Abstract: Disclosed is a method for monitoring cell density during cell expansion resulting from a cell culture process in a bioreactor comprising the steps of: a) cultivating cells in a bioreactor culture chamber according to a cell culture process having cell culture parameters; b) during said process, introducing cell culture fluid inputs and generating waste materials; c) determining the intensity of volatile organic compounds (VOCs) and their chemical species in the waste materials; and d) estimating the density or population of cells in the bioreactor based on said determination.

Abstract: In one embodiment, a method includes accessing visual data from a client system associated with a user, wherein the visual data comprises images portraying one or more objects, receiving, from the client system, a user request, wherein the user request comprises a coreference to a target object, resolving the coreference to the target object from among the one or more objects, resolving the target object to a specific entity, and sending, to the client system, instructions for providing a response to the user request, wherein the response comprises attribute information about the specific entity.

Abstract: A method for stratifying severity of asthma of a patient initially comprises receiving acoustic data corresponding to sounds of the patient from an acoustic sensor and identifying, by a processor, at least one cough sound in the acoustic data. With or without the patient being present, the method further involves determining, by operation of the processor, one or more overall cough sound feature values of the at least one cough sound for each of one or more characteristic features. The overall cough sound feature values are then applied to a classifier that is implemented by the processor and which has been pre-trained with a training set of characteristic feature values from a population of asthmatic and non-asthmatic subjects. The method then involves monitoring an output from the pre-trained classifier to deem the patient cough sound as indicating one of a number of degrees of severity of asthma.

Abstract: Described herein is a conversation engine that can be used in a system such as a personal digital assistant or search engine that combines a dynamic knowledge graph built during execution of a request and one or more static knowledge graphs holding long term knowledge. The conversation engine comprises a state tracker that holds the dynamic knowledge graph representing the current state of the conversation, a policy engine that selects entities in the dynamic knowledge graph and executes actions provided by those entities to move the state of the conversation toward completion, and a knowledge graph search engine to search the static knowledge graph(s). The conversation is completed by building the dynamic knowledge graph over multiple rounds and chaining together operations that build toward completion of the conversation. Completion of the conversation results in completion of a request by a user.

Abstract: The described embodiments relate to a self-regulating patch for taking biopotential measurements and balancing accurate measurements and user comfort. The self-regulating patch including: a heating element operable to generate heat that causes formation of sweat at the skin surface; a biopotential sensor; an exterior surface constructed of a moisture wicking material enveloping the heating element; and a logic to concurrently activate the biopotential sensor and transition the self-regulating patch between a plurality of modes, including a comfort mode and an accuracy mode, where in the comfort mode the heating element is inactive and in the accuracy mode the heating element is active.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts thereof, wherein Ring A, Y, R1-R8, m, n and p are defined herein. The novel cycloalkyl and heterocycloalkyl benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.

Abstract: Multi-User Multiple Input, Multiple Output (MU-MIMO) data transmissions are provided with a forward-predictive precoding matrix to mitigate the effects of a change in a state of a communication channel. First and second soundings are performed, at first and second times, to a receive antenna over a channel and, responsive to each of the soundings, first and second Channel State Information (CSI) are received. Based on the first and second CSI, a change in a state of the channel over a time period between the first and second time is determined. Based on the change in the state of the channel, a forward-predictive channel state matrix and/or a forward-predictive precoding matrix are determined that reflect a state of the channel at a future time and that are consistent with the determined change in the state over the time period. The forward-predictive precoding matrix is applied to a data transmission.

Abstract: An aperture antenna tuning technique is used in an antenna array to improve the performance and, therefore, enhance the overall system efficiency for wireless devices. The aperture tuning occurs by using an aperture tuner to change the phase response of the antenna array radiation pattern. The aperture tuning improves the signal to noise ratio (SNR) by enhancing an array radiation pattern in a desired direction.

Abstract: Embodiments relate to devices, systems and methods for monitoring neuromuscular blockage. In an embodiment, a neuromuscular blockage monitoring system comprises a patch device comprising a unitary patch body, at least two electrodes and at least one sensor, the at least one sensor arranged between the at least two electrodes on the unitary patch body; and a stimulator device operatively coupled to the patch device and configured to provide at least one electrical signal to the at least two electrodes to stimulate a muscle motor point and to receive a signal from the at least one sensor related to a result of the stimulation of the muscle motor point.

Abstract: A system and method for identifying relevant content from other documents and presenting candidate documents/content in a document authoring application is described. A computer-implemented method includes performing an analysis of text of a document being authored by a user with a document authoring application, searching a document library for content elements and documents based on the analysis of the text, identifying candidate documents and candidate content based on the searching, presenting a list of candidate documents or candidate content with the document authoring application, receiving a selection of a candidate document or candidate content from the list in the document authoring application, and including an instance of the selected candidate document or candidate content in the document.

Abstract: A structure (1) for providing a physical or visual barrier comprises at least one post (2) mounted to a supporting surface and to which is secured at least one slat (8) by at least one wedge (10). The post (2) has a beam 31 (16) extending upwards from a footing. The beam (16) comprises at least one longitudinally extending plate which at least partially encloses a hollow (18). The beam has at least one plate that extends between opposite left and right sides (33, 34). The beam has at least one plate that extends between opposite front and rear sides (31, 32). The beam (16) is cut through by at least one slot (28) extending rearwards from the front side (31) part of the way towards the rear side (32). The slot (28) is configured to receive a portion of a slat (8) when inserted into the slot (28) in an insertion direction from the front side (31) of the beam (16). The slat (8) then extends laterally away from at least one of the sides (33, 34).

Abstract: A method of providing a geographically distributed live mixed-reality meeting is described. The method comprises receiving, from a camera at a first endpoint, a live video stream; generating an mixed reality view incorporating the received video stream; rendering the mixed reality view at a display at the first endpoint and transmitting the mixed reality view to at least one other geographically distant endpoint; receiving data defining a bounding area; calculating a real world anchor for the bounding area using the data defining the bounding area; rendering the bounding area in the mixed reality view at a real world position determined using the real world anchor; and applying different rule sets to content objects placed into the mixed reality view by users dependent upon the position of the content objects relative to the bounding area in real world space.

Abstract: Decentralized computer systems and methods are disclosed for establishing and conducting payment processing with loyalty points using distributed ledger. One method includes: receiving a consumer identification, an issuer identification, and transaction information from a point of sale system when the loyalty card is presented for a transaction of a good or service at a merchant, identifying the network node containing distributed ledger associated with the issuer according to received issuer identification prompting, to participants of the shared ledger, to validate whether the consumer distributed ledger has required loyalty points for the transaction; if all of the participants of the shared ledger accepts the transaction, generating, a new immutable entry to the distributed ledger for the transaction with remaining loyalty points in the loyalty card after deducting the points required for the transaction; and sending a transaction approved message to the point of sale system at the merchant.

Abstract: The invention relates to an operational state determination apparatus (1) for determining whether a variation in a determined electrical parameter of an electrical network (2) is caused by a variation in an operational state of an electrical consumer of the electrical network. The electrical network comprises multiple electrical consumers (3, 4, 5) and a voltage source (6), wherein a variation classification unit (10) determines whether a variation in the determined electrical parameter of the electrical network is caused by a variation in the operational state of an electrical consumer of the network depending on a decision variable which depends on a variation in a measured voltage and a variation in a measured current of the electrical network. This determination can be performed, without directly using the variation in the determined electrical parameter of the electrical network and is therefore less influenced by random voltage fluctuations in the electrical network.

Abstract: Disclosed are systems and methods for managing consent to share data from a user device. In some examples, the system stores user identifiers referenced to the user's individual consent preferences. The consent preferences may include data types, data generating devices to which the user consents, types of third parties the user consents to share the data with and other consent preferences. Third parties may communicate with the system, and determine whether a user has consented to share their data.

Abstract: In one embodiment, a method includes, by one or more computing systems, receiving, from a client system, an input in a multi-turn message thread, parsing the input to identify a plurality of hypothesis dialog states associated with the input, generating a plurality of functions corresponding to the plurality of hypothesis dialog states, calculating a plurality of probability scores for the plurality of functions, respectively, based on a prior dialog state associated with the message thread and a current user context, wherein each probability score represents a likelihood that the respective function is associated with an intended dialog state, and storing the plurality of functions if each of the probability scores is below a threshold probability score, wherein the plurality of functions is stored as a hierarchical set of functions that is used as the prior dialog state in response to a next input in the message thread.

Abstract: A wearable baby carrier includes: a pad; a first strap coupled to, or configured for coupling to, the pad via a first strap connector; a second strap coupled to, or configured for coupling to, the pad via a second strap connector; and a first device connector coupled to the pad; wherein the wearable baby carrier has a first operation mode, and a second operation mode; wherein in the first operation mode, the wearable baby carrier is configured to support a weight of a baby while the wearable baby carrier is worn by the user via the first strap and the second strap; and wherein in the second operation mode, the wearable baby carrier is configured to detachably couple to a baby device via the first device connector while the wearable baby carrier is not worn by the user.

Abstract: In one embodiment, a method includes receiving a user request from a first user from a client system associated with a first user, wherein the user request comprise a gesture-input from the first user and a speech-input from the first user, determining an intent corresponding to the user request based on the gesture-input by a personalized gesture-classification model associated with the first user, executing one or more tasks based on the determined intent and the speech-input, and sending instructions for presenting execution results of the one or more tasks to the client system responsive the user request.

Abstract: This invention relates to the compound (2R)-2-(6-{5-chloro-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1-oxo-2,3-dihydro-1H-isoindol-2-yl)-N-[(1S)-1-(3-fluoro-5-methoxyphenyl)-2-hydroxyethyl]propanamide, and in particular to novel physical forms of the compound, a process for preparing the compound and synthetic intermediates for use in the process, and novel formulations containing the compound, as well as therapeutic uses of the compound.

Abstract: In one embodiment, a method includes receiving a user input from a client system associated with a user, determining a task based on the user input and a confidence score associated with the task, generating one or more first dialog acts based on a task policy which specifies dialog acts associated with the task, generating one or more second dialog acts based on an override policy responsive to the confidence score being less than a threshold score, wherein the override policy specifies dialog acts that modify dialog acts specified by the task policy; and sending instructions for presenting a response to the user input to the client system, wherein the response is based on one or more of the first dialog acts or the second dialog acts.