Abstract: An anchoring guidewire and methods for use, where the anchoring guidewire comprises: (a) an outer core, (b) an anchoring basket, (c) a steerable tip, and (d) an actuator core. The outer core, the anchoring basket and the steerable tip are axially aligned with one another. Further, the actuator core may be movably disposed within both the outer core and the anchoring basket and may be coupled to the steerable tip.

Abstract: A drug delivery balloon apparatus and methods for use, where the drug delivery balloon apparatus comprises: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in communication with the first lumen, (c) a drug delivery port in communication with the second lumen, (d) a guidewire port in communication with either the second lumen or a third lumen, (e) an occlusion balloon, (f) a drug delivery balloon having an outer surface with a plurality of grooves, where the occlusion balloon is disposed between the drug delivery balloon and the balloon inflation port, and the occlusion and drug delivery balloons are in communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.

Abstract: The present invention provides formulations comprising polymers and therapeutics and methods for their manufacture. The present invention also provides medical devices coated with such formulations and methods for their manufacture. The drug-loaded polymer formulations, solutions, and films tailor the drug release characteristics for medical devices.

Abstract: An anchoring guide wire and methods for use are provided, where the guide wire comprises a non-coiled segment, a first expandable segment, and a leading segment, wherein the first expandable segment is configured to transition between a constrained state and a deployed state.

Abstract: A visceral double-barreled main body stent graft and methods for its use, the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 100-120 mm and diameter at the proximal end ranges from about 30-45 mm, first and second lumens defined at the main body stent graft's distal end, the first lumen's diameter ranges from about 18-20 mm, the second lumen's diameter ranges from about 16-18 mm, the first and second lumens have about the same length from about 50-70 mm, the first lumen is secured to the second lumen along a shared length, and the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body must exit through one of the first or second lumens.

Abstract: A drug delivery balloon apparatus and methods for use, where the drug delivery balloon apparatus comprises: (a) at least two lumens, comprising a first lumen and a second lumen, (b) a balloon inflation port in communication with the first lumen, (c) a drug delivery port in communication with the second lumen, (d) a guidewire port in communication with either the second lumen or a third lumen, (e) an occlusion balloon, (f) a drug delivery balloon having an outer surface with a plurality of grooves, where the occlusion balloon is disposed between the drug delivery balloon and the balloon inflation port, and the occlusion and drug delivery balloons are in communication with the first lumen, (g) one or more drug delivery channels extending the length of the second lumen, and (h) one or more drug delivery ducts extending from the one or more drug delivery channels to an exterior surface of the second lumen.

Abstract: An anchoring guidewire and methods for use, where the anchoring guidewire comprises: (a) an outer core, (b) an anchoring basket, (c) a steerable tip, and (d) an actuator core. The outer core, the anchoring basket and the steerable tip are axially aligned with one another. Further, the actuator core may be movably disposed within both the outer core and the anchoring basket and may be coupled to the steerable tip.

Abstract: A stent deployment device and methods for use, where the device comprises: (a) an outer sheath having a proximal end and a distal end, (b) a pull apparatus at least partially disposed within the outer sheath, where a portion of the pull apparatus is sized and shaped to receive a stent or a stent graft, (c) a push apparatus, where a portion of the push apparatus is sized to fit within a portion of the pull apparatus, and (d) a push-pull drive mechanism in mechanical communication with the pull and push apparatuses, where the push-pull drive mechanism includes at least a push and a pull gear or a push and a pull reel sized and shaped based on a stent ratio.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen having an inlet defined at a proximal end of the main body stent graft and having an outlet defined at a distal end of the main body stent graft, (b) a visceral-vessel opening defined in a sidewall of the main body stent graft between the proximal end and the distal end of the main body stent graft, (c) a diaphragm disposed within the lumen of the main body stent graft and coupled to the main body stent graft, wherein a first renal inlet, a second renal inlet, an infrarenal inlet and a visceral inlet are defined in the diaphragm and (d) a visceral chamber defined by a sidewall coupled to the visceral inlet and to the visceral-vessel opening.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen that has a first end and a second end, (b) a diaphragm coupled to the main body stent graft, where the diaphragm defines at least three openings and (c) at least three stent graft extensions each defining a lumen, where a first end of each of the three stent graft extensions is coupled to one of the three openings.

Abstract: A visceral double-barreled main body stent graft and methods for its use, the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 100-120 mm and diameter at the proximal end ranges from about 30-45 mm, first and second lumens defined at the main body stent graft's distal end, the first lumen's diameter ranges from about 18-20 mm, the second lumen's diameter ranges from about 16-18 mm, the first and second lumens have about the same length from about 50-70 mm, the first lumen is secured to the second lumen along a shared length, and the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body must exit through one of the first or second lumens.

Abstract: A visceral double-barreled main body stent graft and methods for its use, the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 100-120 mm and diameter at the proximal end ranges from about 30-45 mm, first and second lumens defined at the main body stent graft's distal end, the first lumen's diameter ranges from about 18-20 mm, the second lumen's diameter ranges from about 16-18 mm, the first and second lumens have about the same length from about 50-70 mm, the first lumen is secured to the second lumen along a shared length, and the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body must exit through one of the first or second lumens.

Abstract: A combination double-barreled and debranching stent graft and methods for its use, where the stent graft comprises, a main body stent graft defining a single lumen with distal and proximal ends, a first bifurcation in the main body defining first and second lumens, the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body stent graft must exit by entering one of the first or second lumens, (c) a second bifurcation within the first lumen defining a first leg and a second leg, (d) a third bifurcation within the first leg defining a third leg and a fourth leg, and (e) a fourth bifurcation within the second leg between about 10 mm and about 20 mm distal from the second bifurcation defining a fifth leg and a sixth leg.

Abstract: Example stent grafts and methods for placement thereof are provided. An example stent graft may include (a) a main body stent graft defining a lumen having an inlet defined at a proximal end of the main body stent graft and having an outlet defined at a distal end of the main body stent graft, (b) a visceral-vessel opening defined in a sidewall of the main body stent graft between the proximal end and the distal end of the main body stent graft, (c) a diaphragm disposed within the lumen of the main body stent graft and coupled to the main body stent graft, wherein a first renal inlet, a second renal inlet, an infrarenal inlet and a visceral inlet are defined in the diaphragm and (d) a visceral chamber defined by a sidewall coupled to the visceral inlet and to the visceral-vessel opening.

Abstract: Example gear systems and methods for use are provided herein. An example gear system may include (a) an expandable gear that defines a plurality of circular sectors, (b) a hub disposed in the gear, where the hub includes an expandable portion, and (c) an expander, where the expandable gear has an expanded position when the expander is disposed within the hub and the expandable gear has an unexpanded position when the expander is disposed outside of the hub.

Abstract: A stent deployment device and methods for use, where the device comprises: (a) an outer sheath having a proximal end and a distal end, (b) a pull apparatus at least partially disposed within the outer sheath, where a portion of the pull apparatus is sized and shaped to receive a stent or a stent graft, (c) a push apparatus, where a portion of the push apparatus is sized to fit within a portion of the pull apparatus, and (d) a push-pull drive mechanism in mechanical communication with the pull and push apparatuses, where the push-pull drive mechanism includes at least a push and a pull gear or a push and a pull reel sized and shaped based on a stent ratio.

Abstract: A stent deployment device and methods for use, where the device comprises: (a) an outer sheath having a proximal end and a distal end, (b) a pull apparatus at least partially disposed within the outer sheath, where a portion of the pull apparatus is sized and shaped to receive a stent or a stent graft, (c) a push apparatus, where a portion of the push apparatus is sized to fit within a portion of the pull apparatus, and (d) a push-pull drive mechanism in mechanical communication with the pull and push apparatuses, where the push-pull drive mechanism includes at least a push and a pull gear or a push and a pull reel sized and shaped based on a stent ratio.

Abstract: A combination double-barreled and debranching stent graft and methods for its use, where the stent graft comprises, a main body stent graft defining a single lumen with distal and proximal ends, a first bifurcation in the main body defining first and second lumens, the main body stent graft defines a tubular wall that is contiguous with the first and second lumens such that any fluid entering the main body stent graft must exit by entering one of the first or second lumens, (c) a second bifurcation within the first lumen defining a first leg and a second leg, (d) a third bifurcation within the first leg defining a third leg and a fourth leg, and (e) a fourth bifurcation within the second leg between about 10 mm and about 20 mm distal from the second bifurcation defining a fifth leg and a sixth leg.

Abstract: An aortic arch double-barreled main body stent graft and methods for its use, where the stent graft comprises, a main body stent graft having distal and proximal ends, the main body stent graft's length ranges from about 50-70 mm and the diameter at the proximal end ranges from about 40-60 mm, first and second lumens defined at the distal end of the main body stent graft, the first lumen's diameter ranges from about 18-30 mm, the second lumen's diameter ranges from about 18-30 mm, the first lumen is secured to the second lumen along a shared length, the shared length of the first and second lumens ranges from about 30-65 mm, and the main body stent graft defines a tubular wall that is contiguous with the first lumen and the second lumen such that any fluid entering the main body must exit through one of the first or second lumens.