Abstract: Indoline sulfonamide compounds that can inhibit DapE and/or bacterial metallo-?-lactamases (MBLs), such as NDM-1, are disclosed. Also disclosed are methods of treating an individual suffering from a bacterial infection using the indoline sulfonamide compounds disclosed herein.

Abstract: A distributed remote sensing system including at least one gateway, at least one sensing device and a communication interface providing radio frequency communication through a shared frequency scheme between each sensing device and one of the at least one gateway and between each sensing device and another of the at least one gateway through a different frequency scheme.

Abstract: Determining whether a compression garment is worn by a wearer of the garment by analyzing a pressure signal waveform indicative of a fluid pressure in an inflatable and deflatable bladder of the compression garment. Variance detected in the pressure signal waveform during the analysis is indicative of a change in condition of the compression garment. In one aspect the change in condition is verified using confirmatory analysis. In another aspect, the variance is one of a pressure rise and a pressure impulse. In yet another aspect, the variance is an oscillating amplitude as a function of time representative of a pulse of the wearer.

Abstract: A spring element that includes a spring body that is at least chiefly formed from an elastomer, wherein at least one reinforcement fiber is embedded into the elastomer. The at least one reinforcement fiber has an arcuate course in a non-loaded condition of the spring element, so that the spring element has a non-linear spring characteristic.

Abstract: Wheel hub and method for forming a wheel hub. Wheel hub includes a rim having a circumferential surface with axial ends, and one rim flange being arranged at each axial end of the circumferential surface. The rim includes a fiber-reinforced plastic as a main component and each of the rim flanges is releasably connectable to the rim.

Abstract: A versatile detection circuit is optimized for low sensor voltages and contains a microprocessor. The microprocessor contains an integrated analog-to-digital converter with an input pin. The integrated analog-to-digital converter is configured to rely on a reference voltage of no more than 2 volts. The detection circuit also has a transformation circuit for transforming a sensor signal, the transformation circuit being connected to the input pin of the integrated analog-to-digital converter. The transformation circuit contains an impedance converter and with the exception of the impedance converter relies only on passive electric elements.

Abstract: A versatile detection circuit is optimized for low sensor voltages and contains a microprocessor. The microprocessor contains an integrated analog-to-digital converter with an input pin. The integrated analog-to-digital converter is configured to rely on a reference voltage of no more than 2 volts. The detection circuit also has a transformation circuit for transforming a sensor signal, the transformation circuit being connected to the input pin of the integrated analog-to-digital converter. The transformation circuit contains an impedance converter and with the exception of the impedance converter relies only on passive electric elements.

Abstract: A spring element that includes a spring body that is at least chiefly formed from an elastomer, wherein at least one reinforcement fibre is embedded into the elastomer. The at least one reinforcement fibre has an arcuate course in a non-loaded condition of the spring element, so that the spring element has a non-linear spring characteristic.

Abstract: A pneumatic compression garment includes a flexible member for placement on a limb of a human body. A bladder in the flexible member defines an inflatable chamber. The bladder has an opening through which the inflatable chamber is inflated. A port mounted on the bladder has an air inlet adapted for communication with a source of pressurized air and an air outlet in communication with the inflatable chamber via the opening in the bladder. Pressurized air is delivered from into the inflatable chamber for inflating the inflatable chamber and thereby applying a compression force to the limb when the flexible member is in place on the limb. An air diverter affixed to an inside surface of a first sheet of the bladder and configured to divert air entering the inflatable chamber from directly impinging against an inside surface of a second sheet of the bladder.

Abstract: Wheel hub and method for forming a wheel hub. Wheel hub includes a rim having a circumferential surface with axial ends, and one rim flange being arranged at each axial end of the circumferential surface. The rim includes a fiber-reinforced plastic as a main component and each of the rim flanges is releasably connectable to the rim.

Abstract: A distributed remote sensing system including a group of gateways and a sensing device group associated with each gateway in the group of gateways wherein the sensing device group associated with one gateway is different than another sensing device group associated with a different gateway.

Abstract: A distributed remote sensing system including at least one gateway, at least one sensing device and a communication interface providing radio frequency communication through a shared frequency scheme between each sensing device and one of the at least one gateway and between each sensing device and another of the at least one gateway through a different frequency scheme.

Abstract: A vehicle detection sensor apparatus including a frame and a dual mode sensor connected to the frame, the dual mode sensor having an active and a passive sensing mode wherein at least one of the active and passive sensing mode is automatically cycled between on and off states when providing a positive reading condition.

Abstract: A mineral insulated heating cable for a heat tracing system. The heating cable includes a sheath having at least a first, and optionally a second layer, wherein the thermal conductivity of the second layer is greater than a thermal conductivity of the first layer. In addition, the first and second layers are in intimate thermal contact. The heating cable also includes a least one heating conductor for generating heat and a dielectric layer located within the sheath for electrically insulating the heating, conductor, wherein the sheath, heating conductor and dielectric layer form a heating section. In addition, the heating cable includes a conduit for receiving the heating section. Further, the heating cable includes a cold lead section and a hot-cold joint for connecting the heating and cold lead sections. In addition, a high emissivity coating may be formed on the first layer.

Abstract: A pneumatic compression garment comprises a flexible member for placement on a limb of a human body. A bladder in the flexible member defines an inflatable chamber. The bladder has an opening through which the inflatable chamber is inflated. A port mounted on the bladder has an air inlet adapted for communication with a source of pressurized air and an air outlet in communication with the inflatable chamber via the opening in the bladder. Pressurized air is delivered from into the inflatable chamber for inflating the inflatable chamber and thereby applying a compression force to the limb when the flexible member is in place on the limb. Noise attenuating means associated with the bladder opening is provided for reducing noise from air flow through the opening into the inflatable chamber.

Abstract: A pneumatic compression garment comprises a flexible member for placement on a limb of a human body. A bladder in the flexible member defines an inflatable chamber. The bladder has an opening through which the inflatable chamber is inflated. A port mounted on the bladder has an air inlet adapted for communication with a source of pressurized air and an air outlet in communication with the inflatable chamber via the opening in the bladder. Pressurized air is delivered from into the inflatable chamber for inflating the inflatable chamber and thereby applying a compression force to the limb when the flexible member is in place on the limb. Noise attenuating means associated with the bladder opening is provided for reducing noise from air flow through the opening into the inflatable chamber.

Abstract: A heat tracing device has one or more heating elements positioned adjacent to a heatable surface, an aerogel high temperature insulation layer adjacent to the one or more heating elements, a low temperature insulation layer adjacent to the aerogel high temperature insulation layer and a locking mechanism effective to fix the position of the low temperature insulation layer to the aerogel high temperature insulation layer.

Abstract: A bowling pin storage bin assembly for use as part of a bowling pin delivery system of a pinspotter apparatus, as well as a method of manufacturing such bin. The storage bin is molded as a one-piece article having a plurality of cavities or pockets for storing bowling pins in an essentially horizontal plane above a pin spotter and for delivering the pins to a plurality of pin cups or a pin spotter for spotting on a pin deck.

Abstract: A heat tracing device has one or more heating elements positioned adjacent to a heatable surface, an aerogel high temperature insulation layer adjacent to the one or more heating elements, a low temperature insulation layer adjacent to the aerogel high temperature insulation layer and a locking mechanism effective to fix the position of the low temperature insulation layer to the aerogel high temperature insulation layer.

Abstract: The invention relates to combinations of (a) an epothilone with (b) two or more other antineoplastic agents for simultaneous, separate or sequential use, in particular for the delay of progression or treatment of a proliferative disease.