Abstract: A device for packaging and applying a cosmetic product, of longitudinal axis X, the device having a container for containing the product and a stem connected by a first end to a gripping part and by a second end to an application element having an application head and an end piece mounted in a housing of the stem, the end piece having a frustoconical portion fitted in a complementary frustoconical space in the housing of the stem.

Abstract: Device including a cap having a skirt provided with at least one thread element and with at least one relief that is separate from the thread element. A container provided with a neck having at least one screw thread in which the thread element can engage, at least one housing, the relief on the cap being configured to snap-fit in the housing at the end of a movement for pre-positioning the cap on the neck. The preferably has at least one ramp having an opposite slope and at least one space for receiving the thread element in the pre-positioned position, situated between a passage for introducing the thread element into the screw thread and an upright at least partially delimiting said housing.

Abstract: The closure cap for a container comprises an internal skirt (16) comprising a bore (16b) provided with at least one helical screw thread (19) for screwing said cap onto the container, an external skirt (18) radially surrounding said internal skirt at least partially, and a front wall (14) from which said internal and external skirts extend. The cap is produced by moulding at least one synthetic material. At least one recess (30) is formed on an outer surface (16a) of the internal skirt, remaining axially away from a front end face (16c) of said skirt.

Abstract: The closure cap for a container comprises an internal fastening skirt (16), an external skirt (18) radially surrounding said internal skirt at least partially, and a front wall (14) from which said skirts extend. The internal skirt (16) has a variable thickness in the direction of its axial length, said thickness being at a minimum at least for a proximal portion (22) of said skirt which extends from the front wall (14). The internal skirt (16) comprises the proximal portion (22) with a thickness E that is substantially constant, a distal portion (24) with a thickness E2 that is substantially constantand greater than the thickness E1, and a connecting portion (26) that connects the proximal portion and thedistal portionand has a variable thickness E3 along its length. The axial length of the proximal portion (22) of the internal skirt varies around the circumference of said skirt.

Abstract: This invention relates to a packaging and distribution assembly (10) for a fluid product, of the type comprising: a storage member (22), comprising a tubular reservoir (40) able to receive a first fluid composition; a closed chamber (130) in communication with the tubular reservoir; and a pressurization member (24), able to move axially in such a way as to decrease a volume of said closed chamber. The closed chamber is sealed from the air in a deployed configuration of the storage and pressurization members, corresponding to a maximum volume of the closed chamber. The storage member (22) and the pressurization member (24) comprise means (76) for breaking the seal of the closed chamber in a compact configuration of said storage and pressurization members, said compact configuration corresponding to a minimum volume of the closed chamber.

Abstract: A transgenic non-human animal model for Neurofibromatosis type 1, wherein the Nf1 gene is specifically inactivated in BC cells and derivatives thereof. Also, an in vitro method of producing cutaneous and plexiform Neurofibromas (NFBs) and/or for studying the development and composition of plexiform NFBs, including culturing in vitro Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model. Further, a method for screening a candidate compound for use as a drug to treat Neurofibromatosis type 1, cutaneous NFBs and/or plexiform NFBs including contacting the candidate compound Prss56-expressing cells and-derivatives thereof obtained from the transgenic non-human animal model or administering the candidate compound to the transgenic non-human animal model.

Abstract: The closure cap for a container comprises an internal skirt (16) comprising a bore (16b) provided with at least one helical screw thread (19) for screwing said cap onto the container, an external skirt (18) radially surrounding said internal skirt at least partially, and a front wall (14) from which said internal and external skirts extend. The cap is produced by moulding at least one synthetic material. At least one recess (30) is formed on an outer surface (16a) of the internal skirt, remaining axially away from a front end face (16c) of said skirt.

Abstract: The closure cap for a container comprises an internal fastening skirt (16), an external skirt (18) radially surrounding said internal skirt at least partially, and a front wall (14) from which said skirts extend. The internal skirt (16) has a variable thickness in the direction of its axial length, said thickness being at a minimum at least for a proximal portion (22) of said skirt which extends from the front wall (14). The internal skirt (16) comprises the proximal portion (22) with a thickness E that is substantially constant, a distal portion (24) with a thickness E2 that is substantially constantand greater than the thickness E1, and a connecting portion (26) that connects the proximal portion and thedistal portionand has a variable thickness E3 along its length. The axial length of the proximal portion (22) of the internal skirt varies around the circumference of said skirt.

Abstract: Closure cap intended to close off an open end of a reservoir, comprising a substantially cylindrical body (12) of longitudinal axis (Z) that is intended to be mounted on the open end of the reservoir and is provided with a flow orifice (12e) and a lid (14) that is articulated about a transverse pivot axis (A0) with respect to the body (12), by means of at least two hinges (16), between an open position of the flow orifice (12e) and a closed position of said flow orifice (12e), said lid (14) having an outside diameter greater than the outside diameter of the body (12) and forming a radial lip, said closure cap (10) also comprising a return member (18) that is disposed in a plane passing between the two hinges (16) and is able to keep the lid (14) in each of the positions. The return member (18) has a bent shape configured to be inserted into cavities (12f, 14d) made in the body (12) and in the lid (14), respectively, and to be flush with the radial lip of the lid (14) in the closed position.

Abstract: This invention relates to a packaging and distribution assembly (10) for a fluid product, of the type comprising: a storage member (22), comprising a tubular reservoir (40) able to receive a first fluid composition; a closed chamber (130) in communication with the tubular reservoir; and a pressurization member (24), able to move axially in such a way as to decrease a volume of said closed chamber. The closed chamber is sealed from the air in a deployed configuration of the storage and pressurization members, corresponding to a maximum volume of the closed chamber. The storage member (22) and the pressurization member (24) comprise means (76) for breaking the seal of the closed chamber in a compact configuration of said storage and pressurization members, said compact configuration corresponding to a minimum volume of the closed chamber.

Abstract: Closure cap intended to close off an open end of a reservoir, comprising a substantially cylindrical body (12) of longitudinal axis (Z) that is intended to be mounted on the open end of the reservoir and is provided with a flow orifice (12e) and a lid (14) that is articulated about a transverse pivot axis (A0) with respect to the body (12), by means of at least two hinges (16), between an open position of the flow orifice (12e) and a closed position of said flow orifice (12e), said lid (14) having an outside diameter greater than the outside diameter of the body (12) and forming a radial lip, said closure cap (10) also comprising a return member (18) that is disposed in a plane passing between the two hinges (16) and is able to keep the lid (14) in each of the positions. The return member (18) has a bent shape configured to be inserted into cavities (12f, 14d) made in the body (12) and in the lid (14), respectively, and to be flush with the radial lip of the lid (14) in the closed position.

Abstract: The method for producing a member for applying a cosmetic product comprising: an application portion (3); a longitudinal core (5), housed in the application portion (3); the method comprising the following successive steps: a first step for injecting the application portion (3) into a cavity (29) of a mold (27); a second step for injecting the longitudinal core (5) into the cavity (29) of the mold (27). In the first step, a pin (31) is arranged in the cavity (29) and in the second step, the pin (31) is moved relative to the cavity (29), and the longitudinal core (5) is injected into a space (47) freed up by the pin (31).

Abstract: The invention relates to a package (10) containing a cosmetic product (12), the package comprising a basic body (14), a neck (18) and a closure member or product dispensing member (20) mounted on the neck (18), so as to form an internal volume (16) containing the cosmetic product. According to the invention, the package resists an increase in pressure of at least 0.245 bar within the internal volume (16) together with a rise in the temperature of the product to above 85° C., in particular between 85° C. and 150° C.

Abstract: This cosmetic product dispensing head (30) comprises: a dispensing member (32) for the cosmetic product, having a tubular duct (34) defining a passage (36) for the cosmetic product, and a stopper (60) for closing off the passage (36), movable between a position freeing the passage (36) and a position closing off the passage (36), the stopper (60) comprising a finger (62) and a skirt (64), the outer face (48) of the duct (34) and the inner face (78) of the skirt (64) having complementary cooperating means (80, 82) for securing the stopper (60) to the dispensing member (32). The finger (62) bears a peripheral scraping member (70) protruding radially from a peripheral face (72) of the finger (62), the scraping member (70) having at least one perimeter line (74) suitable for being in contact with the duct (34) when the stopper (60) is in the closing off position.

Abstract: The invention relates to a package (10) containing a cosmetic product (12), the package comprising a basic body (14), a neck (18) and a closure member or product dispensing member (20) mounted on the neck (18), so as to form an internal volume (16) containing the cosmetic product. According to the invention, the package resists an increase in pressure of at least 0.245 bar within the internal volume (16) together with a rise in the temperature of the product to above 85° C., in particular between 85° C. and 150° C.

Abstract: This cosmetic product dispensing head (30) comprises: a dispensing member (32) for the cosmetic product, having a tubular duct (34) defining a passage (36) for the cosmetic product, and a stopper (60) for closing off the passage (36), movable between a position freeing the passage (36) and a position closing off the passage (36), the stopper (60) comprising a finger (62) and a skirt (64), the outer face (48) of the duct (34) and the inner face (78) of the skirt (64) having complementary cooperating means (80, 82) for securing the stopper (60) to the dispensing member (32). The finger (62) bears a peripheral scraping member (70) protruding radially from a peripheral face (72) of the finger (62), the scraping member (70) having at least one perimeter line (74) suitable for being in contact with the duct (34) when the stopper (60) is in the closing off position.

Abstract: The device (3): a sealed flexible bag (7); a submerging tubular body (11) opening into the flexible bag (7) through a sampling orifice (15); and a valve (17) for sealing the sampling orifice (15). The valve (17) includes: a shutter (53) for sealing the sampling orifice (15), a core (55) engaged in the sampling orifice (15), a portion (57) provided with an elastic member (59) that recalls the valve (17) to the sealing position, with the shutter (53), core (55) and the end portion (57) consisting of a single piece.

Abstract: Bottle comprising:—a body (2) having a transversely deformable zone (1),—a cap member (3),—a product taking up between 25% and 98% of the internal volume of the body (2) of the bottle in the initial filling state of the bottle.

Abstract: The method for producing a member for applying a cosmetic product comprising: an application portion (3); a longitudinal core (5), housed in the application portion (3); the method comprising the following successive steps: a first step for injecting the application portion (3) into a cavity (29) of a mold (27); a second step for injecting the longitudinal core (5) into the cavity (29) of the mold (27). In the first step, a pin (31) is arranged in the cavity (29) and in the second step, the pin (31) is moved relative to the cavity (29), and the longitudinal core (5) is injected into a space (47) freed up by the pin (31).

Abstract: The present invention discloses the identification and characterization of a novel mammalian pluripotent neural cell population. More particularly, the present invention relates to compositions and methods allowing the identification, monitoring, culture and differentiation of boundary cap cells and their progeny. The invention also relates to methods of screening compounds that alter the growth, migration and/or differentiation of these cells, as well as to methods of producing functional cells in vitro, ex vivo or in vivo using said pluripotent cells. The invention can be used to detect, diagnose, monitor and/or treat various pathological conditions in mammalian subjects, including nervous diseases such as neurodegenerative condition, demyelination, pain, etc. The invention can be used for tissue engineering, to produce various differentiated cell types by differentiation of said pluripotent cells under appropriate conditions.