Patents by Inventor Patrick J. Casey

Patrick J. Casey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inhibitors of Isoprenylcysteine Carboxyl Methyltransferase
    Publication number: 20080171782
    Abstract: The present invention relates, in general, to isoprenylcysteine carboxylmethyltransferase (Icmt) and, in particular, to inhibitors of Icmt and to methods of disease treatment using same.
    Type: Application
    Filed: March 20, 2006
    Publication date: July 17, 2008
    Inventors: Patrick J. Casey, Rudi Baron, Ann Winter-Vann
  • Pyrazole compounds and uses thereof
    Patent number: 6191147
    Abstract: The present invention is directed to compounds of the formula: and pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising same, and to methods for inhibiting protein prenylation in an organism using the same, where R1, R2, R3, R4, R5, R6, R7 and X are defined herein.
    Type: Grant
    Filed: November 15, 1999
    Date of Patent: February 20, 2001
    Assignees: PPD Discovery, Inc., Duke University
    Inventors: Bradley B. Brown, Patrick J. Casey, Casey Pritchard Purdy, Zita Latona, Sarah Tavares
  • Protein prenyltransferase
    Patent number: 5789558
    Abstract: The present invention relates, in general, to a protein prenyltransferase and, in particular, to protein geranylgeranyltransferase (GGTase-I) and to a nucleic acid sequence encoding same. The invention also relates to methods of producing GGTase-I and geranylgeranyl modified polypeptides. The invention further relates to a method of screening compounds for the ability to alter GGTase-I activity.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: August 4, 1998
    Assignees: Merck & Co., Inc., Duke University
    Inventors: Patrick J. Casey, Fang Zhang, Ronald E. Diehl, Nancy E. Kohl, Charles A. Omer
  • Modulators of multidrug resistance transporters
    Patent number: 5571687
    Abstract: The present invention relates, in general, to multidrug resistance and, in particular, to compounds that modulate multidrug resistance transporters. The invention also relates to methods of selecting or designing compounds for the ability to modulate multidrug resistance transporters, and to methods of modulating multidrug resistance.
    Type: Grant
    Filed: June 7, 1994
    Date of Patent: November 5, 1996
    Assignee: Duke University
    Inventors: Patrick J. Casey, Lili Zhang