Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: The present invention relates to a compound according to formula (I) wherein R1 is selected from the group consisting of 5- and 6-membered heteroaryl, (C1-C6)alkyl, (C3-C6)cycloalkyl, (4-6)-membered heterocycloalkyl and phenyl; R2 is selected from (C1-C3)alkyl and halo(C1-C3)alkyl; R3 is selected from phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R4 is selected from hydrogen, halogen, (C1-C4)alkyl and halo(C1-C4)alkyl; X1 is selected from CH, C(Rb) and N, X2 is selected from CH and N; Y is selected from —NH— and —O—; m is 0 or 1; n is 0 or 1; L represents a bond, —O—, —NH— or —N(Rc)—; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: The present invention relates to a compound according to general formula (I) wherein X represents N or CH; R1 is —CN, (C1-C6)alkyl, (C3-C7)cycloalkyl, (3-7 membered)heterocycloalkyl, (5-6 membered)heteroaryl, (C3-C7)cycloalkyl(C1-C4)alkyl, (3-7 membered)heterocycloalkyl-(C1-C4)alkyl or (5-6 membered)heteroaryl-(C1-C4)alkyl; R2 is halogen, cyano, (C1-C4)alkyl or (C3-C7)cycloalkyl; R3 is halogen, cyano, (C1-C4)alkyl, (C1-C4)haloalkyl or (C3-C7)cycloalkyl; R4 is (C1-C4)alkyl or (C1-C4)haloalkyl; R5 is (C1-C6)alkyl, (C3-C7)cycloalkyl, (C1-C6)alkyl-(C3-C7)cycloalkyl, (C3-C7)cycloalkyl-(C1-C6)alkyl, (3-7 membered)heterocycloalkyl, phenyl, (5-6 membered)heteroaryl or —ORa. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds and to intermediates for preparation of said compounds.

Abstract: A breakout box, breakout box system, and method for management of optical fibers. The breakout box system provides a pass-through system for connecting optical fibers to network rack modules. The external routing of incoming and outgoing cables around the rack is kept neat and orderly, with one large cable serving a plurality of shelves. The breakout of the cable and distribution of the fibers to the individual modules occurs inside the breakout boxes and bridges, which provide protection for the fibers while still allowing easy access for fiber handling by means of the removable lids.

Abstract: Described is an inflatable implant suitable for placement in the human body and left there for an indeterminate and potentially lengthy period of time. The implant is one that has a low profile when introduced into the body and a larger profile when it is inflated with one or more filler materials. Depending upon design and use choices the delivered implant may be removable and adjustable in situ in size, position, location, form, and rigidity. Indeed, in some variations, the design of the implant may be such that it may be removed at a potentially fairly lengthy time after implantation. The implant includes at least one bladder wall that generally is at least partially non-elastic (or unexpandable) after the preselected size is reached. The bladder wall will define at least one fillable volume and may form more than one independent fillable volumes. The bladder wall, in some variations, may be partially elastic or expandable to permit adjustment of implant size or configuration after or during delivery.

Abstract: A rack-level breakout box, system, and method for distributing high-fiber count optical fiber cables to one or more network racks. External routing of incoming and outgoing cables around the rack is kept neat and orderly, with one large cable serving a fully populated rack and, optionally, multiple racks. A flexible mounting configuration is further provided.

Abstract: A rack-level breakout box, system, and method for distributing high-fiber count optical fiber cables to one or more network racks. External routing of incoming and outgoing cables around the rack is kept neat and orderly, with one large cable serving a fully populated rack and, optionally, multiple racks. A flexible mounting configuration is further provided.

Abstract: Described is an inflatable implant suitable for placement in the human body and left there for an indeterminate and potentially lengthy period of time. The implant is one that has a low profile when introduced into the body and a larger profile when it is inflated with one or more filler materials. Depending upon design and use choices the delivered implant may be removable and adjustable in situ in size, position, location, form, and rigidity. Indeed, in some variations, the design of the implant may be such that it may be removed at a potentially fairly lengthy time after implantation. The implant includes at least one bladder wall that generally is at least partially non-elastic (or unexpandable) after the preselected size is reached. The bladder wall will define at least one fillable volume and may form more than one independent fillable volumes. The bladder wall, in some variations, may be partially elastic or expandable to permit adjustment of implant size or configuration after or during delivery.

Abstract: A breakout box, breakout box system, and method for management of optical fibers. The breakout box system provides a pass-through system for connecting optical fibers to network rack modules. The external routing of incoming and outgoing cables around the rack is kept neat and orderly, with one large cable serving a plurality of shelves. The breakout of the cable and distribution of the fibers to the individual modules occurs inside the breakout boxes and bridges, which provide protection for the fibers while still allowing easy access for fiber handling by means of the removable lids.

Abstract: Stent-grafts for treating thoracic aortic aneurysms and abdominal aortic aneurysms include graft portions having inflatable channels and graft extensions. The graft extensions include an undulating wire stent and porous, but substantially fluid impermeable, polytetrafluoroethylene (PTFE) graft materials.

Abstract: The present invention relates to a compound according to formula (I) wherein R1 is selected from the group consisting of 5- and 6-membered heteroaryl, (C1-C6)alkyl, (C3-C6)cycloalkyl, (4-6)-membered heterocycloalkyl and phenyl; R2 is selected from (C1-C3)alkyl and halo(C1-C3)alkyl; R3 is selected from phenyl, 5-membered heteroaryl and 6-membered heteroaryl; R4 is selected from hydrogen, halogen, (C1-C4)alkyl and halo(C1-C4)alkyl; X1 is selected from CH, C(Rb) and N, X2 is selected from CH and N; Y is selected from —NH— and —O—; m is 0 or 1; n is 0 or 1; L represents a bond, —O—, —NH— or —N(Rc)—; or pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention relates further to intermediates for the preparation of said compounds, to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases with said compounds, and to the use of said compounds in the manufacture of medicaments.

Abstract: A breakout box, breakout box system, and method for management of optical fibers. The breakout box system provides a pass-through system for connecting optical fibers to network rack modules. The external routing of incoming and outgoing cables around the rack is kept neat and orderly, with one large cable serving a plurality of shelves. The breakout of the cable and distribution of the fibers to the individual modules occurs inside the breakout boxes and bridges, which provide protection for the fibers while still allowing easy access for fiber handling by means of the removable lids.

Abstract: Stent-grafts for treating thoracic aortic aneurysms and abdominal aortic aneurysms include graft portions having inflatable channels and graft extensions. The graft extensions include an undulating wire stent and porous, but substantially fluid impermeable, polytetrafluoroethylene (PTFE) graft materials.

Abstract: A system includes a plurality of mail encryption gateways and a router. Each mail encryption gateway encrypts email according to an encryption policy of a customer. The router stores a plurality of sender policy framework (SPF) records. The router also receives an email and compares a source IP address of the email with the plurality of SPF records. The router determines that the source IP address corresponds to an SPF record of the plurality of SPF records and in response to that determination, determines that a Simple Mail Transfer Protocol From Field of the email comprises a domain of a cloud provider corresponding to the SPF record. In response to that determination, the router determines that a Multipurpose Internet Mail Extension From Field of the email comprises a domain of a customer and in response to that determination, routes the email to a mail encryption gateway.

Abstract: An obstruction light can include a parabolic reflector having a first end, a second end disposed opposite the first end, and a surface having a curvature disposed therebetween. The obstruction light can also include a light assembly coupled to the parabolic reflector, where the light assembly includes at least one array of light sources, where the light assembly is disposed adjacent to the first end of the parabolic reflector, and where the at least one array of light sources is directed toward the surface.

Abstract: An obstruction light is disclosed herein. The obstruction light can include a reflector having a first parabolic portion and a second parabolic portion. The obstruction light can also include a light assembly having at least one array of light sources disposed adjacent to the reflector between the first parabolic portion and the second parabolic portion.

Abstract: An endovascular delivery system an elongate outer tubular sheath, an elongate inner tubular member releasably disposed within the elongate outer tubular sheath and an elongate crossover guidewire slidably disposed within the elongate outer tubular sheath.

Abstract: A system includes a plurality of mail encryption gateways and a router. Each mail encryption gateway encrypts email according to an encryption policy of a customer. The router stores a plurality of sender policy framework (SPF) records. The router also receives an email and compares a source IP address of the email with the plurality of SPF records. The router determines that the source IP address corresponds to an SPF record of the plurality of SPF records and in response to that determination, determines that a Simple Mail Transfer Protocol From Field of the email comprises a domain of a cloud provider corresponding to the SPF record. In response to that determination, the router determines that a Multipurpose Internet Mail Extension From Field of the email comprises a domain of a customer and in response to that determination, routes the email to a mail encryption gateway.

Abstract: An endovascular delivery system includes a bifurcated prosthesis including a main tubular body having an open end and opposed ipsilateral and contralateral legs and a delivery catheter for deployment of the prosthesis. The delivery catheter includes an elongate outer tubular sheath, an elongate inner tubular member releasably disposed within the elongate outer tubular sheath and an elongate crossover guidewire slidably disposed within the elongate outer tubular sheath and extending through the ipsilateral and contralateral legs.

Abstract: A thermal control system that includes a combination of active and passive components is described herein. In one or more implementation, the thermal control system compensates for non-uniformities in a temperature profile for an arrangement of components within a computing device. One or more active components of the thermal control system transfer heat away from heat-generating devices by active means, such as active transfer to a moving fluid that is driven by a blower or fan. Additionally, one or more passive components are positioned to transfer heat to selected areas of the device using passive transfer devices, such as heat-pipes and thermal spreaders made of conductive materials. The active and passive components operate together to compensate for temperature variations across the device surfaces, produce a controlled temperature profile having greater uniformity, reduce overall differences in surface temperatures, and provide greater capability for heat dissipation.