Abstract: An apparatus and methods for use are provided, where the apparatus includes: (a) a filter, and (b) a frame having a first end and a second end, wherein the frame includes a first support and a second support extending between the first end and the second end, wherein at least the first support and the second support of the frame are coupled to at least a portion of a periphery of the filter, wherein the frame and the filter together define a lumen, wherein the frame has shape memory and is movable between a first position in which the lumen has a first diameter and a second position in which the lumen has a second diameter, and wherein the first diameter is smaller than the second diameter.

Abstract: The present disclosure provides a stent graft defining a lumen having a first end and a second end, the stent graft comprising (a) a first portion at the first end of the stent graft having a first diameter and a first length, wherein a first stent structure of the first portion is balloon-expandable, (b) a second portion of the stent graft having a second diameter and a second length, wherein a second stent structure of the second portion is self-expanding, (c) a breakable restraint configured to be coupled to the second portion in a pre-deployment state and decoupled from the second portion in a deployed state, and (d) a third portion at the second end of the stent graft has a third diameter and a third length, wherein a third stent structure of the third portion is balloon-expandable.

Abstract: A drug delivery balloon apparatus is disclosed herein, comprising: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in fluid communication with the first lumen, (c) a drug delivery port in fluid communication with the second lumen, (d) a guidewire port in fluid communication with the second lumen, wherein the second lumen is configured to receive both a guidewire and a drug solution, (e) an occlusion balloon, (f) a drug delivery balloon, where the occlusion balloon and the drug delivery balloon are in fluid communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.

Abstract: The present disclosure provides a catheter tip comprising a flexible housing comprising a cavity extending between an expandable opening arranged at a first end of the catheter tip and a second end of the catheter tip, wherein the expandable opening is configured to increase in diameter from a first position to a second position in response to application of an external force to the second end of the flexible housing.

Abstract: A pulmonary embolism apparatus and methods for use are provided. The apparatus includes a first catheter having a proximal end and a distal end, wherein a distal portion of the first catheter includes a first one or more outlets. The apparatus also includes a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet. The apparatus also includes one or more pressure sensors coupled to the distal end of the first tubular housing.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: The present disclosure provides a stent graft comprising (a) a self-expandable stent structure having a first end and a second end, wherein the self-expandable stent structure defines a lumen, (b) at least one restraint configured to be coupled to an exterior surface of the stent graft in a compressed condition, and wherein the at least one restraint is configured to be broken to permit the stent graft to transition to an expanded condition, and (c) a first plurality of anchoring projections coupled to the exterior surface of the stent graft adjacent to the first end of the self-expandable stent-structure.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen having an inlet defined at a proximal end of the main body stent graft and having an outlet defined at a distal end of the main body stent graft, (b) a visceral-vessel opening defined in a sidewall of the main body stent graft between the proximal end and the distal end of the main body stent graft, (c) a diaphragm disposed within the lumen of the main body stent graft and coupled to the main body stent graft, wherein a first renal inlet, a second renal inlet, an infrarenal inlet and a visceral inlet are defined in the diaphragm and (d) a visceral chamber defined by a sidewall coupled to the visceral inlet and to the visceral-vessel opening.

Abstract: An anchoring guidewire and methods for use, where the anchoring guidewire comprises: (a) an outer core, (b) an anchoring basket, (c) a steerable tip, and (d) an actuator core. The outer core, the anchoring basket and the steerable tip are axially aligned with one another. Further, the actuator core may be movably disposed within both the outer core and the anchoring basket and may be coupled to the steerable tip.

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: An apparatus and methods for use are provided, where the apparatus includes: (a) a first catheter having a proximal end and a distal end, and wherein a distal portion of the first catheter includes a first one or more outlets, (b) a first tubular housing having a proximal end and a distal end, wherein the first tubular housing is coupled to the first catheter proximal to the at least one first outlet, (c) one or more pressure sensors coupled to the distal end of the first tubular housing, and (d) a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second one or more outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within one of (i) the first catheter or (ii) a second tubular housing coupled to one or more of the first catheter and the first tubular housing, when the second catheter is in a first position.

Abstract: The present disclosure provides a stent graft comprising (a) a self-expandable stent structure having a first end and a second end, wherein the self-expandable stent structure defines a lumen, (b) at least one restraint configured to be coupled to an exterior surface of the stent graft in a compressed condition, and wherein the at least one restraint is configured to be broken to permit the stent graft to transition to an expanded condition, and (c) a first plurality of anchoring projections coupled to the exterior surface of the stent graft adjacent to the first end of the self-expandable stent-structure.

Abstract: A combination double-barreled and debranching stent graft and methods for its use, where the stent graft comprises, a main body stent graft defining a single lumen with distal and proximal ends, a first bifurcation in the main body defining first and second lumens, the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body stent graft must exit by entering one of the first or second lumens, (c) a second bifurcation within the first lumen defining a first leg and a second leg, (d) a third bifurcation within the first leg defining a third leg and a fourth leg, and (e) a fourth bifurcation within the second leg between about 10 mm and about 20 mm distal from the second bifurcation defining a fifth leg and a sixth leg.

Abstract: The present disclosure provides a catheter tip comprising a cavity extending between an expandable opening arranged at a first end of the catheter tip and a second end of the catheter tip, wherein the expandable opening is configured to increase in diameter from a first position to a second position in response to application of an external force to the second end of the catheter tip.

Abstract: Example gear systems and methods for use are provided herein. An example gear system may include (a) an expandable gear that defines a plurality of circular sectors, (b) a hub disposed in the gear, where the hub includes an expandable portion, and (c) an expander, where the expandable gear has an expanded position when the expander is disposed within the hub and the expandable gear has an unexpanded position when the expander is disposed outside of the hub.

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract: A drug delivery balloon apparatus is disclosed herein, comprising: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in fluid communication with the first lumen, (c) a drug delivery port in fluid communication with the second lumen, (d) a guidewire port in fluid communication with the second lumen, wherein the second lumen is configured to receive both a guidewire and a drug solution, (e) an occlusion balloon, (I) a drug delivery balloon, where the occlusion balloon and the drug delivery balloon are in fluid communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.