Abstract: A blower includes a housing including an inlet and an outlet, a motor to drive a rotatable shaft, first and second impellers provided to the shaft, the first and second impellers each including a plurality of impeller blades, a first stationary component provided to the housing and including stator vanes downstream of the first impeller, and a second stationary component provided to the housing and including stator vanes downstream of the second impeller. A first set of stator vanes of the first stationary component is provided around the motor and are configured and arranged to direct airflow along the motor, to de-swirl the airflow and to decelerate air to increase pressure. A blower including a third impeller and third stationary component positioned above the first impeller is also described.

Abstract: Aspects described herein generally relate to a sol-gel that is the reaction product of an organosilane, a metal alkoxide, an acid, and a thio-lanthanide salt having a solubility of about 1 gram or greater per gram of sol-gel at 23° C. The thio-lanthanide salt includes a cation and a thio-ligand. The cation can be lanthanum, cerium, praseodymium, neodymium, promethium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, scandium, yttrium, cobalt, calcium, strontium, barium, and zirconium. In another aspect, a component, such as a vehicle component, includes a metal substrate and a sol-gel disposed on the metal substrate. Methods can include forming a sol-gel by mixing a metal alkoxide and an acid to form a first mixture; mixing with the first mixture an organosilane to form a second mixture; and mixing with the second mixture a lanthanide salt to form a third mixture.

Abstract: The disclosure is in part directed to a method of treating a cancer in a patient in need thereof, comprising administering to the patient an effective amount of a HSF1 pathway inhibitor, wherein the cancer comprises solid tumors identified as having an ARID1A mutation.

Abstract: A p38 MAPK inhibitor for use in the treatment or prevention of severe influenza in a human patient. In some embodiments, the severe influenza may be characterised by hypercytokinemia involving elevated levels of one or more pro-inflammatory cytokines. The p38 MAP kinase inhibitor may act to inhibit the release of such pro-inflammatory mediators from endothelial cells. In some embodiments, the p38 MAP kinase inhibitor may inhibit the release of IP 10 from endothelial cells, preferably in a dose-dependent manner.

Abstract: Disclosed herein are systems and methods for colocating virtual content. A method may include receiving first persistent coordinate data, second persistent coordinate data, and relational data. A third persistent coordinate data and a fourth persistent coordinate data may be determined based on input received via one or more sensors of a head-wearable device. It can be determined whether the first persistent coordinate data corresponds to the third persistent coordinate data. In accordance with a determination that the first persistent coordinate data corresponds to the third persistent coordinate data, it can be determined whether the second persistent coordinate data corresponds to the fourth persistent coordinate data. In accordance with a determination that the second persistent coordinate data corresponds to the fourth persistent coordinate data, a virtual object can be displayed using the relational data and the second persistent coordinate data via a display of the head-wearable device.

Abstract: Disclosed herein is a method of treating Idiopathic Pulmonary Fibrosis (IPF). The method includes administering to a subject in need thereof the deuterium-enriched pirfenidone LYT-100 at a total daily dose from about 1650 mg to about 2500 mg.

Abstract: Systems and methods are disclosed to implement a delta data collection technique for collecting machine characteristics data from client machines. In embodiments, the collected data is used by a machine assessment service to maintain a virtual representation of the client machine for assessments. To initialize the collection process, the client uploads an initial copy of the data in full. Subsequently, the client determines periodic deltas between a current baseline of the data and a last reported baseline, and the deltas are uploaded as patches. The machine assessment service then applies these patches to update the virtual representation of the client machine. In embodiments, to facilitate the generation or uploading of the patches, the client may generate the baselines in a different encoding format as used by the data. For example, baselines in the new encoding format may be more easily compared and manipulated during the patch generation process.

Abstract: A wide field fundus camera having multiple illumination beam projectors and to capture multiple retinal images at various viewing angles to facilitate wide field retinal examination. The wide field fundus camera images an entire retina at a single alignment. The wide field fundus camera provides visualization of a retina and Purkinje reflections simultaneously to facilitate alignment. The wide field fundus camera further contemplates narrow and broad slit beam illuminations to enhance autofocusing, imaging through less transparent crystalline lens, and reduction of haze due to reflected and scattered light from camera and ocular surfaces other than the retina. The wide field camera contemplates a real-time algorithm to reduce said reflected and scattered light haze in said retinal images. The wide field camera further contemplates automated montage of said multiple retinal images into a single wide field FOV retinal montage and automated removal reflected and scattered light haze from said retinal montage.

Abstract: A system for regulating speed of a vehicle along a road surface, the system including: at least one controller; at least one throttle sensor in communication with the at least one controller; at least one brake sensor in communication with the at least one controller; at least one gear sensor in communication with the at least one controller; at least one speed sensor in communication with the at least one controller; at least one motor in communication with the at least one controller; and at least one energy source in communication with the at least one controller and the at least one motor; wherein the at least one controller further includes a proportional integral and derivative controller; and at least one retardive braking system in communication with the at least one controller and controlled by the proportional integral and derivative controller.

Abstract: A system for providing power to a datacenter includes an information technology (IT) load, a grid connection, a grid information source, a discretely refuellable energy source, and an energy controller. The grid connection provides electrical communication between the IT load and a power grid. The grid information source is in communication with the grid connection and configured to obtain grid information. The discretely refuellable energy source is in electrical communication with the IT load. The energy controller is in data communication with the grid information source and configured to discharge the discretely refuellable energy source to the IT load based at least partially on the grid information.

Abstract: A toilet protection device prevents the human waste contents of a portable toilet from spilling/splashing onto the toilet and/or the walls/floor of the portable toilet enclosure. The toilet protection device includes an expandable rubber seal enabling the toilet protection device to fit in most, if not all, portable toilets regardless of shape or size. Moreover, by using a disposable cover, there is minimal cleanup of toilet protection device.

Abstract: The present disclosure is directed to processes, compositions and agents for inhibiting corrosion in various substrates, for example metal substrates. The present disclosure is also directed to corrosion inhibitors comprising organometallic polymers such as metal-organic frameworks (MOFs), including compositions and processes comprising MOFs for inhibiting corrosion in metal substrates.

Abstract: A blower includes a housing including an inlet and an outlet, a motor to drive a rotatable shaft, first and second impellers provided to the shaft, the first and second impellers each including a plurality of impeller blades, a first stationary component provided to the housing and including stator vanes downstream of the first impeller, and a second stationary component provided to the housing and including stator vanes downstream of the second impeller. A first set of stator vanes of the first stationary component is provided around the motor and are configured and arranged to direct airflow along the motor, to de-swirl the airflow and to decelerate air to increase pressure. A blower including a third impeller and third stationary component positioned above the first impeller is also described.

Abstract: An includes a soil-sensing arrangement. The apparatus (1) includes a seed-delivery mechanism. The soil-sensing arrangement includes one or more soil-sensing elements. Each of the one or more soil-sensing elements senses one or more conditions of the soil. The one or more soil-sensing elements can take the form of one or more soil-sensing tines (19). In the method, material is delivered to a locally-optimised soil depth LOD. In the method, there is at least periodic sensing of one or more conditions of the soil, and at two or more depths at mutually differing proximities to the locally-optimised depth.

Abstract: Playback devices comprising a network interface, an optional speaker(s), and one or more processors are disclosed herein. In some embodiments, the playback device is configured to communicate with a computing system that stores configuration data corresponding to each of a plurality of users. The playback device detects one or more users near the playback device and retrieves user configuration data corresponding to each of the one or more detected users, and thereafter, uses the user configuration data of the one or more detected users to process voice commands, play media content, and/or perform other voice and/or media related functions.

Abstract: Disclosed herein are systems and methods for colocating virtual content. A method may include receiving first persistent coordinate data, second persistent coordinate data, and relational data. A third persistent coordinate data and a fourth persistent coordinate data may be determined based on input received via one or more sensors of a head-wearable device. It can be determined whether the first persistent coordinate data corresponds to the third persistent coordinate data. In accordance with a determination that the first persistent coordinate data corresponds to the third persistent coordinate data, it can be determined whether the second persistent coordinate data corresponds to the fourth persistent coordinate data. In accordance with a determination that the second persistent coordinate data corresponds to the fourth persistent coordinate data, a virtual object can be displayed using the relational data and the second persistent coordinate data via a display of the head-wearable device.

Abstract: The present disclosure relates to agents, compositions, and methods for inhibiting corrosion in various substrates, for example in metal substrates. The present disclosure also relates to compositions for inhibiting corrosion comprising at least one organic heterocyclic compound and at least one metal salt or mixed metal salt selected from rare earth, alkali earth and transition metals.

Abstract: The present disclosure relates to systems, apparatuses, and methods for assembling cartridges for aerosol delivery devices. A system may include assembly cells each including an assembly track and assembly carriages that ride thereon and which engage components of partially-assembled cartridges. A transfer apparatus may transfer partially-assembled cartridges between the assembly cells. In another example system, cartridges may be assembled on platforms on a rotary track. The platforms may include assembly grippers with sequentially-opening clamps configured to receive the components of the partially-assembled cartridges. Related methods are also provided.

Abstract: The invention provides a p38 MAPK inhibitor of Formula I, or a pharmaceutically acceptable salt or solvate thereof: for use in the treatment or prevention of hypercytokinemia in a human patient; wherein R is C1-3alkyl, optionally substituted by one or more halo, NR1R2 or hydroxy, and R1 and R2 are independently H, halo or C1-3alkyl, optionally substituted by one or more F. Also provided are compositions for use in the treatment or prevention of hypercytokinemia comprising the p38 MAPK inhibitor of Formula I; and methods for treating or preventing hypercytokinemia in a human patient in need thereof comprising administering to the patient a therapeutically or prophylactically effective amount of a p38 MAPK inhibitor of Formula I. The invention also provides a p38 MAPK inhibitor and an antimicrobial agent, such as an antiviral agent, for use in the treatment or prevention of hypercytokinemia.

Abstract: A brake test device and method for testing the braking system of a vehicle, to ensure compliance with safety regulations and ensure the braking system is functional, said brake test system including: i. at least one on/off switch; ii. at least one display; iii. at least one on/off status indicator; iv. at least one controller; v. at least one brake sensor; vi. at least one brake status indicator; vii. at least one throttle (or accelerator) sensor; viii. at least one throttle (or accelerator) status indicator; ix. at least one motor torque sensor; x. at least one motor torque status indicator; xi. at least one gear sensor; xii. at least one gear status indicator; xiii. at least one brake test status indicator; xiv. at least one data logging component to log data from a brake test; and xv. at least one communication component to communicate the data from the brake test.