Abstract: A compound of formula (I): wherein: Y is (CH2)n, where n is from 2 to 4; W1 and W11 are independently selected from OH and ORP, where RP is Me or Et.

Abstract: Decentralized computer systems and methods are disclosed for establishing and conducting payment processing with loyalty points using distributed ledger. One method includes: receiving a consumer identification, an issuer identification, and transaction information from a point of sale system when the loyalty card is presented for a transaction of a good or service at a merchant, identifying the network node containing distributed ledger associated with the issuer according to received issuer identification prompting, to participants of the shared ledger, to validate whether the consumer distributed ledger has required loyalty points for the transaction; if all of the participants of the shared ledger accepts the transaction, generating, a new immutable entry to the distributed ledger for the transaction with remaining loyalty points in the loyalty card after deducting the points required for the transaction; and sending a transaction approved message to the point of sale system at the merchant.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, R1-R8, and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

Abstract: Described herein are high intensity illumination systems including lighting arrays of lights, such as light emitting diodes, configured to illuminate a surface. The lighting arrays are configured to illuminate the surface with illumination comparable to or multiple times brighter than the ambient illumination, such as sunlight. Also described herein are methods of using a high intensity illumination system to illuminate a surface for applications including imaging, object detection, and object localization. The systems and methods described herein may be applied to a range of industries including farming, agriculture, construction, and autonomous vehicles.

Abstract: A sampling system is provided for sampling fluids flowing through a pipe. The system includes at least two accumulator vessels; a single sampling pump for collection of samples and delivering samples via sampling lines to one or more of the at least two accumulators; one or more product valves associated with each of the accumulator vessels actuatable to direct sample flow to a particular accumulator vessel depending on the status of each of the at least two accumulator vessels; and a control system in connection with the sampling pump, product valves and accumulator vessels for automation of the pumping of samples to a particular accumulator vessel, depending on status of each of the at least two accumulator vessels, to ensure consistent sample taking and accumulation. The control system and sample pump is configured to accommodate bi-directional flow of fluid travelling through the pipe.

Abstract: A stormwater treatment system and method for removing sediment, chemical pollutants, and debris from stormwater runoff by utilizing bioretention practices including physical, chemical and biological processes. Stormwater is directed into a primarily open-bottomed, multi-dimensional container whereby entrained sediment and other transportable materials are filtered and treated through a media filter layer consisting of inorganic and/or organic materials. A live plant (preferably a tree) situated within the container with roots resident in the media filter layer with the ability for expansion beyond the perimeter of the container through openings in one or more sidewalls. The treated water may be further conveyed beyond the perimeter of the container by additional openings and/or piping. A vertically positioned overflow/bypass/clean out piping apparatus may be included within the stormwater treatment system to provide additional water conveyance.

Abstract: A method for remotely witnessing a medical workflow is provided. The method includes authenticating a clinician at a witnessing device. The method also includes receiving, at the witnessing device, a request to perform a medical workflow. The method further includes determining, at the witnessing device and based at least in part on the medical workflow, that a witness is required to observe the medical workflow. The method also includes initiating, at a witnessing client remotely coupled with the witnessing device, a witnessing session, wherein the witnessing client allows a witness to remotely observe the medical workflow. The method also includes enabling, in response to at least the initiation of the witnessing session, completion of the medical workflow. Related systems and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: Described herein are high intensity illumination systems including lighting arrays of lights, such as light emitting diodes, configured to illuminate a surface. The lighting arrays are configured to illuminate the surface with illumination comparable to or multiple times brighter than the ambient illumination, such as sunlight. Also described herein are methods of using a high intensity illumination system to illuminate a surface for applications including imaging, object detection, and object localization. The systems and methods described herein may be applied to a range of industries including farming, agriculture, construction, and autonomous vehicles.

Abstract: Examples herein describe systems and methods for aligning elements, such as conduit, ductwork, and plumbing within a computer-aided design (“CAD”) application. A plugin can provide an element alignment option on a graphical user interface (“GUI”) of the CAD program. An anchor point from which to align elements is selected in the GUI so that the plugin can choose locations within a structure to run multiple elements in parallel alignment. The system can recommend an alignment plane based on the slopes of the selected multiple elements and provide a direction for a run of the multiple elements. The systems retrieve the specifications and parameters of each individual element to determine its spacing among the run of multiple elements. The run of multiple elements is displayed and manipulated by the plugin via the GUI.

Abstract: A system and method for implanting heart assist devices. A model of a heart of a patient is formed based on images taken of the cardiothoracic cavity of the patient. A point is selected for insertion of the heart assist device based on the model. A graft location is selected on the aorta and a graft length for the graft is determined as a function of the implant location and the selected graft location.

Abstract: A smart heating system (10) for detecting leaks comprising a boiler (12), a plurality of radiators (14a, 14b, 14c, 14d), and a water circulation system (16). A valve is at or adjacent to the inlet and/or outlet of each radiator (14a, 14b, 14c, 14d) and an electronic pressure gauge is at each radiator (14a, 14b, 14c, 14d) configured to measure a water pressure in the radiator (14a, 14b, 14c, 14d) and/or water circulation system (16) adjacent to the radiator (14a, 14b, 14c, 14d) to generate a pressure reading. Each electronic pressure gauge has an identifier. A user electronic device (20) with a user display is communicatively connected with the electronic pressure gauges so as to be configured to receive and display the pressure readings and identifiers.

Abstract: Introduced here are computer programs that are able to generate computer vision data through local analysis of image data (also referred to as “raw data” or “input data”). The image data may be representative of one or more digital images that are generated by an image sensor. Also introduced here are apparatuses for generating and handling the image data and computer vision data.

Abstract: An electric grooming appliance includes a housing, a grooming device, an electric motor, and a controller. In some embodiments, the electric grooming appliance is capable of operating in different modes and includes a user interface which allows a user to communicate with the controller and select at least one of the modes. The electric grooming appliance may provide information to the user relating to information determined and/or detected during a grooming session. In addition, the electric grooming appliance may record or store grooming session information on a memory and estimate future operating parameters based on the grooming session information. The electric grooming appliance may include a trimmer assembly that is positionable between a stowed position and an operative position.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: One or more techniques and/or computing devices are provided for implementing synchronous replication. For example, a synchronous replication relationship may be established between a first storage controller hosting local storage and a second storage controller hosting remote storage (e.g., replication may be specified at a file, logical unit number (LUN), or any other level of granularity). Data operations and offloaded operations may be implemented in parallel upon the local storage and the remote storage. Error handling operations may be implemented upon the local storage and implement in parallel as a best effort on the remote storage, and a reconciliation may be performed to identify any data divergence from the best effort parallel implementation. Storage area network (SAN) operations may be implemented upon the local storage, and upon local completion may be remotely implemented upon the remote storage.

Abstract: In one embodiment, a method includes receiving a user request from a first user from a client system associated with a first user, wherein the user request comprise a gesture-input from the first user and a speech-input from the first user, determining an intent corresponding to the user request based on the gesture-input by a personalized gesture-classification model associated with the first user, executing one or more tasks based on the determined intent and the speech-input, and sending instructions for presenting execution results of the one or more tasks to the client system responsive the user request.

Abstract: A method for remotely witnessing a medical workflow is provided. The method includes authenticating a clinician at a witnessing device. The method also includes receiving, at the witnessing device, a request to perform a medical workflow. The method further includes determining, at the witnessing device and based at least in part on the medical workflow, that a witness is required to observe the medical workflow. The method also includes initiating, at a witnessing client remotely coupled with the witnessing device, a witnessing session, wherein the witnessing client allows a witness to remotely observe the medical workflow. The method also includes enabling, in response to at least the initiation of the witnessing session, completion of the medical workflow. Related systems and articles of manufacture, including apparatuses and computer program products, are also disclosed.

Abstract: The invention is a taper jig that provides a significant improvement of previous art by using pins and horizontal clamping to secure the workpiece. It is ideally suited for tapering square and rectangular workpieces for table and chair legs. The use of pins in the hold-downs into the workpiece enable the user to more safely hold the workpiece while tapering up to all four of the longitudinal sides. The use of horizontal clamping pressure enables a workpiece at or near the full capacity of the saw to be tapered. While all researched taper jigs use some variation of Carter's jig to provide the angle of taper, this invention improves on those designs in the manner the workpiece is secured.

Abstract: A compound of formula (I): wherein: R1 is selected from (i) H, (ii) C3-6cycloalkyl, (iii) C3-7heterocyclyl optionally substituted with a group selected from: methyl and ester, and (iv) linear or branched C1-4alkyl optionally substituted with a group selected from: alkoxy, amino, amido, acylamido, acyloxy, alkyl carboxyl ester, alkyl carbamoyl, alkyl carbamoyl ester, phenyl, phosphonate ester, C3-7heterocyclyl optionally substituted with a group selected from methyl and oxo, and a naturally occurring amino acid, optionally N-substituted with a group selected from methyl, acetyl and boc; A1 is CRA or N; A2 is CRB or N; A3 is CRC or N; A4 is CRD or N; where no more than two of A1, A2, A3, and A4 may be N; one or two of RA, RB, RC, and RD, (if present) are selected from H, F, Cl, Br, Me, CF3, cyclopropyl, cyano, OMe, OEt, CH2OH, CH2OMe and CH2NMe2; the remainder of RA, RB, RC, and RD, (if present) are H; Y is O, NH or CH2; RY is selected from: (RYA) and (RYB).