Abstract: A gas detection device for a drum containing lithium-ion batteries, may include a sensing component configured to be received by a threaded port of a lid of the container, the sensing component including at least one sensor configured to detect a gas concentration and a temperature of the drum, and a controller configured to receive the gas concentration and the temperature from the sensing component, and issue an alert in response to one of the gas concentration and the temperature exceeding an associated predefined threshold.

Abstract: Antigen binding proteins that bind Lymphocyte Activation Gene 3 (LAG-3), and more particularly to antigen binding proteins that cause depletion of LAG-3+ activated T cells.

Abstract: Systems and methods are disclosed to implement an endpoint command invocation system (“ECIS”). In some embodiments, ECIS can quickly dispatch a command to a large number of endpoint components, where the endpoint components are online. ECIS can receive an invocation of a command, which can include the command recipients. In some embodiments, ECIS determines that some of the command recipients are online, while some of the command recipients are offline. ECIS determines connections to the online command recipients based on a connection map, which is updated whenever an endpoint component opens a connection to ask for a command. ECIS can deliver the command to the online command recipients using the connections. ECIS can also deliver the command to dispatch queues corresponding to the offline command recipients, where the dispatch queues store the command as a pending command that can be delivered to their respective command recipients whenever they come online.

Abstract: Systems and methods are disclosed to implement an endpoint command invocation system (“ECIS”). In some embodiments, ECIS can quickly dispatch a command to a large number of endpoint components, where the endpoint components are online. ECIS can receive an invocation of a command, which can include the command recipients. In some embodiments, ECIS determines that some of the command recipients are online, while some of the command recipients are offline. ECIS determines connections to the online command recipients based on a connection map, which is updated whenever an endpoint component opens a connection to ask for a command. ECIS can deliver the command to the online command recipients using the connections. ECIS can also deliver the command to dispatch queues corresponding to the offline command recipients, where the dispatch queues store the command as a pending command that can be delivered to their respective command recipients whenever they come online.

Abstract: A ball valve includes a valve body. The valve body is driven to rotate through a drive train that includes a planetary gear set. A gear of the planetary gear set is integrally formed with the valve body. In an embodiment, a ring gear of the planetary gear set is integrally formed with the valve body.

Abstract: It is the object of the present invention to provide a new polymer coating for low temperature plastics and plastic foams that allows for the application of disperse dyes in a sublimation process that preserves the original properties of the underlying plastic substrate. The composition includes an optically clear synthetic organic polymer base holding two layers, a first reflective layer supported by the low temperature plastic substrate that includes IR radiation reflecting additives, and a second layer supported by the first layer having light scattering particulate additives. The disperse dyes utilized in the invention may include additives to absorb IR radiation provided by an external IR source positioned above the disperse dyes causing the dyes to sublimate and diffuse quickly into the light scattering layer. The combination of these layers allows for diffusion of the disperse dye ink into the light scattering layer while protecting the low temperature plastic below.

Abstract: The description relates to battery safety and more specifically to containing battery fires. One example can include displacement sub-systems configured to physically separate an affected battery pack from other battery packs. Another example can include a 3D deployable fire curtain configured to automatically deploy around a battery pack to limit the spread of fire between battery packs. A further example can include a media reservoir positioned over a battery pack that is configured to hold non-combustible smothering media. A media retainer can be interposed between the battery pack and the media reservoir and configured to automatically release the non-combustible smothering media into the battery pack support structure when the battery pack experiences a fire.

Abstract: The disclosed systems and methods relate to allowing trading of over the counter (“OTC”) foreign exchange (“FX”) contracts on a centralized matching and clearing mechanism, such as that of the Chicago Mercantile Exchange's (“CME”'s) futures exchange system (the “Exchange”). The disclosed systems and methods allow for anonymous transactions, centralized clearing, efficient settlement and the provision of risk management/credit screening mechanisms to lower risk, reduce transaction costs and improve the liquidity in the FX market place. In particular, the disclosed embodiments increase speed of execution facilitating growing demand for algorithmic trading, increased price transparency, lower cost of trading, customer to customer trading, and automated asset allocations, recurring trades as well as clearing and settlement efficiencies.

Abstract: The present disclosure relates to an aerosol delivery device that includes a reservoir housing that defines a mouthpiece channel. The aerosol delivery device includes a sealing member configured to be received within the reservoir housing to define a reservoir chamber configured to retain an aerosol precursor composition therein. The aerosol delivery device also includes a substrate member that is configured to be received within the reservoir housing and to be directly engaged with a vaporizing assembly for forming an aerosol. The reservoir housing, sealing member, substrate member, and/or vaporizing assembly can be used for forming aerosols with precise and reproducible compositions.

Abstract: A system and method for utilizing a plain-old-telephone (“POT”) to interface with a digital assistant system. The POT is linked to an interface adapted to selectively provide a bidirectional audio connection to a standard telephone communication network, or to provide an interface to a digital assistant system in response to user voice commands. The functionality of the POT digital assistant interface being dependent upon the user input—DTMF tone/pulse dialing signals as opposed to voice commands spoken into the POT mouthpiece. Audio cues and prompts, as well as audio responses from the digital assistant system are provided to the user via the POT earpiece. Digital assistant functionality is provided via a simple and familiar interface, without impeding any standard voice telephony functionality (making/receiving calls, call waiting, caller ID, etc.

Abstract: The present invention provides processes for the preparation of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3, 5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3, 5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same.

Abstract: Systems and methods are disclosed to implement a delta data collection technique for collecting machine characteristics data from client machines. In embodiments, the collected data is used by a machine assessment service to maintain a virtual representation of the client machine for assessments. To initialize the collection process, the client uploads an initial copy of the data in full. Subsequently, the client determines periodic deltas between a current baseline of the data and a last reported baseline, and the deltas are uploaded as patches. The machine assessment service then applies these patches to update the virtual representation of the client machine. In embodiments, to facilitate the generation or uploading of the patches, the client may generate the baselines in a different encoding format as used by the data. For example, baselines in the new encoding format may be more easily compared and manipulated during the patch generation process.

Abstract: Provided herein are indole compounds that bind to BF3 of an androgen receptor (AR), which can modulate the AR for the treatment of Kennedy's disease.

Abstract: A roller tool 1 that can be connected into a string for deployment into an oil or gas well includes at least two rollers or wheels 10 located on each side of the roller tool 1, with axes of rotation that are perpendicular to the axis of the roller tool 1. The roller tool further includes at least two interconnecting tubular portions, where one tubular portion 41 comprises a mandrel 45 that connects to another tubular portion 42. An annular hub 20 is fitted over the mandrel 45 and the rollers 10 are connected onto the hub 20. The tubular portions 41, 42 comprise circumferential sleeve sections 56a, 56b that partially extend over the rollers 10 and resist detachment of the rollers 10 from the roller tool 1. The roller tool 1 can aid passage of a string through a well by holding the string away from the walls of the well and reducing frictional contact.

Abstract: Disclosed are compositions and methods that can be used for the prevention, mitigation, and/or prophylactic treatment of a viral infection, such but not limited to a coronavirus infection, such as but not limited to a COVID-19 infection. In some embodiments, a chemically modified tetracycline (CMT) derivative for the prevention, mitigation and/or prophylactic treatment of a viral infection is provided. In some embodiments, the CMT derivative lacks anti-microbial activity; comprises a phenol ring; and/or comprises a chemical structure sufficient to chelate and/or bind a divalent cation. In some embodiments, the divalent cation comprises Zn2+. In some embodiments, the viral infection is a coronavirus infection. In some embodiments, the viral infection is a COVID-19 infection.

Abstract: An auto injector apparatus includes a syringe and an auto injector. The syringe includes a barrel holding a therapeutic fluid including an anti-calcitonin gene-related peptide (anti-CGRP) antibody. The syringe also includes a stopper disposed within the barrel and the stopper moves axially within the barrel between a first position and a second position to expel at least some of the therapeutic fluid from the syringe. The auto injector includes a rod that abuts the stopper and an injection spring that drives the rod to apply a dispensing force through the rod to the stopper. The dispensing force includes a first dispensing force of between 20 N and 40 N and a second dispensing force of between 12 N and 20 N. The injection spring initially applies the first dispensing force and then applies the second dispensing force to move the stopper to the second position.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: A pessary system for providing pelvic floor support for USL and other ligaments. The pessary has an elongated probe with independently inflatable balloons each located substantially the same distance from the insertion end of the probe and which inflate into separate radial sectors. The probe can be inserted into a vaginal cavity and the balloons inflated provide mechanical support to the USLs. Independent inflation of each balloon allows the mechanical USL support provided to be varied on left and right sides to compensate for differences in the degree of degradation and positioning of the USL ligaments on either side.

Abstract: Vaporizers and systems for vaporizing liquid precursor for forming glass optical fiber preforms are provided. The vaporizer includes an expansion chamber at least partially enclosed by a side wall, the expansion chamber comprising an upper end and a lower end with the side wall disposed between the upper end and the lower end. The vaporizer further includes a closed-loop liquid delivery conduit positioned in the expansion chamber proximate to the upper end of the expansion chamber, wherein the closed-loop liquid delivery conduit comprises a plurality of nozzles oriented to direct a spray of liquid precursor onto an inner surface of the side wall. Further, the vaporizer includes at least one supply conduit positioned proximate the upper end of the expansion chamber and coupled to the closed-loop liquid delivery conduit, and a vapor delivery outlet coupled to the expansion chamber and configured to direct vaporized liquid precursor from the expansion chamber.

Abstract: The present invention concerns antigen binding proteins and fragments thereof which specifically bind B Cell Maturation Antigen (BCMA), particularly human BCMA (hBCMA) and which inhibit the binding of BAFF and APRIL to the BCMA receptor. Further disclosed are pharmaceutical compositions, screening and medical treatment methods.