Patents by Inventor Patrizio Mattei

Patrizio Mattei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminocycloalkanes as DPP-IV inhibitors
    Patent number: 7411093
    Abstract: The present invention relates to compounds of formula (I) wherein R1 is as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: December 13, 2005
    Date of Patent: August 12, 2008
    Assignee: Hoffman-La Roche Inc.
    Inventors: Markus Boehringer, Daniel Hunziker, Bernd Kuhn, Bernd Michael Loeffler, Hans Peter Marty, Patrizio Mattei, Robert Narquizian
  • SULFONAMIDE DERIVATIVES
    Publication number: 20080153805
    Abstract: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R1, R2, R3, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
    Type: Application
    Filed: December 6, 2007
    Publication date: June 26, 2008
    Inventors: Simona M. Ceccarelli, Odile Chomienne, Patrizio Mattei, Ulrike Obst Sander
  • INDAZOLE DERIVATIVES
    Publication number: 20080103182
    Abstract: The invention is concerned with novel indazole derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used in the prevention or treatment of diseases which are modulated by L-CPT1 inhibitors.
    Type: Application
    Filed: October 19, 2007
    Publication date: May 1, 2008
    Inventors: Jean Ackermann, Konrad Bleicher, Simona M. Ceccarelli, Odile Chomienne, Patrizio Mattei
  • Novel diazepan derivatives
    Publication number: 20070249589
    Abstract: The invention is concerned with novel diazepan derivatives of formula (I) wherein A, X, R3, R4, R5, R6, R8, R9, R10, R11, R12, R13, m and n are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds are antagonists of CCR-2 receptor, CCR-5 receptor and/or CCR-3 receptor and can be used as medicaments.
    Type: Application
    Filed: April 19, 2007
    Publication date: October 25, 2007
    Inventors: Johannes Aebi, Luke Green, Patrizio Mattei, Fabienne Ricklin, Olivier Roche, Peter Zahm
  • Anthranilamide and 2-amino-heteroarene-carboxamide compounds
    Publication number: 20070219261
    Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 19, 2007
    Publication date: September 20, 2007
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • Novel bicyclic sulfonamide derivatives which are L-CPT1 inhibitors
    Publication number: 20070191603
    Abstract: The invention is concerned with novel heterobicyclic derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, V, W, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
    Type: Application
    Filed: February 7, 2007
    Publication date: August 16, 2007
    Inventors: Jean Ackermann, Konrad Bleicher, Simona M. Ceccarelli, Odile Chomienne, Patrizio Mattei, Ulrike Obst Sander
  • Heterobicyclic amide compounds
    Publication number: 20070185154
    Abstract: Compounds of formula I processes for their preparation and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 19, 2007
    Publication date: August 9, 2007
    Inventors: Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger, Michelangelo Scalone
  • Heteroaryl and benzyl amide compounds
    Publication number: 20070185113
    Abstract: Compounds of formula I processes for their preparation, their use as pharmaceuticals and to pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 29, 2007
    Publication date: August 9, 2007
    Inventors: Christoph Faeh, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Philippe Pflieger
  • Heteroaryl carboxamide compounds
    Publication number: 20070185182
    Abstract: Compounds of formula I their manufacture, pharmaceutical compositions containing them and their use as medicaments.
    Type: Application
    Filed: January 26, 2007
    Publication date: August 9, 2007
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • Heteroaryl and benzyl amide compounds
    Publication number: 20070185058
    Abstract: Compounds of formula I wherein R1, R2, R4, R5, A, B, D and n are as defined, and pharmaceutically acceptable salts thereof, processes for their preparation, their use as pharmaceuticals and pharmaceutical compositions comprising them.
    Type: Application
    Filed: January 25, 2007
    Publication date: August 9, 2007
    Inventors: Aurelia Conte, Holger Kuehne, Thomas Luebbers, Patrizio Mattei, Cyrille Maugeais, Werner Mueller, Philippe Pflieger
  • Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles
    Patent number: 7253281
    Abstract: The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a]indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
    Type: Grant
    Filed: June 28, 2005
    Date of Patent: August 7, 2007
    Assignees: Hoffmann-La Roche Inc., Vernalis Research Limited
    Inventors: Jonathan Mark Bentley, Paul Hebeisen, Patrizio Mattei, Marc Muller, Hans Richter, Stephan Roever, Sven Taylor
  • Aminothiazole derivatives
    Patent number: 7253197
    Abstract: Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R4 have the significance given in the specification, and the compounds, salts and esters can be used for the treatment of obesity.
    Type: Grant
    Filed: August 5, 2003
    Date of Patent: August 7, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wolfgang Guba, Patrizio Mattei, Werner Neidhart, Matthias Heinrich Nettekoven, Philippe Pflieger
  • Novel heteroaryl substituted piperidine derivatives which are L-CPT1 inhibitors
    Publication number: 20070129544
    Abstract: The invention is concerned with novel substituted piperidine derivatives of formula (I) wherein R1, R2, R3, R4, R5, R6, R7 and X are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
    Type: Application
    Filed: November 29, 2006
    Publication date: June 7, 2007
    Inventors: Jean Ackermann, Konrad Bleicher, Simona Ceccarelli Grenz, Odile Chomienne, Patrizio Mattei, Tanja Schulz-Gasch
  • Anti-obesity 1,2,3,4,10,10a-hexahydropyrazino [1,2-a] indoles
    Publication number: 20070106076
    Abstract: The present invention is directed to 1,2,3,4,10,10a,-hexahydropyrazino[1,2-a] indole derivatives as well as pharmaceutically acceptable salts, solvates and esters thereof, wherein R1 to R8 have the significance given in claim 1 be used in the form of pharmaceutical preparations for the treatment or prevention of disorders of the central nervous system, damage to the central nervous system, cardiovascular disorders, gastrointestinal disorders, diabetes insipidus, obesity and sleep apnea.
    Type: Application
    Filed: January 3, 2007
    Publication date: May 10, 2007
    Inventors: Jonathan Bentley, Paul Hebeisen, Patrizio Mattei, Marc Muller, Hans Richter, Stephan Roever, Sven Taylor
  • Quinazoline derivatives
    Patent number: 7205309
    Abstract: Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3 and A have the significance given in the specification are provided. The compounds can be used for the treatment or prevention of obesity.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: April 17, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Werner Mueller, Werner Neidhart, Matthias Heinrich Nettekoven, Philippe Pflieger
  • Novel indolyl derivatives which are L-CPT1 inhibitors
    Publication number: 20070060567
    Abstract: The invention is concerned with novel heterobicyclic derivatives of formula (I): wherein R1, R2, R3, R4, R5, R6, R7, A, X and Y are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
    Type: Application
    Filed: September 12, 2006
    Publication date: March 15, 2007
    Inventors: Jean Ackermann, Konrad Bleicher, Simona Ceccarelli Grenz, Odile Chomienne, Patrizio Mattei, Tanja Schulz-Gasch
  • Quinoline derivatives
    Patent number: 7166589
    Abstract: Compounds of formula I as well as pharmaceutically acceptable salts and esters thereof, wherein R1, R2, R3, A1 and A2 have the significance given in claim 1, can be used in the form of pharmaceutical preparations for the treatment or prevention of arthritis, cardiovascular diseases, diabetes, renal failure, eating disorders and obesity.
    Type: Grant
    Filed: March 16, 2006
    Date of Patent: January 23, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael G. Klug, Patrizio Mattei, Werner Mueller, Werner Neidhart, Matthias Heinrich Nettekoven, Philippe Pflieger, Jean-Marc Plancher
  • Novel sulfonamides as L-CPT1 inhibitors
    Publication number: 20060276494
    Abstract: The invention is concerned with novel sulfonamide derivatives of formula (I) wherein R2, R3, R4, A, X, Y1, Y2, Y3, Y4 and Z1 are as defined in the description and in the claims, as well as physiologically acceptable salts and esters thereof. These compounds inhibit L-CPT1 and can be used as medicaments.
    Type: Application
    Filed: June 1, 2006
    Publication date: December 7, 2006
    Inventors: Konrad Bleicher, Simona Ceccarelli, Odile Chomienne, Patrizio Mattei, Tanja Schulz-Gasch, Christoph Stahl
  • Process for the preparation of (S)-4-fluoromethyl-dihydro-furan-2-one useful in the preparation of the DPP-IV inhibitor (S)-1 ((2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7, 11b-hexahydro-2h-pyrido[2,1-a] isoquinolin-3-yl)-4-fluoromethyl-pyrrolidin-2-one
    Publication number: 20060270853
    Abstract: This invention relates to a process of the preparation of the novel intermediate (S)-4-fluoromethyl-dihydro-furan-2-one of the formula and with its use for the manufacture of pyrido[2,1-a]isoquinoline derivatives of the formula which are useful for the treatment and/or prophylaxis of diseases which are associated with DPP IV.
    Type: Application
    Filed: May 19, 2006
    Publication date: November 30, 2006
    Inventors: Stefan Abrecht, Jean-Michel Adam, Alec Fettes, Joseph Foricher, Bruno Lohri, Patrizio Mattei, Gerard Moine, Rudolf Schmid, Ulrich Zutter
  • Pyrido [2,1-a] isoquinoline derivatives
    Patent number: 7122555
    Abstract: The present invention provides compounds of formula (I) wherein R1, R2, R3 and R4 are as indicated in the description, or a pharmaceutically acceptable salt thereof. The compounds are useful for the treatment of diseases which are associated with DPP-IV, such as diabetes, particularly non-insulin dependent diabetes mellitus, and impaired glucose tolerance.
    Type: Grant
    Filed: June 17, 2004
    Date of Patent: October 17, 2006
    Assignee: Hoffmann-la Roche Inc.
    Inventors: Markus Boehringer, Bernd Kuhn, Patrizio Mattei, Robert Narquizian