Patents by Inventor Patrick L. Coleman
Patrick L. Coleman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090023722Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.Type: ApplicationFiled: June 30, 2008Publication date: January 22, 2009Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
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Patent number: 7393859Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.Type: GrantFiled: May 19, 2004Date of Patent: July 1, 2008Assignee: Coley Pharmaceutical Group, Inc.Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
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Patent number: 7238269Abstract: A device includes a substrate having first and second major surfaces and a hub that defines an axis of rotation for the substrate, and an unvented channel having a plurality of connected compartments. Methods for using devices of the invention are also disclosed.Type: GrantFiled: July 1, 2003Date of Patent: July 3, 2007Assignee: 3M Innovative Properties CompanyInventors: Samuel J. Gason, William Bedingham, Bathsheba E. Chong Conklin, Patrick L. Coleman, Peter D. Ludowise, Isidro Angelo E. Zarraga
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Patent number: 6783838Abstract: A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.Type: GrantFiled: April 30, 2001Date of Patent: August 31, 2004Assignee: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Kurt J. Halverson, James I. Hembre, Sanjay L. Patil, Anila Prabhu, Raj Rajagopal, Jerald K. Rasmussen, Barbara C. Swenson, Patrick S. Quint
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Patent number: 6756382Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.Type: GrantFiled: December 21, 2001Date of Patent: June 29, 2004Assignee: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
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Publication number: 20030144283Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.Type: ApplicationFiled: December 21, 2001Publication date: July 31, 2003Inventors: Patrick L. Coleman, Stephen L. Crooks, George W. Griesgraber, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
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Publication number: 20020160367Abstract: A coated laminate having an ionic surface including a shrinkable polymeric film, an ionic coating and, optionally, a hydrogel is disclosed. A method for transferring sample molecules from a matrix to a coated laminate having an ionic surface also is disclosed.Type: ApplicationFiled: April 30, 2001Publication date: October 31, 2002Applicant: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Kurt J. Halverson, James I. Hembre, Sanjay L. Patil, Anila Prabhu, Raj Rajagopal, Jerald K. Rasmussen, Barbara C. Swenson, Patrick S. Quint
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Publication number: 20020160530Abstract: Methods of transferring molecules from a matrix to a coated laminate having an ionic surface are disclosed. Coated laminates having an ionic surface also are disclosed.Type: ApplicationFiled: April 30, 2001Publication date: October 31, 2002Applicant: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Kurt J. Halverson, James I. Hembre, Sanjay L. Patil, Anila Prabhu, Raj Rajagopal, Jerald K. Rasmussen, Barbara C. Swenson, Patrick S. Quint
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Publication number: 20020150951Abstract: A method for cell selection is disclosed. The method uses an azlactone-functional support, which is derivatized with and covalently coupled to a substance that is biologically active with a desired type of whole cell. The method allows the whole cells in the mixture to interact with and bind to the coupled biologically active substance, after which a remainder of the mixture is removed from the support. Optionally, one can elute the bound whole cells from the coupled biologically active substance to produce a purified collection of the whole cells.Type: ApplicationFiled: March 1, 2002Publication date: October 17, 2002Applicant: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Patrick L. Coleman
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Publication number: 20020142306Abstract: A method for transferring molecules from a matrix to a laminate comprising a shrinkable polymeric film and a surface coating is disclosed.Type: ApplicationFiled: March 28, 2001Publication date: October 3, 2002Applicant: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Kurt J. Halverson, James I. Hembre, Sanjay L. Patil, Anila Prabhu, Raj Rajagopal, Jerald K. Rasmussen, Barbara C. Swenson
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Patent number: 6451810Abstract: Imidazoquinoline and tetrahydroimidazoquinoline compounds that contain amide functionality at the 1-position are useful as immune response modifiers. The compounds and compositions of the invention can induce the biosynthesis of various cytokines and are useful in the treatment of a variety of conditions including viral diseases and neoplastic diseases.Type: GrantFiled: June 7, 2000Date of Patent: September 17, 2002Assignee: 3M Innovative Properties CompanyInventors: Patrick L. Coleman, Stephen L. Crooks, Kyle J. Lindstrom, Bryon A. Merrill, Michael J. Rice
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Patent number: 6379952Abstract: Azlactone-functional supports are used to provide cell selection from a mixture such as bone marrow or peripheral blood having a desired target cell population. An azlactone-functional support is derivatized by covalently coupling to the support a biologically active substance that binds the target cells. A mixture containing the target cells is contacted with the derivatized support to bind the target cells to the biologically active substance, and unbound remaining mixture is removed from the support. Bound cells may be eluted from the support to obtain purified target cells. Biologically active substances include antibodies, lectins, proteins, antigens and avidin. The biologically active substance may directly or indirectly bind cells in the mixture. Indirect binding may be through a second, intermediary biologically active substance that is bifunctional.Type: GrantFiled: February 1, 1999Date of Patent: April 30, 2002Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Patrick L. Coleman
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Patent number: 5993935Abstract: A composite article is provided having covalently reactive particles incorporated in a continuous, porous matrix. The reactive particles have surfaces of covalently reactive functional groups capable of directly forming covalent chemical bonds with ligands without need for an intermediate activation step. An adduct composite article is also provided comprising a continuous, porous matrix and derivatized particles dispersed therein. The derivatized particles comprise a direct, covalent reaction product of ligand with the covalently reactive particles. Methods of making and using the composite articles and adduct composite articles are also provided. Preferred covalently reactive functional groups are azlactone-functional groups of the formula: ##STR1## wherein: R.sup.1 and R.sup.Type: GrantFiled: October 11, 1991Date of Patent: November 30, 1999Assignee: 3M Innovative Properties CompanyInventors: Jerald K. Rasmussen, Steven M. Heilmann, Larry R. Krepski, Patrick L. Coleman, Dean S. Milbrath, Margaret M. Walker, Donald F. Hagen, Paul E. Hansen, John C. Campbell
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Patent number: 5709943Abstract: The present invention provides biological assay and adsorption supports comprising an inert substrate supporting a nanostructured surface comprising metal coated, oriented, discrete submicron-size whiskers. Optionally, conformally metal coated whiskers may be partially encapsulated or conformally coated with a second material. The nanostructured surface adsorbs biomolecules rapidly at high levels of tight binding without vortexing or agitation. Advantageously, the bound biomolecules retain their biological activity.Type: GrantFiled: May 4, 1995Date of Patent: January 20, 1998Assignee: Minnesota Mining and Manufacturing CompanyInventors: Patrick L. Coleman, Mark K. Debe, Julie B. Stahl
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Patent number: 5486358Abstract: An azlactone-functional thermoplastic composition is disclosed, The composition is a blend of an azlactone-functional composition and a thermoplastic polymer. A method of making azlactone-functional homopolymers by bulk homopolymerization is disclosed, optionally also concurrent or sequential blending of a thermoplastic polymer. A method of blending azlactone-functional compositions and thermoplastic polymers is disclosed. Molded articles coupled with biologically active substances are claimed.Type: GrantFiled: April 3, 1995Date of Patent: January 23, 1996Assignee: Minnesota Mining and Manufacturing CompanyInventors: Patrick L. Coleman, Steven M. Heilmann, Steven L. Kangas, Jerald K. Rasmussen, Richard J. Rolando, Julie B. Stahl
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Patent number: 5466747Abstract: Graft copolymers comprising a poly-alpha-olefin base polymer selected from the group consisting of polyethylene, polypropylene, polystyrene, and compatible mixtures thereof, having grafted thereto an olefinic monomer. The grafted monomer is present in an amount effective to increase the amount of protein that will bind to the graft copolymer as compared with the base polymer. Also disclosed are polymer/protein compositions comprising a graft copolymer having a protein immobilized on the surface thereof, processes for the preparation of the above-described graft copolymers and compositions, methods of immobilizing proteins, and methods of immunoassay based on such immobilization.Type: GrantFiled: September 26, 1994Date of Patent: November 14, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Richard J. Rolando, Patrick L. Coleman, Steven L. Kangas, Thomas A. Kotnour
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Patent number: 5466749Abstract: Graft copolymers comprising a poly-alpha-olefin base polymer selected from the group consisting of polyethylene, polypropylene, polystyrene, and compatible mixtures thereof, having grafted thereto an olefinic monomer. The grafted monomer is present in an amount effective to increase the amount of protein that will bind to the graft copolymer as compared with the base polymer.Also disclosed are polymer/protein compositions comprising a graft copolymer having a protein immobilized on the surface thereof, processes for the preparation of the above-described graft copolymers and compositions, methods of immobilizing proteins, and methods of immunoassay based on such immobilization.Type: GrantFiled: September 14, 1994Date of Patent: November 14, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Richard J. Rolando, Patrick L. Coleman, Steven L. Kangas, Thomas A. Kotnour
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Patent number: 5451453Abstract: Supports having azlactone-functional surfaces, adduct supports prepared from such azlactone-functional supports, and methods of preparing both are disclosed. Azlactone functionality is introduced to surfaces of a pre-existing support in a manner which retains useful physical and chemical characteristics of the pre-existing support. One method involves exposing surfaces with high energy radiation to generate free radical reaction sites on the surfaces and causing azlactone-functional moieties to react with the free radical reaction sites. Another method involves coating surfaces with azlactone monomers, crosslinking monomers, and optionally co-monomers and polymerizing the monomers to form a polymerized coating of azlactone-functionality on the surfaces. Another method involves dispersion polymerization of azlactone-functional moieties to produce azlactone-functional particles within pores and interstices of a pre-existing support.Type: GrantFiled: June 20, 1994Date of Patent: September 19, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: David R. Gagnon, Patrick L. Coleman, Gary J. Drtina, Oh-Seung Kwon, Christopher S. Lyons, Dean S. Milbrath, Jerald K. Rasmussen, Julie B. Stahl
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Patent number: 5408002Abstract: An azlactone-functional thermoplastic composition is disclosed. The composition is a blend of an azlactone-functional composition and a thermoplastic polymer. A method of making azlactone-functional homopolymers by bulk homopolymerization is disclosed, optionally also concurrent or sequential blending of a thermoplastic polymer. A method of blending azlactone-functional compositions and thermoplastic polymers is disclosed. Molded articles and adduct molded articles formed from the thermoplastic composition are disclosed.Type: GrantFiled: September 9, 1993Date of Patent: April 18, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Patrick L. Coleman, Steven M. Heilmann, Steven L. Kangas, Robert H. Menzies, Jerald K. Rasmussen, Richard J. Rolando, Jennifer J. Sahlin, Julie B. Stahl
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Patent number: 5405618Abstract: A biomosaic polymer is provided. Biologically active materials are bound at surfaces of such polymers polymerized from emulsions containing hydrophobic polymerizable monomers, such biologically active materials, and surface active agents. The biomosaic polymers may be formed into membranes, films, beads, or other structures for a variety of assays, bioseparations, or catalyzed reactions and other uses. A single step polymerization of the emulsion provides significant retention of the biologically active material bound and congregated at surfaces of the polymer.Type: GrantFiled: November 5, 1992Date of Patent: April 11, 1995Assignee: Minnesota Mining and Manufacturing CompanyInventors: Howard J. Buttery, Patrick L. Coleman, Dean S. Milbrath