Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.

Abstract: The present invention is directed to novel calicheamicin derivatives useful as payloads in antibody-drug-conjugates (ADC's), and to payload-linker compounds and ADC compounds comprising the same; to pharmaceutical compositions comprising the same and to methods for using the same to treat pathological conditions such as cancer.

Abstract: A fluid dispenser includes a reservoir for storing a fluid, an outlet port connected with the reservoir by a dispense passage for dispensing fluid stored in the reservoir, an external supply port connected with the reservoir by a supply passage to supply fluid to the reservoir, a supply access valve defining a portion of the supply passage between the external supply port and the reservoir, and a controller in circuit communication with the supply access valve for controller operation of the supply access valve from a closed position to an open position in response to receipt of an authorized supply signal at the controller.

Abstract: Disclosed are methods of antimicrobial treatment using ionic liquids (ILs), IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds. Also disclosed are novel IL complexes, polymers comprising ILs, and polymers comprising neutral ethylene diamine compounds.

Abstract: The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.

Abstract: An apparatus configured to couple to an electrical penetration assembly is disclosed in which the apparatus comprises a connector comprising an inorganic seal to seal an inorganic flange and/or housing to an electrical penetration assembly.

Abstract: A counter mountable fluid dispenser includes a below deck assembly and an above deck assembly. The below deck assembly includes a reservoir for storing a fluid, a dispensing mechanism in fluid communication with the reservoir, and a controller in circuit communication with the dispensing mechanism for operation of the dispensing mechanism. The above deck assembly includes a spout defining an outlet port in fluid communication with the reservoir for dispensing fluid stored in the reservoir upon operation of the dispensing mechanism, an external supply port in fluid communication with the reservoir by a supply passage to supply fluid to the reservoir, an access door movable between a closed position blocking access to the external supply port and an open position permitting access to the external supply port, and a switch mechanism configured to disable the dispensing mechanism when the access door is in the open position.

Abstract: A system for interconnecting electronic boards, which is intended to be incorporated into a computer cabinet, and a computer cabinet including such a system, to be used for interconnecting electronic boards in computer cabinets placed particularly in data centres or computer rooms, where the system has a front wall and a rear wall each having an external face and an internal face, the external face of the front wall including at least one front connection intended to allow the connection of an electronic board, the front connection being linked to one or more front connection cables on the side of the internal face of the front wall, where the front and rear walls can be temporarily rigidly connected via the respective internal faces thereof by a fixing means, such as to form a casing inside which the connection cables are placed.

Abstract: The invention provides an article of adjustable furniture (10), preferably an adjustable chair or bed, comprising a floor standing base section (16), adjustable seat (18), backrest (20) and headrest (130) sections and actuator means (100) for moving the backrest and headrest sections. The seat section is movably mounted with respect to the base section. The backrest is movably mounted with respect to the seat section and the headrest is movably mounted with respect to the backrest section. The actuator means includes a single actuator (102) for co-ordinated movement of the adjustable backrest and headrest sections for selectively altering the configuration of the article of furniture. The actuator has a first range of movement for moving the headrest with respect to the backrest, and a second range of movement for moving the backrest with respect to the seat section to provide a recliner function.

Abstract: A feed beam, a rock drilling unit and to a method of manufacturing a feed beam is provided. The feed beam includes a basic profile element, which has two or more superimposed material layers. At least one of the material layers may be made of a composite material.

Abstract: Disclosed are capacitors containing surface active ionic liquids, and methods of use. The capacitors have high capacitance and function over broad ranges of temperature, and are particularly appropriate for high-temperature (˜200° C.) applications.

Abstract: An adjustable bed (10) includes a frame (20) and an adjustable mattress support platform having a plurality of articulated mattress support sections (12-18) pivotally mounted for relative angular adjustment with respect to the frame. The mattress support sections including at least one adjustable backrest support section (12) and at least one adjustable mattress bend support section (13) adjacent to the backrest section, actuator means (40) for effecting co-ordinated pivotal movement of the adjustable mattress support sections for reconfiguring the bed between a flat lowered configuration and a raised configuration for supporting an occupant in flat or raised positions.

Abstract: The present invention generally relates to methods and systems for capturing a Lewis acid gas (e.g., CO2). In some embodiments, the methods and systems utilize an ionic liquid incorporated into one or more electrochemical cells.

Abstract: An apparatus includes a first cable clamp and a first apparatus section coupled to the first cable clamp. The apparatus includes a second cable clamp and a second apparatus section coupled to the second cable clamp. The second apparatus section is slidably coupled to the second apparatus section. The apparatus includes a first measuring device portion coupled to the first apparatus section, a second measuring device portion coupled to the second apparatus section, wherein the first measuring device portion and the second measuring device portion are in at least one of mechanical, optical, and electromagnetic communication.

Abstract: An article of footwear includes an injection molded outsole of a first material having a durometer reading of at least 28 to at most 38 on the Asker C scale, an injection molded insole of a second material having a durometer reading of at least 28 to at most 38 on the Asker C scale, and an upper, at least a section of a peripheral edge of the upper being sandwiched between the insole and the outsole.

Abstract: Material preparation devices and related methods include a material or substrate assembly and an application assembly for applying a fiber material.

Abstract: Systems, methods and devices are provided for registering DNS hostnames of Internet host devices for very large domain zones (VLZ) stored on a DNS server on a network, including setting a pseudo-zone as the VLZ, intercepting DNS updates to the pseudo-zone, mapping the entries in the pseudo-zone into a hierarchy of real parent zones and sub-zones using a mapping formula, and translating DNS updates to the pseudo-zone from an original fully qualified domain name (FQDN) into a at least one new FQDNs and adding the at least one new FQDNs to an authoritative DNS Server.

Abstract: A product dispenser includes a housing adapted to receive a refill unit having a product reservoir. A multidirectional pushbar is carried by the housing and movable in a plurality of directions to actuate the pump. The multidirectional pushbar may be carried by a collar pivotally secured around a pushbar support member in the shape of a spherical zone. Pivoting movement of the multidirectional pushbar is converted into an actuating force by a transfer mechanism, which may include a vertically movable carriage. In other embodiments, the multidirectional pushbar may include ramped surfaces and may support a carriage having rolling elements. Lateral movement of the multidirectional pushbar causes the carriage to roll up the ramped surfaces and actuate a pump to dispense a product.

Abstract: A counter mountable fluid dispenser includes a below deck assembly and an above deck assembly. The below deck assembly includes a reservoir for storing a fluid, a dispensing mechanism in fluid communication with the reservoir, and a controller in circuit communication with the dispensing mechanism for operation of the dispensing mechanism. The above deck assembly includes a spout defining an outlet port in fluid communication with the reservoir for dispensing fluid stored in the reservoir upon operation of the dispensing mechanism, an external supply port in fluid communication with the reservoir by a supply passage to supply fluid to the reservoir, an access door movable between a closed position blocking access to the external supply port and an open position permitting access to the external supply port, and a switch mechanism configured to disable the dispensing mechanism when the access door is in the open position.

Abstract: Provided is a flexible and conformal wearable, self-contained medical device. The medical device comprises an integral housing formed by a flexible upper portion and a flexible lower portion joined along their perimeters. The medical device is also provided in a plurality of shapes and configurations for increasing the flexibility and conformability of the housing. The components contained within the housing, such as a drug reservoir, printed circuit board, and power supply are preferably constructed from flexible materials and are formed, connected and positioned according to the configuration of the housing in a manner for enhancing flexibility of the housing. A thermal bubble micropump is provided for controlling flow of a drug from the flexible reservoir, that utilizes a thermal resistor provided locally to a thermal expansion fluid that causes a surrounding membrane to expand and displace a volume of drug to be provided to the user.