Abstract: The present invention relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1—R16, n and p are defined herein. The novel nitrogen-linked benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth, such as cancer, in patients.

Abstract: A wideband antenna array includes a wide angle impedance matching (waim) board, a manifold board including multiple tower receiving features and at least one conductive tower extending outward from the manifold board and received in a corresponding tower receiving feature. Each of the at least one conductive towers including at least one metalized component. The metalized component forms a circuit connecting the manifold board to the waim board. The waim board is adhered to a first end of the at least one conductive tower opposite the manifold board.

Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).

Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

Abstract: Techniques for providing heat load balancing in an autonomous bi-directional vehicle utilize a first coolant loop thermally coupled to a first drive motor and a first end of the autonomous bi-directional vehicle and a second coolant loop thermally coupled to a second drive motor and a second end of the autonomous bi-directional vehicle to exchange thermal energy. A conduit thermally couples the first coolant loop with the second coolant loop to allow transfer of the coolant in between. A controller is usable to increase an amount of thermal energy transferred between the first coolant loop and the second coolant loop based at least in part on a direction of travel of the autonomous bi-directional vehicle.

Abstract: A dispensing head for application of shave lubricating material such as foam, gel or lotion to the skin of a user includes a spreading blade portion with a flexible blade with a concave spreading surface and an outer spreading edge. A dose of the material is applied to the blade from a source to be released from the spreading edge for spreading between the spreading surface and the skin. Dimples on the spreading surface hold it away from the skin. The spreading blade portion is generally fan shaped with side edges extending outwardly from an inner edge to an arcuate outer edge at the spreading edge A vibration motor located behind the spreading surface for vibrating the spreading surface and the spreading edge thereon is provided to assist in spreading the material.

Abstract: A communication adapter of a gas turbine engine of an aircraft includes an internal sensor system including a plurality of sensors within the communication adapter, a memory system, and processing circuitry. The processing circuitry is configured to receive a plurality of time series data at the communication adapter from an engine control of the gas turbine engine, record a plurality of internal sensor data of the internal sensor system, correlate the time series data with the internal sensor data based on an alignment in time to form an enhanced data set, and transmit the enhanced data set from the communication adapter to an offboard system.

Abstract: A data request workflow system comprises vehicle operational data. A file delivery request comprises a data request for a subset of the vehicle operational data. A file processing system receives the vehicle operational data and includes at least one set of predefined file editing rules. The file processing system automatically applies at least one set of predefined file editing rules to filter out a predefined sub-set of the vehicle operational data and to automatically edit data that is part of the data request per predefined criteria for each type of vehicle operational data to provide a converted data file to be transmitted to a user that submitted the file delivery request.

Abstract: A structuring fabric for use in a machine to produce a structured fiber web, such as a structured tissue fiber web, has a machine direction, a cross machine direction, and a thickness direction. The structuring fabric includes a woven base fabric with a web facing side and a machine side. A plurality of structuring beads of polymeric material are formed on the web facing side of the woven base fabric, the structuring beads being suitable to provide a visible structure to the fiber web that is produced on the structuring fabric. The structuring beads rest on an upper foundation surface of corresponding sublayer beads of polymeric material. The sublayer beads thereby provide a foundation for the structuring beads. There is also described a production method for producing such a structuring fabric.

Abstract: An extrusion die makes a structuring fabric which has structuring-beads resting on sublayer-beads. The extrusion die has a flat first surface and a flat second surface, the first and second surfaces contact each other along a contact line. The first and second surfaces are inclined with respect to each other. The first surface has a first nozzle of a pair of nozzles for extruding a sublayer-bead and the second surface has a second nozzle of the pair of nozzles for extruding a structuring-bead on top of the sublayer-bead. The first nozzle has a substantially rectangular shape and the second nozzle has a shape that resembles a square with all four side edges bulged inwardly. Both the first nozzle and the second nozzle are located in close proximity to the contact line. The first nozzle has a first symmetry axis that is perpendicular to the contact line.

Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

Abstract: An array of membranes comprising amphipathic molecules is formed using an apparatus comprising a support defining an array of compartments. Volumes comprising polar medium are provided within respective compartments and a layer comprising apolar medium is provided extending across the openings with the volumes. Polar medium is flowed across the support to displace apolar medium and form a layer in contact with the volumes, forming membranes comprising amphipathic molecules at the interfaces. In one construction of the apparatus, the support that comprises partitions which comprise inner portions and outer portions. The inner portions define inner recesses without gaps therebetween that are capable of constraining the volumes comprising polar medium contained in neighbouring inner recesses from contacting each other. The outer portions extend outwardly from the inner portions and have gaps allowing the flow of an apolar medium across the substrate.

Abstract: In some embodiments, a method for operating a radio-frequency amplifier can include providing a bias signal to an amplifier implemented between an input node and an output node, and generating a detected voltage representative of a peak of a radio-frequency signal present at the input node. The method can further include enabling a protection mode when the detected voltage is greater than a first threshold value and disabling the protection mode when the detected voltage is less than a second threshold value that is less than the first threshold value.

Abstract: A suspension plasma spray deposition system comprising a suspension plasma spray device configured to deposit coating material on a surface of a component. The surface of the component includes a plurality of apertures. The system further includes a fluid flow system configured to flow fluid through the plurality of apertures in the surface of the component to reduce deposition of coating material in plurality of apertures. The fluid flow through each respective aperture of the plurality of apertures in the surface of the component is between about 0.095 and about 0.200 cubic feet per minute (cfm).

Abstract: An apparatus for spot polishing the work rolls of a metal sheet or plate leveler having a series of upper work rolls and a series of lower work rolls. The apparatus includes an assembly comprising a spot polisher frame, an airbag or other position translation element, and a polisher, including an abrasive surface, configured to radially polish only a portion of an upper or lower work roll. The apparatus further includes a polisher arm, to which the abrasive polisher is attached, at a first end of the polisher arm. The apparatus further includes a second end of the polisher arm hingedly connected to the spot polisher frame so as to enable the repositioning of the abrasive surface between a polishing and non-polishing orientation.

Abstract: A system includes a memory system configured to store a plurality of instructions to provide aircraft communication visualization and a processing system. The processing system configured to execute the instructions to result in retrieving a plurality of status data associated with aircraft communication at a target location from a database, determining a plurality of geographic location information for a plurality of aircraft parking locations at the target location, accessing a plurality of imagery data associated with a view at the target location, and generating an aircraft communication visualization map for the target location. The aircraft communication visualization map includes aircraft communication information overlaid upon an image based on the imagery data and the aircraft parking locations at the target location.

Abstract: Examples described herein provide a method that includes receiving engine data from a sensor associated with the engine. The method further includes associating a header with the engine data to generate packaged engine data. The method further includes transmitting the packaged engine data to an aircraft communication unit, wherein the header provides for the aircraft communication unit to transmit the packaged engine data to a ground station communication unit via a communication protocol.

Abstract: A system includes first, second and third input data sets. The first input data set includes demographic information characterizing a patient. The second and third input data sets characterize a healthcare treatment history of the patient. A neural network includes first, second and third neural subnetworks. The first neural subnetwork is configured to process the first input data set to produce a first output data set. The second neural subnetwork is configured to process the second input data set to produce a second output data set. The third neural subnetwork is configured to process the third input data set to produce a third output data set. An autoencoder layer has an input layer comprising the first, second and third output data sets and is configured to process the first, second and third output data sets to produce a secondary output data set.

Abstract: A wireless sensor system of a gas turbine engine of an aircraft can include a plurality of wireless sensors distributed within an engine core of the gas turbine engine and an energy harvesting system including one or more energy harvesting devices configured to convert mechanical or thermal energy within the gas turbine engine into electric power and provide the electric power to the wireless sensors. The wireless sensor system can also include a data concentrator coupled to the gas turbine engine. The data concentrator can be configured to receive a plurality of wireless sensor data from the wireless sensors and transmit the wireless sensor data to a communication adapter of the gas turbine engine.

Abstract: A gas turbine engine of an aircraft includes an engine control configured to monitor and control operation of the gas turbine engine in real-time and a communication adapter that includes a housing and a plurality of antennas in the housing. The communication adapter is configured to establish communication with the engine control and wireless communication with an offboard system external to the aircraft through at least one of the antennas of the communication adapter. The housing includes a metal chassis with a non-conductive substrate between the metal chassis and the antennas. The antennas are partitioned into two or more portions. A communication interface of the communication adapter is configured to establish wireless communication through the antennas using two or more different wireless communication protocols.