Patents by Inventor Patrick Gray

Patrick Gray has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11045544
    Abstract: In one aspect, the invention provides a method of making a bioactive peptide-bearing antibody, or fragment thereof, comprising (a) engrafting the amino acid sequence of at least one bioactive peptide of interest into (i) at least one of CDR-H1, CDR-H2 or CDR-H3 of a heavy chain variable region comprising one or more chicken framework regions and/or (ii) at least one of CDR-L1, CDR-L2 or CDR-L3 of the light chain variable region comprising one or more chicken framework regions, and (b) determining whether the antibody has substantially the same biological activity as the bioactive peptide.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: June 29, 2021
    Assignee: Omeros Corporation
    Inventors: W. Jason Cummings, Patrick Gray, Larry Tjoelker, Munehisa Yabuki
  • Publication number: 20210079117
    Abstract: In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
    Type: Application
    Filed: August 4, 2020
    Publication date: March 18, 2021
    Inventors: W. Jason Cummings, Patrick Gray, Larry W. Tjoelker, Munehisa Yabuki
  • Publication number: 20190183824
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: December 6, 2018
    Publication date: June 20, 2019
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Publication number: 20190127484
    Abstract: In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation.
    Type: Application
    Filed: September 14, 2018
    Publication date: May 2, 2019
    Inventors: Hans-Wilhelm Schwaeble, Gregory A. Demopulos, Thomas Dudler, Patrick Gray
  • Publication number: 20180043612
    Abstract: A device printing a three dimensional cosmetic article from a build material including a cosmetic formula has an extruder, a build plate, a controller and a positioning system. The controller is programmed to instruct the positioning system to position the extruder relative to the build plate. The extruder includes a piston extrusion system. The build material is provided to the extruder as a pre-formed stick. The build material is extruded onto a substrate to form the article. The build plate includes a sizing system for receiving substrates of various sizes.
    Type: Application
    Filed: August 4, 2017
    Publication date: February 15, 2018
    Inventors: Timothy Patrick Gray, Isaac David COHEN, Agostinho MARTINS, Bruce Laurence VICTOR, Charles Aaron CURTISS, Madalyn Ellice PAPPAS
  • Publication number: 20170247431
    Abstract: In one aspect, the invention provides a method of making a bioactive peptide-bearing antibody, or fragment thereof, comprising (a) engrafting the amino acid sequence of at least one bioactive peptide of interest into (i) at least one of CDR-H1, CDR-H2 or CDR-H3 of a heavy chain variable region comprising one or more chicken framework regions and/or (ii) at least one of CDR-L1, CDR-L2 or CDR-L3 of the light chain variable region comprising one or more chicken framework regions, and (b) determining whether the antibody has substantially the same biological activity as the bioactive peptide.
    Type: Application
    Filed: March 15, 2017
    Publication date: August 31, 2017
    Inventors: W. Jason Cummings, Patrick Gray, Larry Tjoelker, Munehisa Yabuki
  • Patent number: 9640018
    Abstract: A system and method for conducting a lottery game is described. The game may include providing a player with a free pre-printed first game piece having a first set of game play data, wherein game play data on the first game piece is insufficient to ascertain an outcome of the lottery game. The game may further include receiving information identifying the first game piece and an indication the player wishes to purchase a chance in the lottery game. Responsive to receiving the indication, the game outcome may be determined and a second set of game play data chosen based on the outcome, so that a comparison of the first set of game play data and the second set game play data is indicative of the outcome of the chance according to predetermined game rules. The second set of game data may be provided to the player on a second game piece also having data associating the second game piece with the first game piece and a unique identifier.
    Type: Grant
    Filed: May 11, 2006
    Date of Patent: May 2, 2017
    Assignee: IGT RHODE ISLAND LLC
    Inventors: Richard Finocchio, Andrew Patrick Gray, Brian J. Roberts
  • Publication number: 20160015715
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: July 22, 2015
    Publication date: January 21, 2016
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Patent number: 9119822
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: September 1, 2015
    Assignee: Omeros Corporation
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Publication number: 20150017162
    Abstract: In one aspect, the invention provides an isolated antibody, or antigen-binding fragment thereof, comprising a bioactive peptide amino acid sequence, wherein the bioactive peptide amino acid sequence is an inhibitor of the complement system and is fused to at least one of: (i) the amino terminal region of at least one of: a light chain variable region and/or a heavy chain variable region; or (ii) the carboxy terminal region of at least one of: a light chain constant region and/or a heavy chain constant region, wherein the antibody inhibits complement activation.
    Type: Application
    Filed: March 14, 2014
    Publication date: January 15, 2015
    Inventors: W. Jason Cummings, Patrick Gray, Larry W. Tjoelker, Munehisa Yabuki
  • Publication number: 20140363433
    Abstract: In one aspect, the invention provides a method of making a bioactive peptide-bearing antibody, or fragment thereof, comprising (a) engrafting the amino acid sequence of at least one bioactive peptide of interest into (i) at least one of CDR-H1, CDR-H2 or CDR-H3 of a heavy chain variable region comprising one or more chicken framework regions and/or (ii) at least one of CDR-L1, CDR-L2 or CDR-L3 of the light chain variable region comprising one or more chicken framework regions, and (b) determining whether the antibody has substantially the same biological activity as the bioactive peptide.
    Type: Application
    Filed: March 12, 2014
    Publication date: December 11, 2014
    Inventors: W. Jason Cummings, Patrick Gray, Larry Tjoelker, Munehisa Yabuki
  • Publication number: 20140179717
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Applicant: OMEROS CORPORATION
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Patent number: 8637528
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Grant
    Filed: May 4, 2009
    Date of Patent: January 28, 2014
    Assignee: Omeros Corporation
    Inventors: John E Bergmann, Neil S Cutshall, Gregory A Demopulos, Vincent A Florio, George Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Publication number: 20130344073
    Abstract: In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation.
    Type: Application
    Filed: June 18, 2013
    Publication date: December 26, 2013
    Inventors: Hans-Wilhelm Schwaeble, Gregory A. Demopulos, Thomas Dudler, Patrick Gray
  • Patent number: 8339141
    Abstract: A voltage pulse is transmitted into a test object, and returned reflection pulses are evaluated to determine the location of a fault in the test object. The return signal includes a reflection from the fault and undesired interfering reflection pulses, which are removed or compensated-out from the return signal to produce a corrected pulse diagram. A circuit arrangement for this includes a bi-directional coupler, a separation filter, a measured signal detection circuit with two input channels, a memory storing a database, a computer processor, and a measured signal evaluation unit. A method in this regard includes a first step of measuring the input impedance of the test object, and a second step of measuring the return signal pulses, transforming the return signal to the frequency domain, compensating the frequency domain data to remove interference, transforming the data back to the time domain, and representing or evaluating the pulse diagram.
    Type: Grant
    Filed: January 27, 2010
    Date of Patent: December 25, 2012
    Assignee: Hagenuk KMT Kabelmesstechnik GmbH
    Inventors: Patrick Gray, Hubert Schlapp
  • Publication number: 20110091388
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: December 21, 2010
    Publication date: April 21, 2011
    Applicant: OMEROS CORPORATION
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George A. Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Publication number: 20100211348
    Abstract: A voltage pulse is transmitted into a test object, and returned reflection pulses are evaluated to determine the location of a fault in the test object. The return signal includes a reflection from the fault and undesired interfering reflection pulses, which are removed or compensated-out from the return signal to produce a corrected pulse diagram. A circuit arrangement for this includes a bi-directional coupler, a separation filter, a measured signal detection circuit with two input channels, a memory storing a database, a computer processor, and a measured signal evaluation unit. A method in this regard includes a first step of measuring the input impedance of the test object, and a second step of measuring the return signal pulses, transforming the return signal to the frequency domain, compensating the frequency domain data to remove interference, transforming the data back to the time domain, and representing or evaluating the pulse diagram.
    Type: Application
    Filed: January 27, 2010
    Publication date: August 19, 2010
    Inventors: Patrick Gray, Hubert Schlapp
  • Publication number: 20100113486
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: May 4, 2009
    Publication date: May 6, 2010
    Applicant: Omeros Corporation
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng
  • Patent number: 7561848
    Abstract: A method of inventory management is described. Upon activation of a button on a wireless device, the wireless device having a light source and a transceiver with a unique media address corresponding to a unique product, the device broadcasts a first signal including an order command and the unique media address by the transceiver via a wireless medium. A central controller then receives the first signal, identifies the unique media address included in the first signal, and using a database, identifies the unique product associated with the unique media address.
    Type: Grant
    Filed: September 23, 2004
    Date of Patent: July 14, 2009
    Assignee: Symbol Technologies, Inc
    Inventors: Robert K. T. Chen, Mark E. Depperschmidt, James E. Lee, Jr., Patrick Gray
  • Publication number: 20080260643
    Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.
    Type: Application
    Filed: March 27, 2008
    Publication date: October 23, 2008
    Applicant: OMEROS CORPORATION
    Inventors: John E. Bergmann, Neil S. Cutshall, Gregory A. Demopulos, Vincent A. Florio, George Gaitanaris, Patrick Gray, John Hohmann, Rene Onrust, Hongkui Zeng