Abstract: Systems of methods of combining imaging modalities for improved target detection within a sample are disclosed herein. The system can be configured to receive two or more images captured using different imaging modalities, create a score image from one of the captured images, fuse the second image and the score image together, identify the target within the score image or the fused image, register the received images together, and overlay the detected target on the first image. The first image can include an image captured using molecular chemical imaging and the second image can include a RGB image, for example.

Abstract: A method for multi-target detection and an apparatus for multi-target detection are capable of detecting at least two targets in real time or near real time. The real-time detection or near real time detection can be achieved by at least one of a Recipe Group Approach, an End Member Grouping Approach, and a Pixelated Grouping Based Approach.

Abstract: Methods, non-transitory computer readable media, and surgical video analysis devices are disclosed that provide an improved, automated surgical report generation. With this technology, a video associated with a surgical procedure comprising a plurality of frames is obtained. The plurality of frames of the obtained video are compared to a historical set of surgical procedure images, wherein the historical set of surgical procedure images are associated with contextual information. One or more objects of interest are identified in at least a subset of the plurality of frames based on the comparison and the associated contextual information. The identified one or more objects of interest are tracked across the at least the subset of the plurality of frames. A surgical report based on tracked one or more objects.

Abstract: Systems for and methods for in situ optimization of tunable light emitting diode sources are disclosed herein. During operation, the systems and methods obtain real-time feedback from an image sensor, and that feedback is used to tune the tunable LEDs. By tuning the tunable LEDs, the best values for the LED spectral output can be selected based on the feedback from the image sensor, and an image with improved contrast is obtained. Alternatively, the amount of time to obtain an image with acceptable contrast is reduced.

Abstract: An endoscope has an improved chip-on-tip configuration that includes both a first configuration of source illumination fibers and a second plurality of source illumination fibers, along with a camera chip. The combination of the camera chip and the source illumination fibers on the tip of the endoscope results in endoscopes with reduced size and weight.

Abstract: The disclosure provides methods, systems, and computer program products for detecting compounds of interest that are deposited on or associated with objects of interest. The compounds of interest are not limited and include drugs, alcohol, cannabis, narcotics, controlled substances as defined by state, federal, or international law, ammonium-based explosives, MGE-based explosives, toxic compounds, organic compounds, inorganic compounds, nerve agents, or biological compounds. The disclosure increases the speed and efficiency of processing hyperspectral images, especially on low-power or portable devices.

Abstract: Systems and methods of detecting and monitoring edema in a subject are described. The systems and methods include light sources, image detectors, filters, and processors that determine whether a subject has edema and the degree of severity. In some embodiments, the processor fuses data from more than one imaging modality.

Abstract: A system and method for analyzing unknown materials on surfaces including, but not limited to, chemical materials, biological materials, hazardous materials, drug materials, and non-threat materials using SWIR and/or extended range SWIR hyperspectral and spectroscopic techniques. A system comprising a collection optics, a tunable filter, and a first detector for generating a test data set representative of the unknown sample. A second detector, comprising a visible imaging device, may be configured to operate in a scanning mode to locate areas of interest for further interrogation using SWIR. A method comprising generating a SWIR test data set representative of the unknown sample and analyzing the unknown sample to detect, identify and/or distinguish an unknown material as a known material. This analysis may be achieved by comparing the test data set to a reference data set using at least one chemometric technique.

Abstract: A portable system and method for analyzing biological tissue samples and detecting analytes associated with tissue oxygenation using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.

Abstract: The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.

Abstract: A system and method for detecting analytes using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.

Abstract: The present disclosure describes security screening systems and methods for identifying a suspect material in a sample. In general terms, the system and method disclosed herein provide collection optics configured to collect a first plurality of interacted photons from an illuminated sample and generating a first optical signal. The first optical signal is separated into a plurality of optical components where the plurality of optical components are filtered by a plurality of filters. Each filter of the plurality of filters is configured to filter the plurality of optical components into a passband wavelength to generate a plurality of filtered components. The plurality of filtered components are detected by one or more detectors and one or more wavelength specific spectral images are generated. A processor is configured to analyze the one or more wavelength specific spectral images in order to identify the suspect material in the sample.

Abstract: A first location comprising an unknown material may be scanned using SWIR hyperspectral imaging in a dual polarization configuration. Surveying may also be applied to thereby determine whether or not a human is present. This surveying may be achieved my assessing LWIR data, data acquired from motion sensors, and combinations thereof. If no human is present, a second location may be interrogated using Raman spectroscopic techniques to thereby obtain a Raman data set representative of the region of interest. This Raman data set may be assessed to associate an unknown material with a known material. This assessment may be achieved by comparing the Raman data set to one or more reference data sets in a reference database, where each reference data set is associated with a known material.

Abstract: The present disclosure provides for a system and method for analyzing a sample comprising at least one unknown material. A first location may be scanned to generate a SWIR hyperspectral image. The SWIR hyperspectral image may be generated using dual polarization techniques. The SWIR hyperspectral image may be analyzed to target a second location comprising the unknown material. This second location may be further analyzed using Raman spectroscopic techniques and a Raman data set may be generated. The Raman data set may be further analyzed to associate the unknown material with a know material.

Abstract: A portable system and method for analyzing biological tissue samples and detecting analytes associated with tissue oxygenation using a conformal filter. A conformal filter, which may comprise a tunable filter, is configured to filter interacted photons conforming to a spectral shape correlated with an analyte of interest. Conformal filter configurations may be selected by consulting a modified look-up table associated with an analyte. An iterative methodology may be used to calibrate a conformal design for an analyte of interest, refine a previous conformal filter design for an analyte of interest, and/or generate a new conformal filter design for an analyte of interest.

Abstract: A method and a portable device for assessing the occurrence of an agent in a sample. A sample is illuminated with photons emanating from a portable device to produce photons reflected, emitted, or absorbed from a set of multiple points in the sample having a defined geometric relationship. The portable device is used to simultaneously illuminate the sample and analyze the photons reflected, emitted, or absorbed from the set of multiple points using spectroscopic methods, including infrared, fluorescence, and UV/visible. The agent assessed may include a hazardous agent, a chemical agent, a biological agent, a microorganism, a bacterium, a protozoan, a virus, and combinations thereof.

Abstract: The disclosure provides for a portable device for detecting hazardous agents, including explosives using SWIR hyperspectral imaging. The device may comprise a collection optics, a SWIR multi-conjugate filter, a SWIR camera, and a display. The device may also comprise an RGB camera. The disclosure also provides for a method of using said portable device wherein interacted photons are collected and passed through a SWIR multi-conjugate filter. The interacted photons are detected to generate at least one SWIR hyperspectral image. The SWIR hyperspectral image may be analyzed to determine the presence or absence of a hazardous agent on a target. An RGB image of a target may also be generated and analyzed to survey a sample scene.

Abstract: System and method for differentiating tissue margins in a biological sample using pulsed laser excitation and time-gated detection. A region containing a biological tissue is irradiated with substantially monochromatic pulsed laser light to thereby produce Raman scattered photons. The Raman scattered photons are detected using time-gated detection to thereby obtain a Raman spectroscopic image from the irradiated region characteristic of either a neoplastic portion or a non-neoplastic portion of the region containing the biological tissue. A boundary between a neoplastic portion and a non-neoplastic portion is differentiated and the boundary location in the Raman spectroscopic image is displayed.

Abstract: A system and method for standoff detection of explosives and explosive residue. A laser light source illuminates a target area having an unknown sample producing luminescence emitted photons, scattered photons and plasma emitted photons. A first optical system directs light to the target area. A video capture device outputs a dynamic image of the target area. A second optical system collects photons, and directs collected photons to a first two-dimensional array of detection elements and/or to a fiber array spectral translator device which device includes a two-dimensional array of optical fibers drawn into a one-dimensional fiber stack. A spectrograph is coupled to the one-dimensional fiber stack of the fiber array spectral translator device, wherein the entrance slit of the spectrograph is coupled to the one dimensional fiber stack.

Abstract: The invention relates to apparatus and methods for assessing occurrence of a hazardous agent in a sample by performing multipoint spectral analysis of the sample. Methods of employing Raman spectroscopy and other spectrophotometric methods are disclosed. Devices and systems suitable for performing such multipoint methods are also disclosed.