Abstract: System and Method pertaining to the modification and integration of an existing consumer digital camera, for example, with an optical imaging module to enable point and shoot fundus photography of the eye. The auto-focus macro capability of existing consumer cameras is adapted to photograph the retina over an extended diopter range, eliminating the need for manual diopter focus adjustment. The thru-the-lens (TTL) auto-exposure flash capability of existing consumer cameras is adapted to photograph the retina with automatic flash exposure eliminating the need for manual flash adjustment. The consumer camera imaging sensor and flash are modified to allow the camera sensor to perform both non-mydriatic focusing of the retina using infrared illumination and standard color flash photography of the retina without the need for additional imaging sensors or mechanical filters.

Abstract: The present invention relates to a method for creating a three- dimensional structure for cell growth by creating a template of a polymer, applying a hydrogel support onto the template and removing the template. The present invention further provides a device for cell growth comprising a polymer template embedded in a hydrogel.

Abstract: Examples are disclosed that relate to arranging electrical contacts on a hinge of a wearable device. One example provides a wearable device comprising a frame, a first temple piece, a second temple piece, a first hinge connecting the first temple piece to the frame, a second hinge connecting the second temple piece to the frame, and a first contact and a second contact arranged on one or more of the first hinge and the second hinge, the first contact and the second contact being configured to connect with external circuitry.

Abstract: Systems and methods are disclosed to implement an endpoint command invocation system (“ECIS”). In some embodiments, ECIS can quickly dispatch a command to a large number of endpoint components, where the endpoint components are online. ECIS can receive an invocation of a command, which can include the command recipients. In some embodiments, ECIS determines that some of the command recipients are online, while some of the command recipients are offline. ECIS determines connections to the online command recipients based on a connection map, which is updated whenever an endpoint component opens a connection to ask for a command. ECIS can deliver the command to the online command recipients using the connections. ECIS can also deliver the command to dispatch queues corresponding to the offline command recipients, where the dispatch queues store the command as a pending command that can be delivered to their respective command recipients whenever they come online.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy’s disease

Abstract: A modular sensor and display module comprises an enclosure with a rigid frame and front and back visor lens encapsulating sensors, waveguide optics, and display/projection devices that provide various functions for a typical head-mounted device. A front visor may conceal sensors and other components and may further provide dimming for holographic displays. The modular sensor and display module may include a standard interface for attachment to various fit systems, including, for example, headband, VR headset, glasses temples, helmet, and the like. A further module, such as a rear-attachment module, may be provided that can provide auxiliary compute, storage, and power resources for the modular sensor and display module.

Abstract: Playback devices comprising a network interface, an optional speaker(s), and one or more processors are disclosed herein. In some embodiments, the playback device is configured to communicate with a computing system that stores configuration data corresponding to each of a plurality of users. The playback device detects one or more users near the playback device and retrieves user configuration data corresponding to each of the one or more detected users, and thereafter, uses the user configuration data of the one or more detected users to process voice commands, play media content, and/or perform other voice and/or media related functions.

Abstract: Example implementations may involve using a prompt to prevent inadvertent control or playback of audio content. When a mobile device receives input data indicating a command to play back audio content on a first playback device, the mobile device determines whether the mobile device is in proximity to the first playback device. If the mobile device determines that the mobile device within a given proximity to the first playback device, the mobile device transmits, via the network interface, one or more commands to instruct the first playback device to play back the audio content. However, if the mobile device determines that the mobile device outside the proximity, the mobile device displays a prompt indicating that the mobile device is the outside the given proximity to the first playback device and a selectable control that, when selected, transmits the one or more commands to play back the audio content.

Abstract: This application discloses antigen binding proteins that bind Lymphocyte Activation Gene 3 (LAG-3), and more particularly to antigen binding proteins that cause depletion of LAG-3+ activated T cells.

Abstract: The present disclosure relates to an aerosol delivery device that includes a reservoir housing that defines a mouthpiece channel. The aerosol delivery device includes a sealing member configured to be received within the reservoir housing to define a reservoir chamber configured to retain an aerosol precursor composition therein. The aerosol delivery device also includes a substrate member that is configured to be received within the reservoir housing and to be directly engaged with a vaporizing assembly for forming an aerosol. The reservoir housing, sealing member, substrate member, and/or vaporizing assembly can be used for forming aerosols with precise and reproducible compositions.

Abstract: A patient interface comprises a plenum chamber and at least three plenum chamber inlet ports. A seal-forming structure is arranged to form a seal at least an entrance to the patient's nares and to maintain a therapeutic pressure in the plenum chamber throughout the patient's respiratory cycle. The interface further comprises a positioning and stabilising structure comprising at least four straps, at least three of the straps defining a channel therein, wherein a conduit is provided within each channel. Each conduit comprises an interface connector for connecting the conduit to a respective one of the inlet ports and a connection port for connection, in use, to an air circuit, wherein the connection port is in fluid communication with each of the conduits. The plenum chamber is provided with at least one pressure measurement port. A positioning and stabilising structure is also disclosed.

Abstract: An improved method is described for measuring a dimension (e.g. diameter) of a non-toothed tool, for example a grinding tool such as a diamond coated burr. The method may be implemented on a machine tool, such as a lathe, machining centre or the like. The method comprises passing a beam of light from a transmitter to a receiver. The receiver produces a received intensity signal related to the intensity of received light. Analysis of variations in the received intensity signal is performed when a rotating tool is moved relative to the light beam to enable a dimension of the tool to be measured. In particular, it may be determined when the received intensity signal has crossed a threshold for at least a defined duration, the defined duration being less than the time taken for one complete rotation of the tool.

Abstract: This invention relates to methods and materials for providing a benefit to a plant by associating the plant with a complex endophyte comprising a host fungus further comprising a component bacterium, including benefits to a plant derived from a seed or other plant element treated with a complex endophyte. For example, this invention provides purified complex endophytes, purified complex endophyte components such as bacteria or fungi, synthetic combinations comprising said complex endophytes and/or components, and methods of making and using the same.

Abstract: The disclosed systems and methods relate to allowing trading of over the counter (“OTC”) foreign exchange (“FX”) contracts on a centralized matching and clearing mechanism, such as that of the Chicago Mercantile Exchange's (“CME”'s) futures exchange system (the “Exchange”). The disclosed systems and methods allow for anonymous transactions, centralized clearing, efficient settlement and the provision of risk management/credit screening mechanisms to lower risk, reduce transaction costs and improve the liquidity in the FX market place. In particular, the disclosed embodiments increase speed of execution facilitating growing demand for algorithmic trading, increased price transparency, lower cost of trading, customer to customer trading, and automated asset allocations, recurring trades as well as clearing and settlement efficiencies.

Abstract: An electronic system for a drug delivery device is provided. The electronic system comprises: at least one user interface member, which is arranged to be manipulated by a user of the drug delivery device, and an electrical user proximity detection unit. The user interface member has an exterior operation surface arranged and configured to be touched by a user of the drug delivery device during operation of the drug delivery device. The electrical user proximity detection unit is configured to generate a signal when the user is close to or touches the exterior operation surface.

Abstract: A toilet protection device prevents the human waste contents of a portable toilet from spilling/splashing onto the toilet and/or the walls/floor of the portable toilet enclosure. The toilet protection device includes an expandable rubber seal enabling the toilet protection device to fit in most, if not all, portable toilets regardless of shape or size. Moreover, by using a disposable cover, there is minimal cleanup of toilet protection device.

Abstract: Aspects described herein generally relate to a sol-gel that is the reaction product of an organosilane, a metal alkoxide, an acid, and a thio-lanthanide salt having a solubility of about 1 gram or greater per gram of sol-gel at 23° C. The thio-lanthanide salt includes a cation and a thio-ligand. The cation can be lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium, yttrium, cobalt, calcium, strontium, barium, and zirconium. In another aspect, a component, such as a vehicle component, includes a metal substrate and a sol-gel disposed on the metal substrate. Methods can include forming a sol-gel by mixing a metal alkoxide and an acid to form a first mixture; mixing with the first mixture an organosilane to form a second mixture; and mixing with the second mixture a lanthanide salt to form a third mixture.

Abstract: Embodiments are described herein that provide searches, including a multi-dimensional search, a cross-source search, or both in a media playback system. The search can be initiated by way of a selection of a location on user interface of a controller. The location corresponds to one or more metadata that is used in the search. Results are sorted and displayed. In some embodiments, metadata is used to filter and/or sort the results.

Abstract: Multiple aspects of systems and methods for voice control and related features and functionality for various embodiments of media playback devices, networked microphone devices, microphone-equipped media playback devices, and speaker-equipped networked microphone devices are disclosed and described herein, including but not limited to designating and managing default networked devices, audio response playback, room-corrected voice detection, content mixing, music service selection, metadata exchange between networked playback systems and networked microphone systems, handling loss of pairing between networked devices, actions based on user identification, and other voice control of networked devices.