Patents by Inventor Paul A. Renhowe

Paul A. Renhowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted imidazole derivatives
    Publication number: 20060009472
    Abstract: The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the new compounds together with pharmaceutically acceptable carriers, and uses of the new compounds.
    Type: Application
    Filed: June 20, 2005
    Publication date: January 12, 2006
    Inventors: Weibo Wang, Paul Barsanti, Yi Xia, Rustum Boyce, Sabina Pecchi, Nathan Brammeier, Megan Phillips, Kris Mendenhall, Kelly Wayman, Liana Lagniton, Ryan Constantine, Hong Yang, Elizabeth Mieuli, Savithri Ramurthy, Elisa Jazan, Anu Sharma, Rama Jain, Sharadha Subramanian, Paul Renhowe, Kenneth Bair, David Duhl, Annette Walter, Tinya Abrams, Kay Huh, Eric Martin, Mark Knapp, Vincent Le
  • Quinolinone derivatives
    Publication number: 20050209456
    Abstract: A method for synthesizing a 4-amino substituted quinolinone includes reacting a substituted or unsubstituted 2-benzimidazolyl-2-acetate with a substituted or unsubstituted 2-aminobenzonitrile in the presence of a base or an acid. A 4-amino substituted quinolinone compound is formed by the reaction, and the 4-amino substituted quinolinone compound comprises a benzimidazole group.
    Type: Application
    Filed: March 29, 2005
    Publication date: September 22, 2005
    Inventors: Paul Renhowe, Cynthia Shafer, Timothy Machajewski, Sabina Pecchi, Christopher McBride
  • Benzimidazole quinolinones and uses thereof
    Publication number: 20050203101
    Abstract: Methods of treating cancer include contacting a cancer cell with 4-amino-5-fluoro-3-(5-piperazin-1-yl-1H-benzimidazol-2-yl)quinolin-2(1H)-one, 4-amino-5-fluoro-3-[5-(4-methyl-4-oxidopiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one, tautomers thereof, pharmaceutically acceptable salts thereof, pharmaceutically acceptable salts of the tautomers thereof, or a mixture thereof.
    Type: Application
    Filed: May 5, 2004
    Publication date: September 15, 2005
    Inventors: Paul Barsanti, Dirksen Bussiere, Stephen Harrison, Carla Heise, Johanna Jansen, Elisa Jazan, Timothy Machajewski, Christopher McBride, William McCrea, Simon Ng, Zhi-Jie Ni, Sabina Pecchi, Keith Pfister, Savithri Ramurthy, Paul Renhowe, Cynthia Shafer, Joel Silver, Allan Wagman, Marion Wiesmann, Kelly Wayman
  • Substituted benzazoles and methods of their use as inhibitors of Raf kinase
    Publication number: 20050192287
    Abstract: New substituted benzazole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
    Type: Application
    Filed: October 15, 2004
    Publication date: September 1, 2005
    Applicant: Chiron Corporation
    Inventors: Abran Costales, Teresa Hansen, Barry Levine, Christopher McBride, Daniel Poon, Savithri Ramurthy, Paul Renhowe, Cynthia Shafer, Sharadha Subramanian, Joelle Verhagen
  • Heterocyclic compounds
    Publication number: 20050137188
    Abstract: Organic compounds having the structural formula I are provided where the variables have the values described herein and R1 and R2 join together to form a 6 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group. Pharmaceutical formulations include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: April 14, 2004
    Publication date: June 23, 2005
    Inventors: Paul Renhowe, Timothy Machajewski, Cynthia Shafer, Mary Wernette Hammond, Sabina Pecchi
  • 2,6-Disubstituted quinazolines, quinoxalines, quinolines and isoquinolines and methods of their use as inhibitors of RAF kinase
    Publication number: 20050085482
    Abstract: New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
    Type: Application
    Filed: October 15, 2004
    Publication date: April 21, 2005
    Applicant: Chiron Corporation
    Inventors: Savithri Ramurthy, Paul Renhowe, Sharadha Subramanian
  • Quinolinone derivatives
    Publication number: 20050054672
    Abstract: Organic compounds having the formula I are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Application
    Filed: July 8, 2004
    Publication date: March 10, 2005
    Inventors: Paul Renhowe, Sabina Pecchi, Timothy Machajewski, Cynthia Shafer, Clarke Taylor, William McCrea, Christopher McBride, Elisa Jazan
  • Quinolinone derivatives
    Patent number: 6800760
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: July 3, 2003
    Date of Patent: October 5, 2004
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
  • Small molecule PI 3-kinase inhibitors and methods of their use
    Publication number: 20040176385
    Abstract: Compounds having formula I are provided where the variables have the values described herein.
    Type: Application
    Filed: November 21, 2003
    Publication date: September 9, 2004
    Inventors: John N. Nuss, Sabina Pecchi, Paul A. Renhowe
  • Quinolinone derivatives
    Patent number: 6774237
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: October 30, 2002
    Date of Patent: August 10, 2004
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
  • Quinolinone derivatives
    Patent number: 6762194
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: March 12, 2003
    Date of Patent: July 13, 2004
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Eliza Jazan
  • Heterocyclic compounds
    Patent number: 6759417
    Abstract: Organic compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group in structures I and II. Pharmaceutical formulations include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: June 2, 2003
    Date of Patent: July 6, 2004
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Cynthia M. Shafer
  • Heterocyclic derivatives of quinolinone benimidazoles
    Patent number: 6756383
    Abstract: Organi c compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group in structures I and II. Pharmaceutical formulations include the organic compound or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: June 29, 2004
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Timothy D. Machajewski, Cynthia M. Shafer, Mary Ellen Wernette Hammond, Sabina Pecchi
  • Substituted benzazoles and methods of their use as inhibitors of Raf kinase
    Publication number: 20040122237
    Abstract: New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
    Type: Application
    Filed: September 29, 2003
    Publication date: June 24, 2004
    Inventors: Payman Amiri, Wendy Fantl, Barry Haskell Levine, Daniel J. Poon, Savithri Ramurthy, Paul A. Renhowe, Sharadha Subramanian, Leonard Sung
  • Quinolinone derivatives
    Publication number: 20040097545
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.
    Type: Application
    Filed: July 3, 2003
    Publication date: May 20, 2004
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
  • Benzimidazole quinolinones and uses thereof
    Publication number: 20040092535
    Abstract: Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 13, 2004
    Applicant: Chiron Corporation
    Inventors: Paul A. Barsanti, Dirksen Bussiere, Stephen D. Harrison, Carla C. Heise, Johanna M. Jansen, Elisa Jazan, Timothy D. Michajewski, Christopher McBride, William R. McCrea, Simon Ng, Zhi-Jie Ni, Sabina Pecchi, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Cynthia M. Shafer, Joel B. Silver, Allan S. Wagman, Marion Wiesmann
  • Substituted benz-azoles and methods of their use as inhibitors of Raf kinase
    Publication number: 20040087626
    Abstract: New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
    Type: Application
    Filed: March 31, 2003
    Publication date: May 6, 2004
    Inventors: Paul A. Renhowe, Savithri Ramurthy, Payman Amiri, Barry Haskell Levine, Daniel J. Poon, Skaradha Subramanian, Leonard Sung, Wendy Fantl
  • Quinolinone derivatives
    Publication number: 20040006101
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.
    Type: Application
    Filed: March 12, 2003
    Publication date: January 8, 2004
    Applicant: CHIRON CORPORATION
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Eliza Jazan
  • Heterocyclic compounds
    Publication number: 20040002518
    Abstract: Organic compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group in structures I and II.
    Type: Application
    Filed: June 2, 2003
    Publication date: January 1, 2004
    Applicant: Chiron Corporation
    Inventors: Paul A. Renhowe, Cynthia M. Shafer
  • Indazole benzimidazole compounds
    Publication number: 20030207883
    Abstract: Organic compounds having the structure I are provided where the variables have the values described herein.
    Type: Application
    Filed: July 2, 2002
    Publication date: November 6, 2003
    Applicant: Chiron Corporation
    Inventors: Paul A. Renhowe, Cynthia M. Shafer, Christopher McBride, Joel Benjamin Silver, Sabina Pecchi, Timothy D. Machajewski, William R. McCrea, Daniel J. Poon, Teresa Thomas