Patents by Inventor Paul A. Renhowe

Paul A. Renhowe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Guanidinobenzamides
    Patent number: 6638927
    Abstract: Compounds of formula IA and IB are new where the variables R1 through R10 have the values set forth herein. Such compounds have use in treating diseases such as obesity and type II diabetes, and may be provided as pharmaceutical formulations in conjunction with a pharmaceutically acceptable carrier.
    Type: Grant
    Filed: August 31, 2001
    Date of Patent: October 28, 2003
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Daniel Chu, Rustum S. Boyce, Zhi-Jie Ni, David Duhl, Effie Tozzo, Kirk Johnson, David C. Myles
  • Novel guanidinobenzamides
    Publication number: 20030199499
    Abstract: Compounds of formula IIA and IIB are novel guanidine compounds 1
    Type: Application
    Filed: March 4, 2003
    Publication date: October 23, 2003
    Applicant: Chiron Corporation
    Inventors: Paul A. Renhowe, Daniel Chu, Rustum S. Boyce, David Duhl
  • Quinolinone derivatives
    Publication number: 20030158224
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.
    Type: Application
    Filed: October 30, 2002
    Publication date: August 21, 2003
    Applicant: Chiron Corporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea Jr, Christopher McBride, Elisa Jazan
  • Quinolinone derivatives
    Patent number: 6605617
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharmaceutically acceptable carrier and may be prepared by mixing the organic compounds or pharmaceutically acceptable salts of the organic compounds with a carrier and water. A method of treating a patient includes administering a pharmaceutical formulation according to the invention to a patient in need thereof.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: August 12, 2003
    Assignee: Chiron Corporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Jr., Christopher McBride, Elisa Jazan
  • Inhibitors of glycogen synthase kinase 3
    Publication number: 20030130289
    Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
    Type: Application
    Filed: December 3, 2002
    Publication date: July 10, 2003
    Applicant: Chiron Corporation
    Inventors: John M. Nuss, Stephen D. Harrison, David B. Ring, Rustum S. Boyce, Sean P. Brown, Dane A. Goff, Kirk W. Johnson, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Lynn Seely, Sharadha Subramanian, Allan S. Wagman, Xiaohui A. Zhou
  • Quinolinone derivatives
    Publication number: 20030028018
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.
    Type: Application
    Filed: April 5, 2002
    Publication date: February 6, 2003
    Applicant: Chiron Coporation
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
  • Inhibitors of glycogen synthase kinase 3
    Patent number: 6489344
    Abstract: New pyrimidine or pyridine based compounds, compositions and methods of inhibiting the activity of glycogen synthase kinase (GSK3) in vitro and of treatment of GSK3 mediated disorders in vivo are provided. The methods, compounds and compositions of the invention may be employed alone, or in combination with other pharmacologically active agents in the treatment of disorders mediated by GSK3 activity, such as in the treatment of diabetes, Alzheimer's disease and other neurodegenerative disorders, obesity, atherosclerotic cardiovascular disease, essential hypertension, polycystic ovary syndrome, syndrome X, ischemia, traumatic brain injury, bipolar disorder, immunodeficiency or cancer.
    Type: Grant
    Filed: June 18, 1999
    Date of Patent: December 3, 2002
    Assignee: Chiron Corporation
    Inventors: John M. Nuss, Stephen D. Harrison, David B. Ring, Rustum S. Boyce, Sean P. Brown, Dane A. Goff, Kirk W. Johnson, Keith B. Pfister, Savithri Ramurthy, Paul A. Renhowe, Lynn Seely, Sharadha Subramanian, Allan S. Wagman, Xiaohui A. Zhou
  • Novel guanidinobenzamides
    Publication number: 20020137939
    Abstract: Compounds of formula IA and IB are new 1
    Type: Application
    Filed: August 31, 2001
    Publication date: September 26, 2002
    Inventors: Paul A. Renhowe, Daniel Chu, Rustum S. Boyce, Zhi-Jie Ni, David Duhl, Effie Tozzo, Kirk Johnson, David C. Myles
  • Quinolinone derivatives
    Publication number: 20020107392
    Abstract: Organic compounds having the formulas I and II are provided where the variables have the values described herein.
    Type: Application
    Filed: September 11, 2001
    Publication date: August 8, 2002
    Inventors: Paul A. Renhowe, Sabina Pecchi, Timothy D. Machajewski, Cynthia M. Shafer, Clarke Taylor, William R. McCrea, Christopher McBride, Elisa Jazan
  • Heterocyclic compounds
    Publication number: 20020103230
    Abstract: Organic compounds having the structural formulas I, II, and III are provided where the variables have the values described herein and R1 and R2 in structure I join together to form a 5 to 7 membered substituted or unsubstituted ring including at least one O, N, or S atom, and Z is an O, S, NH or NR group in structures I and II.
    Type: Application
    Filed: August 30, 2001
    Publication date: August 1, 2002
    Inventors: Paul A. Renhowe, Timothy Machajewski, Cynthia M. Shafer, Mary Ellen Wernette-Hammond, Sabina Pecchi
  • Combinatorial libraries of substrate-bound cyclic organic compounds
    Patent number: 5958792
    Abstract: The invention relates to libraries of cyclic organic compounds and method of producing and assaying such libraries. According to the invention, each cyclic organic compound is constructed from a starting material in the form of a solid surface derivatized with a starting resin. Compounds are reacted with the resin to add or to form a cyclic group. The reactions are preferable carried out using a split resin procedure so that different compounds can be reacted with a plurality of subamounts so as to increase the size of the library. For example, compounds are reacted with a solid support bound starting resin to obtain a compound which includes an aldehyde functional group wherein the aldehyde compound or compounds reacted with it have substituents which are varied such that a mixture of products is obtained.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 28, 1999
    Assignee: Chiron Corporation
    Inventors: Manoi C. Desai, John M. Nuss, Kerry L. Spear, Rajinder Singh, Paul A. Renhowe, Edward G. Brown, Lutz Richter, Barbara O. Scott