Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: A detection device comprised of a hybrid nucleic acid assembly. The device further comprises a nucleic acid polymer, a first nanoparticle conjugated to the nucleic acid polymer, a second nanoparticle conjugated with the nucleic acid polymer, a means for introducing energy into the first nanoparticle, means for detecting energy from the second nanoparticle, and means for determining a physical property of the nucleic acid polymer, wherein the means of introducing energy into the first nanoparticle is a source of mechanical energy.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: An apparatus for regulating the concentration of insulin within the blood of a living organism, wherein said apparatus is comprised of an in vitro cell culture for producing insulin, an in vitro cell culture for producing glucagon, an in vitro cell culture for producing somatostatin, means for measuring the concentration of glucose within the blood of such living organism, means for measuring the concentration of insulin within the blood of such living organism, means for delivering a specified amount of insulin to the blood of such living organism, means for delivering a specified amount of glucagon to the blood of such living organism, means for delivering a specified amount of somatostain to the blood of such living organism, and means for reducing the amount of insulin within such blood of such living organism.

Abstract: A flow cytometer containg a device for sampling cellular material within a body. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, to maintain the sorted cells cells in a viable state, and to remove the marker from the marked cells. Two marker removal devices are used in the flow cytomter.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: A cell-scaffold composition that comprised of a at last five layers biocompatible material, each of which layers is coated with a biological sealant material and contains different cells The cell-scaffold composition is located in a bioreactor that contains devices for mechanically stimulating each of the cells in each of the layers at distinct frequencies.

Abstract: The invention is based on the discovery of a new class of heterocyclic compounds having, for example, antibacterial properties. The D-Ala-D-Ala ligase enzyme is a critical pathway enzyme in the bacterial cell-wall synthesis. The compounds can bind to and inhibit the enzyme D-Ala-D-Ala ligase. The new compounds' activity combined with their ability to cross bacterial cell membranes makes them suitable for use as antibacterial drugs or other antibacterial applications.

Abstract: An artificial joint assembly that contains a first member of bone and, attached to the first member, a second member that contains shape memory material; the second member is located, at least in part, within the first member.

Abstract: The invention is based on the discovery that certain small molecules can bind to the ATP binding site of D-Ala-D-Ala ligase, even in the absence of the enzyme's substrate, and can cause a conformational change in the enzyme structure similar to that which occurs upon binding of ATP and substrate to the enzyme. Without wishing to be bound by any theory, it is believed that such a conformational change is required for either activation or inhibition of the enzyme. The information obtained from this discovery has enabled identification of key interactions in the active site of the enzyme, as well as the design and opimization of inhibitors.

Abstract: An implantable apparatus for delivering a first therapeutic agent within a living biological organism. The apparatus is comprised of a first in vitro cell culture for producing a first therapeutic agent, an implantable pump for delivering the first therapeutic agent, a controller, and a power supply.

Abstract: Novel methods for drug discovery including identification of targets and identification of the functions of targets are disclosed. The methods provide for rapid identification and high throughput screening of targets for developing therapeutics to treat disease conditions.

Abstract: A cardiac assist device containing a device for connecting the cardiac assist device to a heart, for furnishing electrical impulses from the cardiac assist device to the heart, for ceasing the furnishing of electrical impulses to the heart, for receiving pulsed radio frequency fields, for transmitting and receiving optical signals, and for protecting the heart and the cardiac assist device from currents induced by the pulsed radio frequency fields. The cardiac assist device contains a control circuit comprised of a parallel resonant frequency circuit.

Abstract: A flow cytometer containg a device for sampling cellular material within a body, comprising. The flow cytometer is adapted to mark cells within bodily fluid with a marker to produce marked cells, to analyze the marked cells, to sort the cells within the bodily fluid to produce sorted cells, and to maintain the sorted cells cells in a viable state.

Abstract: A detection device containing of a hybrid nucleic acid assembly. The device contains a nucleic acid polymer, a first complementary oligonucleotide annealed to a first consensus sequence on the nucleic acid polymer, a second complementary ogligonucleotide annealed to a second consensus sequence on the nucleic acid polymer, a first nanoparticle conjugated with the first complementary oligonucleotide, a second nanoparticle conjugated with the second complementary oligonucleotide, means for introducing energy into the first nanoparticle, means for withdrawing energy from the second nanoparticle, means for detecting the withdrawal of energy from the second nanoparticle, and means for determining a physical property of the nucleic acid polymer while energy is introduced into the first nanoparticle.

Abstract: An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

Abstract: A prosthetic implant that contains a stem integrally connected to a neck, a head that sits on top of the neck, and a porous assembly disposed around them stem. The porous assembly contains a first porous tube and a second porous tube, wherein the second porous tube is disposed within the first porous tube, and the stem is disposed within the second porous tube. The porous assembly is a heat absorbent porous assembly which tends to maintain its temperature within a specified range.