Abstract: A liquid fuel injector connected to the fuel line manifold and return line manifold by plastic tubing, standard petrol fittings, or high pressure hosing so aiding ease of installation, each injector having a separate inlet and return line to assist in fuel temperature control. The injectors are designed to assist in keeping the temperature of the fuel as low as possible with the injector coil not being cooled by the fuel, but by ambient air.

Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.

Abstract: A system that selectively couples one or more IC chips to card slots. The system contains a Z-bar switch which includes: a select input; a first IC port coupled to a first IC pin; a second IC port coupled to a second IC pin; a first card slot port coupled to a first card slot pin; and a second card slot port coupled to a second card slot pin. If the select input receives a first control pattern, the Z-bar switch is configured to: couple the first IC port to the first card slot port; and to couple the second IC port to the second card slot port. If the select input receives a second control pattern, the Z-bar switch is configured to: couple the first IC port to the second card slot port; leave the second IC port floating; and to leave the first card slot port floating.

Abstract: The invention relates to databases of T cell epitopes, especially helper T cell epitopes, for rapid interrogation of protein sequences for the presence of T cell epitopes. The invention includes full or partial databases and data structures of T cell epitopes including epitopes identified especially by ex vivo T cell assays with test peptides and includes T cell epitopes identified by extrapolation of data from test peptides. The present invention also includes high throughput methods for determining the T cell epitope activity of peptides for subsequent inclusion in databases and data structures including methods where subsets of T cell especially regulatory T cells are removed or inhibited from T cell assays in order to maximize the sensitivity of detection of T cell epitope activity.

Abstract: A heat exchanger (10) has an outer housing (16) and a first helical fluid flow path or coil (12) located in the housing (16) defining a plurality of turns and having an inlet (24) and an outlet (22) for entry and exit of fluid into the flow path to be heated or cooled. A second helical coil (14) defining a second fluid flow path is located within the housing (16) adjacent to the first coil. The second coil also has an inlet (24) and outlet (22) for a passage for hot or cold service media. A conductive or non-conductive sheath (18) is disposed between the coils. A transfer medium is disposed in the housing for transfer of heat between the first and second flow paths. A plurality of baffles (20) are located between the outer housing and sheath and disposed between turns of the first coil. A plurality of baffles (21) are also disposed between turns of the second coil (14).

Abstract: In one aspect, the invention relates to a method of producing high-quality diamond comprising the steps of providing a mixture comprising hydrogen, a carbon precursor, and oxygen; exposing the mixture to energy at a power sufficient to establish a plasma from the mixture; containing the plasma at a pressure sufficient to maintain the plasma; and depositing carbon-containing species from the plasma to produce diamond at a growth rate of at least about 10 ?m/hr; wherein the diamond comprises less than about 10 ppm nitrogen. The invention also relates to the apparatus, gas compositions, and plasma compositions used in connection with the methods of the invention as well as the products produced by the methods of the invention. This abstract is intended as a safety scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.

Abstract: Disclosed are Fc-interferon-beta (Fc-IFN-?) fusion proteins and nucleic acid molecules encoding them. The Fc-IFN-? fusion proteins include variants of the interferon-beta (IFN-?) protein that are altered to achieve enhanced biological activity, prolonged circulating half-life and greater solubility. Also disclosed are methods of producing the fusion proteins and methods of using the fusion proteins and/or nucleic acid molecules for treating diseases and conditions alleviated by the administration of interferon-beta.

Abstract: A gaming device includes a single player poker game that includes one or more opportunities for selecting or forming player hands. In one embodiment, wagers are placed on several player hands, and the gaming device matches these wagers for each of several dealer hands. A play of the game includes one or more opportunities for a player to fold or cancel one of the player hands and withdraw the wager associated with the withdrawn hand. The gaming device may also cause one or more of the dealer hands to be folded. In another embodiment, the game includes dealing several initial player hands and enabling a player to select one of the player hands to compete against one or more dealer hands. In another embodiment, a play of the game includes dealing a plurality of player cards and enabling a player to form multiple player hands from the dealt player cards. The game also includes dealing a plurality of dealer cards and forming multiple dealer hands from the dealt dealer cards.

Abstract: One embodiment of the present invention provides a system that switches between frame buffers which are used to refresh a display. During operation, the system refreshes the display from a first frame buffer which is located in a first memory. Upon receiving a request to switch frame buffers for the display, the system reconfigures data transfers to the display so that the display is refreshed from a second frame buffer which is located in a second memory.

Abstract: The present application relates to compositions of modified toxins exhibiting reduced immunogenicity and reduced binding to vascular endothelium or vascular endothelial cells, thereby reducing the incidence of Vascular Leak Syndrome. Also provided are polypeptide toxophores from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope. Another aspect relates to a polypeptide toxophore from a modified diphtheria toxin, where modifications are in at least one amino acid residue of at least one T-cell epitope and at least one amino acid residue of at least one VLS motif of an unmodified native diphtheria toxin. Another aspect relates to a fusion protein which comprises a modified diphtheria toxin and a non-diphtheria toxin fragment that is a cell binding portion. Another aspect relates to the use of a modified diphtheria toxin for the treatment of a malignant disease or a non-malignant disease.

Abstract: One embodiment of the present invention provides a system that facilitates changing a clock frequency in a memory system. During operation, the system receives a command to change the clock frequency to a new clock frequency. The system then iteratively changes the clock frequency to the new clock frequency. More specifically, the system starts an iteration by slewing the clock frequency toward the new clock frequency by an increment to reach an intermediate frequency without interfering with normal memory-system operation. Next, the system signals a memory controller to pause normal memory system operation by completing or cancelling all in-flight or outstanding memory system operations and not accepting additional memory operation requests.

Abstract: The present invention provides composite proteins, including antibodies, which show reduced immunogenicity. In particular, composite antibodies for use in humans are provided, in particular antibodies which have been modified to remove one or more T-cell epitopes. Methods for generating such proteins are also provided.

Abstract: A heat exchanger (10) has an outer housing (16) and a first helical fluid flow path or coil (12) located in the housing (16) defining a plurality of turns and having an inlet (24) and an outlet (22) for entry and exit of fluid into the flow path to be heated or cooled. A second helical coil (14) defining a second fluid flow path is located within the housing (16) adjacent to the first coil. The second coil also has an inlet (24) and outlet (22) for a passage for hot or cold service media. A conductive or non-conductive sheath (18) is disposed between the coils. A transfer medium is disposed in the housing for transfer of heat between the first and second flow paths. A plurality of baffles (20) are located between the outer housing and sheath and disposed between turns of the first coil. A plurality of baffles (21) are also disposed between turns of the second coil (14).

Abstract: Paper incorporating a wide elongate impermeable element with regions at least partially exposed at one surface of the paper at two sets of windows at spaced locations has its windows formed by two sets of raised portions on the support surface of the papermaking machine. A first set of raised portions has a width transverse to the machine direction in which the paper travels during manufacture which is narrower than the width of the elongate element. A second set of raised portions has a width transverse to the machine direction which is at least equal to the width of the elongate element. During manufacture of the paper the elongate element is brought into contact with both sets of raised portions, with edges of the elongate element being supported by the second set of raised portions.

Abstract: A system that selectively couples one or more IC chips to card slots. The system contains a Z-bar switch which includes: a select input; a first IC port coupled to a first IC pin; a second IC port coupled to a second IC pin; a first card slot port coupled to a first card slot pin; and a second card slot port coupled to a second card slot pin. If the select input receives a first control pattern, the Z-bar switch is configured to: couple the first IC port to the first card slot port; and to couple the second IC port to the second card slot port. If the select input receives a second control pattern, the Z-bar switch is configured to: couple the first IC port to the second card slot port; leave the second IC port floating; and to leave the first card slot port floating.

Abstract: The present invention provides an apparatus and methods for the functionality of an integrated circuit. An exemplary embodiment according to an aspect of the present invention includes a ball grid array having open spaces therein. Within the open spaces, pairs of opposite polarity vias are clustered to minimize current path inductance by exploiting mutual inductance between vias of opposite current flow. In an illustrative embodiment, capacitors are coupled to the vias to further reduce current path inductance.

Abstract: Described herein are nitrated lipids and methods of making and using the nitrated lipids.

Abstract: One embodiment of the present invention provides a system that facilitates changing a clock frequency in a memory system. During operation, the system receives a command to change the clock frequency to a new clock frequency. The system then iteratively changes the clock frequency to the new clock frequency. More specifically, the system starts an iteration by slewing the clock frequency toward the new clock frequency by an increment to reach an intermediate frequency without interfering with normal memory-system operation. Next, the system signals a memory controller to pause normal memory system operation by completing or cancelling all in-flight or outstanding memory system operations and not accepting additional memory operation requests.

Abstract: An occupant protection apparatus comprises an inflatable airbag with a panel, the panel including a first vent opening that permits inflation fluid to escape out of the airbag; and a valve sheet including a second vent opening movable relative to the first vent opening, the valve sheet having opposite ends that are each fixed to a surface of the airbag. One end of the valve sheet moves with the panel during inflation of the airbag to move the second vent opening relative to the first vent opening. The apparatus also includes a valve guide to guide movement of the valve sheet relative to the panel, the valve sheet is capable of sliding between the valve guide and the panel. Both ends of the valve sheet remain fixed to the panel during and after inflation of the airbag.