Abstract: A compound of formula (I): which inhibits the activity of one or more KATs of the MYST family, i.e., TIP60, KAT6B, MOZ, HBO1, and MOF.

Abstract: A wearable baby carrier includes: a pad; a first strap coupled to, or configured for coupling to, the pad via a first strap connector; a second strap coupled to, or configured for coupling to, the pad via a second strap connector; and a first device connector coupled to the pad; wherein the wearable baby carrier has a first operation mode, and a second operation mode; wherein in the first operation mode, the wearable baby carrier is configured to support a weight of a baby while the wearable baby carrier is worn by the user via the first strap and the second strap; and wherein in the second operation mode, the wearable baby carrier is configured to detachably couple to a baby device via the first device connector while the wearable baby carrier is not worn by the user.

Abstract: In an approach for storage optimization for products manufacturing, a processor pulls parts data for a set of part numbers. A processor calculates an average shelf time for each part number of the set of part numbers. A processor calculates a priority index for each part number of the set of part numbers based on the average shelf time for each part number of the set of part numbers. A processor determines a category for each part number of the set of part numbers based on the priority index for each part number of the set of part numbers and a quantity of parts cumulative percentage for each part number of the set of part numbers.

Abstract: Bus mounted surge protection devices are provided that are configured to be positioned in a panelboard alongside one or more similarly sized circuit breaker devices. The bus mounted surge protection device is configured to be received by a same provisional bus as the one or more circuit breaker devices and the bus mounted surge protection device is configured to protect all of the one or more circuit breaker devices in the panelboard.

Abstract: The new Shock Absorber Under Arm Adjustable Height Walking Crutches are standard aluminum adjustable height walking crutches modified with 4 coil springs added under the arm rest, one spring in each crutch pipe below the arm rest. Two per crutch 4 per pair of crutches, the springs are accommodated by a Pipe Spring Adapter which holds the springs in place and also allows the springs to move freely. The crutches are used exactly the same as standard aluminum adjustable height crutches but with the addition of the springs and pipe spring adapters the crutches now have a shock absorber effect under the arm rest. The springs actuate each time the user applies weight to the arm rest therefore alleviating the pain caused to the under arms by standard crutches.

Abstract: A rotary steerable drill string (16) employs a drill bit (10) selected to positively contribute to underpressure in a preselected azimuthal segment of the borehole relative to an opposing azimuthal section. Generally, a high flow velocity of drilling fluid in the selected azimuthal segment relative to in other segments will result in a more pronounced underpressure in the selected azimuthal segment. Drill bit designs which locally enhance the drilling fluid flow velocity are proposed to be employed in the present rotary steerable drill string.

Abstract: A method for X-ray measurement includes generating and directing an X-ray beam to a sample including at least first and second layers stacked on one another, the X-ray beam incident on a sample location at which the first and second layers include respective first and second high aspect ratio (HAR) structures. X-ray scatter profiles are measured, that are emitted from the sample location in response to the X-ray beam as a function of tilt angle between the sample and the X-ray beam. A shift is estimated, between the first and second layers and a characteristic tilt of the first and second layers, based on the X-ray scatter profiles measured as a function of the tilt angle.

Abstract: The described embodiments relate to a self-regulating patch for taking biopotential measurements and balancing accurate measurements and user comfort. The self-regulating patch including: a heating element operable to generate heat that causes formation of sweat at the skin surface; a biopotential sensor; an exterior surface constructed of a moisture wicking material enveloping the heating element; and a logic to concurrently activate the biopotential sensor and transition the self-regulating patch between a plurality of modes, including a comfort mode and an accuracy mode, where in the comfort mode the heating element is inactive and in the accuracy mode the heating element is active.

Abstract: An apparatus assesses a condition of a patient. The apparatus may contain a patient interface for communicating a treatment generated by a respiratory treatment apparatus to the respiratory system of a patient. The apparatus may also include a sensing module containing one or more electrochemical sensors to sense chemicals in exhaled breath in real time, or over an extended period of time. The apparatus may also include one or more collectors to accumulate a breath condensate over an extended period of time. The sample collectors may contain an absorbent material, and may also be adapted for replacement within a sensing module. The absorbent material may also include a preservative for preserving a chemical component of the breath, such as an analyte of the exhaled breath.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: A method of printing an object comprises a first step in which a first region (2) is printed by delivering flowable material from a print nozzle travelling at a first print speed (V1). During a second step, an intermediate region (6) is printed by delivering material from the nozzle travelling (8) for: a first travel distance (D1) at a first travel speed (S1), a second travel distance (D2) at a second travel speed (S2), and a third travel distance (D3) at a third travel speed (S3). In a third step, the nozzle prints a second region 4 by delivering material from the nozzle travelling at a second print speed (V2). The first and third travel speeds (S1, S3) are both greater than the first and second print speeds (V1, V2) and the second travel speed (S2).

Abstract: A stormwater treatment system and method for removing sediment, chemical pollutants, and debris from stormwater runoff by utilizing bioretention practices including physical, chemical and biological processes. Stormwater is directed into a primarily open-bottomed, multi-dimensional container whereby entrained sediment and other transportable materials are filtered and treated through a media filter layer consisting of inorganic and/or organic materials. A live plant (preferably a tree) situated within the container with roots resident in the media filter layer with the ability for expansion beyond the perimeter of the container through openings in one or more sidewalls. The treated water may be further conveyed beyond the perimeter of the container by additional openings and/or piping. A vertically positioned overflow/bypass/clean out piping apparatus may be included within the stormwater treatment system to provide additional water conveyance.

Abstract: Nanostructures and associated compositions, systems, and methods are provided. In some embodiments, a nanostructure may comprise polymers, intermolecular bonding groups, and a particle. The polymers may be associated with the particle and the intermolecular bonding groups may be associated with at least some of the polymers. In some embodiments, at least some of the intermolecular bonding groups may have a different chemical composition and/or chemical property than the polymers. In some embodiments, nanostructures may reversibly associate with each other via the intermolecular bonding groups to form a material. In some such cases, the intermolecular bonding groups on different nanostructures may reversibly associate with each other. In some embodiments, the nanostructures may be designed, such that the energy required to disassociate at least a portion of the nanostructures in the material is greater than the energy required to dissociate a single association between intermolecular bonding groups.

Abstract: Technologies are provided for generation of firmware configured to restrict use of a firmware tool. Some embodiments include a computing system that can obtain firmware source code comprising a module configured to copy contents of a digitally signed binary file to an advanced configuration and power management interface (ACPI) table at runtime of a firmware. The computing system can generate a firmware image of the firmware, the firmware image comprising the module, a first firmware globally unique identifier (GUID), and a defined area storing digital content that remains unchanged upon a change to the firmware. The computing system also can obtain a binary file comprising a second firmware GUID, a firmware tool GUID, and a feature GUID, and can digitally sign the binary file using a private encryption key to generate the digitally signed binary file. The computing system can store the digitally signed binary file within the defined area.

Abstract: There is provided a method, apparatus and system for method for tailoring at least one subsequent communication to a user. Data acquired on the user in connection with a plurality of communications to the user is processed to determine a value for one or more characteristics indicative of a state of the user in connection with each communication. At least one communication parameter is varied in respect of each communication. The values for the one or more characteristics indicative of the state of the user that are determined in connection with each communication are compared to identify one or more communication parameters that are most suitable for the user. One or more communication parameters are set for the at least one subsequent communication to the user according to the one or more identified communication parameters. The subsequent communication to the user is enabled based on the set one or more communication parameters.

Abstract: A method of manufacture of a shaft including positioning a prefabricated wedge member onto a cylindrical mandrel, winding a fibre material onto the mandrel, the fibre material extending over at least a part of the wedge member, allowing a matrix material impregnated into the fibre material to cure, and machining away at least part of the fibre material in the region of the wedge member to expose fibres thereof.

Abstract: A gas delivery component of a CPAP system is configured to magnetically connect to a second gas delivery component of the CPAP system to deliver a pressurized flow of breathable gas to a patient's airways. The gas delivery component includes a lumen forming a first part of a gas flow path for the breathable gas. A connection end of the gas delivery component is configured to engage the second gas delivery component. In addition, a magnetic connection assembly is located at the connection end and includes a magnet positioned at least partially within the lumen. The magnetic connection assembly is configured to magnetically secure the gas delivery component to the second gas delivery component.

Abstract: An improved computer system and method for use with a distributed, preferably immutable, blockchain ledger stores transactional data that can be independently verified while still allowing subsequent updates of the transactional data for a period of time and is advantageously implemented for a blockchain-based voting system to permit updated voting until the voting period closes.

Abstract: Examples herein describe systems and methods for aligning elements, such as conduit, ductwork, and plumbing within a computer-aided design (“CAD”) application. A plugin can provide an element alignment option on a graphical user interface (“GUI”) of the CAD program. An anchor point from which to align elements is selected in the GUI so that the plugin can choose locations within a structure to run multiple elements in parallel alignment. The system can recommend an alignment plane based on the slopes of the selected multiple elements and provide a direction for a run of the multiple elements. The systems retrieve the specifications and parameters of each individual element to determine its spacing among the run of multiple elements. The run of multiple elements is displayed and manipulated by the plugin via the GUI.

Abstract: A method for remotely witnessing a medical workflow is provided. The method includes authenticating a clinician at a witnessing device. The method also includes receiving, at the witnessing device, a request to perform a medical workflow. The method further includes determining, at the witnessing device and based at least in part on the medical workflow, that a witness is required to observe the medical workflow. The method also includes initiating, at a witnessing client remotely coupled with the witnessing device, a witnessing session, wherein the witnessing client allows a witness to remotely observe the medical workflow. The method also includes enabling, in response to at least the initiation of the witnessing session, completion of the medical workflow. Related systems and articles of manufacture, including apparatuses and computer program products, are also disclosed.