Abstract: Provided herein are compounds binding to KRAS protein or a mutant thereof, pharmaceutical compositions comprising said compounds, and methods for using said compounds for the treatment of diseases.

Abstract: A knife includes a blade defining an aperture, a handle pivotably coupled to the blade and selectively repositionable between a first position and a second position relative to the blade, a catch extending between a first catch end and a second catch end, the catch movably coupled to the handle and including a protrusion proximate the first catch end, and a spring coupled to the handle and configured to apply a biasing force on the catch proximate the second catch end. The biasing force biases the protrusion of the catch toward the blade, and the protrusion is received by the aperture to restrict rotation of the handle relative to the blade when the handle is in the first position.

Abstract: A knife includes a blade, a first handle having pivotably coupled to the blade, a second handle pivotably coupled to the blade, the second distal end of the second handle defining a first locking mechanism and a second locking mechanism, a latch pivotably coupled to the second distal end portion and supporting a locking pin, the locking pin configured to selectively engage each of the first locking mechanism and the second locking mechanism separately, wherein the first handle and the second handle are each selectively repositionable between an open position and a closed position, wherein in the open position, the first handle and the second handle extend away from the blade, and wherein in the closed position, the first handle and the second handle extend along the blade.

Abstract: Various disclosed embodiments include illustrative telescoping tailgate systems for an automotive vehicle and illustrative automotive vehicles with a telescoping tailgate system for carrying cargo or passengers. In an illustrative embodiment, a telescoping tailgate system for an automotive vehicle includes: a primary tailgate configured to be movably attached to a body of an automotive vehicle, the primary tailgate defining an opening therethrough; a secondary tailgate movably attached to the primary tailgate; and a telescoping mechanism configured to move the secondary tailgate between a retracted position and an extended position, the secondary tailgate being configured to close the opening in the primary tailgate when the secondary tailgate is in an extended position.

Abstract: A sheath has a sheath body having a front plate and a back plate spaced apart from the front plate. The front plate and back plate define a cavity within the sheath body. The cavity is externally accessible through an opening formed between the front plate and the back plate. Snapping fasteners are positioned about a front side and a back side of the back plate. The snapping fasteners each include a male component and a female component. The male component and female component of each fastener are mounted on opposite sides of the back plate. The male component includes a protrusion extending away from the sheath body. The female component defines a recess that is complimentary to the protrusion.

Abstract: A knife includes a blade, a first handle having pivotably coupled to the blade, a second handle pivotably coupled to the blade, the second distal end of the second handle defining a first locking mechanism and a second locking mechanism, a latch pivotably coupled to the second distal end portion and supporting a locking pin, the locking pin configured to selectively engage each of the first locking mechanism and the second locking mechanism separately, wherein the first handle and the second handle are each selectively repositionable between an open position and a closed position, wherein in the open position, the first handle and the second handle extend away from the blade, and wherein in the closed position, the first handle and the second handle extend along the blade.

Abstract: A robot comprises a first part and a second part moveable relative to the first part. The robot operates in an audio output mode in which the first and second parts are in a first configuration relative to each other and in which the robot outputs audio from an array of speakers using an audio output technique. The robot operates in a user interaction mode in which the first and second parts are in a second, different configuration relative to each other and in which the robot interacts with a user. The robot is configured to change from the audio output mode to the user interaction mode in response to the robot detecting a trigger event. Changing from the audio output mode to the user interaction mode comprises causing the first part to lift up relative to the second part.

Abstract: Various disclosed embodiments include methods of locating an intended passenger of an automotive vehicle and vehicle-based systems for locating an intended passenger of an automotive vehicle. In an illustrative embodiment, a method of locating an intended passenger of an automotive vehicle includes: moving an automotive vehicle to an approximate location of an intended passenger based on a location signal from the intended passenger received via a wireless network; after moving to the approximate location of the intended passenger, receiving, by the vehicle, an image from an electronic device of the intended passenger, the image being an image of the intended passenger or an image of local physical surroundings of the intended passenger; processing the image to determine additional location information of the intended passenger based on matching the image against one or more reference images; and accepting by the vehicle, the intended passenger responsive to the image processing.

Abstract: A surgical instrument suitable for preparing an intervertebral disc space includes an outer sleeve, an instrument head, an inner shaft, a handle, a universal joint, a coupling member, and a drive mechanism. The outer sleeve includes a proximal end, a distal end and a longitudinal axis. The instrument head defines a longitudinal axis and is disposed at the distal end of the outer shaft. The inner shaft is slidably disposed within the outer sleeve and includes a proximal end, a distal end and a longitudinal axis coaxially aligned with the longitudinal axis of the outer sleeve. The drive mechanism is coupled between the outer sleeve and the inner shaft and actuates the outer sleeve axially relative to the inner shaft, thereby setting an angle of the longitudinal axis of the instrument head in relation to the longitudinal axis of the inner shaft.

Abstract: A knife includes a blade defining an aperture and a handle. The handle includes a body pivotably coupled to the blade, a catch movably coupled to the body, and a biasing member coupled to the body. The catch includes a protrusion. The biasing member is configured to apply a biasing force on the catch. The handle is selectively repositionable between a first position and a second position relative to the blade. The biasing force biases the protrusion of the catch toward the blade when the handle is in the first position. The protrusion is received by the aperture to prevent rotation of the handle relative to the blade when the handle is in the first position.

Abstract: Disclosed embodiments include methods, systems, and non-transitory computer readable medium for augmented reality detection for locating a particular autonomous vehicle. In a non-limiting embodiment, an illustrative method includes providing, by an electronic device to a remote server, a request for an autonomous vehicle. A first signal indicating that the autonomous vehicle is within an accessible range to an intended passenger is received by an electronic device. The passenger is prompted by the electronic device to orient an image sensor of the electronic device towards a designated area of the accessible range. The designated area is imaged by the image sensor for the autonomous vehicle. A visual representation of the imaged designated area is generated on a graphical user interface of the electronic device. The autonomous vehicle is identified within the generated visual representation.

Abstract: Disclosed embodiments include methods, systems, and non-transitory computer readable medium for augmented reality detection for locating a particular autonomous vehicle. In a non-limiting embodiment, an illustrative method includes providing, by an electronic device to a remote server, a request for an autonomous vehicle. A first signal indicating that the autonomous vehicle is within an accessible range to an intended passenger is received by an electronic device. The passenger is prompted by the electronic device to orient an image sensor of the electronic device towards a designated area of the accessible range. The designated area is imaged by the image sensor for the autonomous vehicle. A visual representation of the imaged designated area is generated on a graphical user interface of the electronic device. The autonomous vehicle is identified within the generated visual representation.

Abstract: Various disclosed embodiments include methods of locating an intended passenger of an automotive vehicle and vehicle-based systems for locating an intended passenger of an automotive vehicle. In an illustrative embodiment, a method of locating an intended passenger of an automotive vehicle includes: moving an automotive vehicle to an approximate location of an intended passenger based on a location signal from the intended passenger received via a wireless network; after moving to the approximate location of the intended passenger, receiving, by the vehicle, an image from an electronic device of the intended passenger, the image being an image of the intended passenger or an image of local physical surroundings of the intended passenger; processing the image to determine additional location information of the intended passenger based on matching the image against one or more reference images; and accepting by the vehicle, the intended passenger responsive to the image processing.

Abstract: Various disclosed embodiments include illustrative telescoping tailgate systems for an automotive vehicle and illustrative automotive vehicles with a telescoping tailgate system for carrying cargo or passengers. In an illustrative embodiment, a telescoping tailgate system for an automotive vehicle includes: a primary tailgate configured to be movably attached to a body of an automotive vehicle, the primary tailgate defining an opening therethrough; a secondary tailgate movably attached to the primary tailgate; and a telescoping mechanism configured to move the secondary tailgate between a retracted position and an extended position, the secondary tailgate being configured to close the opening in the primary tailgate when the secondary tailgate is in an extended position.

Abstract: Disclosed embodiments include methods, systems, and non-transitory computer readable medium for augmented reality detection for locating a particular autonomous vehicle. In a non-limiting embodiment, an illustrative method includes providing, by an electronic device to a remote server, a request for an autonomous vehicle. A first signal indicating that the autonomous vehicle is within an accessible range to an intended passenger is received by an electronic device. The passenger is prompted by the electronic device to orient an image sensor of the electronic device towards a designated area of the accessible range. The designated area is imaged by the image sensor for the autonomous vehicle. A visual representation of the imaged designated area is generated on a graphical user interface of the electronic device. The autonomous vehicle is identified within the generated visual representation.

Abstract: Systems and methods are provided herein for operating an autonomous vehicle in the presence of hazardous materials. The autonomous vehicle is operated in travel along a selected route. A determination is made, using a sensor, that a hazardous material is present inside the autonomous vehicle during the operation of the autonomous vehicle. In response, a setting of the autonomous vehicle is changed to counteract the presence of the hazardous material inside the autonomous vehicle. Additionally, also in response, a modified route is calculated, the modified route addressing the presence of the hazardous material inside the autonomous vehicle. Then, the autonomous vehicle is operated to travel along the modified route.

Abstract: A sheath has a sheath body having a front plate and a back plate spaced apart from the front plate. The front plate and back plate define a cavity within the sheath body. The cavity is externally accessible through an opening formed between the front plate and the back plate. Snapping fasteners are positioned about a front side and a back side of the back plate. The snapping fasteners each include a male component and a female component. The male component and female component of each fastener are mounted on opposite sides of the back plate. The male component includes a protrusion extending away from the sheath body. The female component defines a recess that is complimentary to the protrusion.

Abstract: An electric vehicle system for transporting human passengers or cargo includes an electric vehicle that includes a body, a plurality of wheels, a cargo area, an electric motor for propelling the electric vehicle, and a primary battery for providing electrical power to the electric motor for propelling the electric vehicle. An auxiliary battery module is attachable to the electric vehicle for providing electrical power to the electric motor via a first electrical connector at the auxiliary battery module and a second electrical connector at the electric vehicle that mates with the first electrical connector. The auxiliary battery module can be positioned in the cargo area while supplying power to the electric motor, and can be removable and reattachable from the electric vehicle. The auxiliary battery module includes an integrated cooling system for cooling itself during operation of the electric vehicle including a conduit therein for circulating coolant.

Abstract: Systems and methods are provided herein for operating an autonomous vehicle. A destination is received from a user. A mode selection input is also received from a user. A selected route is determined based on the destination input. In response to determining that the mode selection input identifies a regular driving mode, the autonomous vehicle is operated to travel along the selected route in the regular driving mode. In the regular driving mode at least one capability of a first plurality of capabilities of the autonomous vehicle is enabled. Further, in response to determining that the selection of the mode identifies a guardian mode, the autonomous vehicle is operated to travel along the selected route in the guardian mode. In the guardian mode at least one capability of a first plurality of capabilities of the autonomous vehicle is disabled.

Abstract: Approaches for charging a battery for an electric vehicle involve obtaining battery usage metrics of the battery of the electric vehicle based upon past usage of the battery and past charging of the battery. The metrics are analyzed to determine a target state of charge (SOC) for a first type of vehicle usage and determine a charging scheme as a function of time to achieve the target SOC at a first predetermined time. The charging scheme includes a first time period and a subsequent second time period, wherein an average rate of delivering charge to the battery during the second time period is greater than an average rate of delivering charge to the battery during the first time period. The battery is charged according to the charging scheme until the battery reaches the target SOC, which is less than a maximum state of charge for the battery.