser scanner.

Abstract: A steam turbomachine includes a housing having a shell that defines a steam flow path, a first stage bowl cavity formed in the shell, a first stage including a plurality of first stage nozzles and a plurality of first stage buckets arranged downstream of the plurality of first stage nozzles, a second stage including a plurality of second stage nozzles and a plurality of second stage buckets arranged downstream of the plurality of second stage nozzles. The second stage is arranged downstream of the first stage along the steam flow path. A bypass circuit is formed in the shell. The bypass circuit extends from a first end fluidically connected to the first stage bowl cavity to a second end fluidically exposed to the steam flow path upstream of the second stage. A valve element is positioned in, and selectively blocks, the bypass circuit.

Abstract: A POS-based checkout/scale system having (i) a bar code symbol reading subsystem for reading bar code symbols on products being purchased at a retail POS station, and (ii) a produce weigh scale having a weigh scale assembly for weighing one or more produce items on a weigh platter during produce weighing operations carried out at the time of checkout at said retail POS station. The system also includes an automatic produce weighing interference detection subsystem, supporting an IR-based light curtain about the weigh platter, automatically detects when any object is overhanging the weigh platter during produce weighing operations, and generates an alert signal when such conditions are automatically detected.

Abstract: A POS-based checkout/scale system having (i) a bar code symbol reading subsystem for reading bar code symbols on products being purchased at a retail POS station, and (ii) a produce weigh scale having a weigh scale assembly for weighing one or more produce items on a weigh platter during produce weighing operations carried out at the time of checkout at said retail POS station. The system also includes an automatic produce weighing interference detection subsystem, supporting an IR-based light curtain about the weigh platter, automatically detects when any object is overhanging the weigh platter during produce weighing operations, and generates an alert signal when such conditions are automatically detected.

Abstract: Approaches are disclosed for displaying rotated character strings within cells of tables. In particular embodiments, the display of the rotated character string is handled such that the character string does not extend beyond the edges of the cell. Further, in certain implementations, the character string may be displayed as wrapped and rotated text within the cell, wherein each line of the wrapped character string does not extend beyond the edges of the cell.

Abstract: Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

Abstract: A method for determining the dimensions of an object comprises projecting a laser pattern (e.g., a visible laser pattern) onto an object, capturing an image of the projected pattern on the object, and determining the dimensions of the object based, at least in part, on the captured image. An exemplary method includes projecting a laser pattern (e.g., a grid or a set of lines) onto a rectangular box. Typically, the box is positioned such that two non-parallel faces are visible to the system or device projecting the laser pattern and a camera system with known field of view characteristics. The camera system is used to capture an image of the laser light reflecting off of the box.

Abstract: Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

Abstract: A support bracket assembly for a steering column assembly comprises a first bracket part, a second bracket part which is fixed to the vehicle by at least one fastener, and at least one capsule which comprises a main body fixed to the first bracket part by a frangible connector. The main body of the capsule is fixed to the second bracket part by the at least one fastener. The main body includes at least one opening which is aligned with a corresponding opening in the first bracket part and the two aligned openings are filled with a frangible material that forms part of the frangible connector which secures the capsule to the first bracket part. A further opening is provided in the second bracket part which is coaxial with an opening in the capsule and filled with additional frangible material which forms a frangible connection between the capsule and the second bracket part.

Abstract: An adjustable steering column assembly includes a first shroud portion comprising an outer tube, a second shroud portion which comprises an inner tube, and a clamp mechanism that includes a part that is fixed relative to the outer tube, the first and second shroud portions being releasably engaged by the clamp mechanism to selectively permit an amount of relative movement between the first and second shroud portions that is required during adjustment of the steering column assembly, the assembly further including an energy absorbing member which includes a strap that interconnects the inner tube and the part of the clamp bolt assembly, the assembly being so arranged that upon collapse the inner tube moves relative to the clamp assembly whereupon the energy absorbing member is deformed beyond its elastic limit, thereby absorbing energy in the system to control the collapse of the assembly.

Abstract: Embodiments of an indicia reading terminal have multiple fields of view (“FOV”). This feature allows decoding of decodable indicia that exhibit different characteristics. These characteristics may affect the ability of the terminal to identify and decode the information stored therein. In one embodiment, the terminal comprises an optical imaging assembly with at least two FOVs. One of the FOVs is adequate to acquire information from decodable indicia with higher density than other decodable indicia.

Abstract: Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

Abstract: Provided herein are methods to prepare Heteroaryl Compounds having the following structure: wherein R1-R4 are as defined herein. The Heteroaryl compounds are useful for treating or preventing cancer, inflammatory conditions, immunological conditions, neurodegenerative diseases, diabetes, obesity, neurological disorders, age-related diseases, or cardiovascular conditions.

Abstract: A multilayer light reflective self assembly film or coating which reflects light of a desired wavelength is obtained by blending block copolymer fractions of different molecular weight. The colour of light reflected by the film or coating depends on the relative amounts of the block copolymers in the blend. Thus, the colour of the reflected light is selectable by varying the relative amounts of the block copolymers in the blend. The polymers may be cross-linked by means of a suitable cross-linking agent. Applications of the film or coating include anti-counterfeiting devices.

Abstract: A hybrid-type bi-optical bar code symbol reading system having a vertical housing section having a vertical scanning window and a horizontal housing section having a horizontal scanning window, from which laser scanning planes are projected and intersect within a 3D scanning volume defined between the vertical and horizontal scanning windows. A digital imaging module is supported within the vertical section of the system housing and automatically projects a field of view (FOV) within the 3D scanning volume.

Abstract: A bi-optical code symbol reading system including a system housing having a vertical housing section with a vertical window and a horizontal housing section with a horizontal window adjacent the vertical scanning window; and a digital video display subsystem, disposed within the vertical section of the system housing, and supporting the display of digital images in substantially the same plane as the vertical window during system operation. The digital images displayed by digital video display subsystem can be video images captured by an integrated digital imaging code symbol reading subsystem, to assist the operator in aligning code symbols during scanning operations. The digital images can also be product and price information captured during product scanning operations.

Abstract: Portable communication devices and methods for use in charging an electrically powered vehicle are disclosed. One example portable communication device includes a first input device configured to scan an optical machine-readable code associated with the charging station, a display device, and a processor coupled to the first input and display devices and configured to determine an identification number of a charging station based on an optical machine-readable code scanned by the first input device, to initiate communication with the charging station through at least one network, and to cause the display device to display a user interface, the user interface including content associated with the charging station.