Abstract: The present disclosure relates generally to certain 6-azabenzimidazole compounds, pharmaceutical compositions comprising said compounds, and methods of making and using said compounds and pharmaceutical compositions. The compounds and compositions disclosed herein may be used for the treatment or prevention of diseases, disorders, or infections modifiable by hematopoietic progenitor kinase 1 (HPK1) inhibitors, such as HBV, HIV, cancer, and/or a hyper-proliferative disease.

Abstract: A barrier ring for a cylinder assembly for an opposed-piston engine fits into a groove fashioned into a portion of the cylinder liner that is adjacent to the top dead center location of the end surfaces of the pistons, in a volume of the cylinder liner that defines the combustion chamber. The barrier ring and groove are part of a barrier assembly that prevents heat generated during combustion from reaching the outer wall of the cylinder assembly, reducing the need for conventional cooling systems and increasing the amount of heat retained in the combustion chamber. The barrier assembly allows for increased engine efficiency because of the combustion heat retained in the combustion chamber, as well as a reduction in the overall size of the engine because of the reduction in engine cooling needed.

Abstract: A microtome includes a blade located at an end of a trough that defines a cavity for holding a liquid; a sample block in which the at least one sample is suspended, the sample block is moveable relative to the blade such that when the sample block is passed across the blade a section is cut from the sample block; a plate that includes a support frame that defines an opening, and a transparent film extending across the opening, the transparent film being transparent to electrons, a grasper being configured to receive and retain the plate, wherein the grasper is moveable relative to the blade; and a pusher section that lacks the sample pusher section.

Abstract: A barrier ring for a cylinder assembly for an opposed-piston engine fits into a groove fashioned into a portion of the cylinder liner that is adjacent to the top dead center location of the end surfaces of the pistons, in a volume of the cylinder liner that defines the combustion chamber. The barrier ring and groove are part of a barrier assembly that prevents heat generated during combustion from reaching the outer wall of the cylinder assembly, reducing the need for conventional cooling systems and increasing the amount of heat retained in the combustion chamber. The barrier assembly allows for increased engine efficiency because of the combustion heat retained in the combustion chamber, as well as a reduction in the overall size of the engine because of the reduction in engine cooling needed.

Abstract: A cylinder cooling construction includes a cylinder liner with a sidewall, exhaust and intake ports opening through the sidewall, a bore, and a plurality of feed channels that are formed with and extend along the sidewall from a central band of the cylinder toward the exhaust and intake ports. A sleeve covering the sidewall includes a plurality of impingement jet ports that are arranged in at least one sequence extending around the central band and that are in liquid communication with the plurality of feed channels. An annular member disposed between the liner and the sleeve reinforces the central band. The sleeve further includes an inside surface with spaced-apart annular recesses that with the sidewall define liquid coolant reservoirs in the vicinity of the ports that are in liquid communication with the feed channels.

Abstract: A microtome includes a blade located at an end of a trough that defines a cavity for holding a liquid; a sample block in which the at least one sample is suspended, the sample block is moveable relative to the blade such that when the sample block is passed across the blade a section is cut from the sample block; a plate that includes a support frame that defines an opening, and a transparent film extending across the opening, the transparent film being transparent to electrons, a grasper being configured to receive and retain the plate, wherein the grasper is moveable relative to the blade; and a pusher section that lacks the sample pusher section.

Abstract: A piston rolling thrust bearing construction is constituted of a pair of bearing plates with opposing faces disposed in a spaced alignment with a rolling ball assembly positioned between the opposing faces to support relative movement between the bearing plates. The piston rolling thrust bearing is mounted to the open end of the skirt of a piston disposed in a cylinder to compensate for non-axial motion relative to the cylinder axis due to the articulating motions of connecting elements or any structural misalignments within an engine drive train assembly.

Abstract: A self-contained demonstration that demonstrates the functionality of an application module. More specifically, the functionality of the application module with respect to information within an external information source that is located remotely from the application module may be demonstrated. In some instances, the components of a system providing the self-contained demonstration may be installed and executed on a single device, while the external information source would be located remotely and externally from the single device. In order to demonstrate the functionality of the application module, the self-contained demonstration may enable the application module to interact with a local information source in substantially the same manner as the application module would interact with an external information source. The local information source may be installed locally on the single device, and may be a scaled-down version of an external information source.

Abstract: Integrated, multi-cylinder opposed engine constructions include a unitary support structure to which cylinder liners are removeably mounted and sealed and on which crankshafts are rotatably supported. The engine constructions include a cooled piston with a resiliently deformable joint connecting crown and skirt and a cooled cylinder liner with wipers to manage lubricant in the cylindrical interstice between the cylinder bore and the piston skirts.

Abstract: A cylinder cooling construction includes a cylinder liner with a sidewall, exhaust and intake ports opening through the sidewall, a bore, and a plurality of feed channels that are formed with and extend along the sidewall from a central band of the cylinder toward the exhaust and intake ports. A sleeve covering the sidewall includes a plurality of impingement jet ports that are arranged in at least one sequence extending around the central band and that are in liquid communication with the plurality of feed channels. An annular member disposed between the liner and the sleeve reinforces the central band. The sleeve further includes an inside surface with spaced-apart annular recesses that with the sidewall define liquid coolant reservoirs in the vicinity of the ports that are in liquid communication with the feed channels.

Abstract: Integrated, multi-cylinder opposed engine constructions include a unitary support structure to which cylinder liners are removeably mounted and sealed and on which crankshafts are rotatably supported. The engine constructions include a cooled piston with a resiliently deformable joint connecting crown and skirt and a cooled cylinder liner with wipers to manage lubricant in the cylindrical interstice between the cylinder bore and the piston skirts.

Abstract: Integrated, multi-cylinder opposed engine constructions include a unitary support structure to which cylinder liners are removeably mounted and sealed and on which crankshafts are rotatably supported. The unitary support structure includes cooling manifolds that provide liquid coolant to the cylinder liners. Exhaust and intake manifolds attached to the support structure to serve respective ports in the cylinder liner. The engine constructions may also include certain improvements in the construction of cooled pistons with flexible skirts, and in the construction of cylinders with sealing structures mounted outside of exhaust and inlet ports to control lubricant in the cylindrical interstice between the through bore and the pistons.

Abstract: A method for communicating data includes selecting a portion of data for communication to a remote computer with the data portion in device-dependent format and comprising at least an integer, a real number, or a binary value. A portable buffer is generated based on the selected data portion, the portable buffer comprising at least one device-independent data representation. The portable buffer is communicated to the remote computer for processing the data portion in a second device-dependent format.

Abstract: The invention provides systems and methods for developing multi-platform graphical user interface (GUI) for a target software application. In invention includes assessing one or more functional requirements of the target software application and defining a functional specification for the multi-platform GUI using the assessed functional requirements. The functional specification is used to develop source code for the graphical user interface. An abstraction framework that evaluates functions of the GUI source code and provides instruction to perform the functions in each of the plurality of operating environments is then developed and used as an intermediary between the GUI source code and each of the plurality of operating environments.

Abstract: A cylinder cooling construction includes a cylinder liner with a sidewall, exhaust and intake ports opening through the sidewall, a bore, and a plurality of feed channels that are formed with and extend along the sidewall from a central band of the cylinder toward the exhaust and intake ports. A sleeve covering the sidewall includes a plurality of impingement jet ports that are arranged in at least one sequence extending around the central band and that are in liquid communication with the plurality of feed channels. An annular member disposed between the liner and the sleeve reinforces the central band. The sleeve further includes an inside surface with spaced-apart annular recesses that with the sidewall define liquid coolant reservoirs in the vicinity of the ports that are in liquid communication with the feed channels.

Abstract: A cylinder cooling construction includes a cylinder liner with a sidewall, exhaust and intake ports opening through the sidewall, a bore, and a plurality of feed channels that are formed with and extend along the sidewall from a central band of the cylinder toward the exhaust and intake ports. A sleeve covering the sidewall includes a plurality of impingement jet ports that are arranged in at least one sequence extending around the central band and that are in liquid communication with the plurality of feed channels. An annular member disposed between the liner and the sleeve reinforces the central band. The sleeve further includes an inside surface with spaced-apart annular recesses that with the sidewall define liquid coolant reservoirs in the vicinity of the ports that are in liquid communication with the feed channels.

Abstract: In a two-cycle, opposed-piston internal combustion engine, opposed pistons disposed in a cylinder are coupled to a pair of side-mounted crankshafts by connecting rods that are subject to substantially tensile forces acting between the pistons and the crankshafts. This geometry reduces or eliminates side forces between the pistons and the bore of the cylinder. The cylinder and the pistons are independently cooled to reduce cylindrical deformation caused by thermal expansion during engine operation.

Abstract: An opposed piston engine includes at least one cylinder with inlet and exhaust ports and opposed pistons disposed in the cylinder for reciprocating opposed motion toward and away from each other. An auxiliary system pumps liquid coolant separately to the cylinder and pistons. Another auxiliary system controls the flow of intake and exhaust gas in the engine.

Abstract: In a two-cycle, opposed-piston internal combustion engine, opposed pistons disposed in a cylinder are coupled to a pair of side-mounted crankshafts by connecting rods that are subject to substantially tensile forces acting between the pistons and the crankshafts. This geometry reduces or eliminates side forces between the pistons and the bore of the cylinder. The cylinder and the pistons are independently cooled to reduce cylindrical deformation caused by thermal expansion during engine operation.

Abstract: A method for interfacing products with a web browser comprises retrieving a product profile, the product profile associated with one product. An agent type is determined based, at least in part, on the product profile. Data is retrieved from the product based on the agent type and processed such that the data is accessible by the web browser.