Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Abstract: A voltage pulse is transmitted into a test object, and returned reflection pulses are evaluated to determine the location of a fault in the test object. The return signal includes a reflection from the fault and undesired interfering reflection pulses, which are removed or compensated-out from the return signal to produce a corrected pulse diagram. A circuit arrangement for this includes a bi-directional coupler, a separation filter, a measured signal detection circuit with two input channels, a memory storing a database, a computer processor, and a measured signal evaluation unit. A method in this regard includes a first step of measuring the input impedance of the test object, and a second step of measuring the return signal pulses, transforming the return signal to the frequency domain, compensating the frequency domain data to remove interference, transforming the data back to the time domain, and representing or evaluating the pulse diagram.

Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Abstract: A method of inventory management is described. Upon activation of a button on a wireless device, the wireless device having a light source and a transceiver with a unique media address corresponding to a unique product, the device broadcasts a first signal including an order command and the unique media address by the transceiver via a wireless medium. A central controller then receives the first signal, identifies the unique media address included in the first signal, and using a database, identifies the unique product associated with the unique media address.

Abstract: A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

Abstract: The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.

Abstract: A pool or spa cover having a generally domed shape caused by bending of previously substantially straight support mechanisms, wherein the circumference is dependent upon curvature of the support mechanisms and is therefore adjustable to fit different size pools or spas, and wherein the pool or spa cover may be utilized as an umbrella when not in use as a pool or spa cover via attaching the pool or spa cover to a central pole having a base.

Abstract: A kit for assembling putters of variable selected designs which includes a plurality of putter heads of varying designs, each putter head being formed with a bore in its upper surface. Also, including a plurality of hosels of varying designs, each hosel having a foot including a projection at a first end and a receptacle at a second end. Each projection being sized to fit into each of the bores in the putter heads. Further including a plurality of shafts of a plurality of lengths and flexes, each of which is sized at one end to fit into the hosel receptacles. The kit provides the components for assembling putters of selected and differing designs by choosing a specific designed putter head from the plurality of putter heads, choosing a specific designed hosel from the plurality of hosels, choosing a shaft of specific length and flexibility from the plurality of shafts and securing them together in the appropriate manner.

Abstract: The present invention provides purified and isolated polynucleotide sequences encoding a novel macrophage-derived C-C chemokine designated “Macrophage Derived Chemokine” (MDC), and polypeptide fragments and analogs thereof. Also provided are materials and methods for the recombinant or synthetic production of the chemokine, fragments, and analogs; and purified and isolated chemokine protein, and polypeptide fragments and analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing. Also provided are assays for identifying modulators of MDC chemokine activity.

Abstract: The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.

Abstract: The present invention provides purified and isolated polynucleotide sequences encoding a novel human macrophage-derived C—C chemokine designated Macrophage Derived Chemokine (MDC), and polypeptide analogs thereof. Also provided are materials and methods for the recombinant production of the chemokine, and purified and isolated chemokine protein, and polypeptide analogs thereof. Also provided are antibodies reactive with the chemokine and methods of making and using all of the foregoing.

Abstract: The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.

Abstract: A method of inventory management is described. Upon activation of a button on a wireless device, the wireless device having a light source and a transceiver with a unique media address corresponding to a unique product, the device broadcasts a first signal including an order command and the unique media address by the transceiver via a wireless medium. A central controller then receives the first signal, identifies the unique media address included in the first signal, and using a database, identifies the unique product associated with the unique media address.

Abstract: A method of inventory management is described. Upon activation of a button on a wireless device, the wireless device having a light source and a transceiver with a unique media address corresponding to a unique product, the device broadcasts a first signal including an order command and the unique media address by the transceiver via a wireless medium. A central controller then receives the first signal, identifies the unique media address included in the first signal, and using a database, identifies the unique product associated with the unique media address.

Abstract: A system and method for playing a wagering game over a network such as the Internet includes a point of sale terminal for issuing a gaming ticket including gaming information to a player. A gaming engine processes ticket results and provides an interactive gaming interface display. A user device displays the gaming interface made available by the gaming engine and permits the user to interact with the gaming engine upon entering the gaming information from the ticket. The gaming engine further obtains and transmits winning information and game results to the player for display on the user device. The game ticket can be validated and redeemed at a point of sale terminal.

Abstract: The invention relates to a bandage or wound dressing fabricated from a natural or synthetic film-forming material, such as a hydrophobic polymeric membrane, incorporating a therapeutically effective amount of one or more therapeutically active (e.g. anti-microbial) compounds, including Triclosan, within the matrix thereof. The incorporation of Triclosan provides continuous inherent control of the growth of a broad range of microorganisms, which promotes better wound care management and wound healing.

Abstract: A putter head formed of a first material having a heel, a toe, a back, a top, a sole and a face forming the designated impact surface with a golf ball. The face comprising a generally planar surface extending from the heel to the toe and from the top to the sole. A plurality of horizontal rows of apertures are formed along substantially horizontal planes through the face into a body area between the face and the back. The apertures are formed to selected and different depths depending upon their location on the face. A filler of selected weight per unit area may be added to selected apertures. A putter head of selected weight, balance and feel is provided.

Abstract: The present invention provides purified and isolated polynucleotide sequences encoding human plasma platelet-activating factor acetylhydrolase. Also provided are materials and methods for the recombinant production of platelet-activating factor acetylhydrolase products which are expected to be useful in regulating pathological inflammatory events.