Abstract: The present invention refers to active substance combinations comprising of a nucleoside analog or antimetabolic agent like Gemcitabine, and either a Nodal/Activin inhibitor or a SHH-Inhibitor and an mTOR-inhibitor, medicaments comprising the same and the use of the active substance combinations in the treatment of cancer, especially of epithelial cancer.

Abstract: The invention relates to a system and method for the selective transmission of data to individuals or groups of viewing locations to thereby allow at selected times at least, the targeting of data which is more focussed or targeted to viewers at said locations. This is achieved by detecting and processing data which is indicative of the interaction of viewers with the receiving apparatus at each location and using this possibly in combination with other data, to assess characteristics of the viewers and then select the data to be transmitted to them.

Abstract: A method for operating a computer system to manage unstructured information about objects representing things of interest to an organization. The method involves defining a plurality of two way relationship types between pairs of object types wherein the objects are each instances of the object types. A user of the system is able to define relationships between objects by selecting from a number of relationship types, each of which is compatible with a pairing of object types. The method ensures that each relationship has associated with it a primary end, being a descriptor of the first object type's relationship to the second object type and a secondary end, being a descriptor of the second object type's relationship to the first object type. Preferred embodiments of the method include steps for presenting information about objects and their relationships to other objects including user selected relationship descriptors.

Abstract: A data switch uses indirect memory addressing to perform switching of digital data streams in a network. Incoming data is organized into timeslots. Each timeslot's data is stored into a predefined location in buffer memory. Indirect addressing is implemented in a crosspoint address table. The addresses stored in the crosspoint address table are used to access locations in the buffer memory so that portions of words stored in the buffer memory can be combined to form an output word destined for a predetermined timeslot.

Abstract: A method for facilitating the exchange of information between vendors and seekers of products and services comprises the steps of