Abstract: Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

Abstract: Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

Abstract: A method for improved cardiac monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring edema in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to cardiac activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A cardiac condition for the patient is determined based on the fused data set. A cardiac monitoring computing device and non-transitory medium are also disclosed.

Abstract: Systems and methods for receiving data characterizing a plurality of images of a surgical region that includes a first target tissue. The plurality of images include a plurality images associated with visible light images, a plurality of images associated with a first wavelength and a plurality of images associated with the second wavelength that is different from the first wavelength. The method also includes generating a first scene by at least overlaying a first set of images of the plurality of images. The first set of images are temporally contiguous and include a first image associated with the first wavelength, a second image associated with visible light, and a third image associated with the second wavelength. The image further includes generating a second scene by at least overlaying a second set of images of the plurality of images. The second set of images are temporally contiguous.

Abstract: A method for improved disease monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring a hypothesis disease in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to disease activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A disease condition for the patient is determined based on the fused data set. A disease monitoring computing device and non-transitory medium are also disclosed.

Abstract: Systems and methods for receiving data characterizing a plurality of images of a surgical region that includes a first target tissue. The plurality of images include a plurality images associated with visible light images, a plurality of images associated with a first wavelength and a plurality of images associated with the second wavelength that is different from the first wavelength. The method also includes generating a first scene by at least overlaying a first set of images of the plurality of images. The first set of images are temporally contiguous and include a first image associated with the first wavelength, a second image associated with visible light, and a third image associated with the second wavelength. The image further includes generating a second scene by at least overlaying a second set of images of the plurality of images. The second set of images are temporally contiguous.

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

Abstract: A method for multi-target detection and an apparatus for multi-target detection are capable of detecting at least two targets in real time or near real time. The real-time detection or near real time detection can be achieved by at least one of a Recipe Group Approach, an End Member Grouping Approach, and a Pixelated Grouping Based Approach.

Abstract: A method of operating a surgical visualization system includes illuminating an anatomical field of a patient using a waveform transmitted by an emitter. The method also includes capturing an image of the anatomical field based on the waveform using a receiver. The emitter and the receiver are configured for multispectral imaging or hyperspectral imaging. The method also includes determining an adjustment to at one operating parameter of the surgical visualization system based on at least one environmental scene parameter. The method also includes automatically implementing the adjustment to the at least one operating parameter to aid in identification of at least one anatomical structure in the anatomical field.

Abstract: A method which may effectively provide an endoscope or other surgical instrument with a synthetic multi-camera array may comprise capturing using one or more cameras located at a distal tip of the surgical instrument, a set of images comprising first and second images. For each image in such set of images, that image may be captured by a corresponding camera from the one or more cameras, may be captured when the distal dip of the instrument is located at a corresponding point in space. Such a method may also comprise generating a three dimensional image based on compositing representations of a structure in the first and second image after applying a non-rigid transformation to one or more of those representations.

Abstract: A system may be provided which comprises an illumination source adapted to simultaneously illuminate a surgical site with spectral light comprising a first wavelength of light and a second wavelength of light, a first set of sensors comprising sensors adapted to detect visible light, and a second set of sensors comprising sensors adapted to detect the first wavelength of light; and sensors adapted to detect the second wavelength of light. In such a case, the system may also comprise a display coupled to a processor configured to display an enhanced image of the surgical site comprising a visible light image from data detected by the first set of sensors and an overlay identifying a target structure based on light detected by the second set of sensors while the surgical site is illuminated by spectral light comprising the first and second wavelengths of light.

Abstract: The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation without processing large amounts of spectral information, which significantly increases the speed of processing spectral information.

Abstract: In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.

Abstract: In order to avoid friendly fire incidents in the combat theater, novel covert identification systems and methods of identifying friendly forces are provided. The systems include at least a spectroscopic imaging device and a marker that interact with each other by using a synchronized, predetermined filter tuning sequence. The filter tuning sequence enables interacted photons to wavelength hop according to the predetermined tuning sequence. As a result, the covert identification system allows friendly forces to clearly identify each while avoiding detection by enemy forces that employ conventional broadband and night vision sensors.

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

Abstract: The conformal spectral library training method (CSLTM) of the disclosure allows sets of voltages for an optical filter to be calculated by way of a direct calculation without processing large amounts of spectral information, which significantly increases the speed of processing spectral information.

Abstract: Methods for improved tissue perfusion monitoring are disclosed. A method includes collecting hyperspectral image data from an image sensor positioned to collect interacted photons from a tissue region resulting from illumination of the tissue sample at a plurality of wavelengths in the visible, near infrared, or shortwave infrared regions. Hypercubes are generated based on the collected hyperspectral image data. The hypercubes are analyzed to identify one or more of the plurality of wavelengths resulting in contrast in the hyperspectral images. One or more regions in the tissue region with altered perfusion states are identified based on the contrast in the hyperspectral images. A tissue perfusion monitoring computing device and non-transitory medium are also disclosed.

Abstract: A method for improved cardiac monitoring is disclosed. The method includes receiving image data from an image sensor configured for monitoring edema in a patient. Additional data is received from one or more additional sensors configured to monitor one or more factors related to cardiac activity of the patient. The received image data is fused with the received additional data from the one or more additional sensors to generate fused data set. A cardiac condition for the patient is determined based on the fused data set. A cardiac monitoring computing device and non-transitory medium are also disclosed.

Abstract: Methods and systems of identifying oral cancer in vivo are disclosed. An oral cavity of a patient is illuminated with a plurality of illuminating photons. A plurality of interacted photos are received from the oral cavity. The interacted photons may have been absorbed, reflected, scattered or emitted by the oral cavity. The interacted photons are filtered into first and second polarized multi-passband wavelengths using first and second tunable conformal filters, respectively. A detector captures the first and second polarized multi-passband wavelengths. A processor automatically discriminates between cancerous tissue and non-cancerous tissue in an image resolved from the first and second polarized multi-passband wavelengths.