Abstract: Rotational atherectomy devices and systems can remove or reduce stenotic lesions in blood vessels by rotating an abrasive element within the vessel. The abrasive element can be attached to a distal portion of an elongate flexible drive shaft that extends from a handle assembly.

Abstract: In some examples, a system includes a processor, a management controller; and a programmable device to provide input/output (I/O) expansion emulation to support communication with a plurality of I/O devices of a subsystem coupled to the system, where the programmable device provides a plurality of virtual registers as part of the I/O expansion emulation, the virtual registers associated with respective I/O devices of the plurality of I/O devices. The processor writes a value to a first virtual register of the plurality of virtual registers to trigger an output event relating to a first I/O device of the plurality of I/O devices at the subsystem. The management controller reads the first virtual register and, in response to the value written to the first virtual register, interact with the subsystem to issue the output event relating to the first I/O device at the subsystem.

Abstract: A game employing user-modifiable game components, such as cards in a collectable card game, employs various features to provide user-modifiability, including sleeves, transparent cards, stickers, and other elements. Electronic versions of the game and various other features are included, including tracking of history associated with such components.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A device and system for purifying a fluid is provided. The system includes a tank having an interior space and a media container disposed within the interior space. A valve is provided that cooperates with an element within the interior, the valve being movable between an open and a closed position. The valve being biased to the open position when the element is not positioned within the interior space, wherein the interior space is fluidly coupled to the atmosphere in the open position. The valve further being configured to move to a closed position when the element is positioned within the interior space.

Abstract: A non-transitory computer readable medium stores at least one database (30) storing clinical competency framework profiles (32) for clinical competencies for a plurality of clinicians at a plurality of medical facilities; and instructions readable and executable by at least one electronic processor (16) to perform a learning activities recommendation method (100) comprising: linking educational content units (38) completed by clinicians to clinical competencies of the clinical competency framework profiles that are fulfilled by the completed learning activities; correlating clinical competency frameworks of different medical facilities that are for the same or similar clinical competencies in the clinical competency framework profiles; and recommending one or more of the educational content units to a clinician seeking to fulfill a clinical competency in one clinical competency framework based on the correlated clinical competency frameworks and the linked educational content units.

Abstract: Decentralized computer systems and methods are disclosed for establishing and conducting payment processing with loyalty points using distributed ledger. One method includes: receiving a consumer identification, an issuer identification, and transaction information from a point of sale system when the loyalty card is presented for a transaction of a good or service at a merchant, identifying the network node containing distributed ledger associated with the issuer according to received issuer identification prompting, to participants of the shared ledger, to validate whether the consumer distributed ledger has required loyalty points for the transaction; if all of the participants of the shared ledger accepts the transaction, generating, a new immutable entry to the distributed ledger for the transaction with remaining loyalty points in the loyalty card after deducting the points required for the transaction; and sending a transaction approved message to the point of sale system at the merchant.

Abstract: The present invention is directed to a method of preparing a molecular sieve of SWY framework type, denominated STA-30. STA-30 is synthesized using 1,4-diazabicyclo[2.2.2]octane, 1-azabicyclo[2.2.2]octane derivates and combinations thereof as structure directing agents. The resulting molecular sieve is useful as catalysts, particularly when used in combination with exchanged transition metal(s) for the Selective Catalytic Reduction (SCR) of NO.

Abstract: A material mover assembly, comprising a chamber having an inlet and an outlet; a first paddle; and a second paddle, wherein the first paddle is positioned in and configured to rotate circumferentially in the chamber, the second paddle is positioned in and configured to rotate circumferentially in the chamber, or is configured to be inserted into and retracted out of the chamber, and wherein relative motion of the first paddle and the second paddle causes material to be pulled into the chamber via the inlet and pushed out of the chamber via the outlet in a forward direction. A material mover assembly may be reversible in pumping direction and further may be used as an energy generator in either direction.

Abstract: Nanostructures and associated compositions, systems, and methods are provided. In some embodiments, a nanostructure may comprise polymers, intermolecular bonding groups, and a particle. The polymers may be associated with the particle and the intermolecular bonding groups may be associated with at least some of the polymers. In some embodiments, at least some of the intermolecular bonding groups may have a different chemical composition and/or chemical property than the polymers. In some embodiments, nanostructures may reversibly associate with each other via the intermolecular bonding groups to form a material. In some such cases, the intermolecular bonding groups on different nanostructures may reversibly associate with each other. In some embodiments, the nanostructures may be designed, such that the energy required to disassociate at least a portion of the nanostructures in the material is greater than the energy required to dissociate a single association between intermolecular bonding groups.

Abstract: The present invention relates to a sterile gel formulation suitable for use in filling a wound cavity and delivering an active ingredient thereto, the gel further having a pH range of 4.5 to 8.5, low bioadhesive strength and cohesive integrity and being formed from a polymer selected from among the group consisting of poly(vinyl) alcohol (PVA) polymer and a PVA-polyvinyl acetate copolymer, a cross-linker being a salt form of boron that produces borate ions in aqueous solution, at least one compound which has a beneficial effect as an active ingredient in the wound and at least one modulator, the modulator being a low molecular weight species that is capable of binding borate or PVA in aqueous solution through a mono-diol or di-diol formation and reduces the pH of PVA-borate hydrogels; wherein the gel is heat and/or gamma sterilised and contains less than 5% acetic acid and the polymer has a degree of hydrolysis of between 98% and 100% and a molecular weight of from 100,000 to 300,000 Daltons.

Abstract: An apparatus for collecting a saliva sample is described herein. In a described embodiment, the apparatus comprises a filter; and a pressure generator operable to generate pressure to cause the saliva sample to be transferred through the filter, the filter being configured to reduce a viscosity of the saliva sample as the saliva sample is transferred through the filter. A method collecting a saliva sample from a user is also described, among other aspects.

Abstract: At least one database stores clinical activity data indicative of clinical activities of medical professionals or maintenance activity by medical equipment servicing personnel. Consumption of educational content units related to one or more medical devices by a medical professional (or maintenance thereof by a servicing person) is tracked. Future clinical (or maintenance) activities to be performed by the medical professional (or servicing person) is predicted based on the clinical (or maintenance) activity data. One or more metrics are calculated related to the medical professional's (or servicing person's) knowledge and/or experience for a future time. The metrics may include a knowledge metric based on the tracked consumption of educational content units, and/or an experience metric based on the clinical (or maintenance) activity data and the predicted future clinical (or servicing) activities. One or more refreshment educational content units are recommended based on the one or more metrics.

Abstract: A non-transitory computer readable medium stores a database (30) storing log data automatically generated by one or more medical devices (12); and instructions readable and executable by at least one electronic processor (16) to perform a method (100) for generating educational content units (38). The method includes: analyzing the log data (32) contained in the database to identify log data for an educational instance of a procedure performed using the one or more medical devices; creating a simulation of the identified educational instance of the procedure using the identified log data for the educational instance of the procedure; and generating an educational content unit (38) from the simulation.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Decentralized computer systems and methods are disclosed for establishing and conducting payment processing with loyalty points using distributed ledger. One method includes: receiving a consumer identification, an issuer identification, and transaction information from a point of sale system when the loyalty card is presented for a transaction of a good or service at a merchant, identifying the network node containing distributed ledger associated with the issuer according to received issuer identification prompting, to participants of the shared ledger, to validate whether the consumer distributed ledger has required loyalty points for the transaction; if all of the participants of the shared ledger accepts the transaction, generating, a new immutable entry to the distributed ledger for the transaction with remaining loyalty points in the loyalty card after deducting the points required for the transaction; and sending a transaction approved message to the point of sale system at the merchant.

Abstract: In one embodiment, a method includes receiving a user request from a first user from a client system associated with a first user, wherein the user request comprise a gesture-input from the first user and a speech-input from the first user, determining an intent corresponding to the user request based on the gesture-input by a personalized gesture-classification model associated with the first user, executing one or more tasks based on the determined intent and the speech-input, and sending instructions for presenting execution results of the one or more tasks to the client system responsive the user request.

Abstract: In one embodiment, a method includes maintaining contextual information from a first dialog session, wherein the contextual information comprises identifiers of entities and slots, receiving a user request during the first dialog session, determining a context carryover is required for an agent to execute a task associated with the user request, determining a first subset of the identifiers of the entities and a second subset of the slots of the contextual information from the first dialog session are shareable with the agent based on the agent and first resources of the identifiers of the entities and second resources of the slots, and executing the task by the agent based on the first subset of the identifiers of the entities and the second subset of the slots of the shareable contextual information.

Abstract: Disclosed herein are compounds of Formula (I), or pharmaceutically acceptable salts thereof, that are inhibitors of Polo Like Kinase 4 (PLK4). Also disclosed herein are pharmaceutical compositions comprising the compounds of Formula (I), or pharmaceutically acceptable salts thereof, and one or more pharmaceutically acceptable excipients. Further disclosed herein are methods of treating cancer in a subject in need thereof, comprising administering to the subject an amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: Correcting for antennae spatial distortions in Radio Frequency (RF) localization may be provided. A plurality of actual locations associated with a plurality of Access Point (APs) may be received. Then a plurality of signal strengths associated with the plurality of APs may be received. Based on the plurality of signal strengths, a model may be created that models a plurality of inference errors respectively corresponding to the plurality of APs between a plurality of inferred locations respectively corresponding to the plurality of APs and the plurality of actual locations. The model may then be used in determining a location of a device.