Abstract: Compounds of Formula (I): wherein R1, R3, R11, R12, X, Y1, Y2, Y3, Y4 and are as defined in the description. Medicinal products containing the same which are useful in treating conditions requiring anti-apoptotic inhibitors.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A cloud computing platform provides zero trust network access as a service to customers that maintain applications on-premises, and a zero trust network access appliance at the customer premises that couples the on-premises applications to the cloud computing platform. A customer may host multiple instances of the appliance in order to support scalable access, where each instance creates a separate secure tunnel to the cloud computing platform. In this context, when a new appliance authenticates a new secure tunnel, information such as a connector name, customer, and port for the tunnel may be shared on a control plane for the computing platform to facilitate programmatic load balancing within the cloud computing platform.

Abstract: A cloud-based platform for zero trust network access (ZTNA) services provides zero trust network access as a service for multiple customers in a multi-tenant architecture. In this context, the configuration for a new ZTNA application is validated with a service proxy in a sandbox or similar environment before release by the cloud-based platform for access through a public network. As a significant advantage, this approach mitigates inadvertent conflicts or instability in a service proxy that supports other applications and customers.

Abstract: A zero trust network access appliance deployed at a customer premises can support gateway and cloud modes. In a gateway mode, the appliance operates as a zero trust network access gateway, and provides zero trust network access to applications hosted at the customer premises, using a firewall at the customer premises for network security. In the cloud mode, the appliance initiates a secure connection with a remote, cloud computing platform that provides a front end for zero trust network access. A threat management facility for the customer provides a control plane for managing zero trust network access provided through the cloud computing platform.

Abstract: Infrastructure for zero trust network access (ZTNA) is deployed as a cloud-based service remotely from a customer premises where user applications are hosted. By connecting an appliance on the customer premises to the cloud-based service through a secure tunnel or the like, an application hosted on the customer premises can then be accessed externally as a ZTNA application without the customer premises opening a firewall to public networks or otherwise exposing potential attack surfaces to the customer premises.

Abstract: A cloud computing platform provides zero trust network access as a service to customers that maintain applications on-premises. In this context, the cloud computing platform may associate customers and/or applications with specific service proxies, and add an abstraction layer for network access that maps an alias domain for each customer and/or application to a network load balancer associated with the specific service proxies associated with the corresponding application(s). This approach advantageously simplifies the configuration of service proxies at the cloud computing platform by permitting dedicated relationships among network load balancers, specific service proxies, and specific applications, while concurrently reducing or avoiding the administrative burden on customers of updating network pointers when the clusters of service proxies are periodically reconfigured to adjust to varying user traffic.

Abstract: A method includes receiving, by a computer system, information related to device health of an electronic device, determining, by the computer system, a health status of the electronic device based at least in part on the received information related to the device health of the electronic device, requesting, by a switch having a port connected to the electronic device, the health status of the electronic device from the computer system, receiving, by the computer system, the request for the health status of the electronic device from the switch, transmitting, by the computer system, the health status of the electronic device to the switch, evaluating, by the switch, the transmitted health status of the electronic device using network access rules associated corresponding to health statuses, and applying, by the switch, a network access control configuration to the port of the switch based on the evaluating the transmitted health status.

Abstract: A medical imaging device for use in imaging a subject using both gamma rays and light rays emanating from the subject, the device comprising: separation means to separate gamma rays and light rays emanating from the subject into a gamma ray channel comprising gamma rays and a light ray channel comprising light rays; first sensor means arranged to receive and detect gamma rays from the gamma ray channel and to generate first signals for use in forming a first image of the subject; second sensor means arranged to receive and detect light rays from the light ray channel and to generate second signals for use in forming a second image of the subject; wherein the first sensor means and the second sensor means are arranged to receive gamma rays and light rays, respectively, which propagate from the subject upon substantially coincident paths.

Abstract: The present invention relates to a method, apparatus, and system for communication with a user's family members using the DNA of the user without making the DNA profile public. According to a first aspect, there is provided a computer implemented method of locating one or more members of a familial network, comprising the steps of: generating one or more encryption keys derived from a first genomic sequence; encrypting a message using the or each encryption key to form an encrypted message; sending the encrypted message to one or more remote devices wherein decrypting the encrypted message at the one or more remote devices uses one or more encryption keys derived from a second genomic sequence; and receiving a confirmation regarding whether the decryption of the encrypted message was successful by any of the one or more remote devices.

Abstract: The disclosure provides a method of treating a human subject afflicted with lung cancer with a lymphocyte activation gene-3 (LAG-3) antagonist. In some aspects, the method comprises combination of the LAG-3 antagonist with an additional therapeutic agent (e.g., a programmed death-1 pathway inhibitor) and/or anti-cancer therapy (e.g., chemotherapy such as a platinum doublet chemotherapy).

Abstract: A toy includes a magnetically responsive member, a fulcrum member, a printed circuit board (PCB), a lid covering the PCB, an activation switch, a touch sensor, a motion sensor, an audio transducer, a signal generator and a controller. The flexible PCB includes an electromagnetic coil, and a plurality of light emitting diodes (LEDs). Opening of the lid actuates the activation switch, and in response, the controller controls the signal generator to generate a coil control signal for the electromagnetic coil to produce a magnetic field that interacts with the magnetically responsive member, to induce oscillatory flapping of the PCB. In response to detecting a touch signal from the controller, or a motion signal from the motion sensor, the controller also generates a LED control signal to control illumination of the LEDs while the PCB is flapping, and an audio control signal to control the audio transducer to output sound.

Abstract: There is described a process for producing at least one of mycoprotein and the components thereof, the process comprising: (i) providing a fermentation media suitable for producing mycoprotein; (ii) fermenting the fermentation media to obtain a mixture comprising mycoprotein; (iii) separating the mycoprotein from the mixture to obtain a mycoprotein phase; and (iv) mechanically disrupting the cell walls of the mycoprotein in the mycoprotein phase thereby releasing at least some of the mycoprotein cell contents. There is also described at least one of mycoprotein and the components thereof obtainable, obtained or directly obtained from the process. Further described is a composition comprising at least one of mycoprotein and the components thereof, wherein the composition is non-fibrous. The composition may comprise at least one of: protein obtained from mycoprotein, and amino acids derived from protein obtained from mycoprotein.

Abstract: Example implementations may involve using a prompt to prevent inadvertent control or playback of audio content. When a mobile device receives input data indicating a command to play back audio content on a first playback device, the mobile device determines whether the mobile device is in proximity to the first playback device. If the mobile device determines that the mobile device within a given proximity to the first playback device, the mobile device transmits, via the network interface, one or more commands to instruct the first playback device to play back the audio content. However, if the mobile device determines that the mobile device outside the proximity, the mobile device displays a prompt indicating that the mobile device is the outside the given proximity to the first playback device and a selectable control that, when selected, transmits the one or more commands to play back the audio content.

Abstract: A coated glazing includes at least the following layers in sequence: a transparent glass substrate, a layer based on an oxide of a metal and/or a layer based on an oxide of a metalloid, and a further layer, wherein either the layer based on an oxide of a metal or the layer based on an oxide of a metalloid is adjacent the transparent glass substrate. The layer that is adjacent the transparent glass substrate has a surface that, prior to a coating of the surface, has an arithmetical mean height of the surface value, Sa, of at least 4.0 nm when tested in accordance with ISO 25178-2:2012, and the coated glazing exhibits an average haze value of at least 0.47% when tested in accordance with ASTM D1003-13.

Abstract: The present invention relates to amorphous thermoresponsive polymers (ATP) and uses thereof in various domains, such as 3D printing and tissue engineering. Furthermore, the present invention relates to compositions, multidimensional structures and coatings comprising said polymer.

Abstract: Example techniques may involve temporary configuration of a media playback system in a place of accommodation, such as a hotel. In particular, the media playback system in a guest's room is configured with one or more settings of the guest's home media playback system. Example settings include user accounts of a various services, such as streaming audio services and/or voice assistant services. Other example settings include artists, albums, audio tracks, audio books, stations, and other audio content that the guest previously designated as a favorite using their home media playback system. When the guest leaves (e.g., checks-out of) of the place of accommodation, these settings are removed from the media playback system in the guest's room.

Abstract: A method of monitoring a wireless communication network and managing priority uplift for mobile communication devices of public stewardship workers.