Abstract: A method is described for reconstituting lyophilized mutant diphtheria toxin in dimethyl sulfoxide for use in producing pneumococcal capsular polysaccharide mutant diphtheria toxin conjugates.

Abstract: A grip for a firearm comprised of an outer layer formed of thermoplastic vulcanite, an intermediate layer having a higher surface energy than the thermoplastic vulcanite, and an inner layer of pressure sensitive adhesive.

Abstract: Compositions and methods for treating myotonic dystrophy type 1 (DM1) with SluCas9 and SaCas9 are encompassed.

Abstract: Methods for reducing electromagnetic interference arising from use of multiple ultrasound transducers in an array, particularly inside a human body that is inside a magnetic resonance imaging device. Electrical signals driving the transducers are offset in phase with respect to one another so as to achieve maximum offset of electrical and magnetic fields arising from such signals and transducers. Phase offsets are dynamically adjusted to respond to changes in driving amplitudes and frequencies so as to maintain optimal reduction of electromagnetic interference.

Abstract: A multi-frequency ultrasound therapy apparatus is configured to operate at its center frequency and at the higher harmonic of its center frequency. The center frequency can be for the entire apparatus or for each ultrasound source element. At least one source element can generate ultrasound energy at its center frequency while, simultaneously, at least another source element can generate ultrasound energy at the higher harmonic of its center frequency. In addition, the same source element can generate ultrasound energy at its center frequency and the higher harmonic of its center frequency, respectively, but at different times. A data storage unit that stores encrypted and encoded data is disposed on the apparatus. The encoded data includes a unique identification code of the apparatus, the condition of use of the apparatus, the center frequency of each source element, the ultrasound efficiency of each source element, and/or other parameters relating to the apparatus.

Abstract: A fuel drain engagement tool and a method for draining fuel from a fuel tank are provided. In one example, a fuel drain engagement tool includes a housing. An engagement mechanism is coupled with the housing and extending upward therefrom. The engagement mechanism is configured to engage a fuel drain valve and to move between a contracted state and an expanded state. A compression applicator is coupled with the housing and is positioned to engage the engagement mechanism when the compression applicator is compressed to apply a force to the engagement mechanism that causes the engagement mechanism to move from the expanded state to the contracted state.

Abstract: Methods for reducing electromagnetic interference arising from use of multiple ultrasound transducers in an array, particularly inside a human body that is inside a magnetic resonance imaging device. Electrical signals driving the transducers are offset in phase with respect to one another so as to achieve maximum offset of electrical and magnetic fields arising from such signals and transducers. Phase offsets are dynamically adjusted to respond to changes in driving amplitudes and frequencies so as to maintain optimal reduction of electromagnetic interference.

Abstract: A grip for a firearm comprised of an outer layer formed of thermoplastic vulcanite, an intermediate layer having a higher surface energy than the thermoplastic vulcanite, and an inner layer of pressure sensitive adhesive.

Abstract: A tool for adjusting an orientation of a nose landing gear of an aircraft is disclosed herein. The nose landing gear has an axle to which a wheel is mounted. The axle has an opening extending therethrough. The opening is defined by an inner surface of the axle. The tool includes, but is not limited to, a unitary member having a handle portion at a first end of the unitary member and an axle-engaging portion at a second end of the unitary member. The handle portion is configured for engagement with a hand of an operator. The axle-engaging portion is configured to be inserted into the opening and to engage with the inner surface.

Abstract: An air intake system for an aircraft, which is switchable between a performance mode and a filtered mode, includes a duct forming filtered air inlet slits. The air intake system also includes interconnected gills adjacent to the filtered air inlet slits. The gills are movable between various gill positions including a closed position substantially covering the filtered air inlet slits and an open position substantially exposing the filtered air inlet slits. The air intake system also includes an actuator configured to move the gills into the closed position in the performance mode and the open position in the filtered mode.

Abstract: A method is described for producing a pneumococcal capsular polysaccharide protein conjugate in which one or more activated pneumococcal polysaccharides of particular pneumococcal serotypes and carrier protein are separately lyophilized, the separately lyophilized polysaccharides and carrier protein are separately reconstituted in an organic solvent, and the reconstituted polysaccharide and carrier protein are then combined together by Tee-mixing and conjugated together to produce polysaccharide carrier protein conjugates. A plurality of conjugates, each comprising polysaccharides of a particular serotype, may be used to produce multivalent pneumococcal immunogenic compositions having a combination of conjugates for use in vaccines.

Abstract: A multi-frequency ultrasound therapy apparatus is configured to operate at its center frequency and at the higher harmonic of its center frequency. The center frequency can be for the entire apparatus or for each ultrasound source element. At least one source element can generate ultrasound energy at its center frequency while, simultaneously, at least another source element can generate ultrasound energy at the higher harmonic of its center frequency. In addition, the same source element can generate ultrasound energy at its center frequency and the higher harmonic of its center frequency, respectively, but at different times. A data storage unit that stores encrypted and encoded data is disposed on the apparatus. The encoded data includes a unique identification code of the apparatus, the condition of use of the apparatus, the center frequency of each source element, the ultrasound efficiency of each source element, and/or other parameters relating to the apparatus.

Abstract: A multi-frequency ultrasound therapy apparatus is configured to operate at its center frequency and at the higher harmonic of its center frequency. The center frequency can be for the entire apparatus or for each ultrasound source element. At least one source element can generate ultrasound energy at its center frequency while, simultaneously, at least another source element can generate ultrasound energy at the higher harmonic of its center frequency. In addition, the same source element can generate ultrasound energy at its center frequency and the higher harmonic of its center frequency, respectively, but at different times. A data storage unit that stores encrypted and encoded data is disposed on the apparatus. The encoded data includes a unique identification code of the apparatus, the condition of use of the apparatus, the center frequency of each source element, the ultrasound efficiency of each source element, and/or other parameters relating to the apparatus.

Abstract: An air intake system for an aircraft, which is switchable between a performance mode and a filtered mode, includes a duct forming filtered air inlet slits. The air intake system also includes interconnected gills adjacent to the filtered air inlet slits. The gills are movable between various gill positions including a closed position substantially covering the filtered air inlet slits and an open position substantially exposing the filtered air inlet slits. The air intake system also includes an actuator configured to move the gills into the closed position in the performance mode and the open position in the filtered mode.

Abstract: Temperature uncertainty maps are calculated based on a rolling window of temperature maps, which is updated as new temperature maps are generated. The rolling window mitigates the effect of transient motion during a thermal therapy procedure. A clinician or an automated control system can then update a portion of an anatomical boundary or the thermal therapy applicator center based on the temperature uncertainty map.

Abstract: Cradle assemblies for supporting a door for uninstalling and/or installing the door to a fuselage of an aircraft, and arrangements and methods for the same are provided. In one example, a cradle assembly includes a first contoured board and a second contoured board that is spaced apart from the first contoured board. The first and second contoured boards are cooperatively configured to support outer sections of a first door. A third contoured board is configured to be selectively positioned adjacent to and extending higher than the first contoured board to support a first outer section of a second door that has a different outer shape than the first door. The third contoured board is contoured to substantially match the first outer section of the second door. The cradle assembly is configured to be positioned proximate to the fuselage.

Abstract: An aircraft lifting assembly includes a jack, a load cell, and a jack adapter. The jack includes an extendable arm having a distal end portion for exerting a force to lift an object. The distal end portion defines a cavity. The jack adapter couples the extendable arm to the load cell and includes a base portion, a cradle portion, and a projection. The base portion defines a jack arm support surface and a load cell support surface. The jack arm support surface opposes the distal end portion of the extendable arm and the load cell support surface opposes the load cell. The cradle portion extends from the base portion to circumscribe a portion of the load cell to secure the jack adapter to the load cell. The projection extends from the base portion into the cavity to secure the jack adapter to the extendable arm of the jack.

Abstract: Compositions and methods for treating excising trinucleotide repeats, as well as for treating diseases and disorders associated with trinucleotide repeats are encompassed.

Abstract: A jack pad device adapted to transfer loads between an aircraft and a jack device for jacking the aircraft, and a method for jacking an aircraft are provided. In one non-limiting example, the jack pad device includes a jack pad body. A jack engagement portion extends from the jack pad body and is configured to engage the jack device. A first coupler is attached to the jack pad body and is configured to couple to the aircraft to hold the jack pad device to the aircraft.

Abstract: A leveling device is disclosed herein. The leveling device includes a body having a body having front surface, bottom surface, side surface and a rear mounting support, the side surface having an aperture configurated to receive a spirt level and a front surface having an aperture therein for viewing the sprit level in the body and the rear mounting support having a first mounting surface configured to be at an angle relative to a plane of the bottom surface, and a second mounting surface orthogonal to the first mounting surface, each of the first and second mounting surfaces having at least one aperture formed therein to receive a magnetic coupling element, whereby, the body containing the sprit level may be magnetically coupled to a vehicle to indicate whether the vehicle remains level during a jacking operation.