Abstract: The present invention provides a compound of formula (I): or a pharmaceutically acceptable salt thereof wherein the variables R1, R2, R3a, R3b, R3b, R3d, and R100 are as defined herein. The invention is also directed to pharmaceutical compositions comprising the compounds of formula (I) and methods of treating a 5-HT2c receptor-mediated disorders with a compound of formula (I) or a pharmaceutical composition comprising a compound of formula (I).

Abstract: The invention relates to materials and methods for evaluating the prognosis of a patient presenting with chronic myelogenous leukaemia (CLL) and for CLL therapy.

Abstract: The disclosure relates to pre-moistened webs and wipes having visible compressed sites that provide the perception of a cloth-like texture. The disclosure also relates to a nonwoven web made of non-thermoplastic fibers with at least one compressed site on the surface of the web that remains visible when the web is pre-moistened.

Abstract: A process for preparing a molded, textured, spunlaced, nonwoven web is provided and wipes made therefrom. Also provided is an apparatus for making molded, textured, spunlaced, nonwoven web. Molded, textured, spunlaced, nonwoven webs prepared by the inventive process and apparatus are also provided. Also provided is a molded, textured, spunlaced, nonwoven web.

Abstract: Processes for making fibrous structures and more particularly processes for making fibrous structures comprising filaments are provided.

Abstract: The nonwoven web 10 of the present invention is a layered structure that takes advantage of the beneficial properties of different types of fibers advantageously distributed in each layer. In particular, the present invention is a multi-layer nonwoven web suitable for use as a wet wipe, the web having a first fibrous outer layer comprising from about 10% to about 60% conjugate fiber, from about 10% to about 90% cellulosic fibers, a fibrous inner layer bonded at discrete bond sites to the first outer layer in a face to face relationship comprising from about 10% to about 60% conjugate fiber, and from about 10% to about 65% cellulosic fibers. A second fibrous outer layer, which can be the same composition as the first outer layer, is bonded at discrete bond sites to the inner layer in a face to face relationship. A method for forming the web of the present invention is also disclosed.

Abstract: A plurality of textured wipes is stored in a dispenser having an orifice in a configuration such that when a wipe is pulled through the orifice, a dispensing force is applied to the wipe. The dispensing force is chosen such that the wipes increase in thickness from about 15% to about 200% during dispensing without losing their structural integrity such as via ripping, tearing, delaminating and the like. During dispensing, a visual signal of the thickening of a wipe is provided.

Abstract: The nonwoven web 10 of the present invention is a layered structure that takes advantage of the beneficial properties of different types of fibers advantageously distributed in each layer. In particular, the present invention is a multi-layer nonwoven web suitable for use as a wet wipe, the web having a first fibrous outer layer comprising from about 10% to about 60% conjugate fiber, from about 10% to about 90% cellulosic fibers, a fibrous inner layer bonded at discrete bond sites to the first outer layer in a face to face relationship comprising from about 10% to about 60% conjugate fiber, and from about 10% to about 65% cellulosic fibers. A second fibrous outer layer, which can be the same composition as the first outer layer, is bonded at discrete bond sites to the inner layer in a face to face relationship. A method for forming the web of the present invention is also disclosed.

Abstract: In certain embodiments, a hybrid radio frequency identification (RFID) tag includes circuitry, a battery, and a first antenna. The circuitry includes one or more passive RFID elements and one or more semi-active RFID elements operable to transmit and receive communications to and from one or more RFID tag tracking systems. The battery is coupled to the one or more semi-active elements. The first antenna is coupled to the passive RFID elements and to the semi-active RFID elements, the first antenna comprising a shape that defines a first open area and a second open area. The circuitry is positioned within one of the first and second open areas defined by the shape of the first antenna, and the battery is positioned within the other of the first and second open areas defined by the shape of the first antenna.

Abstract: The invention relates to materials and methods for evaluating the prognosis of a patient presenting with chronic myelogenous leukaemia (CLL) and for CLL therapy.

Abstract: Stacks of pre-moistened wipes wherein the wipes comprise a composite of at least two layers of fibrous nonwoven webs, which in turn comprise fibers with an average fiber denier from about 2.5 to about 6.0. The stacks of pre-moistened wipes are from about 50 to about 300 millimeters in height and have a saturation gradient index from about 1.0 to about 1.5.

Abstract: The invention relates to aminopyrimidine compounds useful for treating diseases mediated by polo-like kinase 1 (Plk1). The invention also relates to the therapeutic use of such aminopyrimidine compounds and compositions thereof in treating disease states associated with abnormal cell growth and unwanted cell proliferation.

Abstract: The present invention provides a method for determining the carrier that should be used for a particular AIN call. The following information is derived for each call: the originating calling party number, the terminating called party number, the originating LATA, the terminating LATA. Using these components, pre-defined tables are accessed that contain local calling plan information. These tables contain rate center and dial plan information that provides the local calling scope that is available to the originator of the call. Based on the information contained in the tables, the appropriate type of carrier for the call is selected and the call is routed using this carrier.

Abstract: The disclosure is directed to an improved deep needle driver for use when working on patients having significant tissue thicknesses, where conventional instruments are too short or do not provide suitable maneuverability within deep tissue. The driver includes a pair arms bent at two positions, where the arms are pivotally joined to form a movable jaw.

Abstract: Nonwoven substrates suitable for use as wet wipes are disclosed. The nonwoven substrates comprise at least one first region and at least one second region. The second region comprises reinforced protruding elements. In a preferred embodiment, the second region of the nonwoven substrate is reinforced by means of thermal bonding during the creation of the protruding elements of the second region. A liquid can be added to the nonwoven substrate prior to packaging or prior to use to make wet wipes. The reinforced second regions of the nonwoven substrates of the present invention make it possible to retain thickness of the wipe when wet without increasing the dry basis.

Abstract: A process for preparing a molded, textured, spunlaced, nonwoven web is provided and wipes made therefrom. Also provided is an apparatus for making molded, textured, spunlaced, nonwoven web. Molded, textured, spunlaced, nonwoven webs prepared by the inventive process and apparatus are also provided. Also provided is a molded, textured, spunlaced, nonwoven web.

Abstract: A method and apparatus for providing customers with telecommunications intelligence in the form of call management reports. When a call is made to a subscriber of the service provided herein, a call detail record is created using the Telephone Company's Advanced Intelligent Network (AIN). Each call that is made to the customer is processed using AIN service logic programs (SLPs). The SLP is invoked by an AIN trigger that is applied to the track telephone number(s) of the customers that subscribe to this service. For each inbound call, the SLP records several pieces of identifying information in a call detail record. Periodically, the AIN application accumulates the call detail records for all customers subscribing to the service. The information is processed to retrieve the desired data from the call detail records, and the data retrieved is used to develop call management reports for each subscriber of the service.

Abstract: A frequency synthesiser (50) comprising input means for receiving a reference frequency (FreF) and output means for providing a desired output frequency (fo). The synthesiser comprises further means (58) for dividing the desired output frequency by a plurality of divider values. The division is accomplished based on pre-generated control data for controlling the dividing of the desired output frequency by the divider values in accordance with the desired output frequency. The control data is stored in memory means (62) of the synthesiser.

Abstract: A device and a method for producing a batch of products having a multiplicity of interfolded, generally rectangular sheets including wet wipes, from a limited amount of a web material, at a high production speed and in efficiently used floor space.

Abstract: A method for producing a batch of products having a multiplicity of interfolded, generally rectangular sheets including wet wipes, from a limited amount of a web material, at a high production speed and in efficiently used floor space.